Western herbal medicine – Herbal Reality https://www.herbalreality.com The voice of herbal medicine Sat, 18 Apr 2026 11:10:11 +0000 en-GB hourly 1 https://wordpress.org/?v=6.8.5 https://i.herbalreality.com/wp-content/uploads/2025/04/17134732/favicon-96x96-1.png Western herbal medicine – Herbal Reality https://www.herbalreality.com 32 32 Making sense of herbal dosing: How much is enough? https://www.herbalreality.com/herbalism/western-herbal-medicine/making-sense-of-herbal-dosing-how-much-is-enough/ Fri, 20 Mar 2026 12:01:28 +0000 https://www.herbalreality.com/?p=322666 Dosing herbal medicine requires navigating plant variability, preparation methods and individual response.

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Making Sense Of Herbal Dosing How Much Is Enough

Dosing herbal medicine requires navigating plant variability, preparation methods and individual response, blending traditional insight with modern safety and clinical awareness.

No two leaves are identical. Their size, shape, appearance, and chemical profile differ as a result of natural variability. In much the same way, no two people are the same, nor is a body perfectly symmetrical. For herbal medicines, this poses challenges to unify and standardise dosing. 

One of the most common questions asked about herbal medicines is “how much should I take?”. Herbal dosing sits at the intersection of traditional knowledge, experience, pharmacology and individual variability.

Unlike conventional pharmaceuticals, where formulations and doses are standardised, herbal medicine works with complex plant matrices, diverse preparations and considers individual characteristics and constitutions.

Historically, herbal dosing was developed through empirical trial, observation, experience and long-term use. Effective doses, preferred formulations and the knowledge of optimal remedies was passed through the generations (1).

Traditional texts often describe dosing in experiential terms, such as a glass or handful, or an amount tolerated. While these measures may appear imprecise from a modern or conventional perspective, they reflect a responsive approach to medicine — trial and error.

Doses were often adjusted according to the strength of the herb and individual’s response over time. Sometimes doses may have to be adjusted according to the strength and purity of a batch of herbs, as differences in harvesting, drying, storage and processing can impact the strength of the actives. The importance of feedback and adjustment of doses was a valuable part of traditional practice (2).

Plant and formulation factors 

The characteristics of the herb itself must be considered when determining an appropriate dose. Herbs differ widely in their strength, safety profile and therapeutic range; these differences directly inform how they should be used (3). Nutritive herbs such as nettle (Urtica dioica) or dandelion (Taraxacum officinale) are rich in minerals and phytochemicals which are often used in generous doses over extended periods of time for their vast medicinal benefits ranging from anti-inflammatory to blood tonic effects (4,5).

Lily of the valley (Convallaria majalis)
Lily of the valley (Convallaria majalis)

In contrast, aromatic and bitter herbs tend to act more immediately on digestion, circulation and the nervous system and may produce noticeable effects at relatively small doses. For example, peppermint (Mentha x piperita, M. arvensis) stimulates taste receptors and digestive reflexes; even modest amounts can have carminative effects and stimulate gut motility (6).

Similarly, aromatic nervines such as lavender (Lavandula angustifolia) or lemon balm (Melissa officinalis) can have calming effects at relatively low doses (7). Some herbs have a narrow safety profile therefore require great precision and clinical judgement when dosing. Lily of the valley (Convallaria majalis) a cardiotonic can be highly toxic even in small over-doses (8). Hence, careful dosing, appropriate training and awareness of contraindications is so important.

Today, for most people dosing from raw or unprocessed material may be confusing. Telling someone to take a pinch of a powdered herb can lead to significant dosing variability, as a pinch can range on average from 0.3 g to 0.6 g. This variability could lead to double the dose which could have adverse effects rather than a therapeutic benefit. Therefore, quantifying a pinch as a definitive value (e.g., “a pinch is 0.3 g”) makes dosing reproducible, and standardises the process.

When using leaves in preparations (i.e. add two leaves) this can also have inconsistent dosing effects. The variable size, condition and stage of maturity of the leaf can also impact the efficacy of dosing. Furthermore, dried and fresh material will have different effects; dried material may be more concentrated, and the composition of bioactive compounds may have changed (i.e., essential oils may evaporate during drying). All these factors can impact the effective dosing of herbals (2,9,10,11).

Even among commonly used herbs, factors such as duration of use, interactions and individual sensitivity must be considered. For these reasons, effective dosing relies on familiarity with both traditional dosages and contemporary safety data, allowing herbs to be used confidently and appropriately.

Individual factors 

Determining an appropriate dose always begins with the person. Age, gender, body composition, digestive capacity, liver and kidney function, comorbidities and individual sensitivity all influence how someone may respond. A healthy adult with good digestion may require and safely tolerate a higher therapeutic dose to achieve a clinical effect.

In contrast, an older or frail adult, a child, or someone with comorbidities may only tolerate lower doses and respond better when doses are gradually introduced and increased. Response to doses also varies depending on individuals’ experiences as some people may respond to very small doses, particularly with aromatic, bitter or nervine herbs; while others can tolerate larger doses before any clinical response is seen.

Effective dosing, therefore, relies not on standardised quantities alone, but on careful assessment of the individual’s capacity to receive, process and respond to herbal medicines (12).

The nature of the condition being treated is equally important when determining dose. Acute and relatively minor health conditions often respond best to higher or more frequent dosing over a short period of time, with the aim of supporting the body through a transient physiological challenge.

Echinacea (Echinacea purpurea)
Echinacea (Echinacea purpurea)

For example, in the early stages of an upper respiratory tract infection (i.e., cold/flu), herbs such as elderberry (Sambucus nigra) or echinacea (Echinacea purpurea) may be taken as tinctures or infusions regularly to support immune and inflammatory responses, soothing symptoms and reducing recovery time.

Acute musculoskeletal pain (i.e., sprain/strain or minor injury) may respond well to short-term internal use of anti-inflammatory herbs such as turmeric (Curcuma longa) alongside topical applications of arnica (Arnica montana) or rosemary (Salvia rosmarinus) (7,12).

On the other hand, chronic conditions usually require low to moderate doses taken consistently over a longer period. Chronic digestive disorders, hormonal imbalances or stress-related conditions often respond better to sustained doses that work gradually with underlying physiological patterns rather than attempting rapid relief of symptoms.

The use of ashwagandha (Withania somnifera) for reducing stress and anxiety can take up-to two weeks before a clinical effect is observed, as the adaptogen regulates cortisol and other hormones (13). When managing on-going or chronic conditions high doses may be poorly tolerated and unnecessary, therefore a “low and slow approach” would allow for cumulative effects and monitoring to take place (14).

Most conventional pharmaceutical medicines have standard formula and doses. There is a comprehensive pharmacopeia which makes production scalable and reproducible. Aspirin is an example of a synthetic medicine (originally isolated from willow (Salix alba)) whereby a single active compound (acetylsalicylic acid) was identified, and chemically synthesised (15).

The Art & Science of Herbal Formulation: Western Herbal Medicine

The therapeutic effects are evidence based with randomised controlled trials (RCTs) to validate the efficacy. For most herbal medicines, there is often not a single isolated compound responsible for the therapeutic effects. Instead, herbal medicines are a complex mixture with many active constituents.

The mixture of compounds are known to work synergistically to have a therapeutic effect; hence, isolating a single compound would not be as therapeutically beneficial (16). For this reason, dosing is rarely about achieving a precise milligram quantity of one active ingredient. Instead, it involves establishing an effective therapeutic relationship between the plant, the preparation and the person taking it.

Finally, the form of preparation has a significant impact on dosing. Teas and decoctions favour water-soluble constituents and are often taken in larger volumes. Powders and capsules rely on digestion and absorption and may therefore require higher quantities to achieve an effect.

Tinctures are more concentrated and allow for flexible, incremental dosing. Herbal dosing tends to operate within broader therapeutic ranges than pharmaceutical drugs, allowing for a greater degree of flexibility and individualisation. The dose is shaped not only by pharmacology, but also by constitution, strength, sensitivity and condition treated (11).

Dosing Of Herbs And Herbal Medicines

In practice, standardising dosing of herbals is best approached using clearly defined therapeutic ranges rather than fixed doses. Replacing ambiguity in dosing by eyeballing, using a cupful or a few drops/leaves, by standard measures such as volumes for liquids (i.e., millilitre for tinctures) and weights for solids (i.e., gram for dried herbs), can improve dosing. Where reputable suppliers have preparations available with clear strength and doses these may be a preferred option to use. 

It is important to regularly review an individual’s response to herbals, and educate them of the signs of efficacy, intolerance and adverse effects so that dosing can be refined over time. One of the strengths of herbal medicine is that it is responsive. Signs that a dose may be too low include a lack of change to symptoms, after an appropriate trial period, or progress which prematurely stalls.

On the other hand, signs that a dose may be too high may include digestive discomfort, headache, nausea or exacerbation of symptoms. Hence, herbal dosing is a dynamic process. Ongoing observation, communication with practitioners and adjustments are integral to safe and effective herbal practice (17).

There is no single answer to the question of how much is enough when it comes to herbal dosing. Effective dosing emerges from the relationship between plant, preparation and individuals, informed by knowledge, use and experience of the person and practitioners.

  1. Bhamra SK, Slater A, Howard C, Heinrich M, Johnson MRD. Health care professionals’ personal and professional views of herbal medicines in the United Kingdom. Phytotherapy Research. 2019;33(9):2360-2368. https://doi.org/10.1002/ptr.6418 
  2. Kofi Busia. Herbal medicine dosage standardisation. Journal of herbal medicine. 2024;46:100889-100889. https://doi.org/10.1016/j.hermed.2024.100889 
  3. Jürges G, Sahi V, Rios Rodriguez D, et al. Product authenticity versus globalisation—The Tulsi case. Aravanopoulos FA, ed. PLOS ONE. 2018;13(11):e0207763. https://doi.org/10.1371/journal.pone.0207763 
  4. Devkota HP, Paudel KR, Khanal S, et al. Stinging Nettle (Urtica dioica L.): Nutritional Composition, Bioactive Compounds, and Food Functional Properties. Molecules. 2022;27(16):5219. https://doi.org/10.3390/molecules27165219 
  5. Kania-Dobrowolska M, Baraniak J. Dandelion (Taraxacum officinale L.) as a Source of Biologically Active Compounds Supporting the Therapy of Co-Existing Diseases in Metabolic Syndrome. Foods. 2022;11(18):2858. https://doi.org/10.3390/foods11182858 
  6. Hirata M, Fornari Laurindo L, Dogani Rodrigues V, et al. Investigating the Health Potential of Mentha Species Against Gastrointestinal Disorders—A Systematic Review of Clinical Evidence. Pharmaceuticals. 2025;18(5):693. https://doi.org/10.3390/ph18050693 
  7. Chevallier A. Herbal Remedies. DK Pub.; 2007.
  8. Currie GM, Wheat JM, Kiat H. Pharmacokinetic Considerations for Digoxin in Older People. The Open Cardiovascular Medicine Journal. 2011;5(1):130-135. https://doi.org/10.2174/1874192401105010130 
  9. Nakra S, Tripathy S, Srivastav PP. Drying as a preservation strategy for medicinal plants: Physicochemical and functional outcomes for food and human health. Phytomedicine Plus. 2025;5(2):100762. https://doi.org/10.1016/j.phyplu.2025.100762 
  10. Bhamra SK. Investigating the Use and Identity of Traditional Herbal Remedies amongst South Asian Communities Using Surveys and Biomolecular Techniques. Published thesis (PhD). 2016.
  11. Wilde M. Doses and Measures. Napiers. Published August 3, 2021. Accessed January 14, 2026. https://napiers.net/blogs/news/doses-and-measures 
  12. Tyson RJ, Park CC, Powell JR, et al. Precision Dosing Priority Criteria: Drug, Disease, and Patient Population Variables. Frontiers in Pharmacology. 2020;11. https://doi.org/10.3389/fphar.2020.00420 
  13. Fuladi S, Emami SA, Mohammadpour AH, Karimani A, Manteghi AA, Sahebkar A. Assessment of Withania somnifera root extract efficacy in patients with generalized anxiety disorder: A randomized double-blind placebo-controlled trial. Current Clinical Pharmacology. 2020;15. https://doi.org/10.2174/1574884715666200413120413 
  14. Frost R, Bhamra SK, Heinrich M. Herbal Products and Antidepressants: A Safe Combination or a Risky Mix? Phytotherapy Research. Published online January 13, 2026. https://doi.org/10.1002/ptr.70173 
  15. Mahdi JG, Mahdi AJ, Mahdi AJ, Bowen ID. The Historical Analysis of Aspirin discovery, Its Relation to the Willow Tree and Antiproliferative and Anticancer Potential. Cell Proliferation. 2006;39(2):147-155. https://doi.org/10.1111/j.1365-2184.2006.00377.x 
  16. Efferth T, Koch E. Complex Interactions between Phytochemicals. The Multi-Target Therapeutic Concept of Phytotherapy. Current Drug Targets. 2011;12(1):122-132. https://doi.org/10.2174/138945011793591626 
  17. Bhamra SK. The revival of herbal medicines. Prescriber. 2024;35(6):13-16. https://doi.org/10.1002/psb.2157 

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5 herbs to enhance your mood in winter https://www.herbalreality.com/herbalism/western-herbal-medicine/five-herbs-enhance-mood-winter/ https://www.herbalreality.com/herbalism/western-herbal-medicine/five-herbs-enhance-mood-winter/#comments Mon, 19 Jan 2026 14:16:21 +0000 https://www.herbalreality.com/?p=3683 These five herbs bring the comforting qualities of nature inside us helping lift our spirits in the dark winter months.

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These five herbs call on the comforting qualities of nature to support mood and lift the spirits during  the dark winter months.

The depths of winter can be a challenging period for many, the lack of sunlight and reduced daylight hours can have a detrimental impact on the mental health and mood of a large proportion of the population. Prescriptions for antidepressants are on the rise, with a notable peak identified during the winter months, and lower rates during the summer (1). There are those diagnosed with clinical depression, for which medication is essential, however antidepressants are increasingly being prescribed for those who are experiencing periods of low mood or stress (2).

Where low mood and melancholia has not reached the status of clinical depression, there are remedies derived from nature which offer natural approaches to lifting the spirits. In observing the cyclical patterns of nature, we can be afforded some comfort in the knowledge that as humans, we are a part of this cycle and feeling the need for rest and a turning inwards is a reflection of this rhythm.  At the very darkest, coldest, lifeless part of the year when many animals hibernate and are in a state of metabolic depression, studies have demonstrated neurobiological similarities to clinical depression, including changes in cortisol, neurotransmitters, metabolism and other biomarkers (3). Occurring at the same time, seeds and rootstocks are also at their most potent, conserving energy to use later for spring growth (4). 

Hibernating animals rest in the awareness that they will emerge with the next turn of the seasons. For many centuries humans have adapted to the cold, quiet darkness with a shared instinct to foster joy, connection and ritual such as the northern hemisphere midwinter festivals, Christmas, the Roman Saturnalia, Jewish Hannukah, Slavic Koliada, pagan Yule, Persian Yalda, or Asian Dongzhi, are all a call for celebration and community. Earlier in the season the Hindu festival Diwali symbolizes the victory of light over darkness and good over evil. Often the best way to beat the winter blues is in accepting the inherent cyclical nature of the world, and that  darkness has its role in the cycle as the precursor of light and life.

Being able to get out for a walk in nature, taking a moment to observe and be present with the plants, can be enormously enriching and mood enhancing, offering a subtle but profound healing opportunity. Nature can also be brought into the home— in Japan, small gardens are often found on doorsteps, balconies and small corners, bringing life to dense  urban landscapes. Tending a garden, even in pots, is a great source of serenity. The act of walking can also be significant as exercise is an efficient and rapid way to stimulate neurotransmitters including serotonin and dopamine which are responsible for uplifting mood  (5). 

In respecting the cycle of the seasons one is also in connection with the natural instinct to sleep and eat more. In Ayurveda winter is known as kapha time, time to build resources for the hungry gap in spring, when historically people would have worked hard to get the crops in and be left with limited food supplies. A gentle increase in body weight during winter is a normal physiological response to reduced activity, daylight and hormonal shifts, this often reverses itself in spring (6). Similarly, the need for extra sleep and change is impacted by lower light and colder temperatures (7).  

The following plants bring some of the comforting qualities of nature to support the body and mind during the winter period. Each is a powerful tool for lifting the spirits. The best approach is to get to know each herb as an individual first. Ideally, make a single preparation, perhaps a cup of strong tea or decoction, and build up towards a higher dose, the maximum from the range provided below. Taken in this form, at robust levels, benefits can be rapidly felt  and it is soon possible to work out which is most helpful. They can be experimented with to discover which ones resonate best with the body’s constitution. 

These herbs are not antidepressants in the conventional sense. Instead, in different ways they strengthen the constitution, offer a sense of calm and an ability to cope better, whilst also reducing inflammatory pressures on the brain.St John’s wort, widely thought of as a herbal antidepressant, is traditionally used as a tonic specific for the winter months to help bring in the light, offering a feeling of resilience (8). 

For more in depth information on these herbs, please see our herbal monographs. 

Brahmi (Bacopa monnieri)
Brahmi (Bacopa monnieri)

Brahmi (Bacopa monnieri)

A classic Ayurvedic brain tonic, and saponin-rich adaptogen, Brahmi appears to work in a number of ways to protect brain cells and improve cognitive functions, especially when these are challenged by long-term stresses, illnesses and ageing (9). It has been used to help recover from chronic fatigue and associated low energies. Brahmi is also calming and helps directly in anxiety and tension conditions, and in helping cope with stress (9,10).

The recommended dose is 2–6 grams of the dried leaf per day, either as  tea or, as popularly taken in India, several teaspoons of the fresh leaf juice (9). Dosages are meant as a guideline only, and it is recommended to consult a medical herbalist for safety considerations. 

Cinnamon (Cinnamomum verum)

This common spice offers an organoleptic treat, with good quality cinnamon stimulating the taste buds and warming the body. Cinnamon is particularly useful in facilitating recovery from illness or chronic fatigue, and especially for those who are particularly prone to feeling the cold (8) It helps restore a healthy appetite and reduce digestive problems such as sluggish digestion that can be associated with being run down. To increase the heating quality and stimulate more warmth, combine it with fresh ginger (Zingiber officinale) in a tea. Cinnamon can be combined with any of the other herbs on this list as a stimulating, warming remedy (9). 

Take a teaspoonful of freshly powdered cinnamon (Ceylon cinnamon has the most complex flavour profile), add 50 ml of boiling water, stir and steep for 5–10 minutes and sip. Feel the mix of spicy and sweet tones reverberating at the back of the mouth, with a slightly woody quality, followed by a warmth emanating from the chest chest. A slight bitterness can be experienced afterwards, with a profound sense of warmth moving throughout the entire body. 

The suggested dose of cinnamon powder is up to 8 grams per day (9).

Gotu kola (Centella asiatica)

This popular traditional Asia restorative tonic is revered in Asia for ‘opening the mind’, sometimes accompanying meditative practices as a tea. Taken in this way, gotu kola offers an initial bitter flavour, followed by an  aromatic sweetness. It has a particular effect in supporting cognitive function, including improving memory and concentration, especially when these are compromised by increased  stress (9,10).

The dose starts at 3 grams of dried leaf per day, titrating up to 30 grams, if the initial dosage has proved effective with no unwanted side effectsGotu kola is traditionally consumed as a tea (8–10). 

Rosemary (Salvia rosmarinus)
Rosemary (Salvia rosmarinus)

Rosemary (Salvia rosmarinus)

There is something inherently uplifting about the smell and taste of this common garden herb— it can be felt heading straight to the brain. Rosemary is an excellent tonic to raise spirits and boost recovery after illness or periods of low energy. Even inhaling the fresh leaf from a garden or window box will stimulate mental energy and the tea taken internally will expand on this effect. 

There is promising evidence that rosemary may reduce inflammatory pressures on the brain now implicated in many conditions associated with low mood and depression, including chronic fatigue syndrome, dementia as well as clinical depression. Further research indicates it can improve cognitive performance in the elderly adding to its reputation as a  brain tonic (11).

Taking rosemary as a tea can be overpowering, however very uplifting. The dose is up to 4 grams a day of the dried leaf (9).

St. John’s wort (Hypericum perforatum)

This is often described as the herbal antidepressant, however it has a much wider range of actions than its mood enhancing properties. The herb and flowers of St. John’s wort have been used in European traditions to relieve nervous tension and anxiety. Importantly, this calming effect is combined with underlying restorative benefits and the plant was also used as a convalescent treatment for melancholic conditions, depression and recovering from illness or trauma (8–10).

This makes St John’s wort ideal in situations where tension and exhaustion combine. Its most useful modern application is towards a programme of recovery from chronic fatigue conditions. It also has a long reputation as a support to those experiencing symptoms during the menopause (8,10).

Note that St John’s wort has been shown as an active inducer of drug metabolism, so it may reduce the activity and active life of many medicines. It is wise to avoid in conjunction with medications and consult a medical herbalist for further guidance (8–10).  it if there are any powerful treatments underway, where reducing the effect of a medicine may be critical.

St John’s wort can come in a variety of preparations, including powder, tincture and tea. It is recommended to combine the herb with others as a tea, for flavour considerations, however the easiest is to take it as a tincture. The traditional calming and tonic dose was the equivalent of 2 to 5 grams of the dried leaf and flowers per day (9). 

  1. Heald A, Stedman M, Farman S, Ruzhdi N, Davies M, Taylor D. Seasonal Variation in Antidepressant Prescribing. The Primary Care Companion For CNS Disorders. 2021;23(2). https://doi.org/10.4088/pcc.20m02790 
  2. Clery E, Morris S, Cooper C, Das-Munshi J, McManus S, Weich S. Mental health treatment and service use. Adult Psychiatric Morbidity Survey: Survey of Mental Health and Wellbeing, England. Published online 2025.
  3. Tsiouris JA. Metabolic depression in hibernation and major depression: An explanatory theory and an animal model of depression. Medical Hypotheses. 2005;65(5):829-840. https://doi.org/10.1016/j.mehy.2005.05.044 
  4. Klupczyńska EA, Pawłowski TA. Regulation of Seed Dormancy and Germination Mechanisms in a Changing Environment. International Journal of Molecular Sciences. 2021;22(3):1357. https://doi.org/10.3390/ijms22031357 
  5. Ren J, Xiao H. Exercise for Mental Well-Being: Exploring Neurobiological Advances and Intervention Effects in Depression. ProQuest. 2023;13(7):1505. https://doi.org/10.3390/life13071505 
  6. Fahey MC, Klesges RC, Kocak M, Talcott GW, Krukowski RA. Seasonal fluctuations in weight and self-weighing behavior among adults in a behavioral weight loss intervention. Eating and Weight Disorders – Studies on Anorexia, Bulimia and Obesity. Published online May 15, 2019. https://doi.org/10.1007/s40519-019-00707-7 
  7. Honma K, Honma S, Kohsaka M, Fukuda N. Seasonal variation in the human circadian rhythm: dissociation between sleep and temperature rhythm. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 1992;262(5):R885-R891. https://doi.org/10.1152/ajpregu.1992.262.5.r885 
  8. Hedley C, Shaw N. Plant Medicine. (Waddell G, ed.). Aeon Books; 2023.
  9. Bone K, Mills S. Principles and Practice of Phytotherapy: Modern Herbal Medicine. 2nd ed. Edinburgh Churchill Livingstone, Elsevier; 2013.
  10. Mcintyre A. Complete Herbal Tutor : The Definitive Guide to the Principles and Practices of Herbal Medicine (Second Edition). Aeon Books Limited; 2019.
  11. Rahbardar M, Hosseinzadeh H. Therapeutic effects of rosemary (Rosmarinus officinalis L.) and its active constituents on nervous system disorders. Therapeutic effects of rosemary (Rosmarinus officinalis L) and its active constituents on nervous system disorders. 2020;23(9). https://doi.org/10.22038/ijbms.2020.45269.10541 

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New Zealand’s practitioners, plants and policy: Herbalism in Aotearoa  https://www.herbalreality.com/herbalism/western-herbal-medicine/new-zealands-practitioners-plants-and-policy-herbalism-in-aotearoa/ Thu, 16 Oct 2025 17:46:33 +0000 https://www.herbalreality.com/?p=221366 Today in Aotearoa New Zealand, traditional Rongoā Māori medicine coexists with contemporary Western herbalism.

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Today in Aotearoa New Zealand, traditional Rongoā Māori medicine coexists with contemporary Western herbalism, bringing opportunities through herbal practice, education and industry.

Across Aotearoa New Zealand, herbal medicine encompasses both indigenous Rongoā Māori wisdom and contemporary Western herbalism. Sustained by a dedicated professional community and a rigorous educational programme, herbal practice continues to evolve within a shifting policy landscape, supporting national wellbeing and contributing to growing opportunity in Aotearoa New Zealand’s natural health and botanical industries.

New Zealands Practitioners Plants And Policy Herbalism In Aotearoa

Aotearoa New Zealand (NZ) has a devoted and dedicated group of medical herbalists through the New Zealand Association of Medical Herbalists (NZAMH), an organisation which has been in existence since the 1930s. 

As with many countries, the Aotearoa NZ health system is under strain with growing demands from an increasing and aging population, an aging medical workforce and a preference for urban rather than rural practice. In some parts of the country, patients may sometimes wait several weeks to get an appointment with a general practitioner (GP) (1).

Given the above, and the many benefits that plant medicine can have on human health, the NZAMH has for many years been seeking some form of statutory regulation to facilitate increased public access to practitioner expertise and reduce pressure on other areas of the health workforce. In Aotearoa NZ, this entails becoming a registered health profession under the Health Practitioners Competence Assurance Act (HPCAA). Initial attempts by the NZAMH looked promising, with a letter of acceptance to proceed to the next stage received from the then Minister of Health in 2007. Subsequent changes of Government and ongoing reviews of the Act however, have further delayed this process. 

While a growing number of New Zealanders are consulting with medical herbalists and naturopaths for a range of chronic and acute health problems, generally there is no state funding support towards the treatment costs. However, Aotearoa NZ has a unique injury-based system – the Accident Compensation Corporation (ACC), a scheme which provides financial and health service support to all New Zealanders after injury, including certain natural medicine modalities (2).

NZAMH has persistently promoted the benefits of practitioner-provided herbal medicine, and its ability to foster a more prevention focused healthcare system, thus saving healthcare costs overall. It has had some wins with insurance company recognition, and supported the establishment of herbal clinics where some of its members work with those experiencing substance use or mental health disorders. 

Herbalists In New Zealand

Before the arrival of Europeans, Aotearoa NZ Māori used a variety of native plants in their healing practices. Sadly, this was largely suppressed following European colonisation, as was the Māori language and many other aspects of a rich indigenous culture. 

Traditional knowledge lived on, however, through the oral tradition of many elders (kaumātua, and kuia — wise elderly men and women, respectively), the observations and subsequent texts of early botanists and European migrants, and the dependency also of early Europeans on native plants and indigenous knowledge for many healthcare needs. A herbal pioneer in colonial Aotearoa NZ was Mother Mary Joseph Aubert, a French nun who migrated there in the late 19th century. Having studied botany and chemistry, she learned the properties of Aotearoa’s NZ native plants applying knowledge learned from Māori women and healers. She went on to manufacture and sell liquid herbal combinations (3,4). 

During World War II, the Māori battalion, which fought throughout the Middle East and Europe, had native plants such as koromiko (Hebe salicifolia) to help with diarrhoea, or kumerahou (Pomaderris kumeraho) for chest infections, sent from home. Such was the reputation and esteem of Māori medicine that remedies were sought and valued on the other side of the globe to Aotearoa NZ in the midst of war (5).

In recent decades, traditional Māori medicine (Rongoa Māori), as well as the Māori language and culture itself, has undergone an impressive revival in Aotearoa. Rongoa Māori medicine is a holistic form of healing, making use not only of the medicinal plants of Aotearoa, but also of various forms of massage and spiritual healing. Several rural communities have rongoa Māori healing centres near hospitals and there are moves towards more collaborative care (6,7) . In recognition of the value and importance of traditional medicine, Rongoa Māori treatments are now available for rehabilitation and certain other conditions through the ACC (2).   

Western medical herbalists have also increasingly incorporated native plants into their materia medica, and many of these have been made available to herbal practitioners for the past 40 years as tinctures or liquid extracts. These are generally used in the Western way, most commonly as ingredients in liquid formulations and products for both internal and topical use.

The unique healing properties and other benefits of certain native plants in Aotearoa NZ, are also recognised and utilised by elements of the natural health product industry in Aotearoa NZ. Several of these, such as mānuka (Leptospermum scoparium), kānuka (Kunzea ericoides), kawakawa (Piper excelsum) and horopito (Pseudowintera colorata), are ingredients in commercial products used for common health conditions, and their use is increasingly being supported by scientific publications including a growing number of clinical trials. Mānuka honey and mānuka oil have both become highly sought after in global markets, for their antimicrobial and many other healing properties (8,9).

Regulations in Aotearoa NZ are in a desperate need of an update, to not only better recognise the large skillset of trained practitioners, but also to better regulate herbal products. Medical herbalists are largely unregulated but are impacted by the 1981 Medicines Act, which regulates all medicines in the country. This Act was briefly replaced by the Therapeutic Products Act 2023 but then repealed in 2024 after a change in Government (10). The 2023 Act was the first to specifically address natural health products and start to define and better acknowledge Natural Health product practitioners. 

Herbalism In New Zealand

While herbal medicine itself is not well regulated in New Zealand, education is government recognised for a degree level programme. The Bachelor of Natural Medicine taught through the South Pacific College of Natural Medicine (SPCNM) receives Government funding and students have access to loans and allowances. The education environment in herbal medicine and naturopathy has changed greatly in recent years — in the 2000s there were six colleges throughout the country, but this has now reduced to one. South Pacific College is based in Auckland and has been in existence since 1967. It is well regarded with the highest category awarded by the NZ Qualifications Authority, indicating excellent teaching and organisation. The College boasts an on-site medicinal herb garden which is used both in teaching and community classes. 

Herbal education has changed over the years, not only with fewer providers delivering, but also in the development of stronger curricula, educating practitioners with a robust understanding of evidence-based practice. The complexity of health problems requires practitioners to have a more detailed understanding of subjects, such as differential diagnosis and herb-drug interactions. 

For those wanting to see a qualified medical herbalist, it is recommended to look for a member of the NZAMH — registered members are listed on the website. South Pacific College also runs a community clinic, Paua Clinic, from their premises in Ellerslie, Auckland. During the academic year, the public can consult with a senior student supervised by an experienced practitioner, at very reasonable rates. 

Green tea (Camellia sinensis)
Green tea (Camellia sinensis)

Apart from herbal practitioners, there is a flourishing and growing natural health product industry in Aotearoa NZ, with hundreds of small, medium and large businesses operating in this sector. Industry is represented by Natural Health Products NZ, formed in 2002. As successively bigger annual summits and industry wide surveys show, the natural health products sector has grown steadily to contribute more than $1.5 billion annually to the Aotearoa NZ economy (11). 

Medicinal cannabis has also become more popular in recent years, with a number of companies now cultivating and producing products in that area, although consumer access is still somewhat limited, due to the regulatory environment.

Aotearoa New Zealand is a significant producer of food and beverages and exports of these make up a large percentage of its economy and GDP. With changing consumer preferences and a need for the country to further diversify its current agriculture-based economy to become less dependent on animal-based products, the natural health industry and herbal medicines are gaining ground and being more recognised as future export earners. The diverse geography and unique features of the Aotearoa NZ environment, including different microclimates, make it ideal to cultivate numerous species. A range of species — such as echinacea (Echinacea spp.), ginkgo (Ginkgo biloba), green tea (Camellia sinensis), barley grass (Hordeum vulgare), saffron (Crocus sativus) and ginseng (Panax ginseng) — are already being cultivated, for export as well as grown for the local market. 

With ongoing unsettled times owing to geopolitical events and the increasing impacts of climate change and extreme weather events, many consider Aotearoa NZ as an ideal country to grow and supply medicinal plants as well as food and beverages, to both domestic and export markets. Extending the number of species and increasing supply volumes grown locally, are seen by industry advocates as important priorities (12).   Field trials are underway involving cultivation of several species of Asian, European and American plants. These are aimed at optimising agronomy, production efficiency and reliability, and quality. 

With a population of only 5.4 million, and a land mass the same as that of the UK, Aotearoa NZ has many vibrant rural communities, and a strong network of farmers and scientists, that have historically enabled it to adapt relatively quickly to geopolitical events or changes in trading relationships. These qualities, combined with the growing interest and use of indigenous species, and outstanding and committed education providers, practitioners and industry advocates, mean that herbal medicine is very much alive and well in Aotearoa New Zealand!

  1. Medical Council of New Zealand. Workforce Survey Report 2024. Wellington, NZ: Medical Council of New Zealand; 2024.
  2. ACC. Accessing ACC’s Rongoā Māori Service. Auckland, New Zealand: ACC; 2025. Accessed October 9, 2025. https://www.acc.co.nz/im-injured/what-we-cover/using-rongoa-maori-services
  3. Museum of New Zealand Te Papa Tongarewa. Mother Aubert’s medicines. Collections Online. Accessed October 9, 2025. https://collections.tepapa.govt.nz/topic/2077.
  4. Munro J. The story of Suzanne Aubert. Auckland, New Zealand; Auckland University Press; 1996.
  5. Brooker SG, Cambie RC, Cooper RC. New Zealand Medicinal Plants. Published by Reed Books, Auckland, 1987. 
  6. Healthpoint. Te Houtaewa Māori Charitable Trust — ACC-registered Rongoā Māori. Auckland, New Zealand: Healthpoint; 2025. Accessed October 13, 2025. https://www.healthpoint.co.nz/community-health-and-social-services/acc-registered-rongoa-maori/te-houtaewa-maori-charitable-trust/.
  7. Stephens M, Eason, C, Mead A, Chu A, McGowan PR, Rasmussen P, Foster M. He Huarahi Hou: exploring the genesis of a unique approach and design of a regional pharmacopoeia. AlgerNative: An International Journal of Indigenous Peoples. 2025. 1-13. https://doi.org/10.1177/11771801251356030 
  8. Mathew C, Tesfaye W, Rasmussen P, Peterson GM, Bartholomaeus A, Sharma M, Thomas J. Mānuka Oil-A Review of Antimicrobial and Other Medicinal Properties. Pharmaceuticals (Basel). 2020 Oct 26;13(11):343.
  9. Rasmussen PL, Honey as a medicine: Special properties of mānuka honey. Pharmacy Today, 1 Oct 2024; ISBN 1170-1927. The Health Media Ltd, Auckland. 
  10. Ministry of Health. Regulating medicines, medical devices and natural health products. Wellington, New Zealand: Ministry of Health; last updated April 14, 2025.
  11. Natural Health Products New Zealand. www.naturalhealthproducts.nz.
  12. Rasmussen PL, ‘Why New Zealand Grown Herbs are Best’. www.herbblurb.com. June 21, 2019.

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Humoral medicine: A constitutional approach in Western herbalism https://www.herbalreality.com/herbalism/western-herbal-medicine/humoral-medicine-a-constitutional-approach-in-western-herbalism/ Tue, 02 Sep 2025 14:43:47 +0000 https://www.herbalreality.com/?p=190367 Stephen Taylor introduces humoral medicine, an ancient medical system based on the elements.

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Humoral Medicine A Constitutional Approach In Western Herbalism

Whilst Ayurveda and TCM retained a constitutional approach to medicine, it was lost in Western practice. Stephen Taylor introduces humoral medicine, an ancient medical system based on the elements.

Humoral medicine is the traditional ancient health care system of the Western world. It is intrinsically holistic in its viewpoint taking its starting point from the belief that the nature of the cosmos is a harmonious interaction of all its parts.

Humoral medicine evolved out of a world view shared across the Eurasian continent that described all natural phenomena as being combinations of basic elements. These elements are identified by a combination of the ‘qualities’ hot and cold, wet and dry.

Humoral philosophy was formalised in Western culture around 400 BCE within the ‘Hippocratic School’ of medicine. This was the medical practice of the Ancient Greek world and was used within healing temple complexes called Asclepions, it was further refined by the Roman physician Galen in the second century ACE.

In the early medieval period humoral medical philosophy was revived in Europe via the arrival of Arabic translations of the original Hippocratic and Galenic texts. By the Sixteenth century the humoral system had been further enriched by the addition of the mystical philosophy of Hermeticism, a tradition contained in the ‘Corpus Hermeticum’ written around 300 BCE. Hermeticism envisioned existence to be created from a divine source, which through the medium of ether vitalised and connected all living things. 

The basic elements in humoral philosophy are air, fire, earth, water and ether. Ether is akin to space and emptiness, it is thought of as a medium which has no substance or qualities of its own but accommodates and enables the interaction of the four physical elements. It is within ether that the life force or ‘pneuma’ is transmitted and absorbed into the body via the breath. 

The elements, temperaments and humours
The elements, temperaments and humours

When these elements manifest in either physical or non-physical ways in the body they are referred to as ‘humours’. 

The temperamental qualities of the humours engender and impart a particular ‘temperament’ or heat wherever they manifest, and every aspect of the living body has an ideal temperament or humour within which it functions best.

This means that organs, systems and people have a particular correspondence to a humour depending on their ideal or natural temperament. For instance, the lungs, stomach, kidneys, bladder, bowels and brain are all said to have a generally moist and cool temperament, and are therefore considered to be phlegmatic organs connected to the water element. Whilst the gall bladder, full of acidic or ‘hot’ bile is said to be a choleric organ, with an association to the fire element.

The health of any organ, system, tissue, or bodily function is best maintained when it is held in its correct or ideal temperament. The role of medicine is to promote the ideal temperament of the various bodily organs and functions and restore them when they have lost their correct balance or ratio of humours.

When the balance of a temperament is lost, herbs, diet and lifestyle may be used to return the organ, system or person back to the most beneficial temperamental state. This is done through both countering the change with its opposite, for instance using heating remedies when coldness overwhelms etc., or by strengthening the correct temperament through supporting its natural processes of homeostasis. These are called the antipathetic (countering), and the sympathetic (supporting) approaches.

Humoral medicine proposes that the excess of one or more of the humours is the main cause of loss of natural balance, and although this will initially present in the form of excess it often leads to a depletion of vitality. This means that when we see a lack of natural vitality, we must primarily determine what humour has been in excess and has overwhelmed the system causing imbalance. 

The Four Humours

Most of us are already likely to be familiar with the qualities and names of these four Humours:

  • Air: Sanguine or blood humour — hot and wet
  • Fire: Choleric humour — hot and dry
  • Earth: Melancholic humour — cold and dry
  • Water: Phlegmatic humour — cold and wet

Perhaps the first guiding concept of humoral theory that we have not retained in the Western biomedical model is the role of cycles in health and disease.

In all ancient medical systems and traditions, rhythm and cycles are understood as the core expression of life, and the loss of cycle is associated with sickness and ill health.

We frequently find the ancient concept of dynamic cosmic change and repetitive cycles expressed through the symbol of a circle; it has no beginning, no end, it is in continual motion. It also corresponds to the world around us; the circular and cyclical nature of the sun and moon, the circle and cycle of the continual dance of day and night, the cycle of the four seasons coming, going and returning, the circle and cycle of being born from the earth and returning to the earth at death.

The humours themselves are bodily manifestations of the phases of movement in this cycle, a movement we see reflected in the seasonal cycle; winter — cold and wet, through spring — hot and wet, to summer — hot and dry, and back again through autumn — cold and dry. This humoral cycle is seen in the life cycle with spring being birth and youth, summer adulthood, autumn middle age, and winter old age and death. 

The activity of the humours in the body is likened to the seasonal changes that make up the annual cycle of growth and regeneration in the world around us. If the seasonal temperaments are in balance and there is a year without extreme heat and drought, or without extreme cold and wet flooding the land; everything grows well, and there will be a plentiful harvest. 

Similarly, if the humours are well balanced like good seasons, the vitality of the body is nourished. This living vitality then manifests in the body as healthy and strong ‘spirits’. Loss of health arises when one aspect of the cycle becomes excessive and overwhelms the body. 

The cycle of the elements, humours and their interactions
The cycle of the elements, humours and their interactions

A fever may be likened to a heat wave in the summer, which although can be made easier by finding a cool breezy place offering instant respite, it will only properly resolve when the balancing coolness of autumn arrives. 

When treating a fever, we must first address the excess temperature by using cooling strategies, such as swabbing with a tepid cloth and giving antipyretics, such as willow (Salix alba). But, we also need to find a way to move things on to the next cooler phase, for instance using sweat inducing and immune stimulating diaphoretics (traditional cleansing cathartic herbs) such as vervain (Verbena officinalis) or elder (Sambucus nigra). This is like moving the fever cycle from being stuck in summer heat into the cooler days of autumn. 

It is then important to consider what excess humour initially overwhelmed the system and lead to the depletion of the vital spirit and its innate heat, as it is this heat that confers protection against any ‘invasion of poisons’ (infection and fevers).

When the underlying temperamental balance is lost, the most powerful way of bringing the balance back is through using sympathetic supportive strategies, even if we have to initially respond with countering ‘antipathetic’ interventions to address the immediate imbalance.

Sympathetic supportive strategies consist of:

  • Restoring and nourishing weakened tissues and organs ensuring that their temperament is returned to normal.
  • Supporting any weakened ‘spirits’, including the organs that they reside in — the heart, the head, the liver, the reproductive organs.
  • Using constitutional medicines that help to balance the individual’s dominant humour, or effects of their stage of life.

Even today when we ask someone if they are in ‘good spirits’, or if they are feeling ‘dispirited’ we are continuing the use of these ancient humoral concepts in our language.

In humoral physiology there are four spirits which arise in the body.

  • The vital spirit resides in the heart and consists of the innate heat and radical moisture. It activates all the bodily functions, gives the body its vitality, and protects it from infection.
  • The natural spirit resides in the liver, it enables digestion and the dispersal of the humours in healthy blood.
  • The animal spirit resides in the head, corresponds to the element ether, and initiates motivation, movement, and sensory perception.
  • The procreative spirit resides in the testes, ovaries and womb. It arises as desire and provides the ability to conceive and procreate.
Hippocrates
Hippocrates. The Metropolitan Museum of Art, New York. Peter Rubens, Rogers Fund. 1955. Title: Hippocrates the Greek physician, 460-370 BCE.

As the loss of correct temperament is the main underlying cause of sickness, we need to look at its main possible causes.

  1. Life stage
  2. Constitution
  3. External influences

Lifecycle 

Each stage of life is dominated by a particular humour, during each phase it is more likely that a loss of temperament will be caused by the dominant humour of that stage becoming an overwhelming influence: 

  • Youth: Sanguine / air 
  • Adulthood: Choler / fire 
  • Middle age: Melancholic / earth 
  • Old age: Phlegm / water

Individual constitution 

Each person is born with a constitutional temperament, and this remains the same throughout life. We can quickly recognise the dominant temperament of some people, in others it may be a bit more subtle. We automatically recognise ‘warm’ people and ‘hot’ fiery people, as well as those who are ‘cool and chilled’, or perhaps even ‘cold’.

Determining a person’s constitution is important, as the temperament that dominates is always most likely to be the underlying cause of an imbalance for any individual. Having this temperament as a dominant influence in our bodies makes it always most likely to be the one which will become excessive.

Sanguine / air constitution 

We all know the energetic, explorative, creative, embracing but slightly flighty types, the ones who can’t stay still for too long, who being similar to an energetic youngster have an exuberant sanguine/air temperament.

Choleric / fire constitution

These are those with a strong personal drive, focus, high motivation, and often low tolerance of failure and a short temper, this typifies the time of our lives when we are working toward goals as adults and corresponds to the choleric/ fire temperament. 

Melancholic / earth constitution

We expect these types to be more introverted, solitary and studious, also reliable and trustworthy, often going deeply into ideas, but often prone to getting a bit stuck. This corresponds to middle age, when we slow down, become steadier and more anchored in our lives. This more grounded energy is the melancholic/earth temperament.

Phlegmatic / water constitution

Like the water element that rules them, phlegmatics are more likely to accommodate and flow with others, being more tolerant, but also a bit dreamy, and prone to getting overwhelmed. This corresponds to becoming an elder, with the wisdom of age making one more tolerant, and being able to let go of fixed ideas and attitudes. This softer gentler energy corresponds to the phlegmatic/water temperament.

Each of these four temperaments may manifest in combination with another, one still being the dominant aspect and one being secondary. 

External factors affecting the temperament

In humoral medicine, there is a recognition that external factors have a very important influence on health and disease. These are seen as influences that arise from outside of the body rather than from its own nature, thus they are named the ‘six non-naturals.’ 

Air

The natural temperament of air is cold and moist like the lungs. When hot it may irritate the naturally damp lungs and blood, and when too cold and moist it may add to excess moisture causing putrefaction and infection. Each constitution is balanced by air of the opposite temperament — cool air for hot people, etc. Purity of air is of utmost importance.

Diet

Foods all have an intrinsic heat or cold, and each of the different constitutions are challenged or benefitted by them. In summer, the digestive heat is more dispersed due to the summer heat, and in winter, digestive heat is concentrated in the body. This corresponds to us eating more lightly in the summer with a preponderance for cooling foods such as lettuce, chicory and cucumber. Hotter people have stronger digestive heat and better digestion than cool phlegmatics, who benefit from always adding warming herbs, spices and pepper to their food.

Exercise and rest

Exercise activates innate heat and energises the body. The heat of excess exercise damages the body, and lack of exercise leads to stagnation and congestion.

Sleep and wakefulness

Sleep is brought on by the rising upwards of a sweet calming restoring vapour from the heart to the head. It has a moistening and refreshing effect on the brain and the nerves. During sleep the innate heat settles in the liver completing digestion and the production of the humours. Insomnia dissipates the spirits and dries the brain.

Retention and evacuation

The body has a retentive faculty associated with the Earth element and the spleen, and an expulsive faculty associated with the Water element, the bowels and bladder. If either faculty is lowered through disease, an excess of the retentive melancholic humour, or inadequate innate heat or moisture to activate the expulsive faculty then blockage occurs. This kind of congestion can lead to melancholic vapours rising up from the spleen effecting the heart, stomach and head.

Perturbations of the mind and emotions

The maintenance of a calm state throughout the body and mind is beneficial to health. Reducing stress and releasing extreme emotions through cathartic activities is very helpful.  Singing, dancing, and expressing emotions in a healthy way are all considered very important, especially to the health of the vital spirit. Activities that promote joyfulness and practicing kindness are as important as any other measure we may take to maintain health.

Although the physiological and anatomical descriptions that underpin the historic humoral model now seem to be redundant due to our advances in the understanding of human biology and physiology, we shouldn’t discount the many important insights it can offer which have been drawn from millennia of medical observation and practice. Through embracing the humoral system, we gain a therapeutic model with which we can anchor our herbal practice to a holistic core.

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An update on kava regulations: 2025 global overview https://www.herbalreality.com/herbalism/western-herbal-medicine/an-update-on-kava-regulations-2025-global-overview/ Thu, 14 Aug 2025 10:21:40 +0000 https://www.herbalreality.com/?p=156298 Kava herb has been found to alleviate anxiety but it is prohibited in the UK owing to hepatotoxicity concerns. We look at kava regulations in detail.

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Since 2002, kava — a herb native to the Pacific islands found to alleviate anxiety — has been prohibited in the UK owing to hepatotoxicity concerns. Any updates on kava regulations?

The sale of kava-kava (‘kava’) has been prohibited in the UK and much of Europe since the turn of this century. With some restrictions it remains available in Pacific countries and the USA. This article reviews what we now know about the risks and benefits of kava and makes the case for a lifting of bans.

Although the widespread restrictions on kava use have prevented much research with human subjects, there are pointers to appreciable benefits for self-prescription in mild anxiety states. Although hepatotoxic mechanisms remain unresolved the evidence has accumulated that these are rare idiosyncratic reactions that could be outweighed by benefits, with risks mitigated by regulatory controls of quality and recommendations as to use.

An Update On Kava Regulations 2025 Global Overview

Kava-kava (Piper methysticum) is a plant whose roots and other parts have long been used in traditional medicine, and ceremoniously, in Pacific countries for its calming effects. There is modern evidence for its anxiolytic activity, suitable to the management of mild anxiety states. 

Anxiety disorders are the most prevalent among disorders and are a leading cause of disability and economic inactivity. The evidence for efficacy for current over-the-counter and prescription medicines is often lacking, and adverse effects, most especially dependency and withdrawal symptoms, remain a concern for pharmaceutical medications (1). 

Demand for kava as a self-prescribed anxiolytic increased through the 1990s with many products of variable quality being introduced to the UK market, most without regulatory oversight. Medicinal kava products were used elsewhere, and in Germany an estimated 350,000 annual prescriptions were written, with more than one million monthly doses (2).

Kava root (Piper methysticum)
Kava root (Piper methysticum)

In 2001, following reports associating kava consumption with incidents of liver damage around the world, the UK Committee on the Safety of Medicines set up an Expert Working Group (EWG) to evaluate the signals. The EWG determined that, against a lack of consistent evidence of sufficient benefit, kava was associated with an unacceptable risk of idiosyncratic hepatoxicity, which could not be minimised or prevented by any regulatory measures other than the removal of kava products from the market. The Statutory Instrument, The Medicines for Human Use (Kava-kava) (Prohibition) Order 2002 followed this assessment (3). However this Order states that the prohibition shall not apply to a medicinal product which is “the subject of a UK marketing authorisation, certificate of registration or traditional herbal registration within the meaning of the Human Medicines Regulations 2012”.

Also in 2002, the UK Food Standards Agency Committee on Toxicity made a similar risk assessment in publishing its own advice on the herbal preparation of kava in foods, which led in turn to the enactment of the Kava-kava in Food (England) Regulations 2002 (4).

Under the Human Medicine Regulations 2012 and subsequent case law applying EU wide medicines legislation, it is almost certain that any future kava product permitted onto the UK market would be determined firstly as a medicinal product, with the subsequent benefit-risk assessment. 

N.B. In UK and EU law, foods have no therapeutic effects or benefits, so no benefit/risk balance can apply. Food safety assessments are made without regard to health benefits.

Kava (Piper methysticum)
Kava (Piper methysticum)

The Novel Food Regulation 2015/2283 (NFR) provides the harmonised legal framework for non-medicinal products. The NFR takes precedence over national laws in EU member states regarding the marketing of foods and supplements, so because kava has not been listed in the EU’s Union List of Novel Foods, it cannot be sold or marketed anywhere in Europe. However, enforcement is carried out by national authorities, which can lead to variable application.

France and Austria have banned kava outright on the basis of ‘legitimate concerns’ (i.e., public health) and these bans remain valid as long as they do not conflict with EU law (e.g., free trade).

In Germany, court decisions have dismissed the regulator’s ban on kava on the argument that this was disproportionate and unsupported by current evidence. The full legal implications including as an EU Member State are still being worked through the courts.

In the US, kava is legally and widely sold as a dietary supplement, with ‘structure/function’ claims often implying benefits for relaxation and stress relief. In 2020 the Food and Drug Administration (FDA) published a redacted memorandum specifying that kava is not considered Generally Recognised as Safe (GRAS) (5), therefore making kava an unapproved food additive. However, this does not extend to its use as a food (kava steeped in water) or its use as a dietary ingredient (6). The state of Hawaii determined that kava (‘awa’) in its traditional form is GRAS (7).

The Therapeutics Goods Administration initially banned kava and then, after a re-assessment, permitted it with limits of no more than 125 mg kavalactones in solid dosage forms, or 3 g limit in teabags to a maximum daily dose of 250 mg kavalactones. Selected kava preparations continue to be approved as ‘Listed Medicines’ (available over-the-counter for self-treatment) and traditional kava beverages are similarly available.

Kava root (Piper methysticum)
Kava root (Piper methysticum)

Benefit

The effect of the prohibition order outside Pacific regions and the USA was markedly to restrict the clinical research necessary to update the British EWG negative assessment. Most human studies have been conducted in Australia. The published clinical trials there have demonstrated that kava extracts can reduce anxiety and depression symptoms (8,9,10). One 2004 review concluded that “kava is the only botanical anxiolytic whose efficacy is supported by evidence from a systematic review of randomized placebo-controlled trials (evidence Level 1 of the National Health and Medical Research Council of Australia)” (11). More recent meta-analyses also support kava’s efficacy in reducing anxiety symptoms, although the effect size in cases of generalised anxiety disorder (GAD) is small (12,13).

It is relevant that by definition GAD requires a medical practitioner’s diagnosis, so the new evidence points to benefits appropriate to self-management of mild to moderate anxiety (3) and this may be the most appropriate indication for future kava use (14).

The new clinical trial data do help to fill gaps in the evidence base for efficacy that was initially considered by the EWG, when they found a mismatch between products for which there was benefit and those more widely available.

Further investigations have identified effects on GABA activity in humans (15,16,17). Another review summarises the potentially positive profile of kava in relation to cancer (18), and there are additional pharmacological updates (19,20,21,22).

In relation to the following section, adverse events in clinical trials associated with kava treatment were not significantly different from those associated with placebo.

Risk assessments

In fulfilment of a pledge by UK Ministers to review the 2002 order within two years, the UK medicines regulator, the MHRA, engaged in a public and international consultation. In October 2005, the EWG, having considered the responses and new evidence available at the time, concluded that the prohibition order remained “justified and proportional”. Notably, however, the EWG was concerned that “further structured research into the precise mechanism of hepatoxicity was required and that although the data presented justified the original prohibition, it also raised many new questions.”

The EWG noted a particular link to idiosyncratic hepatoxicity, which may have involved herb-drug interactions: “Although its specific route of metabolism has not been established, it has been found to induce and inhibit a variety of cytochrome P450 isoforms in vitro and, as such, has the potential to be associated with significant herb-drug interactions.” Ultimately, however, the EWG could not identify a mechanism of hepatoxicity for kava: “none of the proposals could account for all of the cases and many of the proposed mechanisms of hepatotoxicity appeared implausible.”

In one significant initiative to update safety data since this incomplete conclusion a Monograph and Therapeutic Compendium (a quality, therapeutic, and safety review) on kava is being produced by the American Herbal Pharmacopoeia. This work includes authorship and peer review by medicinal plant experts, including physicians, pharmacologists, pharmacognosists, and experts in pharmacokinetics, toxicology, and herb–drug interactions.

The monograph is being finalised for publication, but a pre-published draft of the safety section includes the following conclusion. “Based on critical assessments, any direct hepatotoxic potential for kava is rare and idiosyncratic, or confounded with use of other hepatotoxic substances, including medications. Hepatotoxicity was rarely reported when kava was used within its traditional context.”

Finally, the continued availability of kava in Australia has not been accompanied by adverse event signals from the Therapeutic Goods Administration. In 2019, a relative harm assessment concluded that kava was the least dangerous of 22 substances known to be used for their psychoactive effects (23). Nor are there signals emerging from Poisons Units or elsewhere in the USA.

Quality issues

The EWG added “One of the main pieces of data that would have been useful is a systematic evaluation of the Kava products available, with an audit of the source material used. It would be extremely useful to have a more systematic evaluation of the constituents of the various Kava cultivars to try to determine what the differences are and whether or not these constituents have a significant role in hepatotoxicity.”

Since the prohibitions, quality control standards have been developed internationally to ensure proper identity, purity, and quality of traded material. These have been reviewed in a useful 2016 technical report published by the FAO and WHO (24).

Kava root (Piper methysticum)
Kava root (Piper methysticum)

In its conclusion to the 2005 EWG re-evaluation the UK MHRA stated it will “review any new evidence that is submitted in relation to the issue of hepatotoxicity suspected to be associated with Kava and will re-evaluate the prohibition of Kava in unlicensed medicines if significant new data are received.”

There does appear to be a case for such a review to consider the regulated release of kava back into the market, with clear quality standards, controlled dosage, and safety advice including its use with other medications. There could be considerable benefits in having an effective self-care option for people in the wider population and workforce who are suffering increasing levels of anxiety. 

In response to a recent submission raising these points, the UK MHRA recalled that the 2002 Prohibition Order does not exclude applicants applying for a Traditional Herbal Medicine Registration or a ‘Marketing Authorisation’ (full medicines licence) under The Human Medicines Regulations 2012. In this latest response the MHRA stated: “Should a Traditional Herbal Registration or a Marketing authorisation application for a Kava medicinal product be submitted to the MHRA, safety would be reviewed on an application-specific basis and on the currently available evidence” (25). There is, therefore, no prospect of a general review of kava’s safety in use without a manufacturer making a specific application. In the UK and Europe, food use is also unlikely to be permitted while the medicine bar remains.

Regulation is of course an incomplete measure of public protection or restriction: kava is accessed frequently on the internet, without quality control or information as to its safest use.

  1. Garakani A, Murrough JW, Freire RC, et al (2020) Pharmacotherapy of Anxiety Disorders: Current and Emerging Treatment Options. Front. Psychiatry 11:595584
  2. Ulbricht C. Basch E, Boon, H et al (2005) Safety review of kava (Piper methysticum) by the Natural Standard Research Collaboration. Expert Opin. Drug Saf. 4, 779–794
  3. https://tinyurl.com/4j7de38e
  4. https://tinyurl.com/4ukrs44a
  5. https://tinyurl.com/tcw7fwwj
  6. https://tinyurl.com/4bm83re3
  7. https://tinyurl.com/wewhxncu
  8. Sarris J, Stough C, Bousman CA, et. (2013) Kava in the treatment of generalized anxiety disorder: a double-blind, randomized, placebo-controlled study. J Clin Psychopharmacol. 33(5): 643-8.
  9. Sarris J, Kavanagh D, Byrne G, et al. (2009). The Kava Anxiety Depression Spectrum Study (KADSS): a randomized, placebo-controlled crossover trial using an aqueous extract of Piper methysticum. Psychopharmacology, 205, 399-407. 
  10. Sarris J, Byrne GJ, Bousman CA, et al (2020). Kava for generalised anxiety disorder: A 16-week double-blind, randomised, placebo-controlled study. Aust N Z J Psychiatry 54(3): 288-2976
  11. Jorm AF, Christensen H, Griffith KM, et al. (2004). Effectiveness of complementary and self-help treatments for anxiety disorders. Med J Aust 181: S29-S46
  12. Oo S, Henderson P, Pak S. (2018). Kava for Generalized Anxiety Disorder: A Review of Current Evidence.. Journal of alternative and complementary medicine, 24 8, 770-78 
  13. Smith K, Leiras C. (2018) The effectiveness and safety of Kava Kava for treating anxiety symptoms: A systematic review and analysis of randomized clinical trials. Complement Ther Clin Pract. 33: 107-117
  14. Thomsen M. Schmidt M (2021). Health policy versus kava (Piper methysticum): Anxiolytic efficacy may be instrumental in restoring the reputation of a major South Pacific crop. J Ethnopharmacol 268: 113582.
  15. Cribb L, Sarris J, Savage KM, et al (2023). Effect of kava (Piper methysticum) on peripheral gene expression among individuals with generalized anxiety disorder: A post hoc analysis of a randomized controlled trial. Phytother Res 37:5897-5903.
  16. Savage K, Sarris J, Hughes M, et al. (2023). Neuroimaging Insights: Kava’s (Piper methysticum) Effect on dorsal anterior cingulate cortex GABA in generalized anxiety disorder. Nutrients 15:4586
  17. Savage K, Firth J, Stough C, Sarris J. (2018). GABA-modulating phytomedicines for anxiety: A systematic review of preclinical and clinical evidence. Phytother Res 32:3-18.
  18. Soares RB, Dinis-Oliveira RJ, Oliveira NG. (2022) An Updated Review on the Psychoactive, Toxic and Anticancer Properties of Kava. J Clin Med. 11(14):4039
  19. White CM. 2018. The Pharmacology, pharmacokinetics, efficacy, and adverse events associated with kava. J Clin Pharmacol 58:1396-405.
  20. Bian T, Corral P, Wang , et al. 2020. Kava as a clinical nutrient: Promises and challenges. Nutrients 12: 3044
  21. Meesakul P, Shea T, Wong SX, et al. (2023) Hawaiian plants with beneficial effects on sleep, anxiety, and mood, etc. Pharmaceuticals (Basel) 16:1228
  22. Zhang W, Yan Y, Wu Y, et al. (2022) Medicinal herbs for the treatment of anxiety: A systematic review and network meta-analysis. Pharmacol Res 179:106204
  23. Bonomo Y, Norman A, Biondo S, et al. (2019). The Australian drug harms ranking study. Journal of Psychopharmacology 33(7): 759–768
  24. FAO/WHO (2022) Kava: a review of the safety of traditional and recreational beverage consumption: a technical report (https://tinyurl.com/yrecnu2u)

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For a healthier America: Kindness, humour and tea https://www.herbalreality.com/herbalism/western-herbal-medicine/for-a-healthier-america-kindness-humour-and-tea/ Sat, 09 Aug 2025 08:04:34 +0000 https://www.herbalreality.com/?p=136134 Could daily kindness, humour and a cup of tea put health and care back into the system of the United States of America? Herbalist Paul Schulick finds out.

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What simple, affordable solutions are there to elevate the wellbeing of the American nation? Could daily kindness, humour and a cup of tea put health and care back into the system?

For A Healthier America Kindness Humour And Tea

“Start by doing what’s necessary; then do what’s possible; and suddenly you are doing the impossible.” — St. Francis of Assisi

A recent Forbes article titled US healthcare is not a system: It’s a market, and it’s broken says it best.

“Spend 30 seconds perusing any comment section, and you’re likely to conclude that Americans can disagree on anything. While common ground seems to have nearly disappeared, there is one agreement that crosses gender, politics, race and religion — healthcare costs in the United States are absurd.”

Not only is the $4.5 trillion dollars America spends on healthcare mushrooming out of control — dramatically more than in any other industrialized country — but this is not translating to better public health. The United States ranks last asmong other high-income countries on key healthcare metrics like infant mortality and rates of chronic disease (1). Worst of all, we are 49th in the world for healthy life expectancy (2). In contrast, Japan consistently ranks in the top three; its citizens live a better quality of life and live eight years longer than we do. For every dollar America spends on health care, Japan spends less than 50 cents!

In the United States, 60% of US adults — about 133 million people — have at least one chronic disease, and 40% have two or more (3). Included and often unseen in this epidemic is the decline in mental health for which it is estimated that 55% of adults do not receive any treatment even when it is most needed. This lack of care costs the US economy over $300 billion every year due to productivity losses (4). From a cup-half-full perspective, measurable progress should not be hard to make even though we are facing a particularly chaotic and unstable time. 

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How to communicate about gender: Language for clinical practice https://www.herbalreality.com/herbalism/western-herbal-medicine/how-to-communicate-about-gender-language-for-clinical-practice/ Wed, 23 Apr 2025 11:34:57 +0000 https://www.herbalreality.com/?p=76328 Amparo Aracil shares guidance on how to foster a gender-inclusive approach to herbal practice.

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This article shares guidance on how to foster a gender-inclusive approach to practice, to offer safe and supportive healthcare for trans and non-binary patients.

Why is the right language important in herbal practice?

How To Communicate About Gender Language For Clinical Practice 1

In healthcare settings, language is not just a tool for communication; it can deeply affect the patient’s experience, their level of comfort, and ultimately, their healing journey (1). The key to respectful communication is empathy. It is important to approach each patient with a nonjudgmental attitude and offer a space where they feel safe and validated in expressing themselves.

There is research showing that gender diverse and trans individuals are at significantly higher risk of mental health challenges compared to cisgender people. One key factor contributing to these challenges is the pervasive use of non-inclusive language. Studies indicate that when transgender individuals are misgendered or subjected to non-inclusive language, it can contribute to feelings of isolation, rejection, distress, anxiety and suicidal ideation (2,3,4). 

Affirmation of gender identity, including the correct use of pronouns and names, is crucial for the mental health of trans people. Studies have demonstrated that when healthcare providers use correct pronouns and respect gender identities, it can have a significantly positive impact on the patient’s well-being (5). 

Creating environments that are supportive of trans and gender diverse individuals and using inclusive language can drastically reduce the mental health risks they face. Gender-affirming language fosters an atmosphere of respect and trust, which can help reduce the stress and anxiety trans individuals’ experience when seeking healthcare services.

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Unique ways that plant medicine can fill modern therapeutic gaps https://www.herbalreality.com/herbalism/western-herbal-medicine/unique-ways-that-plant-medicine-can-fill-modern-therapeutic-gaps/ Wed, 23 Apr 2025 08:57:06 +0000 https://www.herbalreality.com/?p=76233 Simon Mills explores how plant medicine adapts to meet modern health challenges.

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How does plant medicine adapt to meet modern health challenges? Simon Mills explores herbal interactions with the endothelium, gut wall, microbiome and neuroinflammatory processes.

Unique Ways That Plant Medicine Can Fill Modern Therapeutic Gaps

The use of plant medicines predates human history. They were there to remedy urgent health needs, pain, wounds, infections, fevers, infertility, and childbirth. Dosing was heroic because results were needed quickly. There was one simple outcome measure — survival! We can, therefore, be secure with those ‘human bioassay data’ as a basis for herbal efficacy. However, we can be less sure that these old remedies apply to our modern lives.

Our forebears would not have recognised hypertension or most cardiovascular problems, their exposure to dementia, diabetes and immune diseases was probably much more limited and arguably would have been rolled in to later life care or, as with mental disturbances, culturally managed in other ways. What confidence do we have, therefore, that the old remedies still work when all the health rules have changed? Is there any evidence that plants can be retooled to meet the new health care imperatives? How might we direct them to plug therapeutic gaps in modern society?

There are precedents for adapting traditional medicines to modern health challenges. In Europe, with both old traditions and relatively longer exposure to the post-industrial age, hawthorn moved from a fever management tool to a prescription for heart disease. Valerian and St John’s wort, both ancient convalescent tonics, were adapted to treat anxiety and depression. Garlic morphed from warding off the devil (and infectious diseases!) into a remedy to manage blood lipids. Twentieth century Germans transformed echinacea from a remedy used for the bites of snakes and venomous creatures, septicaemia and gangrene, to a gentle immune support; they also extracted a plant medicine never used in tradition at all — ginkgo leaf — and developed applications for it in dementia and circulatory disease. 

So, let us look at whether we can further adapt the old plant medicines to fill some looming health priorities, largely ignored in classic texts:

  • Diabetes and metabolic diseases
  • Circulatory disease
  • Dementia
  • Mental health
  • Immune and chronic inflammatory disease

Here are some cunning plant tricks that could hold the keys to real benefits. Although clinical evidence is still patchy, there are already strong indicators of promise. It is worth noting at the outset that most of these mechanisms can only be delivered meaningfully by plants. No other interventions can match them here.

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Clinical examination in the practice of herbal medicine https://www.herbalreality.com/herbalism/western-herbal-medicine/clinical-examination-in-the-practice-of-herbal-medicine/ Sun, 23 Feb 2025 15:20:07 +0000 https://www.herbalreality.com/?p=39085 Dr Nic Rowley shares how to nurture confidence in students to encourage clinical skill use with patients.

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Are herbalists using clinical examination in practice? Dr Nic Rowley shares why they should and how to nurture confidence in students to encourage clinical skill use with patients.

Do herbalists routinely perform clinical examination?

Clinical Examination In The Practice Of Herbal Medicine

Despite the many hours that students of herbal medicine spend studying clinical examination, it is only a small proportion of practising herbalists that regularly use the examination routines they learnt during their training.

There are many possible reasons for this, but the commonest seem to be:

  • A preference for other diagnostic approaches learned before (and sometimes after) herbal medicine training
  • A lack of confidence in the ability to perform ‘full’ clinical examination and interpret findings accurately
  • A lack of time (and sometimes space) during consultations
  • A lack of opportunity, time and resources to refresh and update clinical examination skills on a regular basis
  • A sense that the examination routines learnt during training are not relevant to the majority of patients seen

Do GPs routinely perform clinical examinations?

Clinical Examination In Herbal Medicine

These days, GPs do not have time to perform the intricate examination routines they learned at medical school, and so they have had to adopt an approach that focuses on those parts of clinical examination that are most likely to help with clinical decision making. GPs thus acknowledge that some parts of the clinical examination process are more important than others, and they concentrate on those parts when a case history suggests the need for some extra clinical information.

But GPs have had the opportunity to practice ‘classical’ examination routines on many hundreds of patients during their years as medical students. In that time they observed countless skilled physicians and surgeons examining patients, and received frequent and focused feedback on the development of their own clinical examination skills.

So, it is not surprising that many herbal medicine students, with only limited hours of clinical training available to them (and often in settings where trainers themselves rarely perform clinical examination), come to regard this part of their training course as something to be endured for the sake of passing the final clinical examination. 

As a result, they enter practice with many unanswered questions concerning the techniques they were taught, and face insecurity about their knowledge of physical examination. This is clearly not good for herbal medicine practitioners, patients, or the profession as a whole.

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Interpreting the full blood count: What could it all mean? https://www.herbalreality.com/herbalism/western-herbal-medicine/interpreting-the-full-blood-count-what-could-it-all-mean/ Sun, 02 Feb 2025 15:08:02 +0000 https://www.herbalreality.com/?p=25676 Dr Phil Deakin demystifies the full blood count, offering guidance to its interpretation.

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Blood tests are valuable investigations to support clinical understanding of patients’ health stories. Dr Phil Deakin demystifies the full blood count, offering guidance to its interpretation.

What is a full blood count?

Interpreting The Full Blood Count What Could It All Mean

A full blood count (FBC) is one of the most commonly performed blood tests. Why should that be? Why might we consider doing it? What can it tell us? …and why does it all look so horribly complicated?

A full blood count report can certainly appear to be a particularly intimidating document — filled with cryptic abbreviations and obscure units of measure. But, fear not! It’s simply a clinical jigsaw puzzle that becomes much clearer once you put it all together, stand back a bit, and take a look at it as a whole.

Unlike the majority of blood tests which focus on the chemistry of the blood, a FBC highlights what is happening to the very cells that make up our bloodstream by looking at them under a microscope. In some ways our blood is an organ in its own right which can be easily and conveniently biopsied and studied.

Welcome to the world of the haematologists.

There are essentially three groups of things in a full blood count; red cells, white cells, and some little sub-cellular bits called platelets. Each one can be measured in different ways to reveal a surprising amount of information about health, illness and wellbeing.

Here are some typical components of a full blood count and some perspectives on what they might signify.

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Ethnobotanical reflections on mind-altering plants https://www.herbalreality.com/herbalism/western-herbal-medicine/ethnobotanical-reflections-on-mind-altering-plants/ https://www.herbalreality.com/herbalism/western-herbal-medicine/ethnobotanical-reflections-on-mind-altering-plants/#comments Wed, 04 Dec 2024 16:35:50 +0000 https://www.herbalreality.com/?p=15135 Fly agaric, coca, ayahuasca, and kava are potent medicinal herbs. This article explores the cultural origins and modern exploitation of mind-altering plants.

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Ethnobotanical Reflections On Mind Altering Plants

Fly agaric, coca, ayahuasca, and kava are potent medicinal herbs that have a rich and ancient history of traditional use. This article explores the cultural origins and modern exploitation of mind-altering plants.

Psychoactive plants and fungi have been used for millennia amongst indigenous cultures around the world. Many of these cultures consider plants as sacred tools of human evolution and consciousness and integral to their ideas around spiritual connection. From Canada, via Gabon and India, to Australia, there are numerous mind altering fungi, cacti, shrubs and herbs. Despite this rich history of ancestral use, many of these natural medicines have since been synthesised into recreational drugs like cocaine and heroin and are now illegal in many countries. After more than half a century of the global drug war,  legal accessibility is slowly being  relaxed, and the use of psychedelic medicines is now being explored by clinicians and researchers for their therapeutic potential. 

Included below are a selection of psychoactive plants which have traditionally been used in different cultures for spiritual and ceremonial purposes. 

Fly agaric (Amanita muscaria)

Fly agaric is the iconic red and white mushroom historically rooted in folklore and ritual.  It grows across large parts of the world, including in the UK and the US and is rising in popularity for spiritual use. Fly agaric has been used ritualistically for centuries throughout Eastern Siberia and Scandinavia and features strongly in Norse mythology and shamanic traditions (1,2). 

Fly agaric (Amanita muscaria)
Fly agaric (Amanita muscaria)

Eaten raw and without careful preparation, it is toxic and can be deadly. However, when it is carefully prepared and dosed properly, its effects range from soothing and pain relieving to euphoric.

Medical herbalists will sometimes use amanita in safe doses for  insomnia, nerve pain, anxiety and cognitive decline.  The mushroom needs to be prepared in such a way that the toxicity of the compounds are neutralised and it can be ingested safely.  The active constituents in fly agaric are ibotenic acid and muscimol which can cause hallucinations (3). Ibotenic acid is an agonist of glutamate receptors (primarily NMDA and trans-ACPD receptor sites), resulting in an influx of calcium ions to the nerve cells. This causes excitotoxicity (overstimulation), which can result in mitochondrial dysfunction, oxidative stress and eventually cell death(4). 

Fly agaric is legal in every US state aside fromLouisiana. It is sold in the form of tinctures, joints, gummies, and capsules, although fly agaric remains illegal for consumption and possession in the UK. Medicinally, fly agaric is used to reduce stress, pain and insomnia. (5). There is currently a lack of human clinical trials into the effect of Amanita muscaria .Research has, however,  been conducted into the therapeutic effects of the active constituent muscimol, a GABA receptor agonist which calms the nervous system. A 2024 study on rodents suggested muscimol has anxiolytic and antidepressant effects (6). A further study suggested that the mechanism of action responsible for this effect is its action on increasing dopamine production (7).

There are also studies examining the effect of the active compound muscimol on treating Huntington’s disease, a condition with very limited treatment options. Muscimol is structurally similar to GABA, and also affects movement because of its influence on nerve cells within the muscles. Although muscimol did not improve the patients’ cognitive functions, chorea (involuntary movement) was significantly improved in the most severely hyperkinetic patient (8).  Another rodent study showed that muscimol from fly agaric helped neuropathic pain, again via GABA-A  receptor stimulation (9). Medical herbalists use amanita in balms for topical application to treat nerve pain. 

Amanita is a fascinating and sacred mushroom in many societies with potential to treat a variety of conditions. However, modern research is sparse and great care must be taken with fungi with such potency.

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How does herbal medicine fit into the German healthcare system? https://www.herbalreality.com/herbalism/western-herbal-medicine/how-does-herbal-medicine-fit-into-the-german-healthcare-system/ https://www.herbalreality.com/herbalism/western-herbal-medicine/how-does-herbal-medicine-fit-into-the-german-healthcare-system/#comments Mon, 18 Nov 2024 09:51:22 +0000 https://www.herbalreality.com/?p=14937 How accessible is herbal medicine in Germany? Jonas Brab explores the regulation and integration of phytotherapy in German healthcare.

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How accessible is herbal medicine in Germany? Jonas Brab explores the regulation and integration of phytotherapy in German healthcare.

Understanding the system

How does herbal medicine fit into the German healthcare system

Herbal medicine has a long tradition in Germany, dating back to ancient Roman and Germanic practices and further shaped by mediaeval herbalists. In more modern times, phytotherapy in Germany has been influenced by scientists and physicians who advocated for plant-based treatments grounded in scientific evidence. Though to understand how herbal medicine fits into Germany’s health care system, it is worth taking a look at this first. 

No two countries are the same when it comes to how they organise and deliver healthcare to their people, which provides a plethora of different approaches and results regarding the efficacy of their healthcare provision. The healthcare system in Germany is marked by using a decentralised healthcare system model, with governance divided between the federal and state levels, and corporatist bodies of self-governance. Compared to other countries, it has a relatively high spending on healthcare with 11.7% of its GDP, compared to, for example, the UK, spending 10.2% of its GDP on healthcare. Health insurance is compulsory and provided either under the statutory health insurance scheme or through a private health insurance (1).

People living in Germany have higher rates of regular expenditures for their healthcare, through monthly insurance payments, but generally have to pay less money out of pocket than in other countries when accessing comparable services (2). And, while all insurances alike cover the most basic medical needs, there is variability on coverage depending on the insurance type, i.e. private or statutory. Private insurance tends to be more expensive to the individual, but access is provided to better services and is more likely to extend to phytotherapy. Mainstream insurances tend not to cover the use of herbal medicine; however, owing to the growing popularity of phytotherapy, some insurers now offer add-on policies that include alternative treatments such as phytotherapy.

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The integration of biomedicine and herbal medicine: A comparison of cost and application https://www.herbalreality.com/herbalism/western-herbal-medicine/the-integration-of-biomedicine-and-herbal-medicine-a-comparison-of-cost-and-application/ https://www.herbalreality.com/herbalism/western-herbal-medicine/the-integration-of-biomedicine-and-herbal-medicine-a-comparison-of-cost-and-application/#comments Tue, 24 Sep 2024 16:30:10 +0000 https://www.herbalreality.com/?p=13972 How do biomedicine and herbal medicine currently coexist and how could we develop an integrated alternative that mitigates cost to the individual?

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How do biomedicine and herbal medicine currently coexist and how could we develop an integrated alternative that mitigates cost to the individual?

The integration of biomedicine and herbal medicine A comparison of cost and application

The integration of herbal medicine and biomedicine in the United Kingdom (UK) presents a valuable opportunity to improve patient care by combining the benefits of both treatment modalities (1).

Both herbal medicine and biomedicine have their own unique strengths in the management of acute conditions, chronic diseases and complex health issues. 

Herbal medicine is widely used in the UK, with an estimated 9 million people regularly using herbal remedies. The UK’s interest in complementary and alternative medicine (CAM) has grown in recent years, with herbal medicine playing a significant role in this trend (2,3). Sometimes patients will visit a qualified medical herbalist, who will prescribe and dispense individually tailored herbal medicines, and other times people will be taking over the counter herbal remedies, such as echinacea for colds, valerian for sleep, and ginger for digestive issues, alongside or instead of mainstream treatments.

A significant number of patients in the UK express a preference for natural and holistic approaches to healthcare (1,4). Integrating herbal medicine into mainstream medicine allows healthcare practitioners to respect patient preferences, improve patient satisfaction, and potentially enhance adherence to treatment plans (5). Equally, many cultural communities in the UK have long traditions of using herbal medicine, such as Ayurveda, Traditional Chinese Medicine (TCM), and Western herbal medicine. Integration could help bridge cultural gaps in healthcare delivery and promote inclusivity (5).

Biomedicine and herbal medicine have been successfully integrated in other healthcare systems in countries such as Ghana, China, Japan and South Korea (6,7,8,9). The UK’s National Health Service (NHS) is a publicly funded healthcare system that offers free or low-cost medical services and treatment to all UK residents.

While the NHS does provide some complementary therapies, such as acupuncture and osteopathy in some Trusts, the inclusion of herbal medicine remains limited (10). Herbal remedies and access to herbalist care is not funded by the NHS, contributing to a big expenditure for those who want to use it.

The cost of herbal medicine and pharmaceutical drugs

NHS prescriptions are free in Scotland and Wales, while in England, most people are required to pay a charge of £9.90 per item, with exemptions available for certain groups, such as those over 60, under 16, or with certain medical conditions (11). Herbal medicines are not subsidised by the NHS, and the cost of herbs can vary significantly depending on the preparation and quality of the product, whether bought over the counter, bought from a qualified herbalist or harvested and prepared at home. 

Modern medicine

Prescription pharmaceuticals can range from a few pounds to hundreds per month depending on the condition they treat and on the type of drug, the manufacturer, and the required dosage. For example, generic drugs, which are chemically identical to brand-name drugs, are typically cheaper. In the UK, generic drugs can cost anywhere from £1 to £10 for a month’s supply.

The cost of over-the-counter pharmaceuticals can range from a few pounds to around £20, depending on the product. For example, a box of ibuprofen may cost around £1–3, while medications like antihistamines or nasal sprays might cost between £5–10.

Herbal supplements and products can vary widely in cost, from a few pounds to over £50, depending on the herb, brand, form (e.g., capsules, teas, tinctures), and quality standards. For example, 100 grams of dried herb to make a tea can cost £6–8 pounds, while 100 ml of a herbal tincture could range from £8-£20 for a week’s supply.

Consultations with qualified herbalists in the UK are not subsided by the NHS, and can range from £35 to £100 or more per session (with the initial consult typically lasting an hour or more, with subsequent sessions of 30 minutes), depending on the practitioner’s experience and location. There are herbalists that will offer consultations for cheaper, on a sliding scale or even for free.

The cost of consulting a herbalist and using herbal medicine in the UK is significantly higher than NHS-funded pharmaceuticals and medical care, making herbal medicine inaccessible for many. It is important to note that while foraging and homemade herbal preparations for self-care would cost very little, the knowledge required for plant identification and to process herbs at home is not always within the reach of everyone. 

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Supporting doctors: How herbs can help reduce opioid use in chronic pain https://www.herbalreality.com/herbalism/western-herbal-medicine/supporting-doctors-how-herbs-can-help-reduce-opioid-use-in-chronic-pain/ https://www.herbalreality.com/herbalism/western-herbal-medicine/supporting-doctors-how-herbs-can-help-reduce-opioid-use-in-chronic-pain/#comments Tue, 24 Sep 2024 15:53:50 +0000 https://www.herbalreality.com/?p=13964 We explore what herbal medicine has to offer in the treatment of chronic pain to reduce opioid use.

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Opioid drugs are effective analgesia for acute conditions, yet bring risk of tolerance and dependency from long-term use. What does herbal medicine have to offer in the treatment of chronic pain?

The overuse of opioids in treating chronic non-cancer pain is a growing concern worldwide, particularly in the United Kingdom (12). The NHS England Medicines Optimisation Executive Group (MOEG) has identified reducing opioid use in this context as a key national priority for 2023/24 (3). Chronic non-cancer pain*, affecting millions in the UK, is often managed through opioids despite their limited efficacy and significant risk of dependence, tolerance, and other adverse effects (2,4). There is a potential role for herbal medicine to help reduce opioid use, thus supporting doctors in pain management.

*Throughout this article, when discussing “chronic pain”, we are referring to chronic non-cancer pain (CNCP).

The opioid crisis in the UK and its challenges

Supporting doctors How herbs can help reduce opioid use in chronic pain

Opioids, including tramadol, morphine, oxycodone, and fentanyl, are commonly prescribed for chronic pain. However, there is growing evidence that they are not particularly effective for long-term pain management in non-cancer patients (4,5,6). A systematic review highlighted that opioids provide only modest pain relief and little improvement in function for chronic pain patients, often leading to significant adverse effects, such as gastrointestinal issues, dizziness, and, most critically, dependency and addiction (4). In the UK, the Office for National Statistics (ONS) reported over 4,000 deaths related to opioid use in 2022 alone, underscoring the urgent need for safer pain management strategies (7).

Furthermore, the pharmacological treatment of chronic pain offers limited benefits and may pose potential risks, especially when compared to effective biopsychosocial interventions. The evidence supporting the use of strong opioids for chronic pain is inadequate to justify their use for this purpose (6). However, it is recognised that due to dependency, many individuals may struggle to discontinue these medications.

Given these challenges, the NHS Medicines Optimisation Executive Group has prioritised reducing opioid use to treat chronic pain. Traditional pharmacological interventions often fall short of providing long-term relief, prompting a growing interest in integrative approaches, including the use of herbal medicine (8).

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A campaign against antibiotics: The Soil Association https://www.herbalreality.com/herbalism/western-herbal-medicine/a-campaign-against-antibiotics-the-soil-association/ https://www.herbalreality.com/herbalism/western-herbal-medicine/a-campaign-against-antibiotics-the-soil-association/#comments Sun, 28 Jul 2024 07:17:47 +0000 https://www.herbalreality.com/?p=13112 This article explores the impact of modern farming practices on animal welfare and the industry’s consequential misuse of antibiotics.

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A campaign against antibiotics The Soil Association

Antibiotic resistance poses a great threat to global human health. This article explores the impact of modern farming practices on animal welfare and the industry’s consequential misuse of antibiotics.

Since their introduction to human medicine in the 1940s, antibiotics have become a cornerstone of modern medicine and helped save enormous numbers of lives.

Antibiotics are not only used to treat patients that have a bacterial infection, they are essential for preventing infections in those undergoing life-saving procedures like cancer chemotherapy, organ transplants or caesareans, or other types of major surgery.

The threat of antibiotic resistance

Unfortunately, according to the World Health Organization, the rise of antibiotic resistance, which occurs when bacteria evolve to resist the action of antibiotics, threatens many of the gains of modern medicine. The WHO says it is one of the top global public health and development threats. 

Antibiotic resistance is not merely a threat for the future, it is already here today and having a major impact. According to the first comprehensive assessment of the global impact of antibiotic resistance, published in 2019 in The Lancet journal, the deaths of 1.27 million people a year are directly attributable to antibiotic resistance, and 4.95 million deaths a year are associated with antibiotic resistance (1).

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Pharmacology of herbal antibiotics https://www.herbalreality.com/herbalism/western-herbal-medicine/pharmacology-of-herbal-antibiotics/ https://www.herbalreality.com/herbalism/western-herbal-medicine/pharmacology-of-herbal-antibiotics/#respond Tue, 23 Jul 2024 09:22:32 +0000 https://www.herbalreality.com/?p=13105 Our ability to treat infections with pharmaceuticals is jeopardised by antibiotic resistance. How can plants combat bacteria?

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Our ability to treat bacterial infection using pharmaceuticals is jeopardised by antibiotic resistance. How are plants able to combat bacteria and how can we use them in practice?

There is a strong history of using herbs to treat or prevent common infections. Many herbs that we use have been found to have antibacterial properties. Exploring how these work will help us to decide when and how they will add positively to healthcare.

Why is understanding herbal antibiotics important?

Pharmacology of herbal antibiotics

In the days before antibiotics, more than half of deaths were due to infectious diseases (1). The use of antibiotics has extended lifespan, both due to increased survival and the advances in medicine, such as surgery, that have only been possible due to our ability to combat infections (1).

However, due to a combination of a lack of investment into antibiotic drug discovery, overuse of these wonder drugs, and the innate ability of bacteria to evolve to resist and survive against them, we are currently in an antibiotic resistance crisis. Whether it will just take more responsible use of antibiotics and more funding for the development of new ones, or a dramatically different take on the problem remains to be seen. Herbal antibiotics, as sustainable and accessible forms of healthcare are likely to be a part of the solution.

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The brain as a vascular organ: Framing new herbal strategies for supporting the nervous system https://www.herbalreality.com/herbalism/western-herbal-medicine/the-brain-as-a-vascular-organ-framing-new-herbal-strategies-for-supporting-the-nervous-system/ https://www.herbalreality.com/herbalism/western-herbal-medicine/the-brain-as-a-vascular-organ-framing-new-herbal-strategies-for-supporting-the-nervous-system/#respond Sat, 13 Jul 2024 08:12:47 +0000 https://www.herbalreality.com/?p=12892 Simon Mills explores cerebral development, circulation and disease and invigorates our approach to mitigating neuroinflammation and its consequences.

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What are the implications of perfusion on brain health? Simon Mills explores cerebral development, circulation and disease and invigorates our approach to mitigating neuroinflammation and its consequences.

Putting the pieces back together

The brain as a vascular organ Framing new herbal strategies for supporting the nervous system

In modern times, Western herbal medicine has had a problem with the brain. In our atomised culture the body tissues and organs have become separated. At school we learnt that the kidneys do their things, the liver does others, the heart is a solitary pump, the lungs are bellows, and the brain is sealed off from the rest of the body —managing its substance the preserve of neurologists, its activity that of psychologists, and prescriptions largely restricted to neurotransmitter modulators.

Physiology has moved on of course, and in theory all the old barriers are down. For example, the liver and kidneys are wholly enmeshed, the heart is better understood as a resonator of the wider vascular pulsation, and the lungs, once a branch of the gut, become an intrinsic part of the circulatory and immune systems.  We now understand the brain is dynamically interactive with the rest of the body, as evidenced by concepts like the gut-brain axis and psychoneuroendocrinology. 

Medical practice is still however relatively fragmentary, and the old Cartesian reductionist language unfortunately still infects even our herbal discourse (what do we really mean by ‘nervines’?). Other herbal traditions never faced this challenge. For example, in Chinese traditional medicine organs are physical manifestations of vital functions (although in Western translations these functions are also misleadingly referred to as ‘organs’). So, for example, the brain is considered an extension of bone marrow and comes within the orbit of the Kidney function (shen), and thus is one manifestation of the most powerful energetic phenomena in the living being, along with bones, birth, development and reproduction. On the other hand, the brain’s activities, such as perception and cognition, are manifestations of the Heart function (xin) and are associated, therefore, variously with pleasure, our sense of self, and the dynamic aspects of circulation (1). These insights arise out of extensive deep reflections on human experiences over many centuries rather than dissection science. Arguably, they have renewed relevance as we discover the limitations of medical fragmentation in understanding complex health conditions.

Fortunately, new insights into brain and mental functions may allow us at last to rethink our therapeutic approaches in Western terms, and unlock the brain from its sealed cavity. In particular, we can see that many problems in this area are essentially vascular, and by extension potentially of inflammatory origin. We can look first at the close links central nervous tissues have with the blood circulation.

The brain and blood vessels start out together

During embryogenesis and early life, the nervous and vascular systems intricately coordinate their development from common origins in the embryonic neural tube, itself derived from a fold in the ectoderm. Neurons and glia are derived from neural tube neuroectodermal stem cells, whereas specialised vascular components, including adapted smooth muscle cells called pericytes, are derived from the neural crest, a segregated portion of the neural tube.

There are no resident vascular precursors among the cells that will form the central nervous system, so vessel sprouts invade the developing brain and spinal cord at the outset, in a form of angiogenesis — the formation of new blood vessels (2).  Once there, they follow cues provided by the developing nervous system to migrate alongside radial glia, neural progenitor cells that form long cell extensions along the neural tube. At medial surfaces (called the ventricular zone) radial glial cells undergo mitosis into daughter cells that migrate to the lateral surface of the tube and differentiate into neurons, microglia, the macroglia astrocytes, oligodendrocytes and ependymal cells, while others remain as stem cells. Invading vessel sprouts initially move to the border of the ventricular zone, but leave the radial glia there and migrate laterally, to form interconnections with the new cells (3).

In early neurovascular crosstalk, astrocytes link vascular endothelial cells and their attached pericytes to form intimate associations with the neurons, (4) particularly in embryological zones called ‘vascular niches’. It even appears that angiogenesis and neurogenesis are regulated by shared growth factors, released both by endothelial cells and neurons. These include members of the vascular endothelial growth factor (VEGF —see below), semaphorin, Wnt and integrin families, and neuropilin (5,6).

Oligodendrocytes, critical to myelination and remyelination of neurons, also migrate through the developing CNS along with blood vessels (7).

Neurovascular communication is the basis for functional magnetic resonance imaging (fMRI) scans, a technique that reveals changes in local blood flow and oxygenation that correlate with immediate and localised neural activity in the brain.

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What has caused the rise of neurodegeneration and what can we do? https://www.herbalreality.com/health-lifestyle/ageing/what-has-caused-the-rise-of-neurodegeneration-and-what-can-we-do/ https://www.herbalreality.com/health-lifestyle/ageing/what-has-caused-the-rise-of-neurodegeneration-and-what-can-we-do/#comments Mon, 22 Apr 2024 14:36:25 +0000 https://www.herbalreality.com/?p=11775 This article explores factors contributing to the development of neurodegenerative disease and lifestyle and herbal approaches to mitigate risk and limit progression.

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This article explores factors contributing to the development of neurodegenerative disease and lifestyle and herbal approaches to mitigate risk and limit progression.

What has caused the rise of neurodegeneration and what can we do

Neurodegenerative conditions such as Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis (ALS), Huntington’s disease, spinal muscular atrophy and spinocerebellar ataxia are associated with progressive loss of neuronal functions (1). The prevalence of these conditions has been on the rise worldwide (2, 3). The World Health Organisation (WHO) estimates that soon neurodegenerative conditions will overtake cancer to become the second leading cause of death, after cardiovascular disease (4).

One of the primary drivers of the rise in neurodegenerative diseases is the ageing population. As life expectancy increases globally, the prevalence of age-related conditions, including Alzheimer’s and Parkinson’s, rises accordingly. Epidemiological data consistently show a strong correlation between age and the risk of developing neurodegenerative disorders (5, 6).

Several lifestyle factors have been linked to an increased risk of neurodegeneration. These include sedentary behaviour, poor diet, smoking and excessive alcohol consumption and (7). Studies have highlighted the importance of adopting healthy lifestyle choices in reducing the risk of cognitive decline and neurodegenerative diseases (7, 8, 9). 

While ageing and lifestyle factors contribute significantly to the rise in neurodegeneration, genetic predisposition also plays a crucial role (6). Epidemiological studies have identified several genetic variants associated with an elevated risk of Alzheimer’s, Parkinson’s, and other neurodegenerative disorders. However, it’s essential to recognise that genetic predisposition alone does not determine disease onset, and interactions with environmental factors are often involved (6, 7). 

Exposure to heavy metals, such as lead, mercury, and aluminium, has been implicated in the pathogenesis of neurodegenerative diseases (10). These metals can accumulate in the brain over time, leading to oxidative stress, neuroinflammation, and neuronal damage (10).

Exposure to heavy metals, such as lead, mercury, cadmium, and arsenic, can significantly contribute to the pathogenesis of neurodegeneration (11). Heavy metals can generate reactive oxygen species (ROS) through Fenton-like reactions. ROS cause oxidative damage to cellular components like proteins, lipids, and DNA. This oxidative stress can lead to neuronal injury and cell death, contributing to neurodegeneration (7, 12).

Heavy metals can also trigger inflammatory responses in the brain by activating microglia, the resident immune cells of the central nervous system. Chronic inflammation can lead to neuronal damage and contribute to the progression of neurodegenerative diseases. Some heavy metals can disrupt the blood brain barrier (BBB), allowing toxic substances to enter the brain more easily. Once inside, these substances can induce neuronal damage and contribute to neurodegeneration (13). 

Heavy metals can impair mitochondrial function, which is crucial for energy production and maintaining cellular homeostasis. Mitochondrial dysfunction leads to energy depletion and an increase in ROS production, further exacerbating oxidative stress and neuronal damage (14). Certain heavy metals have been shown to promote the aggregation of proteins such as amyloid-beta and tau, which are characteristic features of Alzheimer’s disease and other neurodegenerative disorders (15). Protein aggregation disrupts cellular function and can lead to neuronal dysfunction and death.

Moreover, heavy metals can interfere with neurotransmitter systems, such as dopamine, glutamate, and GABA, disrupting neuronal communication and leading to neurodegenerative changes (16).

Epidemiological studies have demonstrated a correlation between lead exposure and cognitive decline in both children and adults (17, 18). Even low levels of lead exposure have been associated with an increased risk of neurodegenerative disorders later in life. Mechanistically, lead interferes with neurotransmitter function, disrupts calcium homeostasis, and promotes the generation of reactive oxygen species (ROS), contributing to neuronal dysfunction and death.

Mercury exposure, primarily through contaminated seafood or dental amalgams, has been linked to neurodegenerative diseases such as Alzheimer’s and Parkinson’s (19, 20). Epidemiological evidence suggests that chronic exposure to mercury can impair neuronal function, disrupt mitochondrial activity, and induce neuroinflammation (21). Additionally, mercury has been shown to facilitate the aggregation of amyloid-beta and tau proteins, characteristic features of Alzheimer’s pathology.

Although the role of aluminium in neurodegeneration remains controversial, epidemiological studies have indicated a potential link between aluminium exposure and cognitive impairment (22). Aluminium can accumulate in the brain, particularly in regions affected by Alzheimer’s disease pathology. It exerts neurotoxic effects by promoting oxidative stress, disrupting neurotransmitter balance, and facilitating the formation of amyloid plaques (22).

Emerging evidence suggests that chronic exposure to organophosphates may contribute to the development of neurodegenerative conditions. Organophosphates are a class of chemicals commonly used as pesticides, insecticides, and nerve agents (23).

Epidemiological studies have identified an association between pesticide exposure, particularly organophosphates, and an increased risk of neurodegenerative disorders (23, 24). Agricultural workers and individuals living in proximity to pesticide-treated areas are at higher risk (25). Organophosphates inhibit acetylcholinesterase, leading to the accumulation of acetylcholine and overstimulation of cholinergic pathways in the brain, which can result in neurotoxicity (24).

Organophosphates can also induce oxidative stress and neuroinflammation, contributing to neuronal damage and dysfunction. These chemicals generate ROS and disrupt antioxidant defence mechanisms, leading to cellular damage and mitochondrial dysfunction (25). As mentioned before, chronic inflammation can exacerbate neurodegeneration by activating microglia and promoting the release of pro-inflammatory cytokines.

It is important to remember that the consequences of neurodegeneration extend beyond individual health outcomes, and can also impact healthcare systems, economies, and society as a whole. Neurodegenerative conditions impose a substantial burden on healthcare systems worldwide, as people suffering with neurodegenerative conditions generally need extensive medical care, long-term support, and specialised services (26).

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Excerpt from The Healing Power of Scent by Ellen Rowland https://www.herbalreality.com/herbalism/western-herbal-medicine/excerpt-from-the-healing-power-of-scent-by-ellen-rowland/ https://www.herbalreality.com/herbalism/western-herbal-medicine/excerpt-from-the-healing-power-of-scent-by-ellen-rowland/#comments Sun, 07 Apr 2024 16:36:52 +0000 https://www.herbalreality.com/?p=11680 Aromatherapist Ellen Rowland shares a section from her book on what smell is and how it can affect our wellbeing.

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Aromatherapist Ellen Rowland shares a section from her book on what smell is and how it can affect our wellbeing.

Excerpt from Chapter 1: What is smell?

The Healing Power of Scent - Ellen Rowland

Scent and sensitivity: Aromas and the nervous system

Our nervous system is very sensitive to scent. When we detect an aroma, the limbic system, a collection of structures in our brain that includes the thalamus, hypothalamus and amygdala, comes into play. This is the part of our brain which relates to mood and emotion. The amygdala in particular, the first port of call for odours reaching the brain, is concerned with interpreting the ‘emotional significance of events in the external world (33).

Smells have a direct impact on our nervous systems since inhaling them can trigger the release or inhibition of certain hormones into the bloodstream. These can activate or inhibit our parasympathetic (our ‘rest and digest’ mode) or sympathetic nervous systems (‘fight/flight/freeze’) by way of the hypothalamus, which controls our autonomic nervous system, of which the parasympathetic and sympathetic system are the main parts. This influence is due to the scent molecules’ direct link to the amygdala and hypothalamus (34). Current science understands that aroma signals mostly bypass the thalamus (35), the part of our brain that deals with conscious recognition, and are transmitted straight to the hypothalamus, which has a major influence on the endocrine (hormonal) system. As such, aromas are not always consciously processed by the frontal cortex, where our usual cognition and interpretation occurs (36), and so the influence aromas have on our body and mind is thought not always to be consciously processed by our brain (18).

Clinical aromatherapy research in practice

Illustration credits to Prudence Rogers for David & Charles Books

Several research studies and systematic reviews have demonstrated the positive effects of different aromas on mood disorders like depression (52), noted improvements in cognitive function in mice, suggesting that aromatherapy could be an effective treatment for Alzheimer’s disease (53), and recorded reduced stress levels in teenagers within academic environments (54). Anxiety in dental waiting rooms has been abated by aromatherapy (55), menopausal anxiety and depression have been relieved,56 and it has been shown to ‘significantly decrease’ (57) labour pain and anxiety. Midwives in the UK do, on occasion and with appropriate training and experience, offer aromatherapy through inhalation and massage to their pregnant patients – this is perhaps the most widely accepted form of aromatherapy within mainstream healthcare contexts like the NHS (National Health Service, UK), probably due to its efficacy (58) and relative safety (59).

Aromatherapy has also been shown to improve postpartum ‘depression, fatigue, sleep quality, pain after caesarean delivery and post-episiotomy pain’ (60) and reduce dysmenorrhea, too, so it is a useful and gentle tool for those who are pregnant or postpartum people to carry all the way through their pregnancy, birth and on into parenthood. In my aromatherapy clinic, for example, I offer a specialised workshop for parents-to-be, which includes a bespoke pregnancy massage tutorial, and a series of customised inhalation and massage oil blends for the three trimesters, as well as specific blends for use during labour. I also provide follow-up information and postpartum products, such as balms or oil blends, if the clients prefer. My clients and I have found this to be an enjoyable, holistic and gentle approach to ensuring that parents and their birth partners feel supported throughout their pregnancy. Treatment can normally be given alongside and in respect of ongoing treatment or appointments within mainstream healthcare.

Biochemistry and the brain: How scent influences mood

The ability of aromas to influence our nervous systems can cause us to feel anger, joy, or fear by altering our biochemistry, impacting both our physical states and mood (39). To understand how this works on a biochemical level, let’s explore the key hormones and brain structures associated with this influence.

Amygdala

This structure is part of the limbic system of our brain, and is responsible for mediating emotions such as fear, aggression and anxiety (40). It does this by sending signals of distress via the nervous system to our adrenal glands, which are located on the top of our kidneys. These glands secrete the hormone epinephrine (adrenaline) and cortisol (41) into our bloodstream (42) which results in stimulation of the sympathetic nervous system, otherwise known as the ‘fight or flight’ response. When we enter this state, our heart rate increases, sending more blood and oxygen around the body, and our breathing speeds up (43) This is a natural response to stressful situations and the body’s natural way of preparing us to encounter (or run away from) life-threatening situations. However, in conditions like Generalised Anxiety Disorder or chronic stress, this response can activate inappropriately (44) and cause health problems, both physical and psychological (45). Thankfully, scent can be used to ‘teach’ the nervous system that it is safe, causing inhibition of the sympathetic nervous system, and activation of the parasympathetic nervous system – our ‘rest and digest’ mode. Later, we’ll explore how this works.

Hypothalamus

This brain structure is also part of the limbic system and is responsible for the release or inhibition of hormones. Hormones (including dopamine, the ‘feel-good’ or ‘pleasure’ hormone) (46,47) are released into the bloodstream and go on to stimulate the pituitary gland to produce more hormones (such as oxytocin, the ‘love hormone’) (48) which influence our thyroid and adrenal glands, reproductive system and autonomic nervous system (49). Since the hypothalamus is the area ‘where the nervous system and endocrine [hormonal] system overlap’ (50), this cascade of hormones can have an impact on anything from our mood, to our sleep and metabolism (51).

In fact, we already have access to this invention: scent is the key to the revival of vivid memories. The brain’s limbic system, in addition to regulating mood and emotion, is also responsible for the creation of memory associations. More specifically, the hippocampus, which is the area of the brain that converts short-term memory to long-term memory (63). In a 2020 talk, ‘Olfaction in Science and Society’, sponsored by the Harvard Museum of Natural History, Dawn Goldworm, co-founder of an olfactive branding company, 12.29, explains:

“…smell and emotion are stored as one memory
and childhood is usually the time of life in
which you create the basis for smells you will
like and hate for the rest of your life.” (64)

While not bottled, these scent-memories are contained subconsciously within the brain’s anterior olfactory nucleus (65), and are ‘uncorked’ when triggered by a certain vocative scent. The smell of mown grass, lavender laundry water in a grandmother’s garden, campfire woodsmoke on a cherished holiday, pine disinfectant on freshly-scrubbed bathroom floors, cedar moth repellent in an old wardrobe, seaweed drying in the sun, and toasting bread in a family home are all scent-memories that students on my aromatherapy and herbalism workshops and retreats have recalled when I have asked which aromas evoke memory responses for them. For some people, the same aroma will have a range of responses, and they can differ wildly! Just as no two lives are alike, it is seldom that two people will have the same associations with a
particular scent.

Memories of scent

“Our senses connect us intimately to the past, connect us in
ways that most of our cherished ideas never could”
Diane Ackerman, A Natural History of the Senses (61)

As well as their neurological and hormonal effects, aromas can influence our mood through memories and associations. Have you ever been walking down the street, and caught a scent on the breeze that immediately transported you back in time, or to a cherished place from your childhood? For me, the smell of eucalyptus has always transported me back to a park on the coast in Tasmania, Australia, where I lived for a year when I was eight years old. Not only is the scent strongly associated with a sense of place, but the colours, textures and sounds, even the breeze and temperature, come clearly into my mind’s eye. When I inhale the resinous, baked and distinctive aroma of the leaves as the sun gently warms them and releases their oils, I picture the park swings, the chipped bark underfoot, and the afternoon light on the wet rocks and dancing across the ocean. I can almost see the seabirds fishing, and feel the breeze and sunlight on my skin.

So why is scent such a powerful and seemingly magical conjurer when it comes to memory? It’s all to do with the limbic system again. In her 1938 novel, Rebecca, Daphne du Maurier’s protagonist wishes:

“If only there could be an invention that
bottled up a memory, like scent. And
it never faded, and it never got stale.
And then, when one wanted it, the bottle
could be uncorked, and it would be like
living the moment all over again.”

Daphne du Maurier, Rebecca (62)

What’s more, the client is then able to take a blend of these aromatic oils with them when they leave the treatment space, by way of an inhaler, roll-on oil blend, or room spray, which with time and practice, will enable them to conjure up the new, positive association when they are struggling to sleep or experiencing high levels of stress, and will have a positive, relaxing effect on their nervous system, emotions and muscles (70). This is what is known as a ‘learned odour response’ (71) and can easily and effectively be employed in a number of different scenarios to elicit ‘measurable effects on cognitive performance, stress, and mood’ (72).

Making new memories

Illustration credits to Prudence Rogers for David & Charles Books

While most scent-memory associations may be crafted and cemented during childhood, as adults we do have the ability to influence, change and create new associations (66). As a practising aromatherapist, before beginning a treatment, I make sure to ask my clients whether there are any aromas they know they absolutely cannot bear so that I avoid triggering any negative scent-memory-emotion responses, and I try to use essential oils and extracts with which they have already formed positive associations. For example, if a client is working with a particular challenge, such as insomnia, we might work together through the course of our treatments to create new aroma-memory associations. Since our brains are plastic (67) (they can learn, adapt and change), and have the amazing ability to form new scent associations through ‘induce[d] emotional olfactory learning’,68 aromatherapists are uniquely placed to support their clients to create and build an association between the scent of German chamomile (Matricaria recutita) and lavender (Lavandula angustifolia), for example.

The relaxing, dimly-lit ambience and safe, therapeutic space that the treatment room provides will further enhance this association. Since odours ‘vividly trigger the evocation of emotional experiences’(69), over the course of regular consultations and treatments, we can build a trusting, therapeutic relationship and work together to strengthen and reinforce the message we are sending to the client’s brain. The aromas of German chamomile and lavender in combination with a soothing massage treatment, a warm, calming space and a listening ear, is effectively telling their brain ‘I’m safe’, ‘I can relax’, ‘I can feel calm and happy’ and ‘it’s time to sleep’.

Olfactory fatigue

In her book, Fragrant: The Secret Life of Scent, Mandy Aftel mentions a phenomenon known as ‘olfactory fatigue’ whereby the overstimulation of our olfactory organ can distort and weaken our ability to perceive different aromas (73). Have you ever tried smelling samples of perfume, or flowers, only to find that after a while you can no longer detect the different notes and aromas? Or perhaps all the scents start to smell the same? This is olfactory fatigue. Contrary to popular belief, smelling coffee beans will not ‘reset your nose’, and actually, Aftel argues, smelling something made out of wool might be a better alternative. Science and food author Harold McGee, in his book Nose Dive, states that lanolin, the waxy coating found on wool, ‘holds’ onto aromas (74). Perhaps this is why wool works well as a sort of ‘olfactory reset button’.

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The role of herbalism in preventative medicine https://www.herbalreality.com/herbalism/western-herbal-medicine/the-role-of-herbalism-in-preventative-medicine/ https://www.herbalreality.com/herbalism/western-herbal-medicine/the-role-of-herbalism-in-preventative-medicine/#comments Tue, 26 Mar 2024 10:50:54 +0000 https://www.herbalreality.com/?p=11525 Through the regulatory effects of medicinal plants, herbalism offers valuable tools for promoting health and preventing illness.

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Through the immunomodulatory, antioxidant, anti-inflammatory, antimicrobial, and metabolic regulatory effects of medicinal plants, herbalism offers valuable tools for promoting health and preventing illness.

The role of herbalism in preventative medicine

Herbal medicine has been a fundamental component of healthcare systems across cultures for centuries. From ancient China and India to indigenous and traditional cultures in Africa and the Americas, herbal remedies have been integral to promoting health and preventing illness (1). In recent years, there has been a notable interest in holistic and natural approaches to healthcare, with herbalism emerging as a prominent contender in the realm of preventative medicine (1,2). Herbal medicine can offer a wealth of benefits for maintaining health and preventing illness. Plants have been used for their medicinal properties since ancient times, and their role in disease prevention is arguably more significant than ever. 

In recent decades, there has been a resurgence of interest in herbal medicine, driven by factors such as dissatisfaction with pharmaceuticals, concerns about adverse effects, and a growing appreciation for holistic and individualised approaches to health (2). Moreover, advances in scientific research have shed light on the biochemical mechanisms underlying the therapeutic effects of many medicinal plants, validating their traditional uses, and providing insights into their potential applications in disease prevention (3).

Herbalism is a holistic practice that acknowledges the interconnectedness of the body and mind. Rather than simply targeting isolated symptoms, herbal remedies work to restore balance and harmony within the body, addressing underlying imbalances that may contribute to disease (4). This holistic approach not only treats existing health problems, but it can also strengthen the body’s natural defences, helping to prevent future illness and promote overall well-being. 

Another strength of herbalism lies in its ability to offer personalised treatment plans tailored to individual needs (5). Herbalists consider a person’s unique constitution, lifestyle, and health goals when selecting appropriate herbs and formulations. By considering the whole person, and by being able to choose herbs that take into account individual needs, herbalism can offer a comprehensive and effective approach to preventative medicine (6).

When compared to many pharmaceutical medications, herbal remedies typically have fewer adverse effects and are generally well-tolerated. This is because plants contain a complex combination of compounds that work synergistically to produce therapeutic effects, often in lower concentrations than synthetic drugs (2). As a result, herbalism offers a gentler alternative for preventative care, reducing the risk of unwanted side effects commonly associated with conventional medications. For example, one of the well-known side effects of the anti-inflammatory drug acetylsalicylic acid (aspirin) is stomach ulcers. Aspirin was synthesised from salicylic acid containing herbs like meadowsweet (Filipendula ulmaria) (7). Meadowsweet not only has anti-inflammatory properties partly due to this phytochemical, but it does not cause stomach ulcers. In fact, it is used to treat digestive complaints (8). This is likely due to the synergistic action of all the constituents found in meadowsweet.

Plants contain bioactive phytochemicals including flavonoids, alkaloids, and terpenes, which have been found to exhibit antioxidant, anti-inflammatory, antimicrobial, and immune-modulating effects. Medicinal plants containing these phytochemicals and many others, can help to improve immune function, reduce oxidative stress, and protect against chronic diseases (8).

Herbal medicine can play a role in disease prevention through different mechanisms.

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An introduction to herbal energetics https://www.herbalreality.com/herbalism/western-herbal-medicine/an-introduction-to-herbal-energetics/ https://www.herbalreality.com/herbalism/western-herbal-medicine/an-introduction-to-herbal-energetics/#comments Mon, 11 Mar 2024 17:23:28 +0000 https://www.herbalreality.com/?p=11460 Herbal energetics are the descriptions Herbalists have given to plants based on the direct experience of how they taste, feel and work in the body.

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Herbal energetics are the descriptions Herbalists have given to plants, mushrooms, lichens, foods and some minerals based on the direct experience of how they taste, feel and work in the body. All traditional health systems use these principles to explain how the environment we live in and absorb, impacts our health. Unsurprisingly for cultures deeply rooted in Nature, a natural and elemental language is used to describe the tastes, qualities and effects of these plants and ingredients. You might consider that energetics are a way to describe the therapeutic character and personality of a plant.

An introduction to herbal energetics

Traditional healing systems understand that human health is an extension of environmental health and that it is the relationship between the two which health depends upon. Understanding the patterns expressed in our ecosystem and whether it is dry, humid, warm or cold, offers valuable insights into how our human organism might respond in our environment. Understanding how these patterns are expressed in individual plants leads to expertise in herbal energetics. Ultimately, on our co-evolutionary path we have developed complex physiological and psychological systems to understand and benefit from plants.

Deduced by acute sensory observation and the direct experience of generations of practitioners, herbal energetics are the way we describe nature’s natural pharmacology. The character of a plant is often described in terms of the polar opposites of temperature, moisture, direction and texture; hot-cold, wet-dry, up-down, rough-smooth but also including tastes, colour, smell, feeling and sound. The language of energetics is the language of nature, it’s the language we use to describe how we experience life and how it makes us feel.  As the Chinese Traditional Inner Classic says ‘Hot diseases must be cooled and cold diseases must be warmed’, so these herbal classifications guide the herbs to be used in a treatment.

This approach to interpreting nature’s pharmacology emphasises the qualitative nature of the plant as opposed to how much of what molecule is in it. However, there are quantitative assessments in terms of strength and hierarchy of some energetics; for example the Galenical classification of ranking extremes of hot or cold in the first, second or third degree. This energetic approach is certainly more macrocosmic than microcosmic, more holistic than reductionist, more vitalistic than chemical, more systemic than cellular. And its just one of the ways that herbalists interpret how to use herbs; herbal energetics are always used in conjunction with the other aspects of knowledge based on the collective insights into specific herbal actions and doses.

We share detail on how Traditional Western, Chinese and Ayurvedic approaches describe the energetics of health. (Whilst broadly in agreement, other Galenic, Eclectic, Physiomedical, Kanpo, Native American and other health traditions contain their own particular insights we have not been able to cover here). The detail can be quite technical and nuanced so a real understanding of energetics must be learnt from a good teacher and directly experienced. It is important to remember that energetic classifications need to be interpreted in the context of the individual’s constitution and presenting patterns, as well as the seasonal climate and the dose. Herbalists always consider ‘who’ is having ‘how much’ of ‘what’ and ‘when’ in order to individualise the theory into practice.

Whilst exploring this world of energetics, experiment for yourself; some plants are hot, heating and lively – just chew some fresh ginger-, and some are much more cooling and calming – sip some chamomile tea. Some plants dry our mouth like a strong cup of black tea and some moisten it by chewing on a few linseeds or a bit of marshmallow root. All sorts of other physiological and emotional responses may be felt at more subtle levels with each herb.  This polarity is also seen in concepts of yin-yang  in Chinese culture  and purusha-prakriti in Indian world views.

The best books on energetics are the original classics of traditional medicine (e.g. Galen, Culpepper, Charaka, Sushruta, Bhavaprakasha, Huang-ti Nei Ching, Shen Nong Bencao, Shang Han lun, Li Shizhen’s Bencao Cangmu).

Some of our favourite modern books on energetics are:

Traditional herbal medicine energetics

The three primary energetic qualities are temperature, tone and moisture. These are used to describe body systems, organs and tissues in the body. They help herbalists understands the patterns of a patient’s condition, so they can prescribe herbs personalised for them and their constitution. 

Temperature 

Temperature in the context of herbal energetics refers to the heating or cooling effects of herbs and foods.

Warming herbs are typically ‘hot’, ‘spicy’ or ‘pungent’ due to the presence of aromatic oils. Generally these herbs bring ‘warmth’ to the tissues by stimulating circulation and dilating the micro-capillaries thus creating an opening effect within the cardiovascular system that increases blood movement and therefore perfusion to the tissues. Warming herbs are often also diaphoretic- meaning that they stimulate the sweat reflex- this action could be seen as a contradictory as it is essentially ‘cooling’. However, the action of warming herbs remains to increase peripheral circulation and therefore is classified as warming to the body tissues. Some examples include chilli, garlic, horseradish, cinnamon and ginger. The nature of the herbs chosen depends on the affected tissues and unique presentation of the patient.

Horseradish (Amoracia rusticana/Cochlearia armoracia)
Horseradish (Amoracia rusticana/Cochlearia armoracia)

In Ayurveda, hot substances are usually used to treat cold, contracted and hypo or sluggish conditions. Beneficial to kapha and vata, it dries damp, phlegm and warms cold. As ‘like increases like’ pungent herbs encourage agni and digestion to function at optimum level. Herbs that are heating usually contain volatile oils or mustard glycosides that stimulate gastric secretions as well as assimilation of nutrients.  Heating herbs have a particular affinity for the heart, head, liver and lungs and are commonly used when they are imbalanced but may damage them if used unjudiciously. Pungent, sour and salty herbs tend to be heating. In TCM warming herbs heat the body, stimulates qi and move the blood. 

Cooling herbs may be used for conditions that are classified as hot or inflammatory by nature. They work via a number of different actions – some by reducing inflammation, others by detoxifying the blood or lymph or by moderating the function of specific tissues. Diaphoresis is another cooling action of herbs which works by stimulating the sweat reflex and reducing heat in the body through the skin. Examples of cooling herbs include; cleavers or  burdock due to their ability to help decrease toxicity and stagnation in the tissues via the lymphatic system. Bitter herbs such as andrographis, dandelion and golden seal root have a systemic cooling effect due to their ability to enhance metabolic function and support liver detoxification which reduces inflammatory heat toxins in circulation around the body. The nature of the herbs chosen depends on the affected tissues and the unique presentation of the patient. 

According to Ayurveda cooling herbs benefit pitta whilst aggravating kapha and vata; cold natured herbs soothe painful and inflammatory heat conditions. Digestion is easily damaged by cold natured herbs and should be used cautiously when there is diarrhoea and sluggish digestion from cold. Cold herbs have an affinity for the stomach, the kidneys and the bladder and can weaken them if used excessively. Bitter, astringent and sweet herbs tend to be cooling. In TCM cooling herbs cool the body, remove heat, reduces redness and bleeding. They also consider that they can slow digestion and increase urination.

Moisture

Moisture refers to the drying or moistening effects of herbs that may be astringent or unctuous, heating or cooling, in their qualities.

Drying herbs tend to have astringent or tonic qualities. This means that they pucker the tissues thus increasing their barrier functions. Drying herbs may have diuretic actions which work by increasing the output of fluid from the body. They may also be astringent due to tannin content. Drying herbs are used to help tonify the tissues to reduce excess secretions, phlegm or mucous. Drying herbs may also be used to help in tissue healing particularly where they have become flaccid and lacking in tone. Drying herbs include rose, lady’s mantle, blackberry leaf, raspberry leaf, agrimony and elderflower. Not all drying herbs will be suitable in all cases of moist/ excess fluid type conditions. Tannin rich herbs are also limited to short term use. A herbalist will select a combination of herbs based on the unique circumstances of the patient.

Any plant with a dry quality is naturally astringent, absorbs moisture and therefore reduces damp-kapha and increases dry-vata. They are usually high in tannins and may also be heating as well (as heat dries fluids). Most plants have tannins in but certain barks and fruits are especially astringent. Haritaki (Terminalia chebula) is dry.

Moistening herbs bring a demulcent or soothing effect to inflamed or dry tissues. These herbs may be used where there is irritation due to dryness or lack of productivity in the tissues. Moistening herbs tend to be rich in mucilage (a carbohydrate rich plant substance) that forms a slippery and softening protective layer over the tissues. Sometimes herbs have a moistening effect due to oil content or by their ability to nourish the tissues- others by their ability to deliver or stimulate fluid production in certain tissues. Moistening herbs that are rich in mucilage include herbs such as marshmallow, slippery elm, psyllium and aloe vera. Oily moistening herbs coconut oil and castor oil. Herbs that stimulate the production of fluids may include; fenugreek  and maca. These all impact different tissues so the nature of the herbs chosen depends on the affected tissues and unique presentation of the patient.

In Ayurveda these moist herbs are referred to as Unctuous (snigdha). These herbs are soft, demulcent and oily. They are strengthening, increase virility, fertility and kapha. They are usually sweet, heavy and contain a high content of volatile oils, mucilage or essential fatty acids. Hemp seeds (Cannabis sativa) and oil are unctuous.

Tone 

Tone refers to how tense or relaxed tissues are. Tone is used to describe the status of the lining of organs called epithelium or to describe the level of integrity of muscles and other tissues. Healthy tone of the tissues or muscles will usually correspond with balanced function of the organs and with a relaxed, and easy composure or stance. Too much tension impedes flow, and flaccidity means that function is at less than optimum. Herbs can affect tone in many different ways. Some herbs are able to increase tone and others are able to relax the tissues where there is excess tension or constriction. Tonics are often confused with toning herbs as ‘toning’ refers to tissue quality whereas ‘tonics’ generally refers to herbs that bring energy and are more like adaptogens.

Catnip (Nepeta cataria)
Catnip (Nepeta cataria)

Relaxing herbs are used when there is too much tension, tightness and constriction. Constriction can be both physically restricting and mentally and emotionally. For example, it can restrict the movement of fluids and blood, as well as creativity. Symptoms of this tissue state can include muscle tension, spasms, insomnia, anxiety, emotional irritability and exhaustion. Relaxing herbs are numerous from lemon balm and chamomile to motherwort and Valerian.

Neutralising herbs are neither relaxing or toning as they operate in a neutral field with regard to tissue quality. They may however be warming, cooling , ascending descending etc.

Toning herbs are used when there is excessive slackness, softness and weakness. Atony is used to describe states where tissues are without tone, flaccid, and too relaxed to be working at optimum. They often overflow with fluids as they can’t hold onto them, and this can include runny mucus or diarrhoea. Indicators of lax/atony include poor muscle tone, weak tissues, clammy skin and random sweats.  Toning herbs vary from astringents such as agrimony and meadowsweet to adaptogens such as astragalus and rhodiola.

Tastes

All traditional herbal systems use taste as a means to understand how herbs work and influence health. The Sanskrit word for taste is rasa, and it is a very pregnant word: as well as meaning taste, it can mean ‘essence’, ‘juice’, ‘sap’, ‘lymphatic fluid’, ‘flavour’ and ‘delicious’. Just saying the word sounds ‘juicy’ … raa-ssa, rasa, RASA. Flavour is the essence of life – it affects everything. 

Sweet: Ayurveda considers the sweet flavour is made from the elements of earth and water. This means that it has the qualities of these two building blocks; ie earth is heavy and descending and, like water, it is wet and cold (when water is subjected to heat it becomes hot but in its ‘primordial’ state it is cold). Sweet is the flavour of love, of sharing and of compassion. We give sweets to friends as an act of sharing and companionship. It is considered the most spiritually sattvic of flavours and is used to heighten experience of clarity and awareness of the spiritual aspect of life. In TCM sweet herbs are often Qi and Spleen tonics.

We all know the sweet flavour. Its main receptors are at the front of the tongue. Sweet comes from sugars; glucose, sucrose, fructose, maltose. They are made up of short (mono) and long (poly) chains of saccharides. It is the flavour of energy. Many carbohydrates, fats and proteins are sweet and their potential energy is measured in kilajoules. Foods and herbs with the sweet flavour are considered to be tonics; they build and nourish all the tissues; licorice (Glycyrrhiza glabra), beetroot (Beta vulgaris) and shatavari (Asparagus racemosa) are sweet and nourish the deeper reproductive tissues. The sweet flavour increases ojas and the integrity of the immune system. Many renowned immune tonics have a sweet flavour and are full of immune-modulating saponins and polysaccharides – such as ginseng/ren shen (Panax ginseng) and astragalus/huang qi (Astragalus membranaceus).

Sweet substances and experiences increase fluid-kapha and reduce hot-pitta and nervous-vata. As a demulcent, soft, soothing and wet flavour it reduces some of the dryness and weakness associated with nervous imbalance. It is a tissue healer and sweet herbs are often used for hastening wound repair (eg aloe vera or licorice). Sweet benefits the mucus membranes lining the mouth, lungs, digestive, urinary and reproductive systems. The sweet taste can help to clear a dry throat and lungs by enhancing expectoration. Its cooling anti-inflammatory tendencies help to remove the intense heat of pitta or ‘-itis’ conditions (eg bronchitis). This is also helped by its softening mild laxative effect. It benefits the complexion, improves hair and nail quality and is the best flavour for a smooth voice. Following the principle of ‘like increases like’ you want to increase your sweet experiences and flavours in life to be truly nourished, loved and cherished. 

Used in concentrated excess, such as with refined sugar/pastries/ice creams, it can increase mucus and promote congestion. It can cause congestion, ama, fever, chest and breathing problems, swollen lymph glands, flaccidity, heaviness, worms, fungal infections, obesity, and diabetes. Exceptions to this rule of sweet substances increasing kapha are honey, mung beans and barley; they are actually considered to balance excess moisture.

Elderberries (Sambucus nigra)
Elderberries (Sambucus nigra)

Sour: Ayurveda considers the sour flavour is made from the elements of earth and fire. Its qualities are hot, oily and light. It creates both dampness and heat in the body and mind. It stimulates digestion and clears dryness. Sour foods make the mouth moist and increase the flow of saliva. When taken in excess it draws the tissues inwards and ‘puckers’ the lips, making the body horripilate all over. This contraction creates an emotional reluctance to share things. Eating too much sour flavoured food encourages envy and can make your experience of life feel like ‘sour grapes’.  According to TCM the sour flavour astringe and prevent leakage of fluids and qi, travels in the sinews, entering the Liver.

The sour flavour is found in acids; citric, lactic, malic, oxalic and ascorbic. The receptors for the sour flavour are found on taste buds on the sides of the tongue. The acids have a direct effect on digestion by promoting liver function through various mechanisms; as sour flavours can reduce stomach acid it also means that the liver needs to produce less acid neutralising alkaline fluids. Sour flavours also increase the flow of bile that helps to encourage digestion of fats. Unripe fruits are sour and are commonly used as digestive chutnies in India. Sour fruits such as amalaki (Emblica officinalis) are high in Vitamin C and protective polyphenols considered to be rejuvenating and tonic herbs. Wu wei zi (Schizandra spp) are one of the sourest and most binding of TCM herbs.

As the sour flavour aggravates heat and liquifies mucus it is not usually beneficial in hot and damp conditions. It is also considered to vitiate the blood and it is recommended that the sour flavour is avoided in skin diseases. Most fermented foods are sour; fermented yoghurt, sour dough breads, vinegar, pickles and alcohol are sour foods that increase heat and mucus in the body. Sour nourishes all the tissues bar the deepest reproductive tissue (shukra). It alleviates aggravations of the nervous system as it is said to draw scattered vitality back. It is a specific carminative useful to promote digestion whilst also removing gas and indigestion. Amalaki, lemons and pomegranate seeds (Punica granatum) are the exception to the rule that the sour flavour aggravates pitta as they actually reduce heat and inflammation.

In excess sour can cause dizziness, thirst, burning sensations, fever, itching, anaemia and skin diseases.

Salty: Ayurveda considers that the salty flavour is predominantly made from the water and fire elements. It creates moisture and heat and is heavy and sinking. A grain dropped onto the tongue is instantly moistening. A sprinkle on food enkindles digestion. It is an easily recognisable flavour and its receptors are at the front of the tongue. Its sinking and heavy effect is very grounding for the nervous system and this encourages stability. People who are solid and reliable become known as ‘the salt of the earth’. In TCM salt purges and softens, travels in the blood and enters the Kidneys.

The use of salt is a good lesson in the importance of dosage. In correct quantities it is vital to our very existence and is as essential to our health as water and food. It can save life when there is dehydration. In contrast to this a sprinkle too much will cause an ulcer and aggravate stomach acidity. Excess salt consumption also causes water retention with the concomitant results of oedema and High Blood Pressure. This physical holding is reflected in its emotional effects as it causes greed and encourages the desire for more flavour. 

Salt is found in minerals and there are different types of salt classified in Ayurveda; rock, sea, black, pink and sonchala. Rock is considered the best as it is very high in minerals and, unlike the other salts, does not cause such water retention and it is not detrimental to the eyes. Salty is the rarest flavour in the Ayurvedic materia medica, not found in many herbs. It is found in shilajit, a natural mineral rock exudate, full of numerous nourishing minerals. Horsetail (Equisetum arvense), seaweeds, and celery are other examples of the salty flavour.

Salt aggravates heat-pitta and fluid-kapha. It also disrupts the blood and is contraindicated in skin diseases as well as bleeding problems. Its use in marinades reflects its softening quality and it is used to soften masses and as a demulcent to liquefy mucus. It stimulating the appetite, moistening dryness and nourishing the nervous system. It is a mild laxative at a medium dose (3g) and an emetic at higher dose (5-10g).

In excess it causes ulcers, skin diseases, grey hair, baldness and thirst.

Pungent/Acrid: Ayurveda considers the pungent flavour is a combination of the fire and air elements. Its qualities are hot, dry and light as well as penetrating and ascending. The acrid heat of hot foods and spices spreads throughout the whole system. Too much heat, whether climatic or dietary, is known to cause ‘hot’ emotions ranging from passion and excitement to anger and irritation. It is the most excitatory and volatile of the tastes. In TCM the acrid flavour disperses and moves, travels in the qi, enters the Lungs.

It is primarily found in the aromatic volatile oils, resins, oleo-resins and mustard glycosides. All these compounds are used to stimulate, invigorate, dry and clear the accumulation of wet, stagnant and congestive conditions. The essential oils of ginger (Zingiber officinale) and black pepper (Piper nigrum) are often used for clearing mucus congestion or warming a cold condition. Pungent resins such as guggul (Commiphora mukul) and frankincense (Boswellia serrata) also invigorate the flow of blood, scrape out toxins and reduce cholesterol. The aromatic cardamom (Elettaria cardamomum) is an excellent digestive for encouraging sluggish digestion. Unlike the other tastes it does not have a specific taste bud receptor site but works through irritation of local tissue and nerve endings.

Trikatu (Zingiber officinale, Piper longum and Piper nigrum)
Trikatu (Zingiber officinale, Piper longum and Piper nigrum)

Pungent herbs and foods are a panacea for excess dampness as they dry the excess moisture and mucus. Pungent herbs are vital for any weight-balancing programme as they stimulate the metabolism and reduce fat. They directly cook and burn toxic-ama as well as also clearing it via diaphoresis. The heat encourages vasodilation of the pores of the skin and encourages the body to sweat, therefore throwing off unmetabolised wastes through the skin. The pungent flavour usually increases vata but, in moderation, it can also help to remove the cold stiffness of the joints whilst also encouraging the elimination of wind and digestive cramps. The heat of pungent herbs irritates pitta and should not usually be used where there is inflammation, especially with aggravation of the plasma (rasa) and blood (rakta) tissues. Its drying effect on bodily fluids can cause constipation.

In excess it creates burning, dizziness, thirst and excessive dryness. Ginger (Zingiber officinale) and cooked garlic (Allium sativum) are the exceptions to the rule that pungent flavours aggravate vata; in fact they benefit it as they increase digestion and reduce intestinal gases.

Bitter: Ayurveda teaches that bitter is created from a combination of space and air elements. Its dominant qualities are cooling, drying and light. It creates space in the body by draining and drying excess fluids. Too many bitter herbs can literally ‘space you out’ and leave you feeling disorientated. Many psychotropics are bitter; eg Psilocybe spp. It has a particular affinity for the blood (rakta). Bitters are usually classified as ‘alteratives’ as they alter the chemical balance of the blood by clearing stagnation and torpor. As they encourage the flow of bile and the activity of the liver this may account for some of bitter’s detoxifying activity. Too much bitter flavour can weaken the kidneys, cause excess urination and emotionally encourages fear and anxiety. In TCM the bitter flavour drains and dries, travels in the bones and enters the Heart.

Whereas in Western herbalism bitters are associated with a tonic effect, in Ayurveda they are considered depleting. The tonic affiliation comes from the low dose, digestive stimulating and liver promoting perspective bitters are associated with. The depleting and cleansing view comes from the experience that relatively larger doses of bitter herbs are cooling, reducing, detoxifying, laxative and diuretic. This is a reminder that any substance can be a food, a medicine or a poison depending on how much is given, who is eating it, when it is eaten and where it is taken.

The bitter flavour is found in sesquiterpenes, anthraquinones, alkaloids and some glycosides. Plants with these properties are renowned for their anti-inflammatory, anti-bacterial, anti-pyretic and digestive secretion enhancing activities. These compounds are usually found intermixed with pungent and aromatic or astringent tasting plants; all drying flavours. Neem (Azadiracthta indicia), andrographis (Andrographis paniculata) and chamomile (Matricaria chamomilla) are well-known bitters famed for their ability to clear infection, heal skin problems and purify the blood. 

Bitter herbs clear damp-kapha and hot-pitta whilst aggravating dry-vata. Excess dampness and heat are reduced as the bitter flavour drains them out of the system. Bitters also promote peristalsis and urination. They are often indicated in lung conditions, especially with infections manifesting with green and sticky mucus. They excel at clearing itching, swelling and oozing on the skin. A little is used as a stimulant to the appetite as the light quality can enhance the appetite and clear the palate. Higher doses are used to kill worms and parasites in the intestines and blood. Bitter herbs also benefit overweight conditions as they can dry and scrape away the adhesions and fatty accumulations.

When misused or incorrectly prescribed they can cause too much dryness and wasting in the body and mind; this can upset the nervous system causing constipation, dizziness, weakness, reduction in semen and dryness of the whole body.

Bilberry (Vaccinium myrtillus)
Bilberry (Vaccinium myrtillus)

Astringent:  Astringent is the driest flavour. Ayurveda considers that the astringent flavour is created from a predominance of the earth and air elements it is heavy, cold and dry. As it draws inwards, it dries and reduces. On eating something astringent your whole mouth contracts and draws the mucus membranes closer together. Having too many ‘dry’ and unfulfilling experiences can leave you with a lack of taste for life and even resentful at its lack of zest. 

The astringent flavour is found in tannins. These polyphenols are particularly concentrated in the bark, leaves and outer rind of fruits of plants and trees. They appear to offer some form of outer protection by repairing wounds and neutralising bacteria. They are especially soluble in water; hence the drying nature of a strong cup of tea left to steep for too long. Astringency is often found in combination with plants that also taste sweet or sour. Bibhitaki (Terminalia belerica), haritaki (Terminalia chebula), arjuna (Terminalia arjuna) and guggul (Commiphora mukul) are especially astringent. 

Therapeutically the astringent flavour clears damp-kapha and hot-pitta whilst aggravating dry-vata. It is very useful where there is any leakage of body fluids; bleeding (externally and internally), excessive sweating, enuresis, diarrhoea, excess catarrh, leucorrhoea and premature ejaculation. It holds tissues together and astringent herbs are often used as a wash to help heal wounds. This holding effect also prevents loose and flaccid tissue from accumulating. Using astringent herbs is appropriate to treat sinking problems such as prolapses. Its effect on the digestive system benefits diarrhoea by astringing the bowel and stopping excessive downward flow. This also helps absorption by drawing fluids and nutrients inwards. Astringents are used for pitta inflammations to draw the swelling inwards, cool the heat and also drying any damp suppuration. 

These dry, rough and light qualities are similar to vata.  Because astringent tastes contract the tissues and obstruct the flow of prana and nervous energy in the system it is detrimental to vata. In excess it can cause vata diseases like rigidity, pain in the heart, convulsions and retention of gas, urine and faeces.

Guna: The qualities of the herbs

The specific ‘quality’ of a herb indicates its potential therapeutic activity.

There are twenty qualities listed in Sushruta but these five listed below are the main ones used in Ayurvedic herbal energetics:

Light (laghu)

Plants, foods and minerals that are light have a quality that moves upwards, are easily digested and also remove sluggishness and heavy-kapha. Aromatic and warming herbs often have a light quality. The bitter and astringent flavoured herbs are usually light in nature. Leaves, seeds and fruits are mainly light.  The aromatic Cardamom (Elettaria cardamomum) seeds are light.

Heavy (guru)

Substances that are heavy sink downwards, are difficult to digest, increase kapha and nourish the whole system. They benefit nervous-vata by opposing its light, dry qualities. Heavy natured herbs are often sweet, salty or sour. Roots, resins, nuts and barks are often heavy. Licorice (Glycyrrhiza glabra), is heavy.

Penetrating or Sharp (tikshna)

Herbs with a penetrating or sharp quality are usually pungent, acrid and aromatic. They spread deeply into the tissues, open the channels and by their intense nature increase hot-pitta and reduce sluggish-kapha and stuck-vata. Lemons and vacha (Acorus calamus) have penetrating properties.

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Herbal treatment for IBS https://www.herbalreality.com/herbalism/western-herbal-medicine/herbal-treatment-for-ibs/ https://www.herbalreality.com/herbalism/western-herbal-medicine/herbal-treatment-for-ibs/#comments Mon, 23 Oct 2023 15:06:39 +0000 https://www.herbalreality.com/?p=10564 IBS is a common debilitating condition that can be treated effectively with herbs. We share 5 IBS herbs.

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IBS is a common debilitating condition that can be treated effectively with herbs.

Irritable Bowel Syndrome (IBS) is one of the most common digestive health diagnoses nowadays (1). Many people suffering with digestive complaints end up being diagnosed with IBS. IBS is characterised by recurrent abdominal pain that is associated with change in bowel movement frequency, whether that is diarrhoea, constipation or alternating between the two (2).

Herbal treatment for IBS

Remember though, that a sudden onset of change in bowel movements that persists in time, as well as blood or mucus in your stools should always be checked by a qualified healthcare professional that can direct you to appropriate testing. 

IBS is a diagnosis of exclusion, which means that people get given that diagnosis when tests for other conditions come back negative. 

There are three IBS subtypes depending on what symptoms people suffer with (2). These are: 

  • IBS-C: mostly constipation 
  • IBS-D: mostly diarrhoea 
  • IBS-M: a combination of both of the above 

Other symptoms of IBS include bloating, flatulence, passing mucus with stools, feeling nauseous and bowel incontinence (1,2). 

IBS is now considered to be a brain-gut interaction disorder, hence why many people find that their psychological and emotional state affect their IBS symptoms considerably (3,4). 

Some factors triggering IBS are the following: psychosocial stress, altered gut-brain interactions, increased intestinal permeability, gut mucosal immune activation, dysbiosis, bile acids, specific food triggers, some medications or supplements, and sometimes gut infections (1,4).

The right herbal strategy can be chosen depending on what symptoms someone has, and what are the individual triggers for that person. Anti-inflammatory and anti-spasmodic herbs are important, for example chamomile, cramp bark, valerian, peppermint, lemon balm or fennel. Demulcent herbs to heal the gut mucosa are very relevant too, these include slippery elm, marshmallow root or plantain though one must be careful with sourcing slippery elm as it has major sustainability issues (for advice on this topic see this article). Because of the gut-brain connection, nervine tonics and relaxants can be very helpful, for example chamomile, lemon balm, valerian, vervain and skullcap. When flatulence is a problem carminative and aromatic herbs like cinnamon, aniseed, angelica, fennel or chamomile are added (3,5). 

People suffering with IBS-D, where diarrhoea is one of main symptoms of IBS, astringent herbs can be very helpful, for example agrimony, yarrow or thyme. For people suffering with IBS-C, where constipation is one of the main symptoms of IBS, mild laxatives like aloe vera juice, licorice or dandelion root are recommended. A meta-analysis showed that soluble fibre such as psyllium seeds was beneficial in IBS especially to alleviate constipation (6).  Our research seed on psyllium husk for ulcerative colitis shares some more on how it can support inflammatory conditions of the gut. When there is marked IBS-C and constipation is a big problem, you can try with bitter herbs like gentian, milk thistle or feverfew. These should however be avoided in IBS-D. A really good option for people dealing with IBS-M, where there is a combination of diarrhoea and constipation, is slippery elm (3, 5), with a more sustainable replacement herb being marshmallow root which has the same soothing mucilaginous properties.

When IBS is paired with abdominal pain or dyspepsia, there is some research supporting the use of globe artichoke in these cases. Globe artichoke contains cynarin and cynaropicrin, phytochemicals which have been shown to stimulate bile production and enhance liver function (7). This can aid in digestion and alleviate symptoms of dyspepsia, such as bloating and indigestion. Additionally, globe artichoke can help regulate bowel movements, making it beneficial for individuals with IBS. Studies have suggested that globe artichoke extract can reduce symptoms of both IBS and dyspepsia, including abdominal pain and discomfort (8). 

There is also some evidence suggesting that dysbiosis and gut barrier dysfunction play a role in IBS, so addressing dysbiosis is considered an important therapeutic strategy (2). Examples of good herbs to improve dysbiosis and gut barrier function are barberry and berberine containing plants, chamomile, cinnamon and turmeric. If you are interested on this topic, you can read more about correcting dysbiosis and keeping a healthy microbiome on our Best herbs for the microbiome article.

For some people IBS symptoms flare up with their menstrual cycle, so when this is the case the medicinal plant chaste tree would be a good addition (5). 

But remember that that diet is important too! Temporarily avoiding hard to digest proteins like gluten and dairy, as well as avoiding gut stimulants such as coffee is recommended (2). Trying the FODMAP diet can also be of benefit. The main objective of the FODMAP diet is to avoid short chain carbohydrates and reduce fructose content in the diet. Examples of high fodmap foods include garlic, onions, asparagus, artichokes, beans, lentils, dairy products, and wheat products. As this can get quite complex and many of the FODMAP foods are overall healthy foods, it is best when done under the guidance of a herbalist or a qualified healthcare practitioner who is familiar with IBS, herbs and dietary advice. 

Common drugs used to treat symptoms of IBS include mebeverine or trimebutine for abdominal pain, loperamide or rifaximin for diarrhoea, and tegaserod or prucalopride for constipation. 

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The sustainability of echinacea within herbal medicine https://www.herbalreality.com/herbalism/sustainability-social-welfare/sustainability-of-echinacea-herbal-medicine/ https://www.herbalreality.com/herbalism/sustainability-social-welfare/sustainability-of-echinacea-herbal-medicine/#comments Mon, 24 Jul 2023 11:30:11 +0000 https://www.herbalreality.com/?p=9952 Echinacea is one of the most popular herbal medicines, but its popularity comes at a cost. We share sustainability issues around the precious medicinal echinacea species.

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Echinacea is one of the most popular herbal medicines, but its popularity has come at a cost. This article shares sustainability issues around the precious medicinal echinacea species.

From local to global medicinal herb

Echinacea is a genus of flowering plants in the daisy family. The name Echinacea comes from the Greek ekhinos and means “sea urchin”, inspired by the spiky cones that hold the seeds. The genus encompasses 9 different species, of which three are well-known around the world for their medicinal use, namely E. angustifolia, E. purpurea and E. palluda. Although now world-famous, Echinacea species originally only grew in eastern and central North America, where they grow in moist to dry prairies and open wooded areas.

The sustainability of echinacea within herbal medicine

Echinacea species were widely used by the Indigenous people of the Great Plains and the Midwest of America. The use of this plant was first recorded by Europeans during an expedition between 1804–1806(1). The Indigenous people used the root and herb, fresh and dried for a variety of ailments, covering snake bites, infections and inflammatory conditions, such as cold, flu and rheumatism. The European settlers who learned about the uses of Echinacea spp. adopted its use as an ailment and by the 1880s, the herb, commonly known as ‘snakebite’ was widely known and large-scale production of echinacea tinctures was proliferating. Fast forward to the 1990s, 100 years later and Echinacea spp. are well known around the world with an ever-increasing demand. As a consequence, Echinacea spp. are now being cultivated for their use (2).

In 2010 the total sales value of echinacea products in the United States was estimated to be $10,914,500 (3). The American Herbal Product Association did a survey to record the harvest of various plant species, comparing wild harvested and cultivated sources. They list results from 23 primary raw material producers and although this may not cover all of the firms that are involved in wild harvesting and cultivation of medicinal herbs may still give an indication for the scale of harvest of echinacea (4). In 2010 alone, 24 tonnes of E. angustifolia root was wild harvested, and approximately 44 tonnes were sourced from cultivation. E. purpurea is more often cultivated, and in 2010, 94.4 tonnes of root from cultivated plants were sold. 

The two species differ in habitat and growing requirements, which may explain the different numbers in regards to wild harvest and cultivation. E. angustifolia is at home in the prairie and prefers very well draining soils. It is drought-resistant but copes less well with too much moisture. Once germinated plants develop their first leaves and will often stay at this stage for the first growing year. E. angustifolia plants generally take a few years to mature, during which they develop a tap root that can grow 2m down into the ground. This enables plants a chance to regrow if only the first 6in have been harvested, as is often done by echinacea harvesters. E. purpurea grows in moister woodland habitats and does not form a tap root, but spreads out instead. It is easier transplanted and easier cultivated in less dry areas of the world, which may be why it is more often grown.

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The sustainability of liquorice https://www.herbalreality.com/herbalism/sustainability-social-welfare/sustainability-of-liquorice/ https://www.herbalreality.com/herbalism/sustainability-social-welfare/sustainability-of-liquorice/#comments Sun, 02 Jul 2023 19:26:12 +0000 https://www.herbalreality.com/?p=9906 Liquorice is one of the most valued herbal medicines globally. We share insights on the sustainability of this plant and solutions to protect it.

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“Inflorescence of Glycyrrhiza glabra” by Pharaoh han is licensed under the Creative Commons Attribution-Share Alike 3.0 Unported licence

Liquorice is one of the most valued herbal medicines globally, yet its population sizes are shrinking rapidly. This article shares insights on the sustainability of this plant and solutions to protect it.

Liquorice (Glycyrrhiza glabra) is a herbaceous perennial plant of the Leguminosae or Fabaceae family. Liquorice has a long history of use as medicine and food, stretching back thousands of years in parts of Africa, Asia and Europe (5). The scientific name Glycyrrhiza originates from the ancient greek “glyka” meaning sweet and “rhiza” for root. The Glycyrrhiza genus includes 20 species, however only four of these are commonly used. These are G. glabra, G. echinata, G. inflata and G. uralensis. Out of these four, G. glabra is the one most commonly described in medicinal monographs, though some treat all 4 species interchangeably, and all are commonly traded interchangeably as Liquorice root on the market (1-4).

Due to its long history of use as medicine and for its sweetness, there has always been a high demand for liquorice, but due to the rise in popularity of natural remedies, particularly in developed countries and an increasing demand across various industries, wild populations of liquorice are becoming progressively overused. 

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Save our antibiotics: 5 antibacterial herbs to fight infection https://www.herbalreality.com/health-lifestyle/immunity/5-herbs-instead-of-antibiotics/ https://www.herbalreality.com/health-lifestyle/immunity/5-herbs-instead-of-antibiotics/#comments Sun, 02 Jul 2023 17:29:19 +0000 https://www.herbalreality.com/?p=9868 The overuse of antibiotics has meant that our pharmaceutical antibiotics do not work as well as they used to. However, herbs can be a natural alternative.

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The overuse of pharmaceutical antibiotics has meant that they do not work as well as they used to. However, herbs can effectively help the body to fight infections, and this article shares five potent antibacterial herbal allies

The antibiotics crisis

Most of us have probably been prescribed a course of antibiotics at some point in our lives (if not more than once!).  Whilst antibiotics can be helpful in the case of serious infections (of bacterial origin, since antibiotics do not work against viruses), their use does not come without risk. After more than a century of ‘modern’ antibiotics, the repercussions of their use are only now beginning to be understood. In this article we share 5 herbs which can be safely used in place of antibiotics for some conditions. 

5 herbs instead of antibiotics

The discovery of antibiotics (as we know them now) in the early 1900’s undoubtedly changed the course of human health. Antibiotics have, over the years, been life-saving medicine, treating serious infectious diseases (pneumonia and tuberculosis to name a few). They have also provided the possibility for advances in new medical interventions such as organ transplants and open-heart surgery (1).

The prescription of antibiotics boomed from the 1940s onwards, initially with little restriction as they were considered a ‘wonder drug’. However, times change and most pharmaceutical drugs have consequences aside from any potential beneficial effects on the condition they are targeting.  The benefit to risk must always be considered. The word antibiotic translates directly to mean ‘against life’.  Although they were only considered against bacteria by those who coined the phrase, its deeper meaning seems to have rung truer than ever imagined.

The overprescribing of antibiotics for conditions which will usually get better in their own time (such as common cold and simple coughs) has been prolific, and this has led to what we now face as an ‘antibiotic resistance crisis’ (1). Unfortunately, antibiotics have been called upon to treat conditions which were not dangerous and did not warrant their use, as we are learning more now they must be used very selectively to preserve their efficacy. 

Overuse has seen many strains of bacteria becoming resistant to antibiotics, so that when they are used they no longer work. There has been a rise in antibiotic-resistant ‘superbugs’, such as MRSA.  Some infections are now simply untreatable by antibiotics, even in cases where they are really needed. This is an unsurprising ‘backlash’ from nature, i.e. bacteria which have evolved to become stronger in order to overcome the ‘attack’ of antibiotic drugs.

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5 herbs instead of anti-anxiety medications https://www.herbalreality.com/health-lifestyle/mood-mind/5-herbs-instead-anti-anxiety-medications/ https://www.herbalreality.com/health-lifestyle/mood-mind/5-herbs-instead-anti-anxiety-medications/#comments Thu, 23 Feb 2023 17:26:37 +0000 https://www.herbalreality.com/?p=8911 Anxiety is prevalent amongst many people, especially after the rise of chronic stress. We share 5 herbs that can support you.

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Anxiety is prevalent amongst many people, especially after the rise of chronic stress. This article shares 5 herbs that can support you.

5 herbs instead of anti-anxiety medications

Anxiety is a common, if not a prolific issue in modern society.  Feelings of anxiety are in fact a normal response to certain situations.  This response can trigger physiological changes which can spur us on to get through these situations, such as activation of the ‘stress response’ via the HPA-axis which may give a short boost of adrenaline to power on and deal with a stressful event.  However, when anxiety lingers, recurs often, or begins to interfere with our day-to-day activities, it can become problematic, and we may wish to solutions to deal with it.

Anxiety disorders are defined as excess worry, hyperarousal, and fear that is counterproductive and debilitating. Affecting a large proportion of the population, anxiety disorders are among the most common psychiatric conditions in the western world (1). In the European Union (EU), over 60 million people are affected by anxiety disorders in a given year, making them the most prevalent psychiatric conditions in the EU (2). The Global Burden of Disease (GBD) study estimated that anxiety disorders contributed to 26.8 million disability adjusted life years in 2010. (3).

Anxiety disorders are a serious health issue which can be debilitating, impact on quality of life, as well as being costly to manage. In the UK conventional treatment approaches for generalised anxiety disorder recommend several measures prior to drug therapy, as follows (4):

  • Psychological Therapy (CBT)
  • Guided Self-help / CBT (workbook on a computer at home, workbook at home with therapist support every 1 – 2 weeks, or weekly group course).
  • Applied Relaxation

It is then suggested that if these psychological therapies either have not worked, or somebody doesn’t want to try them, then medication is an option.

Anti-anxiety medications are usually tried in the following order (4):

  • SSRI’s (such as sertraline, escitalopram, paroxetine)
  • SNRI’s (venlafaxine, duloxetine)
  • Pregabalin
  • Benzodiazepines (such as diazepam).

However, despite the psychological therapies and medications available, treatment of anxiety disorders remains challenging.  This is at least in part because the anti-anxiety medications available often come with a host of side effects which may also impair quality of life. In addition, these drug therapies are not always effective, and can lead to dependence, addiction, abuse, and tolerance (5).  If you take anti-anxiety medication, it is not recommended to suddenly stop taking them as this can exacerbate original symptoms. One must taper off gradually with the guidance of a health professional.

There are many herbs which can help to reduce the symptoms of anxiety, whilst also restoring the nervous system, and aiding better sleep, without the side effects often experienced with anti-anxiety medications.

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Sleep: How it works and herbs to support it https://www.herbalreality.com/health-lifestyle/stress-sleep/sleep-how-it-works-herbs/ https://www.herbalreality.com/health-lifestyle/stress-sleep/sleep-how-it-works-herbs/#comments Thu, 15 Dec 2022 17:56:26 +0000 https://www.herbalreality.com/?p=8448 Healthy sleep is essential for all bodily systems, and crucial for mental and emotional wellbeing.

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Healthy sleep is essential for all bodily systems, and crucial for mental and emotional wellbeing. There are a few stages of sleep which affect our quality of health in different ways.

Sleep: How it works and herbs to support it

A combination of increasingly fast-paced living, advances in technology, and the onset of a ‘24-hour culture’ with the accompanying expectation to be continually ‘switched-on’ and available, make it no wonder that sleep deprivation (a lack of sufficient and good quality sleep) is becoming more common.

Insufficient sleep is prevalent across various age groups and can be considered a public health epidemic that is often unrecognized (1). An estimated 1 in 5 people in the UK are not getting enough sleep (2), which over a prolonged period of time impacts health.

Many factors contribute to the different types of sleep disturbances which range from getting off to sleep (sleep latency), staying asleep, or getting a sufficiently deep sleep. A frazzled nervous system plays a major role in many sleep issues.  There are plenty of herbs which can help to reset the balance to ensure that sleep becomes more healthy, easeful, restorative, and nourishing, exactly as it is supposed to be.

This article will look at what sleep is, its importance for health as well as why so many people are not getting enough sleep. We will also share herbs which can support the different stages of sleep and other holistic solutions which can support better sleep.

Sleep is an altered state of consciousness where changes in the brain’s activity take place (3), and it is essential for human life.

Although sleep is in part for resting, it is also actually quite a busy time for the body and it requires a certain amount of energy to maintain good quality sleep. Sleep is the time for cellular repair and is where maintenance mechanisms are actioned and healing for the body occurs.

Normal sleep consists of two parts: non-rapid eye movement (NREM) sleep, and rapid eye movement (REM) sleep. NREM is broken down into stages 1 -3, and stage 4 of sleep is where REM sleep takes place (4).

These four stages of sleep are thought to gradually merge (3, 5):

Stage 1

This is where the transition between wakefulness and sleep which is normally up to about 5 minutes in duration. During this stage the person may have fleeting thoughts and if they wake think they have not been sleeping. Many people struggle with this stage as it takes them a while to get to sleep.

Stage 2

Light sleep is the first stage of true sleep.  There may be fragments of dreams and the duration is around 10 – 60 minutes.

Stage 3

Moderately deep sleep, referred to as slow-wave (SWS) sleep.  During this stage the body temperature and blood pressure tend to decrease, this usually occurs around 20 minutes after falling asleep. This stage of sleep is thought to be critical to restorative sleep, allowing for growth and recovery of the body. Experts believe it also is vital for the immune system and other bodily processes (5).

Stage 4

The deepest level of sleep, REM sleep. Duration 10 – 60 minutes. The eyes may move rapidly (hence the name). Most vivid dreaming usually occurs during REM sleep.

Sleep ideally consists of a single block of three to five cycles of sleep stages, usually happening during the night (6).  Typically a person goes from stage 1 – 4 of sleep in less than an hour and during a typical night’s sleep of 7 – 8 hours there will be approximately 3 – 5 episodes of REM sleep as a person passes between NREM sleep and REM sleep, with REM sleep occurring approximately every 90 minutes.

A baby’s sleep consists of around 50% of REM sleep, whereas in adults it usually makes up about 25% of sleep.  Although it is not fully understood, this high level of REM sleep in infants suggests that it is important for the maturation of the brain. Neuronal activity is high in REM sleep, brain blood flow and oxygen use are equal to or higher in REM sleep than in intense mental or physical activity while awake (3), indicating that sufficient energy is required to actually be able to sleep well and access all the stages of sleep.

Sleep is in part a time when organising and housekeeping in the brain takes place and is thought to play a vital role in retention of new learning (7). This may be considered again in the context of new-born babies who need between 14 – 17 hours of sleep per day (2). This is because aside from supporting the growth which is taking place in their bodies, they are creating neural networks as they learn new information about the world. Sufficient sleep necessary to facilitate this.

Sufficient good quality sleep is necessary for physical and mental health, and for quality of life.  Sleep is known to be important for regulation of the nervous system, helps with overall resilience, immune system function, ability to deal with stress, mental and emotional health. It is vital for the maintenance of overall health and wellbeing.

Sleep deprivation disturbs the circadian physiology, exerting a negative impact on the brain and behavioural functions, and can cause neuroinflammation and oxidative stress (8). Long term, this can lead to neurodegenerative issues. Mental health issues such as depression have also been linked to neuroinflammation now. Circadian rhythms are natural changes in physiology over a 24-hour day-night period, particularly hormone levels which typically influence sleep and wake cycles and our ability to fall asleep easily at night.

There is an ever-increasing body of evidence to suggest that insufficient sleep contributes to a host of adverse medical and mental dysfunctions, such as unbalanced body systems, increased incidence of cardiovascular morbidity, increased chances of diabetes mellitus, obesity, issues with cognitive function, increased accidents, and depressive symptoms (1).

It is suggested that sleep plays a key role in the optimization of energy as during sleep energy reserves are redirected to processes such as maintenance of cells, anabolism (‘rebuilding’ and repair), immune function, and neural plasticity (6).

Neural plasticity refers to the capacity of the nervous system to modify itself both functionally and structurally in response to experience and injury. Ultimately it ensures the healthy development and function of the nervous system (9) which can also impact on memory.

A recent study has found that sleep also seems to play a role in facilitating the clearance of molecular waste products from the brain which accumulate during waking hours (10). The authors noted that sleep seems to increase the brain’s interstitial volume (meaning the space between the tissues), and that the impact of one night of complete sleep deprivation on the molecular clearance was not recouped in the following 2 -3 night’s sleep.

This potential build-up of molecular waste in the brain which may occur as a result of consistent sleep deprivation is of particular relevance when considering the development of neurodegenerative health conditions such as Alzheimer’s disease (10).

For adults, 7 – 9 hours of sleep per night are usually recommended (2). Although there is a lot of focus on the number of hours of sleep, and whilst this is important, it is also necessary to consider sleep quality and whether the time spent sleeping is actually restorative.

The smooth progression through the stages of the sleep cycle is necessary multiple times during a sleep period to ensure that the rest taken whilst sleeping is high-quality and actually restorative (5). An example of this is the suggestion that whilst sleep stages each have their unique qualities, it is also thought that the change between SWS in NREM sleep stage 3 and REM sleep stage 4 is actually important for memory (7).

It is clear to see that although sleep is in some ways a time of rest from our usual waking activities, there is actually still a lot of activity going on during sleep which can be thought of as the ‘behind the scenes’ housework to keep everything functioning well. This is particularly true for the nervous system, and this requires a certain amount of energy to maintain.

Insufficient sleep is a prominent problem in today’s modern 24-h society, with the increased usage of smart phones and electronic devices worsening this epidemic (1).

Problems with sleep are often caused by (2):

  • Environmental issues: Night-time noise, screen light from phones, TVs and tablets, and light from the outside can trick your body into delaying sleep. Air pollution can also disrupt your sleeping patterns.
  • Life events: You may feel distracted, stressed or worried about something going on in your life while you’re trying to go to sleep, which can affect your ability to relax.
  • Thinking cycle: Anxious thoughts about not getting enough sleep can cause distress, which can prevent you from relaxing and falling asleep. This can become a vicious cycle. Also an overactive mind when going to sleep delays sleep latency.
  • Lifestyle: Developing poor habits around sleep, such as not having a regular routine, can cause problems.
    • Not having a regular sleep-awake routine
    • Eating late at night
    • Consuming alcohol, nicotine or caffeine around bedtime
    • Vigorous exercise late at night
    • Using smart devices (phones, tablets etc.) before bed
    • Checking and responding to work emails outside of working hours

It’s common for most people to experience periods of poor sleep at some point in life, but short bouts of sleep problems don’t usually result in health problems. However, consistently poor sleep can begin to contribute to health issues, including being a symptom and cause of mental health problems (2).

‘Tired but wired’ is a phrase coined to explain when the nervous system is in overload (in sympathetic or ‘fight and flight’ mode) and it can become difficult to switch off. Although one may feel tired or even exhausted, falling asleep (known as ‘sleep latency’) and/or maintaining sleep can become difficult. This is partly because of higher than normal levels of the hormone cortisol tend to circulate the bloodstream when we are over-stressed.

When the body is functioning well, cortisol levels naturally dip at night as part of the circadian rhythm, easing us into a restful night’s sleep. Understanding this contextualises why and how living removed from the rhythms of nature can have an impact on our sleep.

In addition to this from a holistic perspective when the nervous system is depleted due to chronic stress, we are tired and really need sleep. There are often not actually enough energy resources available to achieve and maintain the good quality sleep we really need.  This can become a vicious cycle where the over-tiredness prevents sufficient sleep, and the lack of sleep exacerbates stress on the body and further inhibits the capacity to sleep well.

This is where herbs can really help to reset this cycle.  Herbs which are classed as nervous system tonics can be helpful in restoring the nervous system so that it becomes less frazzled, which can be considered energetically as providing ‘food’ to the nervous system so that it has the sufficient nourishment required to maintain sleep. 

Herbs which are classified as adaptogens can also be beneficial to help reset the stress response, allowing the nervous system to function well, and redress the natural balance of stress hormones throughout the sleep-waking cycle of the circadian rhythm. 

In addition to this, herbs classified as sedatives and hypnotics can assist with getting off to sleep (sleep latency), and often have additional benefits of helping with anxiety or nervousness which often accompany sleep issues. However, the primary goal with herbal support is always to rebalance the body by addressing the root cause of issues.

This means that the natural processes can be restored and systems can function in a healthy way. Therefore, herbs which act as hypnotics and sedatives are only recommended as short-term solutions while the body systems are further restored and regulated, and lifestyle factors are addressed so that a healthy sleep cycle can be re-established.

It is best to note when considering herbal support for sleep is that if there are underlying factors at the root of sleep issues then these must be addressed alongside taking herbs. In the case of long-term issues then the guidance of a herbalist is recommended to tailor a personalised treatment plan. You can find clinical herbalists on our “Where to find a herbalist” page.

Valerian (Valeriana officinalis)
Valerian (Valeriana officinalis)

Valerian (Valeriana officinalis)

Valerian is traditionally considered a convalescent tonic to calm the nervous system and enhance its function. Its name comes from the Latin valere – meaning “to be strong, powerful, healthy”, which explains why, although it is typically considered to be a hypnotic and sedative herb, it can in some people also be stimulating due to providing an increase in vital energy.

Despite this, it is often helpful in restoring the nervous system. Therefore even in cases where it is stimulating as a bedtime remedy, it can sometimes be beneficial to continue taking the herb to help restore the nervous system so that deeper more relaxed sleep can be accessed eventually.

Valerian is often helpful when there is difficulty getting to sleep or staying asleep. It is particularly helpful when this is accompanied by emotional stress, excitability, or a sense of irritability. This is because it not only provides the tonic support to rebuild the nervous system allowing deeper more nourishing sleep to be possible, but it also has a sedative effect so can also be beneficial in assisting with getting off to sleep.  Valerian is also a muscle relaxant so can be a great support where muscle tension is present along with sleep issues.

Ashwagandha (Withania somnifera)

This is a tonic for both the nervous system and for restoring sleep.  It is best thought of as when the body is too exhausted or worn out to be able to sustain good quality sleep, because sleeping also requires a certain amount of energy. When one becomes “tired and wired” the depth of good quality sleep can become difficult to sustain.  In these instances, ashwagandha helps on a deeper level than simply sedating or aiding falling asleep, it can be considered as laying a deep restorative foundation which provides a base from where better-quality sleep becomes possible, allowing the body to truly rest and restore. 

Occasionally because of this restorative effect ashwagandha can sometimes be felt as stimulating, in which case it can be taken during the daytime rather than at night, where it will still have a restorative effect which will over time nurture better quality sleep.  Ashwagandha is considered an adaptogenic herb, so it also improves the bodies resilience to stress, and helps to reset the balance of the stress response. This makes it particularly beneficial when frazzled nerves and being overly stressed is a factor in sleep issues.

St John’s wort (Hypericum perforatum)

This is a nervous system tonic which is traditionally used for insomnia, particularly when emotional stress, anxiety, or depression are also a factor.  Because of its restorative effect on the nervous system, St John’s wort can benefit the onset of sleep and staying asleep (insomnia which involves waking in the night and difficulty getting back off to sleep is common feature of depression).

Passionflower (Passiflora incarnata)
Passionflower (Passiflora incarnata)

Passionflower (Passiflora incarnata)

This is helpful in cases where sleep issues are accompanied by anxiety, excitability or irritability.  Traditionally it has been given as a tea by Native Americans for sedative and anxiolytic effects and continues today to be given for this and its hypnotic effect.

Passionflower can aid getting off to sleep, as well as staying asleep.  It is considered particularly beneficial where circular thinking is preventing sleep onset (for example, worrying and repetitive over thinking). Passionflower helps to switch off this thinking and so getting to sleep becomes easier. It is also a nervine so helps to relax the nervous system and assists the ability to stay asleep.

Vervain (Verbena officinalis)

This herb is not particularly sedative as such, but as more of a tonic for the nervous system it tends to relax the body, energetically bringing a sense of grounding.  This can allow a better quality of sleep which will be overall deeper and more nourishing, especially when combined with other herbs which have sedative or hypnotic qualities such as valerian or passionflower. Herbalists may consider it for people who feel they sleep lightly, wake easily, or simply do not feel well rested after sleep. The grounding effect allows the sleep to become deeper.

Hops (Humulus lupulus)

Hops can be helpful when there is difficulty getting off to sleep or in staying asleep.  It tends to be hypnotic and mildly sedative and is particularly helpful if sleep issues are accompanied by a sense of excitability or restlessness, and also for people who experience excessive libido.  It is also beneficial for people experiencing sleep issues associated with the menopause.  It is best avoided in depression due to its slightly depressive effect.

Limeflower (Tilia x europaea)
Limeflower (Tilia x europaea)

Chamomile (Matricaria recutita)

This is a well-known remedy for sleep and suitable for children due to its gentleness. However, it is traditionally said of chamomile that ‘gentleness should not be confused with weakness’.  Although gentle in nature due to its calming effect Chamomile can be a simple but beneficial sleep remedy. It can be taken as an evening drink to aid getting off to sleep, particularly when sleep issues are accompanied by a feeling of restlessness or mild anxiety.

Limeflower (Tilia spp.)

Popular in France where it is a common home remedy taken as a relaxing evening drink to aid getting off to sleep.  It is relaxing and helpful if anxiety accompanies sleeplessness.

Skullcap (Scutellaria laterflora)

This is a wonderful herb when sleep issues are due to emotional stress, or when excitability, irritability, or anxiety are present with sleep issues.  It is a tonic for the nervous system, and as with other nervous system tonics it helps to restore the ability to achieve good quality deep sleep. It is also sedative so aids getting off to sleep. Herbalists consider it to have an affinity with the head (from the name skullcap), and is helpful to stop worrying about things that you cannot do anything about.

Lemon balm (Melissa officinalis)

Helpful for promoting better sleep quality, a calming herb that blends well with chamomile and lime flower for a pleasant tasting evening beverage. It is also considered energetically helpful for nightmares, and irritability in children and the elderly.

Key components to healthy sleep are ensuring healthy sleep routines and where possible eliminating or managing stressors which may be contributing to a lack of sleep.

The following guidelines have been recommended by Mental Health UK (2) as tips for getting a good night’s sleep:

  • Create a regular sleeping pattern of sleeping and waking
  • Create a restful sleeping environment (dark, peaceful and a comfortable temperature)
  • Assess your stressors from work (for example workload, commute, work environment and boundaries at work)
  • Regular exercise releases stress from the body, and tires us out in a healthy way so we can slip into a deep regenerative sleep. Avoid vigorous exercise too close to bedtime when possible as this can keep you awake.
  • Be mindful of food and drink consumption. Caffeine takes at least 5 hours to leave the body and massively disrupts sleep for most people, as does alcohol. A herbal tea in the evening from the plants mentioned above could be a wonderfully soothing alternative.
  • A sleep diary can be helpful for seeing how much sleep you are actually getting, allowing you to analyse your patterns and take informed action.
  • A wind down routine will help you to relax before bed and nurtures a good night’s rest. This can include a warm bath, some gentle yoga or a relaxing and quiet podcast or music. Its important to support the transition between the day’s chores and activities and rest.
  • Write down your thoughts, especially if you tend to lie and think about all you have to do the next day. Simply writing these down allows us to release them and have a clearer mind so we can get to sleep more quickly. 
  • Create and maintain good sleep hygiene by avoiding bright lights at bedtime and screens for at least 30 minutes to an hour before bed.

In addition, Yoga Nidra can be helpful for re-establishing healthy sleeping habits.  It is also referred to as ‘Yogic sleep’, and is a guided relaxation practice which accesses the space between the conscious and subconscious mind, aiding the release of physical and mental tension, and promoting deep relaxation.

It helps to re-establish balance in the body-mind complex, nourishing the nervous system, and can be a great aid for re-establishing the balance and energy resources necessary to access sufficient good quality sleep. Yoga Nidra can be practised during the daytime, or as part of a wind-down routine before going to bed at night.

  1. Chattu VK, Manzar MD, Kumary S, Burman D, Spence DW, Pandi-Perumal SR. The Global Problem of Insufficient Sleep and Its Serious Public Health Implications. Healthcare (Basel). 2018;7(1):1. doi:10.3390/healthcare7010001
  2. Sleep and mental health. Mental Health UK website. https://mentalhealth-uk.org/help-and-information/sleep/. Accessed December 3, 2022.
  3. Tortora, G, Derrickson, B. Principles of Anatomy and Physiology. Vol. 1. 13th ed. Asia: John Wiley & Sons; 2011.
  4. Patel AK, Reddy V, Shumway KR, et al. Physiology, Sleep Stages. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022. https://www.ncbi.nlm.nih.gov/books/NBK526132/ Accessed December 8, 2022.
  5. Stages of Sleep. Sleep Foundation Website. https://www.sleepfoundation.org/stages-of-sleep.  Accessed December 3, 2022.
  6. Nollet M, Wisden W, Franks NP.Sleep deprivation and stress: a reciprocal relationship. Interface Focus. 2020;10:20190092. http://dx.doi.org/10.1098/rsfs.2019.0092. (Accessed 02.12.22).
  7. Newbury, CR, Crowley R, Rastle K, & Tamminen J. Sleep deprivation and memory: Meta-analytic reviews of studies on sleep deprivation before and after learning. Psychological Bulletin. 2021;147(11):1215–1240. https://doi.org/10.1037/bul0000348.
  8. Bishir M, Bhat A, Essa MM, Ekpo O, Ihunwo AO, Veeraraghavan VP, et al. Sleep Deprivation and Neurological Disorders. BioMed Research International. 2020;5764017. https://doi.org/10.1155/2020/5764017.
  9. R, Bernhardi LE, Eugenín J. What Is Neural Plasticity?. Adv Exp Med Biol. 2017;1015:1-15. doi:10.1007/978-3-319-62817-2_1.
  10. Eide PK, Vinje V, Pripp AH, Mardal KA, Ringstad G. Sleep deprivation impairs molecular clearance from the human brain. Brain. 2021;144:3: 863–874. https://doi.org/10.1093/brain/awaa443.

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Medicine making with children: Recipes to try at home https://www.herbalreality.com/health-lifestyle/childrens-health/medicine-making-children-recipes/ https://www.herbalreality.com/health-lifestyle/childrens-health/medicine-making-children-recipes/#comments Thu, 01 Sep 2022 18:37:31 +0000 https://www.herbalreality.com/?p=7869 Making herbal medicines is a great way to empower children with self-care knowledge. We share some great recipes to make at home.

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Children love making potions and playing with nature and making herbal medicines is a great way to empower them with self-care knowledge. This article shares some great recipes to make at home.

Making herbal medicine is truly one of the most naturally joyous activities for all ages. Whether using freshly foraged herbs or sustainably sourced ingredients, bringing children into the world of herbal medicine has so many delights- both connecting children with nature through practical fun activities and giving them valuable skills to support their health.

Medicine making with children: Recipes to try at home

Medicine making is both an incitement of timeless experiment, with children loving the theatre of making potions. Experimenting with natural materials, carrying out an accurate chemical fusion to create something that heals our body and brings us health. We can offer this heritage of knowledge to them and allow the practice of home herbalism to continue down the generations.

One does not have to be a confident forager to start making and using herbal medicines at home, because it is easy to source good quality, sustainable ingredients from trusted suppliers.

You can even source ingredients from local herbalists, and organic shops are also a great place to start. Many simple herbal medicines can be made using household herbs and spices, and other kitchen ingredients too.

Herbal medicines can be made using a variety of different plant parts such as leaves, flowers, seeds, fruits, roots and barks. Herbal Medicines may also be seaweeds, algae or fungi. With an equally diverse range of preparation types such as teas, syrups, honeys, tinctures, lozenges, glycerine’s, oils, ointments, creams, balms and more!

This article hopes to offer some simple yet exciting, diverse and delicious herbal recipes for the young budding herbalists and children generally. Herbal Medicines have hugely diverse taste profiles than that which is found in our regular western diets. So for the purpose of the recipes included here we will look at medicines that are both useful and effective for a multitude of minor childhood illnesses whilst also pleasing to taste.

Herbal syrups have to be one of the most loved herbal medicines by all, especially children. They are simple and fun to make whilst having a naturally sweet and beautiful taste. Syrups are a brilliant way to carry herbs that also captures their unique taste profile, where alcohol preparations such as tinctures may overpower.

Syrups can be made using honey, maple syrup or cane sugar. Cane sugar is a simple carbohydrate that can be used 2:1 (two parts sugar to one parts herb) whereas honey would need a higher ratio of 3:1 to act as an effective preservative.

Syrups are made from strong teas or decoctions that have been gently concentrated through a process of slow and gentle simmering. Follow the steps below to make a herbal syrup.

Herbal syrup instructions

  1. For floral or herbaceous plant parts a strong tea infusion is made simmering on a low, gentle heat for 20 minutes (roots, fruits or barks would need a longer simmer of up to 1.5 hours). Usually enough water is added to cover the herb (dried or fresh herb can be used), the ratio would be so the herb is covered but also so the bottom of the pan would not be visible whilst moving a spoon through the mixture.
  2. During simmering, stir occasionally with a wooden spoon (if using berries or roots use a potato masher to press the plant material, extracting more of the goodness for your medicine).
  3. After simmering for the appropriate time, remove from heat and strain the infusion/ decoction using a muslin cloth on a fine sieve into a sterile container.
  4. Return the infusion/ decoction to a clean pan and on the lowest heat setting add the appropriate ratio of sugar or honey until dissolved.
  5. Cool the syrup, store and label in sterile glass bottle/ container in the fridge. A syrup can last between 6 months to a year in the fridge.

Calming chamomile honey syrup

Ingredients

  • Chamomile (dried) 100g
  • Lavender (dried) 100g
  • Purified / Spring water approx 200ml (enough to cover herb well)
  • Honey (approx 2 x 500g jars)

How to make chamomile honey syrup

To make this syrup follow the above instructions. Chamomile and lavender work both on the nervous and digestive systems. This sweet syrup would be helpful for anxious children who may be experiencing related digestive issues.

This same method can be used for herbs such as i.e. thyme and marshmallow (for respiratory support) or elderberry and rosehips (for immune support), experiment with blends of different plants to build up your home apothecary!

The chamomile and lavender syrup can be taken by the teaspoon up to 3 times daily. The honey syrups can be taken according to herb dosage instructions as per tinctures (see herb monographs for specific information on each herb).

Lemon balm (Melissa officinalis)
Lemon balm (Melissa officinalis)

Tinctures are made using either alcohol or glycerin. Vegetable glycerin is a clear, odorless liquid with a syrup-like consistency. It is usually made from vegetable oils such as soy, palm or coconut oil using high temperature and pressure, that splits the glycerin molecule from the fatty acids.

While sweet, it is not metabolised by the body like sugar. Look for an organic, sustainably harvested, non-GMO glycerin to use in medicine making (check the Resources section at the bottom).

The benefit of using glycerin is both for those wishing to avoid alcohol consumption, but an added bonus for using glycerin is that it is an excellent preservative of fresh plant juices, particularly for aromatic plants such as lemon balm, rose, violet etc. Glycerin however, is not as effective in extracting compounds from dried herb matter as an alcohol tincture.

Read our article How to make a herbal tincture.

Glycerite tincture instructions

  1. Fill a clean (sterile) jar with, chopped fresh plant material or half-full of dried plant material (dried material will expand as the glycerin is absorbed).
  2. A glycerite tincture should contain a minimum of 55% glycerin to herb ratio. For fresh plants, add enough glycerin to fully cover the plant matter, filling the jar to within one inch of the top. For dried herb, dilute glycerin with distilled water in a 3:1 ratio (3 parts glycerin to one part water) and fill the jar with mixture to within one inch of the top
  3. Use the end of a clean wooden spoon to gently press the herb under the glycerin to ensure release of air bubbles and allow maximum coverage of materials.
  4. Replace the lid and label jar.
  5. Macerate or infuse the tincture for between 4-6 weeks, gently shaking the bottle every two days. Top up with glycerin as necessary if plant material is too exposed above the glycerin.
  6. After 4-6 weeks, strain the tincture into a clean bowl using a muslin cloth (coffee filter paper works but very slowly; nut milk bags are also effective). With clean hands, gather corners of muslin cloth together, squeezing the tincture out until there is barely a drop left. The last few squeezes will have add some very potent mixture to the final tincture so don’t give up squeezing too quickly!
  7. Finally, bottle and label your glycerite tincture. It stays in date for up to a year.

Lemon balm glycerite tincture

Ingredients

  • Lemon balm (fresh leaves)
  • Vegetable glycerin

How to make lemon balm tincture

Lemon balm is gently nervine and works to support our nervous system through stressful times. It is also indicated for digestive upsets and in respiratory complaints. The lemon balm tincture can be taken by the teaspoon up to twice daily.

Calendula (Calendula officinalis)
Calendula (Calendula officinalis)

Herbal infused or ‘macerated’ oils are a wonderful way to preserve herbs for use in topical conditions. They are also quick and incredibly simple to make and diverse in their applications.

There are a number of different methods to make herbal oils both for use in medicine and for culinary use. This method is called the solar infusion and relies on a warm sunny window.

Herbal infused oils can be used neat or can be made into salves or ointments and also blended into creams, so they are a fantastic base from which to explore other herbal preparations.

For best results use dried herbs (fresh herbs add a water element to oil, which can lead to spoiling), there are different methodologies for fresh herb oils.

Carrier oils that are ideal for topical use include sunflower and olive oils, both excellent carriers whilst offering some resistance to oxidation and rancidity. Herbs that are commonly used in herbal infused oils include calendula, St John’s wort, chickweed and plantain, all having their own unique medicinal qualities.

The most simple way to make an infused oil is as follows.

Herbal-infused oil instructions

  1. Add dried herbs in a dry, sterilised container and cover with your chosen carrier oil; usually, the oil should sit 1 inch above the top of the herbs.
  2. Use a spoon to press and mix the herb/ oil so that all surfaces of the herb matter is coated and no air bubbles remain.
  3. Place a square piece of natural waxed paper or greaseproof paper on top of the jar, then seal jar with a tightly fitting lid.
  4. Place the jar in a sunny window for between 4-6 weeks to infuse. The warmth of the sunlight will help to extract the compounds from the herbs into the oil. Stir or shake the mixture every few days.
  5. When the infusion time is up, line a sieve with of muslin cloth (folded to layer up) and filter. the mixture into a clean bowl. Gather the corners of the cloth up and squeeze strongly, squeezing as much oil from the herb as possible
  6. Cover and let aside overnight in a cool, dark location to allow for any herb sediment to settle at the bottom of the jar. You can also strain the oil through an unbleached coffee filter to remove fine sediment.
  7. Pour the oil into dry, sterilised, dark-coloured glass bottles. You can add a couple of drops of Vitamin E into your final oil to slow down the oxidisation process, giving the oil a shelf life of around 1 year.
  8. Label your infused oil, and store in a cool, dark place.

Calendula-infused oil

Ingredients

How to make an oil infused with calendula

Calendula infused oil can be used directly on the skin to treat all manner of skin inflammations and in first aid for minor cuts, grazes, bruises, sprains and strains. Calendula oil is also useful for slow healing wounds and for the healing of minor burns. This blend can be used as and when needed, up to 3 times a day.

A herbal balm is made from a herbal infused oil, simply adding a wax element such as beeswax or (vegan) carnauba wax. Balms and salves are subsets of an ointment. Salves are typically softer, where as a balm or ointment is more solid. The benefit of infusing a wax into an oil to create balms/ salves/ ointments is that it increases binding to the skin, more successfully than an oil alone, they are also potentially, slightly less messy to use than oils.

Learn more about How to make a herbal balm.

Chamomile (Matricaria chamomilla)
Chamomile (Matricaria chamomilla)

Herbal balm instructions

  1. Using a double boiler/ Bain Marie or a water bath method, on a gentle heat. Add your infused oil into the clean pan.
  2. Add around 8- 12 % beeswax and gently stir with a silicone or wooden spoon until the wax has fully dissolved into the oil. Remove from the heat.
  3. You can add an essential oil at this stage if desired; approx 10 drops (depending what is being used). Essential oils act as a preservative but also help to assist circulation and better absorption into the skin.
  4. Slowly pour the mixture into a clean, dark glass jar. Cover but do not close the lid firmly until the balm has fully set/ solidified.
  5. Label your jar and close the lid firmly. Store in a cool, dark place. Balms/ Salves/ Ointments should last for unto a year.

Calendula balm

Ingredients

  • Calendula-infused oil
  • Sweet orange or chamomile pure essential oil
  • Beeswax (unfiltered pellets or solid form)

How to make calendula balm

Calendula balm can be used directly on the skin to treat all manner of skin inflammations and in first aid for minor cuts, grazes, bruises, sprains and strains. Calendula is also useful for slow healing wounds and for the healing of minor burns. This balm can be used as and when needed, up to 3 times a day.

For more information on uses of the herbs discussed in this article or other herbs you may wish to explore in medicine making using these recipes, visit our Herbs section.

Medicine making books and other resources

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Exploring the ancient history of Western herbal medicine https://www.herbalreality.com/herbalism/western-herbal-medicine/ancient-history-western-herbal-medicine/ https://www.herbalreality.com/herbalism/western-herbal-medicine/ancient-history-western-herbal-medicine/#comments Tue, 30 Aug 2022 19:17:27 +0000 https://www.herbalreality.com/?p=7828 Herbal medicine has been used for thousands of years and has a fascinating history. We delve into some of Western herbal medicine's ancient Greek roots.

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Exploring the ancient history of Western Herbal Medicine

Herbal medicine has been used for thousands of years and has a fascinating and rich history. This article delves into some of Western herbal medicine’s ancient Greek roots.

In the 1990s, I delved back into the origins of Western herbal medicine. They can be traced through evidence in texts, artefacts and archaeology primarily to ancient Greek peoples who inhabited areas around the Mediterranean from Marseille and southern Italy to the Greek peninsula and western parts of modern Turkey.

Oral traditions of healing date back some 3,000 years; there are instances of healing with herbs in the epics of Homer. More extensive evidence appears from the 6th century BC.

Healing practices were derived from the lived experience of people interacting with and learning from animals and plants and sifting out what worked practically as medicine. Initially such practices were acknowledged as coming from deities such as Apollo, Artemis and demigods such as Chiron and Aesclepius, who was at first a hero but later raised to the status of a god.

The writings of Hippocrates
Hippocrates

Many are familiar with Hippocrates being considered the ‘father’ of medicine, and with his aphorisms such as ‘Let your food be your medicine and your medicine be your food’ or ‘Nature knows best’. But in fact Hippocrates and his fellow physicians have much more to impart.

I discovered this when I read their writings in detail in the English translation of the Hippocratic Corpus, and strove to understand the milieu in which they were written. The Corpus comprises roughly 60 treatises written by different physician-healers in the late 5th century and the early decades of the 4th century BC.

Written texts on this scale were a recent development. The texts include a diverse range of topics and reflect differing, sometimes even contradictory theories, as the authors explored and tried to establish just what the best approach is for discovering the causes of disease, and what are the best methods and medicines to relieve suffering.

They detail the powers of botanical medicines and how to apply them, based on insights into how the body in a holistic sense is constituted and responds to disease as well as lifestyle and environmental factors.

Practical, theoretical and philosophical insights are evidenced in ancient medical texts. The physicians’ experience and their writings were so transformational that they were collected together, studied and revered from that era and on into the next 2000 years.

What is not often appreciated is the conceptual background amongst Greeks of this time. From about the 6th century BC, Greeks in both a practical and a philosophical sense innovatively began to explore the origins of human existence, of the universe, the phenomenal world and the human body in radical new ways.

Their insights contrasted with the traditional gods-centred view of their societies, in which certain gods were associated with healing and teaching medical skills – e.g. Apollo, Artemis, Aescleplius. Instead these early thinkers conceived unifying eternal principles.

Empedocles
Empedocles

The Kosmos is the divine ultimate source and sustainer of everything. The Kosmos was also spoken of as the “Holos” or Whole – a term often found in the medical writings and from which we derive the word ‘holistic’.

Some writers particularly emphasised Nature (in Greek physis from which we get the words physician, physics) itself as the divine principle in the phenomenal realm. Nature is a universal force combining elements of fire, water, earth and air, and including a fifth element aither, which regulates their qualities of heat, cold, moisture and dryness in the world of living things, the earth, climate, weather and so on.

For example, Empedocles (c 494-434 BC) describes the workings of Nature in terms of the divine Sphere, within which the forces of Love and Strife attract or disrupt the harmonious “mixture” of the elements, and qualities and forms which derive from them.

The medical authors sought to understand the individual constitution – how the elements and qualities expressed themselves in the body, how the parts of the body are all interconnected and sensitive to one another.

Human existence is a microcosm of the universal macrocosm, so understanding and living according to the laws of Nature fosters harmony both with the phenomenal world and with our best self. Some thinkers describe the ultimate purpose of humans is to find their true nature by returning to union with the Divine principle within.

That there was a close relationship between Greek philosophical ideas and medicine is revealed in Plato’s Symposium. Each guest at the dinner is invited to speak on Love. Plato (c 427-347 BC) includes a physician, Erixymachus, as one of the guest, whose words echo the themes above:

“The business of what we call medicine, which is, in a word, the knowledge of the principles of love at work in the body in regard to repletion and evacuation. The most skilful doctor is the doctor who can distinguish between noble and base loves in this sphere, and the man who can cause a body to change the latter for the former and can implant love in a body which lacks but needs it, and remove it where it already exists, will be a good practitioner. He must be able to bring elements in the body which are most hostile to one another into mutual affections and love; such hostile elements are the opposites hot and cold, wet and dry and the like; it was by knowing how to create love and harmony between these that our forefather Asclepius, as our poets say and as I believe, founded our craft.” (1)

This world view is amply reflected in the writings of Hippocratic physicians who endeavoured to follow the ‘healing power of Nature’ as guide in medical practice, by which they meant a scrupulous, rational study of the natural world and human body in order to derive knowledge and the skills with which to both to maintain health and treat diseases. This continued to form the background to subsequent medical practices and texts in subsequent centuries.

De historia plantarum by Theophrastus
De historia plantarum by Theophrastus

Ancient medicine recognised the importance of foods and dietary regimens for both health and in treating disease. This was combined with exercise, rest and therapeutic baths and amplified with a pharmacy of medicinal herbs, and the therapeutic uses of oils, waxes, wines, waters, clays and minerals (blood-letting is evidenced but not routine).

In the Hippocratic work Regimen II. LIV. (2), the author describes the qualities of many herbs and foods, along with their effects on the body: “Purslane when fresh cools, when preserved it warms… Mint warms, passes easily by urine, and stops vomiting” – an effect we still observe today (2).

The Hippocratic physicians were the first to practise recording the case histories of individual patients and the outcomes of their treatments. These can be read in the work of several Epidemics treatises where we find individually named persons, with their addresses recorded. This invaluable approach has continued through the centuries to be a feature of Western medicine.

We learn more of early herbal pharmacy, the way the actions of herbs were understood, how they were sourced and applied from the writings of Theopharastus (c317-287 BC) and Dioscorides (c40-90 AD).

Theophrastus was a pupil and later the successor to Aristotle in the Lyceum school in Athens. Inspired by Aristotle’s systematic investigative approach to nature, he focused on the plant kingdom and is credited with being the first botanist, although he also thought and wrote about many other topics. He left two surviving works on plants, Enquiry into Plants and On the Causes of Plants.

These include many medicinal herbs with details of how they were gathered or cultivated, and used practically. He carefully observed plants in terms of their forms, and modes of reproduction, for which he is credited with being the first botanist. These works later became inspirational to the renewal of learning during the Renaissance, and for Linnaeus himself.

Dioscorides’s De Matiera Medica – On the Materials of Medicine – is a Greek text of five volumes which includes about 850 medicinal substances, the majority of which are herbs. It survived into the early modern medicine via translations in Aramaic, Arabic, and then Latin, becoming accessible in English with a first inclusion of his information in Henry Lyte’s A Niewe Herbal, 1578, which itself was based on Flemish and French translations. Take a look at Dioscorides’s text (3).

Discorides
Discorides

Fast forward to the 1980s when Professor John Riddle re-evaluated Dioscorides’ understanding of the effects of the herbs. Though Dioscorides didn’t have the benefit of modern biochemistry, Riddle found his grouping together of herbs with “drug affinities” revealed accurate knowledge of their effects in and on the human body, as confirmed by modern chemical analysis of their properties (4).

Galen of Pergamon (c129-216 AD) was a Greek physician living several hundred years after Hippocrates during the early Roman Empire. He became physician to the emperor Marcus Aurelius. Galen built on the learning of previous generations. He revered ‘Hippocrates’ and based his approach to medicine on the texts which had been gathered together under his name.

However, though ‘following’ Hippocrates in all things, as he saw it, he in fact applied himself to discovering more about the human body, developed innovative methods of treatment and took advantage of the expanded repertoire of medicinal herbs available from the empire.

He emphasised using the importance of understanding the patient in his or her full complexity, based on judging the ‘mixture’ or temperaments of the elements in the individual. These influence not only the condition but the person’s response to treatments.

Like the Hippocratic physician, his therapy was to be tailored to the patient. This constitutional approach was not always possible, of course. Galen was for a time a physician to gladiators where he practised what today would be emergency medicine, and he paid close attention to the effects of their wounds, and the internal workings of the body which they revealed. He applied his skills as a surgeon, using the medicines of the day in wound healing.

In his prolific writings he called for the use of the best quality of medicines, he emphasised that the physician must carry out investigations of his own into the body and the herbal medicines, not relying on received convention, in order to understand from his own experience. His results were constrained by the context of the times; some things he got wrong. He made significant advances in knowledge himself, discovering the difference between venous and arterial circulation, and theorising that the blood received oxygen from the lungs.

Galen
Galen

There are many other ancient writers whose texts survive, for example Pliny, Celsus, Soranus, Rufus of Ephesus, Alexander of Tralles. The knowledge of these earliest practitioners was essentially still the basis of medicine and domestic medicine until the discoveries of pharmaceutical sciences in the 19th and especially 20th century, for example, the anti-inflammatory effects of aspirin and quinine, and the role of antibiotics.

Yet aspirin was derived from the age-old use of willow bark for fevers, quinine from the South American use of cinchona bark, and digoxin from the folk use of the foxglove.

Since the last quarter of the 20th century traditional medicines – previously dismissed as of little use and “merely old wives tales” have not only been sought after again by the public but become the subject of research and development as a source for new orthodox medicines. For example, Dr. Cassandra Quave’s work at Emory University (6).  

With the acceleration of science and its discoveries from the mid-19th century and continuing today herbalists have responded with innovations in training and practice, mindful to incorporate what is useful and appropriate for the best interests of their patients.

They also learn and adopt from their own experience improved therapeutic approaches, selecting the herbal prescription for a patient both in the light of ongoing research and holistically according to the patient’s individual nature and circumstances. They also continue to use many of the herbs in the ancient pharmacy, such as St John’s wort, agnus castus, yarrow, walnut, vervain. By doing my own research, I realised how the influence of the roots of Greek medicine continues to flow like a living sap into the many branches of modern herbalism (5).

  1. Hamilton, Walter. Translator. Plato The Symposium. Harmmondsworth, England: Penguin Classics, 1971.
  2. Jones, W.H.S. Translator. Hippocrates, Volume IV. London: William Heinemann, 1979.
  3. Several blogs on the Herbal Research Network website address topics in the history of Western herbal medicine and include many more resources and references.
  4. Riddle, John. Dioscorides on Pharmacy and Medicine. Austin: University of Texas Press, 1985.
  5. Pitman Vicki. The Nature of the Whole, Holism in Ancient Greek and Indian Medicine. New Delhi: Motilal Barnasidass, 2006.
  6. Quave C. Quave Research Group. Etnobotanica.us. https://etnobotanica.us/. Published 2022. Accessed August 30, 2022.

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Herbal treatment of children: A holistic overview of children’s health https://www.herbalreality.com/herbalism/western-herbal-medicine/herbal-treatment-children/ https://www.herbalreality.com/herbalism/western-herbal-medicine/herbal-treatment-children/#comments Thu, 25 Aug 2022 19:33:27 +0000 https://www.herbalreality.com/?p=7793 Herbal medicines are a safe and effective way to treat an array of children’s ailments. We explain which herbs are useful.

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Herbal medicines are a safe and effective way to treat an array of children’s ailments. This article explains which herbs are useful, and offers holistic healthcare insights.

Herbal treatment of children: A holistic overview of children’s health

I hear from many herbalists that treating babies and children can feel a bit daunting. They often have concerns about giving herbs to children and babies and particularly about methods of administration and dosage.

Certainly, it can be one thing to treat other people’s children but quite another when treating your own and most likely finding it hard to remain calm and objective. I wrote my first book on treating children in the 1980s when mine were small so that when woken in the middle of the night by a crying child with a high fever and unable to think clearly, I had a manual so that I would know what to do!

In practice it is hard to evaluate the efficacy of herbal treatment of children alone. As we are well aware, herbal medicine does not simply mean the prescribing of medicinal herbs. It encompasses the consultation and the therapeutic relationship between patient and practitioner and the knowledge and expertise of the practitioner within a framework of a theoretical perspective or discipline…whether Western, Chinese, Ayurvedic, Tibetan, Unani etc.

As a synthesis of ancient and modern theories and practices, the underlying philosophy of modern herbal medicine is that health is intimately connected to the harmony of body, mind and spirit which enables a balance of natural forces in the body.  In a clinical context, as herbalists we interpret symptoms of ill health as a disturbance of this balance and consider them within the framework of the patient as a whole – their lives inner and outer.  The now familiar WHO definition of health: “The condition of perfect bodily, spiritual and social well-being and not solely the absence of disease and injury” is a lofty aim but certainly one that we as herbalists aspire to.

Through forty years in practice, in which many of my patients have been children, and having three of my own, I have evolved strategies for their treatment which actually don’t differ much from my strategies for treating adults. In both cases I may need to find tempting ways to ensure compliance! Most of the cases I encounter in practice are chronic, interspersed with some acutes. I will often try to pre-empt acute problems and provide prescriptions and instructions to parents for when they crop up. I have found that the younger children are when first taking herbs the better they are in terms of compliance, especially when this is necessary in treating acute problems.

For each ailment or imbalance a child develops there is a long list of herbs to choose from, some help and others don’t. To understand why, it is useful to look at the basic constitution of the child, set against the environment the child lives in, their diet and lifestyle. The way I have come to understand more about this is through the study and practice of Ayurveda and its constitutional approach to diagnosis and treatment.

From any perspective, the key to a child’s health lies in understanding their natural health tendencies and how to keep them in balance through diet and lifestyle.

Everyone reading this will be aware of most of the factors necessary for health and resilience: plenty of nutritious, preferably organic foods, a balance of work and play, exercise and relaxation, sufficient sleep, a minimum of pollution, and a loving and harmonious home life.

From an Ayurvedic and now modern scientific perspective, good digestion and a healthy microbiome are also central to health, so that the food we eat will be digested and absorbed well and the wastes eliminated efficiently.

Our gut is home to a large, diverse and dynamic population of micro-organisms that serve numerous purposes. These include the breakdown and absorption of nutrients necessary for growth and development, immune system function, hormone development and cognitive function.

The symbiotic relationship between our gut and its microbiota is fundamental to our immune system whether a child or adult. The immune system and microbiota exchange chemical signals allowing the immune system to recognise the types of bacteria that are harmful and combat them, while allowing the helpful bacteria to carry out their functions; in turn, the microbiota influence immune reactivity and targeting.

Until recently, the uterus and the placenta were thought to be germ-free and sterile to keep the baby safe from infection. But at just one week old, babies have a complex collection of microbes in their guts. It was thought that a baby received its first dose of bacteria as it passed through the vagina or from the mother’s skin if the child was born via C-section.

We now know that there are microbial inhabitants in the placenta (which nourishes the growing foetus through the umbilical cord) and these closely resemble those that live in the mouth (1). Also, that a disturbance of these bacteria may well be responsible for pre-eclampsia during pregnancy.

A broad range of bacteria are present, including those necessary for metabolising some of the vitamins and nutrients needed by the foetus. The acquisition of the microbiota continues over the first few years of life, and in fact an infant’s GI tract microbiome begins to resemble that of an adult as early as 1 year old. 

Although it was previously thought that the infant gut microbiota would resemble that of an adult by the age of 3, recent studies indicate that the microbiota continues to evolve in both pre-adolescents and 20-year-olds (2). The adult microbiome consists of over a trillion bacterial cells and up to an estimated 1,000 different bacterial species, communities of symbiotic, commensal and pathogenic bacteria along with fungi and viruses.

The predominant organisms found in healthy human large intestine are Gram-negative Bacteroidetes and Gram-positive low-GC Firmicutes, but this varies greatly between individuals. Once established, the composition of the gut microbiota is relatively stable throughout adulthood but can be altered as a result of bacterial infections, antibiotic treatment, lifestyle, surgical, and a long-term change in diet (3).

Common complaints in babies and children include digestive disorders, infections, respiratory problems, skin conditions, nervous or cognitive disorders, allergies and auto-immune disorders.  All these may well have something in common:

  • Gut dysbiosis: An altered microbial state in the gut, either lack of bacterial biodiversity or overgrowth of pathogenic microorganisms (SIBO) 
  • Leaky gut syndrome: A healthy GI tract serves as a barrier preventing undigested food particles, microbes, toxins and other unwanted substances from entering the body through the bloodstream. When the intestinal epithelium becomes damaged, substances can ‘leak’ into the body where they are attacked by the immune system, which leads to inflammation.

These can affect digestion and absorption of nutrients, disturb immune function and trigger inflammation.

Antibiotics

Even a single dose of antibiotics can create permanent changes in our gut flora, and sometimes the healthy bacteria never fully recover from strong rounds of antibiotics.

Improving fertility and weight loss with a PCOS-like hormonal imbalance

The state of the mother’s gut flora during pregnancy and birth

Some bacterial species are more common and others less common in women who give birth prematurely – before 37 weeks of pregnancy – than the typical bacterial profile of the women who go full term.

It has been found that gum disease raises the risk of premature birth. Oral bacteria from diseased and bleeding gums can allow harmful bacteria to reach and colonise the placenta, potentially triggering premature birth (4).

The microbiota that an infant begins to acquire depends strongly on mode of delivery. Twenty minutes after birth, the microbiota of vaginally delivered infants resembles the microbiota of their mother’s vagina, while infants delivered via Caesarean section harbour more microbial communities typically found on human skin.

Nutrition during the first few years of a child’s life

  • Diets high in sugar, refined carbohydrates and processed foods and low in fermentable fibre (prebiotics) can contribute to small intestinal bacterial overgrowth (SIBO). Avoiding foods that feed pathogenic bacteria, and consuming fibre-rich foods that feed commensal bacteria can help restore the balance.
  • Eating a diet too high in protein, especially if that animal protein has been treated with antibiotics, can disrupt the microbiota.

The Importance of breastfeeding

Every mother produces complex sugars (oligosaccharides). More than 200 human milk oligosaccharides (H.M.O.s) have been identified. They are the third-most plentiful ingredient in human milk, after lactose and fats, and their structure ought to make them a rich source of energy for growing babies—but babies cannot digest them.  

H.M.O.s pass through the stom­ach and the small intestine unharmed, landing in the large intestine, where most of our bacteria live. If babies cannot digest them, they must be food for the microbes!

Bifidobacteria are more com­mon in the stools of breast-fed infants than bottle-fed ones. Human milk contains several oligosaccharides that cow milk does not.

Poor digestion

If our digestive energy is low, enzymes are not secreted as they should be, and food can remain partially digested in the gut, ferment and promote dysbiosis and leaky gut syndrome which can lower resistance to disease.

Mento-emotional state

Stress can severely compromise the quality of our digestive function. We now know that there is a direct connection between the central nervous system and the enteric nervous system in the gut that has been coined the “gut-brain axis”.  When we are stressed, mentally, emotionally or physically, the sympathetic nervous system overrides the functions of the parasympathetic nervous system.

Digestion gets deprioritised because it is less vital to our immediate survival. These factors work together to affect the gut flora, impair nutrient absorption and predispose to leaky gut syndrome.

It is thought that changes in dietary patterns over the last few decades combined with overuse of antibiotics could result in each generation beginning life with a smaller population of ancient microbes than the last as well as being a primary contributor to the epidemic of obesity, diabetes, IBS and allergies that we see today.

Echinacea (Echinacea purpurea)
Echinacea (Echinacea purpurea)

This firstly involves taking a detailed case history of the child and examining the body, paying attention to their build, skin and hair type, body temperature, digestion and bowel function, as well as temperament. Tongue and pulse diagnosis are valuable diagnostic tools.

Re-establishing homeostasis in the gut can bring profound healing to the entire body, relieving digestive symptoms as well as disorders of the immune system, nervous system and skin.

Herbal medicines provide us with the solution to many problems in babies and children associated with disruption of the microbiome. We have…

Herbal antimicrobials to prevent the use of allopathic antibiotics:

Cinnamon sticks (Cinnamomum spp)
Cinnamon sticks (Cinnamomum spp)

Digestives and carminatives to enhance appetite, digestion, absorption and prevent fermentation in the gut.

Spices such as ginger, cinnamon, cardamom, coriander, clove and black pepper are some of the best remedies for the digestion and for increasing immunity. These can be added to cooking and made into tasty hot teas for all the family.

Take ginger for example. Its pungency warms and strengthens digestion, stimulates the flow of digestive juices and invigorates the whole body. It is highly antiseptic, activates immunity, dispels bacterial and viral infections.

A hot cup of ginger tea is an excellent remedy for the first signs of colds, coughs or flu and will help to clear catarrh. 2-3 cups can be sipped through the day.

Antimicrobial digestives to inhibit and combat small intestinal bacterial overgrowth (SIBO):

Astringent herbs to restore the gut wall in leaky gut syndrome:

Nervines and relaxants to balance the nervous system:

The ways of prescribing herbal medicines vary considerably according to the condition being treated, the herbs employed, the age and build of the child, their constitution, even the time of year. The easiest way is in food.

Babies

  • Umbilical powdered herbs
  • Teas in bottles/off the spoon
  • Teas/dilute tinctures/glycerites/hydrosols in syringes
  • Baths/sponging
  • Oils/massage including foot massage
  • Burners in rooms/on radiators/lights

Children

  • Hot/cold infusions and decoctions
  • Syrups
  • Powders rolled in honey, fruit concentrate, ghee, smoothies, warm water/milk
  • Tinctures and glycerites
  • Herbal baths – dilute essential oils, infusions, fresh herbs in muslin
  • Tablets/capsules for older children
  • Hand & foot baths
  • Inhalations
  • Massage – dilute oils/liniments, chest rubs etc
  • Ointments, lotions and creams
  • Compresses
  • Hydrosols
  • Suppositories

Chronic conditions generally require mild herbal remedies which can safely be given, generally 3 times daily, over months at a time if necessary.

Acute conditions may require stronger herbs given up to every 2 hours.

For example, dandelion root has mild laxative properties which can be given to regulate digestion and elimination over a period, while senna root or castor oil have stronger laxative action for acute constipation or to clear heat quickly during a fever.

Some conditions, particularly fevers, colds, catarrh and problems associated with cold, require herbs to be given in hot preparations. Others such as urinary problems are better suited to cool preparations.

Skin problems may improve more rapidly with herbal teas as opposed to tinctures, while tinctures may be preferable when more concentrated medicines are required such as the treatment of a virulent infection.

  1. Olaniyi KS, Moodley J, Mahabeer Y and Mackraj I (2020) Placental Microbial Colonization and Its Association With Pre-eclampsia. Front. Cell. Infect. Microbiol. 10:413. doi: 10.3389/fcimb.2020.00413
  2. Hollister EB, Riehle K, Luna RA, et al. Structure and function of the healthy pre-adolescent pediatric gut microbiome. Microbiome. 2015; 3:36. doi: 10.1186/s40168-015-0101-x.
  3. Juan Miguel RodrÍguez, Kiera Murphy, Catherine Stanton, R. Paul Ross, Olivia I. Kober, Nathalie Juge, Ekaterina Avershina, Knut Rudi, Arjan Narbad, Maria C. Jenmalm, Julian R. Marchesi & Maria Carmen Collado (2015) The composition of the gut microbiota throughout life, with an emphasis on early life, Microbial Ecology in Health and Disease, 26:1, DOI: 10.3402/mehd.v26.26050
  4. Saini R, Saini S, Saini SR. Periodontitis: A risk for delivery of premature labor and low-birth-weight infants. J Nat Sci Biol Med. 2010 Jul;1(1):40-2. doi: 10.4103/0976-9668.71672. PMID: 22096335; PMCID: PMC3217279.

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Healing muscles and joints with essential oils: Recipes from an aromatherapist https://www.herbalreality.com/health-lifestyle/mobility-fitness/healing-muscles-joints-essential-oils-recipes/ https://www.herbalreality.com/health-lifestyle/mobility-fitness/healing-muscles-joints-essential-oils-recipes/#comments Tue, 09 Aug 2022 18:41:53 +0000 https://www.herbalreality.com/?p=7577 All of us need relief from sore muscles and joints from time to time, and this article shares how to make your own healing oils for various conditions.

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All of us need relief from sore muscles and joints from time to time, and this article shares how to make your own healing oils for various conditions.

Healing muscles and joints with essential oils: Recipes from an aromatherapist

Aromatherapy is often thought of as a lovely way to make a room smell nice, calm and relax the mind, or provide an extra, aromatic element to a massage.

It is all of these things, of course, but many people are unaware of the physical, targeted benefits that carefully considered aromatherapy blends and products such as balms, lotions, and massage oils can have for injuries and chronic pain.

Essential oils, when combined in a suitable carrier and applied to the skin, are able to pass through the skin’s barrier and enter the bloodstream, due to their small molecular size.

Once in the bloodstream, essential oils have a range of physical actions on the body: anti-inflammatory, analgesic, antispasmodic and lymphatic being some of the most helpful actions for relieving musculoskeletal pain and tension.

Muscular and joint pains are some of the most common conditions that massage therapists see in their treatment rooms, and although these can be manageable in day-to-day life and don’t necessarily always present in extreme ways, they can cause an extra layer of stress for clients. This in turn can have a negative impact on their physical wellbeing and mental health.

Below, I’ve explored some of the most common ailments I see in my own clinic, and included some suggested therapeutic products and treatments that have been enormously helpful for both myself and my clients.

Lavender oil (Lavandula angustifolia)
Lavender oil (Lavandula angustifolia)

A strain is caused by overstretching a muscle and/or a tendon (1), usually caused by overstretching the fibres, leading to bruising, pain, spasms, weakness, oedema (swelling) inflammation, and cramping in the muscle, and even tears in the muscle fibres (2). A sprain, in contrast, is injury to a ligament, which connects bone to bone, and is often caused by a sharp twisting motion. The symptoms are often similar to those of a strain.

Treatment of sprains and strains should be approached carefully, particularly when in the acute stage, immediately following the injury.

The role of aromatherapy here is primarily to help reduce swelling and pain through the gentle application of anti-inflammatory essential oils, and to help move lymph around the area, through the use of astringent essential oils and herbal extracts. Since temperature also has a role to play with the reduction of pain and swelling, it is advisable to use a cool pack alongside the oil blend to aid the healing process. Although the injury is acute, applying neat or undiluted essential oils to the skin is not advised, since it may cause irritation or damage to the skin.

Instead, a strong blend of around 5% can be made and applied to the area, then occluded with a cold compress, and alternated with a hot compress if desired, to increase blood flow to the area and speed up the absorption of the remedy. A carrier oil will be needed to dilute the blend; a herbal-infused oil such as arnica is helpful for addressing bruising, for example. Alternatively, witch hazel (Hamamelis virginiana), which is astringent, can be blended with a dispersant such as Solubol, and the essential oils added and applied to the area with a cold flannel.

Suggested blend for sprains and strains

5% blend

  • 10ml Arnica Arnica montana-infused carrier oil e.g. Sunflower (Helianthus annuus) (or 10ml of Witch Hazel / Solubol mixture as described above)
  • 10 drops (total) of cooling, anti-inflammatory astringent essential oils, to include any of the following:
    • Grapefruit (Citrus paradisii): Lymphatic drainage, astringent (Safety note: Phototoxic. Avoid application before exposure to sunlight.)
    • Juniper (Juniperus communis): Lymphatic drainage, astringent
    • German Chamomile (Matricaria recutita): Anti-inflammatory
    • Roman Chamomile (Chamaemelum mobile): Anti-inflammatory
    • Peppermint (Mentha piperita): Cooling, analgesic (Safety note: do not use whilst pregnant, breastfeeding or with children under 2 years old.)
    • Lavender (Lavandula angustifolia): Anti-inflammatory, analgesic

Stir well to combine, and apply to the affected area using gentle massage. Cover with a cold flannel or ice pack if desired.

Many of my clients exercise regularly, but also have desk-based jobs. This means that they often arrive at the clinic with various low-level aches, pains and tension which they are unable to relieve through stretching at home.

Usually poor posture or overuse of the muscle are to blame for these kinds of aches and pain, and symptoms can include pain, inflammation, oedema (swelling), tightness or tension, and reduced motion in the affected area. Also tendonitis, plantar fasciitis, or carpal tunnel syndrome may be the result of repetitive strain injury (RSI). In such instances, there are several treatment options available to clients, both at home and on the massage couch.

Rosemary essential oil (Rosmarinus officinalis)
Rosemary essential oil (Rosmarinus officinalis)

Preventative measures include regular stretching as part of the working day (3), and post-exercise, to ensure the muscles are adequately moved and stretched, and tension build up is prevented. Supportive desk chairs, mouse mats, and armrests can prevent RSI in the wrists, for example, and support healthy back posture whilst seated (4).

Maintaining a regular physical practice such as gentler forms of yoga, e.g. yin yoga, can also be enormously helpful for maintaining flexibility, since they focus on releasing the fascia that connects the musculoskeletal system (5), reducing tension in the muscles and keeping joints mobile. Mixing up exercise regimes and not over-working one muscle group can also help to prevent muscle pain from overuse (RSI).

However, there are always times when we might overdo it on a run or in the gym, sit for too long at our desks, or lift something heavy. We then wake up the next morning with a crick in the neck, sore legs, or a painful shoulder. Perhaps we even suffer from a ‘pinched nerve’ due to the inflammation in the surrounding muscle tissues. In these cases, aromatherapy can be a gentle and enjoyable way to help alleviate pain and tension, and to help relax and release muscle tissue.

Since pains and tension of this type tend not to be as limiting or acute as sprains, strains and other injuries, they require a different approach to treatment. Ingrid Martin recommends the use of “strongly analgesic and cooling” (6) essential oils for pain caused by overuse of a muscle, however, oils that are considered warming are also useful for longer-term chronic stiffness (7) and tension.

Some useful oils for chronic pain, tension and RSI

Carrier oils

St John’s Wort (Hypericum perforatum): herbal infused oil, e.g. sunflower Helianthus annuus. A carrier oil infused with St John’s Wort is extremely anti-inflammatory, and is recommended for bruising, reddened skin, as well as being calming for neuralgia and sciatica (inflamed nerves). The herb gives its carrier oil a gorgeous blood red colour.

Jojoba (Jojoba sinensis): Actually a liquid wax, jojoba absorbs very easily into the skin, having a similar molecular structure to that of skin’s natural sebum. It is also anti-inflammatory and is often recommended for treating arthritis and other inflammatory conditions, so can be useful for relieving chronic joint pain.

Essential oils

Cooling, anti-inflammatory essential oils such as those mentioned above for the treatment of acute injuries can also be applied here, but sometimes a more “warming” approach is needed, particularly in cases of stiffness and stagnation in the muscles and joints. Some of these oils include:

Cinnamon (Cinnamomum verum): A warming, stimulating oil that has antirheumatic properties. A lovely addition to a muscle-warming blend.

Black pepper (Piper nigrum): Another stimulating, warming oil, with anti-inflammatory and analgesic properties (9). This oil promotes good blood circulation and is particularly recommended for overworked muscles, chronic inflammation, stiffness, and both osteoarthritis and rheumatoid arthritis (10).

Rosemary (Salvia rosmarinus): A stimulating, invigorating oil, which is an excellent vasodilator (11) and can alleviate muscle tension and pain through bringing blood to the area. “Stiffness and the related pain are usually relieved if local circulation is improved” (12) states Ingrid Martin.

Marjoram (Origanum majorana): Primarily a relaxant and hypotensive oil, which I use a lot in my clinic for clients with muscular pain and tension. Due to its ability to act on the nervous system as well as on smooth muscle tissue (13), it is a powerful oil for treating physical conditions such as muscle aches and rheumatism (14) caused by excessive tension in the body. It is an excellent accompaniment to some of the more stimulating, anti-inflammatory oils mentioned above.

I would normally combine these oils at no more than a 2% dilution in an appropriate carrier oil for use in massage during a treatment, however I regularly make muscle rubs and balms for clients to take home, as these can be useful to carry with them for use at home, work and more.

Usually, a product at a 4-5% dilution is prepared, using a mixture of carrier oils, essential oils and waxes to create a thick balm that is solid at room temperature. This is then applied three times a day to the affected area. A balm of this strength, however, would be too strong for a full-body massage, and is designed for localised, topical use only.

Muscle rub/balm recipe

Makes 1 ~60ml pot

Ingredients

  • 7.15ml Beeswax (or soy wax)
  • 50ml Carrier oil (e.g. herbal infused St John’s Wort oil)
  • 57 drops (~2.85ml)  total essential oil (from list above)

Method

  1. Use a bain-marie over a low heat to melt the carrier oils and wax together. Stir until completely melted and combined.
  2. Take off the heat. Allow to cool to 50-60 degrees centigrade. If the essential oils are mixed in before the mixture is left to cool much of the essential oils will be evaporated and lost.
  3. Add up to 57 drops of essential oils, from those listed above
  4. Stir well to combine, pour into a 60ml sterilised tin and allow to cool
  5. When solid, the balm is ready to use. Use within 6 months.
  6. Apply topically to the affected area up to three times per day, massaging gently.

Fibromyalgia is a chronic health condition that can affect the whole body (15). Symptoms include increased sensitivity to pain, tenderness and soreness, fatigue, and stiffness. Brain fog, insomnia and digestive issues can also be accompanying symptoms. Whilst it has a strong muscular component, when treating fibromyalgia, an aromatherapist will take into consideration the symptoms as a whole, and create a blend of oils according to each individual’s unique needs.

Lemon balm (Melissa officinalis)
Lemon balm (Melissa officinalis)

Massage can be a wonderful way to treat fibromyalgia and other chronic muscular conditions, since it works not only on the site of the pain, i.e. the muscles, but on the emotional body and nervous system, too.

A 2014 systematic review concluded that “Massage therapy with duration ≥5 weeks had beneficial immediate effects on improving pain, anxiety, and depression in patients with [Fibromyalgia]. Massage therapy should be one of the viable complementary and alternative treatments for [Fibromyalgia]” (16) although more, large-scale research is needed to provide confirmation of the findings.

My favourite essential oils for treating fibromyalgia are those that work synergistically on the nervous system as well as the physical body, since my clients presenting with fibromyalgia often experience depression, anxiety, and frustration along with their chronic pain.

Inhalation as well as topical application of essential oils is key in treatment of conditions such as this, since inhalation is the most effective method of application of aromatherapy for psychotherapeutic effect (17).

Coriander seed (Coriandrum sativum)

Coriander seed is analgesic and antispasmodic, but also a powerful antidepressant oil. It is also excellent for digestive issues, and in Traditional Chinese Medicine, it is indicated for clearing ‘painful obstruction’ which refers to rheumatic pain (18).

Marjoram (Origanum majorana)

Marjoram is mentioned above, and is an excellent dual function oil, working to calm the nervous system whilst simultaneously relaxing the muscle tissue

Grapefruit (Citrus paradisii)

Grapefruit is also mentioned above; a “cooling, cleansing and decongesting” (19) oil that is helpful for clearing the mind, stimulating lymph and can help ease feelings of frustration and tension.

Cardamom (Elettaria cardamomum)

Cardamom is a digestive oil, helpful for treating IBS and other digestive complaints that are often associated with Fibromyalgia. It is also considered a “gentle tonic of the brain and nervous system”(20) and therefore complements the more stimulating oils with its gentler nature.

Melissa or lemon balm (Melissa officinalis)

Melissa is one of the most regularly-used oils in my clinic. Particularly as an inhalation oil, it works beautifully, though I often include it in massage blends, too. Analgesic and anti-inflammatory, it is also calming and sedative, so can be wonderfully effective for calming the nerves and the muscle tissues. The fresh or dried leaves can also be taken as an infusion in hot water.

A balm or oil blend for fibromyalgia can be made in much the same way as in the other recipes suggested above, though for full-body application, the dilution of essential oils should be no more than 2% in total, with those essential oils which are potential irritants or sensitisers being used at their much lower, appropriate dilutions.

Alternatively, a bath oil at a 2% dilution could be prepared. Heat aids the absorption of essential oils into the bloodstream, and the steam will increase the evaporation, aiding inhalation and speeding up the therapeutic properties. Equally, the heat will help to increase blood flow to the sore muscles as well as releasing tension. For a further benefit, Epsom salts (Magnesium sulphate) may be added to the bath.

The magnesium in these healing salts is known for speeding up muscle recovery and reducing inflammation (21), as well as for reducing tiredness and fatigue more generally so it may be helpful for post-workout recovery too. It can cause dehydration, though, so make sure to top up on water before and after an Epsom salt bath.

It is clear that aromatherapy products such as massage oils, therapeutic baths and muscle rubs have a large part to play in the prevention and treatment of both chronic and acute musculoskeletal conditions. These recipes and oil blend suggestions have been specifically designed for treatment of the conditions explored here.

Do check allergy information and consult a health professional before using these products on children, if you have any health conditions, are pregnant or breastfeeding.

  1. Martin, I. Aromatherapy For Massage Practitioners. 1st ed. Baltimore: Lippincott Williams & Wilkins; 2007: 209.
  2. Mulcahey, MD, FAAOS, M., 2020. Sprains, Strains and Other Soft-Tissue Injuries – OrthoInfo – AAOS. [online] Orthoinfo.aaos.org. Available at: <https://orthoinfo.aaos.org/en/diseases–conditions/sprains-strains-and-other-soft-tissue-injuries/> [Accessed 29 July 2022].
  3. nhs.uk. 2019. Common posture mistakes and fixes. [online] Available at: <https://www.nhs.uk/live-well/exercise/strength-and-flexibility-exercises/common-posture-mistakes-and-fixes/> [Accessed 29 July 2022].
  4. Pruthi, M.D., S., 2021. Office ergonomics: Your how-to guide. [online] Mayo Clinic. Available at: <https://www.mayoclinic.org/healthy-lifestyle/adult-health/in-depth/office-ergonomics/art-20046169#:~:text=If%20you%20 sit%20behind%20a,joints%20stay%20 comfortable%20at%20work.> [Accessed 29 July 2022].
  5. Morris, N., 2022. 5 Common Questions About Yin Yoga. [online] Yoga International. Available at: <https://yogainternational.com/article/view/questions-about-yin-yoga> [Accessed 29 July 2022].
  6. Martin, I. Aromatherapy For Massage Practitioners. 1st ed. Baltimore: Lippincott Williams & Wilkins; 2007: 211
  7. Martin, I. Aromatherapy For Massage Practitioners. 1st ed. Baltimore: Lippincott Williams & Wilkins; 2007: 211
  8. Tisserand, R. and Balacs, T., 2000. Essential oil safety. London: Churchill Livingstone, pp.129-130.
  9. Caddy, R. Essential oils in colour (2nd ed.). Amberwood Publishing. 1997, pp 8.
  10. Caddy, R. Essential oils in colour (2nd ed.). Amberwood Publishing. 1997, pp 8.
  11. Martin, I. Aromatherapy For Massage Practitioners. 1st ed. Baltimore: Lippincott Williams & Wilkins; 2007: 121
  12. Martin, I. Aromatherapy For Massage Practitioners. 1st ed. Baltimore: Lippincott Williams & Wilkins; 2007: 121
  13. Martin, I. Aromatherapy For Massage Practitioners. 1st ed. Baltimore: Lippincott Williams & Wilkins; 2007: 100
  14. Caddy, R. Essential oils in colour (2nd ed.). Amberwood Publishing. 1997, pp 49.
  15. nhs.uk. 2022. Fibromyalgia. [online] Available at: <https://www.nhs.uk/conditions/fibromyalgia/> [Accessed 29 July 2022].
  16. Li, Y., Wang, F., Feng, C., Yang, X. and Sun, Y., 2014. Massage Therapy for Fibromyalgia: A Systematic Review and Meta-Analysis of Randomised Controlled Trials. PLoS ONE, [online] 9(2), p.e89304. Available at: <https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3930706/> [Accessed 29 July 2022].
  17. Mojay, G. Aromatherapy for healing the spirit. London: Gaia. 2005, pp 15.
  18. Mojay, G. Aromatherapy for healing the spirit. London: Gaia. 2005, pp 64.
  19. Mojay, G. Aromatherapy for healing the spirit. London: Gaia. 2005, pp 80.
  20. Mojay, G. Aromatherapy for healing the spirit. London: Gaia. 2005, pp 57.
  21. Cleveland Clinic. 2022. Epsom Salt: Potential Benefits and How to Use It. [online] Available at: <https://health.clevelandclinic.org/7-things-you-probably-didnt-know-about-epsom-salt/#:~:text=Epsom%20salt%20is%20used%20to,recovery%20period%20after%20a%20workout.> [Accessed 29 July 2022].

Bibliography

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Western herbal classifications glossary https://www.herbalreality.com/herbalism/western-herbal-medicine/western-herbal-glossary/ https://www.herbalreality.com/herbalism/western-herbal-medicine/western-herbal-glossary/#comments Sat, 30 Jul 2022 15:24:52 +0000 https://www.herbalreality.com/?p=7503 We put together a list of the most important Western herbal medicine terms in a practical glossary.

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Western herbalism is based both on ancient wisdom and modern biomedical knowledge. It is multi-faceted and aims to soothe, balance and restore people’s whole being. In this doctrine of medicine, it is not only herbs which are used, but also nutrition and holistic healthcare techniques are often incorporated into a treatment plan. 

Plant and fungi medicine works on many different levels, from pharmacologically to energetically. Patterns in one’s constitution and in a condition are identified, and then plants with the appropriate herbal action are blended to make healing formulas with complex chemodiversity. 

Importantly, it also offers us a way back to the Earth.

Western herbal classifications glossary

Here is a non-exhaustive list of plant/substance classification terms according to Western herbal actions and pharmacology. Click on the name of the herbal action to see a list of all herbs with this action.

Adaptogens are strengthening herbs that help us adapt to stress by interacting with the endocrine system. They help normalise metabolism and nourish the tissues. Examples include licorice (Glycyrrhiza glabra), ashwagandha root (Withania somnifera), rhodiola root (Rhodiola rosea) and ginseng root (Panax ginseng)

Alteratives are herbs that ‘alter’ the condition in a tissue by eliminating metabolic waste via the liver, large intestine, lungs, lymphatic system, skin and kidneys. Examples include burdock root (Arctium lappa), dandelion root (Taraxacum officinalis), cleavers (Galium aparine), poke (Phytolacca decandra) and nettle leaf (Urtica dioica).

Amphoterics are herbs that bring balance to different organs, tissues and systems by regulating hyper and hypo functioning. Amphoterics create harmony. Examples include licorice root (Glycyrrhiza glabra), oatstraw flowering tops (Avena sativa), hawthorn berry (Crataegus oxycanthoides).

Analgesics are medications that are applied internally or externally to reduce pain, Many of them work by depressing the functions of the central nervous system. Examples of effective analgesics include Jamaican dogwood (Piscidia erythrina), pasqueflower (Anenome pulsatilla), California poppy (Eschscholzia californica), corydalis (Corydalis yanghusuo) and wild lettuce (Lactuca virosa). Topically, aconite (Aconitum napellus) and cayenne (Capsicum minimum) are powerful anodynes.

Anthelmintic plants kill or assist in the expulsion of intestinal worms. These plants include andrographis (Andrographis paniculata), cloves (syzygium aromaticum), feverfew (Tanacetum parthenium) and myrrh (commiphora molmol).

Anti-inflammatory herbs reduce inflammation in the body. There are different systems in the body that anti-inflammatory plants target. For example for the gastrointestinal tract chamomile, fenugreek and meadowsweet are useful. For the musculoskeletal system rosehips, turmeric and celery seed are useful. For inflammation against immune mediated inflammation gotu kola (centella asiatica), rehmannia (rehmannia glutinosa) and feverfew (tanacetum parthenium) can be useful.

Antimicrobials are herbs that interfere with the proliferation and life-cycle of microbes; bacteria, fungi, and viruses. Examples include thyme leaf (Thymus vulgaris), echinacea (Echinacea species), elderberry (Sambucus nigra).

Antioxidant substances that protect against oxidation and degradation from free radical damage. Plants rich in antioxidant include bacopa (bacopa monnieri), bilberry (vaccinium myrtillus), green tea (camelia sinensis) and thyme (thymus vulgaris).

Antirheumatic medicines prevent or relieve rheumatic symptoms such as joint pains, limited mobility and swelling. Plants that have this effect include celery seed (apium graveolens), black cohosh (cimicifuga racemose), nettle leaf (urtica dioca), devils claw (harpagophytum procumbens) and willow bark (salix alba).

Antispasmodic plants reduce or relieve smooth muscle spasm. They can be helpful for an array of issues including menstrual cramps. Also known as spasmolytics, these plants include aniseed (Pimpinella anisum), blue cohosh (caulophyllum thalictroides), cramp bark (viburnum opulus) and lavender (Lavandula angustofolia).

Antitussive a substance that reduces the amount of, or severity of coughing. Licorice, peppermint and bupleurum are examples of this.

Aphrodisiac herbs are those that nourish, build and stimulate sexual desire and potency. Examples include saffron (Crocus sativa) and ashwagandha root (Withania somnifera).

Astringents contain tannins that act to precipitate proteins and draw tissues together, tightening and toning them to reduce secretions and discharge. Astringents also tend to stop bleeding and can act on tissues with which there is no direct contact. Examples include raspberry leaf (Rubus ideaus), Lady’s Mantle leaf (Alchemilla vulgaris), agrimony leaf (Agrimonia eupatoria), shepherd’s purse leaf (Capsella bursa-pastoris), witch hazel leaf (Hamamelis virginiana) and yarrow leaf (Achillea millefolium).

Bitters stimulate digestion by enhancing digestive secretion and peristaltic movements of the gut. They act via a reflex from the taste buds to the brain then through the vagus nerve to the whole digestive system. Often these herbs are combined with warming digestives to balance the cold nature of bitters. Examples include artichoke leaf (Cynara scolymus), gentian root (Gentiana lutea), wormwood leaf (Artemisia absinthium), Oregon grape root (Mahonia aquifolium), goldenseal root (Hydrastis canadensis).

Bronchodilator plants cause widening of the bronchi. The bronchi are any of the major air passages of the lungs which diverge from the windpipe. Plants with this action include ephedra (ephedra sinica), nigella sativa and bala (Sida cordifolia).

Cardiotonics are herbs that bring order and strength to the cardiovascular system, speed up or slow down the heart as needed. Examples include hawthorn berry and leaf (Crataegus oxycanthoides), motherwort leaf (Leonurus cardiaca), Lily of the Valley leaf (Convalleria majalis), garlic bulb (Allium sativum), lime flower (Tilia platyphyllos), mistletoe leaf and berry (Viscum album).

Carminative herbs are high in essential oils and help ease digestion by relieving gas, spasms and cramps. Examples include aniseed (Pimpinella anisum), fennel seed (Foeniculum vulgare) and peppermint leaf (Mentha piperita).

Cholagogues and choleretics: Cholagogues promote the production of bile in the liver. A choleretic a type of cholagogue that promotes the release of bile from the gall bladder into the duodenum. Cholagogues have an alterative and laxative effect. Cholagogues are contra-indicated if there is acute liver failure, obstructive jaundice, painful gallstones or cholecystitis. Examples include celandine leaf (Chelidonium majus), barberry root (Berberis vulgaris), dandelion root and leaf (Taraxacum officinalis root), and blue flag root (Iris versicolor).

Demulcents are soothing mucilaginous and silky herbs that can be taken internally to soothe and protect damaged or inflamed tissue. Examples include slippery elm bark (Ulmus rubra), marshmallow root (Althea officinalis) and limeflower (Tilia cordata).

Depurative is a substance that improves detoxification and aids elimination to reduce the accumulation of metabolic waste products within the body. They were formerly known as alteratives or blood purifiers and are largely used to treat chronic skin and musculoskeletal disorders. Depurative plants include burdock, echinacea root (echinacea angustofolia), nettle leaf (urtica diocia) and yellow dock (rumex crispus).

Diaphoretics are herbs that cause sweating by increasing circulation in the periphery of the body. Usually used to help to relieve fevers, some examples are Yarrow aerial parts (Achillea millefolium), Elder flowers (Sambucus niger), ginger root (Zingiber officinalis).

Diuretics are herbs that stimulate the flow of urine, and help remove fluids from the body. Common examples are dandelion leaf (Taraxacum officinalis), burdock root (Arctium lappa) and corn silk (Zea mays).

Emmenagogues are herbs that stimulate and promote menstruation. Examples include marigold flowers (Calendula officinalis) and chaste tree fruits (Vitex agnus-castus), turmeric root (Curcuma longa).

Expectorants are herbs that assist the body in expelling mucus from the upper respiratory tract. Examples include licorice root (Glycyrrhiza glabra), elecampane root (Inula helenium) and Thyme leaf (Thymus vulgaris).

Febrifuge or antipyretic plants reduce or prevent fever. Rehmannia (rehmannia glutinosa), rhubarb root (rheum palmatum), yarrow (achillea millefolium) and willow bark (salix alba) all have antipyretic properties.

Galactagogues are herbs that encourage the flow of breast milk. Examples include Fennel seed (Foeniculum vulgare), Celery seed (Apium graveolens) and Shatavari root (Asparagus racemosus).

Hepatics are herbs that generally support liver function by decongesting as well as supporting bile flow. Examples include dandelion root (Taraxacum officinalis), yellow dock root (Rumex crispus), turmeric root (Curcuma longa).

Hypnotics and sedatives are plants that promote a deep and relaxing sleep. They may work through muscle relaxant properties, through the action of volatile oils on the limbic system, or through the presence of alkaloids that affect the central nervous system. Chamomile flowers (Matricaria recutita), lime flower (Tilia platyphyllos), lemon balm leaf (Melissa officinalis), wood betony aerial parts (Stachys betonica), skullcap leaf (Scutelleria lateriflora), wild lettuce leaf (Lactuca virosa), passionflower aerial parts (Passiflora incarnata), ashwagandha root  (Withania somnifera), valerian root (Valeriana officinalis), corydalis root (Corydalis yanhusuo), Californian poppy aerial parts (Eschscholzia californica).

Hypolipidemics are herbs which mildly reduce serum lipids, including triglycerides and cholesterol. Examples include hawthorn berry and leaf (Crataegus oxycanthoides), turmeric root (Curcuma longa), guggulu resin (Commiphora mukul), garlic bulb (Allium sativum), and cayenne fruit (Capsicum annuum).

Hypotensives act to reduce high blood pressure by relaxing muscles or through a calming effect upon the central nervous system. Examples include hawthorn berry and leaf (Crataegus oxycanthoides), garlic bulb (Allium sativum), lime flower (Tilia platyphyllos), cramp bark (Viburnum opulus), valerian root (Valeriana officinalis), motherwort leaf (Leonorus cardiaca) and mistletoe leaf and berry (Viscum album)

Immunomodulants restore balance to a dysfunctional immune system. These are often used in chronic autoimmunity, such as Crohn’s and multiple sclerosis. Many immunomodulants are adaptogens, and vice versa. Examples include reishi mushroom (Ganoderma lucidum), Astragalus root (Astragalus membranaceus), licorice root (Glycyrrhiza glabra), Siberian ginseng root (Eleuthrococcus senticosus), ashwagandha root (Withania somnifera) and cordyceps (Cordyceps sinensis).

Immunostimulants stimulate the immune system to protect against infection, including non-specific mechanisms, and the specific mechanisms of humoral and cell-mediated immunity. Many immunostimulants are antimicrobials and vice versa, and are used in both acute and chronic infection. Examples include echinacea root and leaf (Echinacea spp.), Garlic bulb (Allium sativum), myrrh resin (Commiphora myrrha), thyme (Thymus vulgaris, andrographis leaf (Andrographis paniculata) and wild indigo (Baptisia tinctoria).

Laxative herbs are those that stimulate or promote bowel movements. There are different types of herbs; gentle aperients, like dandelion root (taraxacum officinalis), that have a mild effect; bulk-forming laxatives, like flaxseed (Linum usitatissimum), that increase the water and bulk of the stool; stimulant laxatives is senna leaf (Senna alexandria) that invigorate the muscles of the lower bowel to create a stronger motion. 

Nervines are herbs that soothe the nervous system and have a calming effect on the emotions. Examples include oatstraw flowering tops (Avena sativa), passionflower (Passiflora incarnata), lavender (Lavandula officinalis), St. John’s Wort (Hypericum perforatum), Rosemary leaf (Rosmarinus officinalis), and gotu kola leaf (Centella asiatica).

Relaxant plants promote relaxation and can reduce tension. Herbs with this property include passionflower (Passiflora incarnata) and valerian (valeriana officinalis).

Rubefacients are applied externally and cause a mild local irritation and draw blood to the area through capillary dilation. Rubefacients are used to enhance blood supply to localized areas to remove congestion and promote healing. Examples include cayenne fruit (Capsicum minimum), mustard seed (Brassica spp.), ginger root (Zingiber officinalis), and peppermint leaf (Mentha piperita oil).

Sedatives are substances that reduces activity, particularly in the nervous system and decreases nervous tension. It may alleviate pain, anxiety or spasm and induce sleep. Sedatives include Californian poppy (eschscholzia californica), hops (humulus lupulus), true unicorn (aletris farinosa), and valerian (valeriana officinalis).

Sialogogues are medications that stimulate the production of saliva to treat dry mouth, poor digestion, receding gums and infection including prickly ash bark (Zanthoxylum americanum), echinacea root (Echinacea spp) and spilanthes flower (Spilanthes acmella).

Stimulant substances raise levels of physiological or nervous activity in the body. Plants that are stimulating include cacao, coffee, green tea (Camelia sinensis), yerba mate (Ilex paraguariensis), kola nut (cola nitida) and guarana (Paullinia cupana).

Stomachic promote the appetite or assist digestion, for example psyllium husk is a bulk laxative that supports the digestive tract.

Thymoleptic medicines modify people’s moods, and oftentimes are antidepressants. Plants that have this action include St John’s Wort (Hypericum perforatum), lavender (Lavandula angustifolia) and saffron (Crocus sativus).

Tonics is a slightly controversial term as it seems to apply to herbs that bring tone to an organ or tissue. It is also used to refer to herbs that help the whole system to function better acting as general energy boosters. Examples of herbs that bring tone to the tissues are the astringent goldenseal (Hydrastis canadensis) and ground ivy (Glechoma hederacea). Those that bring energy are cacao (Theobroma cacao), oatstraw flowering tops (Avena sativa) and ashwagandha root (Withania somnifera).

Trophorestorative are substances that which has a healing and restorative action on a specific organ or tissue. Nervous system restoratives include oat straw (avena sativa), skullcap (scuttelaria lateriflora) and damiana (Turnera diffusa).

Uterine tonics are substances that increase the tone of the uterine muscle. Uterine tonics include black cohosh (Cimicifuga racemose), blue cohosh (Caulophyllum thalictroides), false unicorn root (Chamaelirium luteum) and true unicorn (Aletris farinosa).

Vasodilators are substances that dilates or widens the blood vessels, for example olive leaves (olea europea).

Vulneraries are wound-healing herbs used internally and externally. Astringent herbs such as witch hazel (Hamamelis virginiana) and shepherd’s purse leaf (Capsella bursa-pastoris) directly stop bleeding and promote the formation of an eschar (scab). Mucilaginous herbs such as plantain leaf (Plantago lanceolata) and selfheal leaf (Prunella vulgaris)  soothe inflammation. Some vulneraries are used internally to speed tissue healing, including marigold flower (Calendula officinalis), plantain leaf (Plantago lanceolata), selfheal leaf (Prunella vulgaris), and marshmallow root (Althaea officinalis).

These are based on a combination of Galenic, Thompsonian, Eclectic and Physiomedical approaches.

Treatment plans developed within the Thompsonian and Eclectic traditions looked to find harmony and vitality within the tissue states, with a focus on:

  1.  relaxation of tissues
  2.  contraction of tissues
  3.  stimulation of circulation and vital force
  4.  soothing irritated tissues where there is excess
  5.  nourishing and deficiency in the tissues, organs and vital force
  6.  neutralisation of excess toxins and stagnation

Over time, and with enhanced knowledge of anatomy and physiology, the Physiomedicalists developed a specific set of therapeutics to restore health:

Eliminative functions at the intra-cellular, organ and specific organs of elimination (skin, lungs, bowels and kidneys).

Circulatory dynamics involve the state of capillary contraction or relaxation. Relaxing diaphoretics or stimulating astringents are used to restore balance to the circulatory system. 

Nervous equilibrium through regulating levels of irritation or depression of the nervous system. Nervine relaxants and sedatives as well as nervine stimulants focusing on specific organs are utilised.

Trophorestoration is required when any tissue or organ expresses a deficiency of vitality and tone caused by hereditary patterns or overexposure to irritation or depression.

Alteratives enhance the eliminative function of the organs as well as enhance digestion and nutritional absorption.

The three primary energetic qualities are temperature, tone and moisture. These are used to describe body systems, organs and tissues in the body. They help herbalists understands the patterns of a patient’s condition, so they can prescribe herbs personalised for them and their constitution. 

Temperature in herbalism does not just refer to somebodies body temperature, it also refers to their level of metabolic activity. 

Tone (energetic diagnostics) refers to how tense or relaxed tissues are. Tone is used to describe the status of the lining of organs called epithelium or to describe the level of integrity of muscles and other tissues. Healthy tone of the tissues or muscles will usually correspond with balanced function of the organs and with a relaxed, and easy composure or stance.

Too much tension impedes flow, and flaccidity means that function is at less than optimum. Herbs can affect tone in many different ways. Some herbs are able to increase tone and others are able to relax the tissues where there is excess tension or constriction- see the definitions of ‘relaxants’ and ‘tonics’ for more information on herbal energetics relating to tone. 

Moisture (energetic diagnostics) as a word used in energetic diagnostics may be relating to over production of fluids in the body (i.e. phlegm, mucous, digestive fluid). Excess fluid production is often also associated with poor tone and flaccidity in the tissues. There may also be problems with tissue function. It can also be as a result of overstimulation or be associated with specific environmental or dietary triggers such as allergens.

Patients may also experience symptoms of congestion and stagnation in the tissues.  Mineral imbalance, heart or kidney problems may also be indicated where there is ‘excess moisture’, congestion or fluid retention in the body. The nature of the condition would require specific treatment that targets the unique condition of the patient.

Heat (energetic diagnostics)is the term used to describe inflammation and excitation in the tissues. This pathological heat may be caused by excess toxins in circulation around the body, viruses and other pathogens but it classically refers to inflammation or excitation in the tissues which may have a number of different causes. For example, it may also be linked with hormonal or immunological imbalances or excess stress hormones which can lead to over function and inflammation. Indicators of excitation and heat can include inflammation in the joints, irritation, swelling, dryness (e.g in hair and skin, or if one is abnormally thirsty), an overactive thyroid and irritability.

Allergic reactions can also be thought of as excessive excitation in tissues. Cooling herbs may be used to decrease inflammation or heat as well as herbs that moderate the activity of the tissues. Not all cooling herbs are suitable in all cases of heat and excitation. A herbalist will select a combination of herbs to address the unique circumstances of the patient.

Cooling (herbs) may be used for conditions that are classified as hot or inflammatory by nature. They work via a number of different actions – some by reducing inflammation, others by detoxifying the blood or lymph or by moderating the function of specific tissues. Diaphoresis is another cooling action of herbs which works by stimulating the sweat reflex and reducing heat in the body through the skin.

Examples of cooling herbs include; cleavers or burdock due to their ability to help decrease toxicity and stagnation in the tissues via the lymphatic system. Bitter herbs such as andrographis and dandelion have a systemic cooling effect due to their ability to enhance metabolic function and support liver detoxification which reduces inflammatory toxins in circulation around the body. The nature of the herbs chosen depends on the affected tissues and the unique presentation of the patient.

Coldness (energetic diagnostics) is the opposite of heat and excitation in the tissues of the human body. It is present when there are deficient or inadequate levels of activity and metabolic function. It can indicate low vitality and over time may lead to damage and death in tissues. Characteristics include being unusually physically cold, patients may also have low energy levels and suffer from fatigue, being prone to illness and infection and low metabolic rates. Warming herbs may be used to increase the circulation or stimulate tissue function depending on what is required. However- not all warming herbs are suitable in all cases of coldness.

For example, sometimes the issue is more associated with damage and fragility in the cardiovascular system- hot stimulating herbs in this circumstance may be too pushy before work has begun to address the structural integrity of the cardiovascular system. A herbalist will always select a combination of herbs based on the unique circumstances of the patient.

Warming (herbs) Warming herbsare typically ‘hot’, ‘spicy’ or ‘pungent’ due to the presence of aromatic oils. Generally these herbs bring ‘warmth’ to the tissues by stimulating circulation and dilating the micro-capillaries thus creating an opening effect within the cardiovascular system that increases blood movement and therefore perfusion to the tissues. Warming herbs are often also diaphoretic- meaning that they stimulate the sweat reflex- this action could be seen as a contradictory as it is essentially ‘cooling’.

However, the action of warming herbs remains to increase peripheral circulation and therefore is classified as warming to the body tissues. Some examples include chilli, garlic, horseradish, cinnamon and ginger. The nature of the herbs chosen depends on the affected tissues and unique presentation of the patient. Due to their potent nature, a herbalist will usually only use a small amount of aromatically hot, warming herbs in a formula.

Drying (herbs) tend to have astringent or tonic qualities. This means that they pucker the tissues thus increasing their barrier functions. Drying herbs may have diuretic actions which work by increasing the output of fluid from the body. They may also be astringent due to tannin content. Drying herbs are used to help tonify the tissues to reduce excess secretions, phlegm or mucous.

Drying herbs may also be used to help in tissue healing particularly where they have become flaccid and lacking in tone. Drying herbs include rose, lady’s mantle, blackberry leaf, raspberry leaf, agrimony and elderflower. Not all drying herbs will be suitable in all cases of moist/ excess fluid type conditions. Tannin rich herbs are also limited to short term use. A herbalist will select a combination of herbs based on the unique circumstances of the patient.

Dry (energetic diagnostics) in energetic herbalism dryness means tissues are atrophied or insufficiently nourished. This leads to the, ineffective balance of fluids in the cells. This either be relating to a deficiency in fats, oils or fluids but it is also sometimes related to under function of the tissues.

Some herbal actions that cause drying are diuretics and astringents as they stimulate the release of fluids. Indicators of dryness and atrophy can be dry skin/hair/eyes, constipation with hard stools, joint stiffness and cracking, dry skin conditions such as eczema and psoriasis. Moistening herbs are indicated for dry tissue states to nourish and support the effective balance of fluid and oils in the tissues.

Damp stagnation occurs when too many fluids build up, which leads to a lack of proper clearance and movement and therefore becomes stagnant. Elimination and detoxification is reduced, as is nutrient absorption. It is similar to what happens to a pool of water if it is not flowing or is not drained. Characteristics include swollen tissues, oedema, brain fog and lethargy.

Moist (herbs) Moistening herbs bring a demulcent or soothing effect to inflamed or dry tissues. These herbs may be used where there is irritation due to dryness or lack of productivity in the tissues. Moistening herbs tend to be rich in mucilage (a carbohydrate rich plant substance) that forms a slippery and softening protective layer over the tissues. Sometimes herbs have a moistening effect due to oil content or by their ability to nourish the tissues- others by their ability to deliver or stimulate fluid production in certain tissues.

Moistening herbs that are rich in mucilage include herbs such as marshmallow, slippery elm, psyllium and aloe vera. Oily moistening herbs coconut oil and castor oil. Herbs that stimulate the production of fluids may include;  fenugreek;  and maca. These all effect different tissues so the nature of the herbs chosen depends on the affected tissues and unique presentation of the patient.

Constriction can be both physically restricting and mentally and emotionally. For example, it can restrict the movement of fluids and blood, as well as creativity. Symptoms of this tissue state can include muscle tension, spasms, insomnia, anxiety, emotional irritability and exhaustion. 

Atony is used to describe states where tissues are without tone, flaccid, and too relaxed to be working at optimum. They often overflow with fluids as they can’t hold onto them, and this can include runny mucus or diarrhoea. Indicators of lax/atony include poor muscle tone, weak tissues, clammy skin and random sweats.  

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Inflammation: The global epidemic we should be worried about https://www.herbalreality.com/health-lifestyle/immunity/inflammation-global-epidemic/ https://www.herbalreality.com/health-lifestyle/immunity/inflammation-global-epidemic/#comments Sat, 23 Jul 2022 11:55:52 +0000 https://www.herbalreality.com/?p=7440 In herb book Inflammation, Christine Herbert discusses the complex networks which create chronic inflammation and the use of herbs and natural healing to strengthen them.

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In her book Inflammation, Christine Herbert discusses the complex networks which create chronic inflammation and the use of herbs and natural healing to strengthen them

Inflammation: The global epidemic we should be worried about

There is an epidemic of chronic inflammatory diseases in the world, with incidences increasing all the time due mostly to our changing lifestyles. Instead of dying suddenly of acute infections, we now die more slowly of chronic inflammatory diseases.

Many factors interact with each other that determine chronic inflammatory disease. Our genes determine our individual strengths and weaknesses, but epigenetics determines how our genes express themselves and the way we live our lives will determine this.

Variable factors include diet, the environment in which we live, the health of our gut microbiome, our digestive systems, and our immune system. Most of these variable factors are under our control and can be improved. We will find some of the methods of doing this here.

This article is about chronic inflammation – the inflammation that doesn’t have a useful or positive outcome in the body. Acute inflammation, redness, swelling and heat that follow injury are an important part of healing from an injury and need to be allowed to proceed. It is not holistic simply to stop an inflammatory response because inflammation is a result of and not a cause of disease.

Inflammation is simply the body’s way of defending itself against attack. This is where we have to play detective and determine the cause of the inflammation; then, we can actually treat it. Anti-inflammatory medication may appear to help at first, but it then becomes part of the problem if used long term.

The health of the body and the presence or absence of inflammation is dependent on the health and proper functioning of all systems and organs. Just because a knee joint is swollen and sore doesn’t mean that the knee joint can be treated alone. Any malfunctioning body systems or organs will also need to be treated and returned to health to treat the knee. This is always more obvious when there is inflammation throughout the body, such as in fibromyalgia or rheumatoid arthritis, but it applies to almost all chronic inflammatory processes.

The immune system is the key to inflammation, but it doesn’t work alone; it requires all body systems to play their role well in a complex interconnecting dance that will maintain a harmony of health when it functions as it should. A strong immune system will maintain a healthy body.

The gut plays a vital part in immune system homeostasis, as most immune cells are in the gut. If the gut is not healthy, the immune system won’t be healthy, and there will be chronic inflammation to one extent or another. This is something that the older traditional medicine systems knew, and those who practise herbal medicine today also know. The health of the body begins in the gut (1).

In most cases of chronic inflammation, the initial problem begins in the gut, generally with the diet. Either too many inflammatory foods such as sugar, trans fats or refined grains are present, or foods are eaten to which there is an intolerance, most commonly dairy or wheat.

The immune system can be seen as the housekeeping system of the body. It protects us from pathogenic organisms and removes or isolates dead or malignant body cells and foreign bodies.

Innate or non-specific immunity is the immunity we were born with and refers to the general protective function of the immune system. It includes the barrier functions of the skin and internal mucous membranes in the mouth, digestive system, lungs and urinary system. It also includes tears in the eye and ear wax.

Macrophages are also part of the innate immune system, and they can eat or phagocytose foreign particles to render them harmless. Fever is an innate immune response that creates a hostile environment for an invading microorganism and stimulates the immune response.

Adaptive or specific immunity develops over time in response to exposure to various antigens. It involves lymphocytes B cells and T cells – which produce specific antibodies against the invader (B lymphocytes) and has various cytotoxic mechanisms (T lymphocytes) to clear up dead or compromised tissue cells. These cells also have an ability to remember earlier invasions which means that future attacks are more efficiently dealt with.

A healthy immune system will recognise which cells it needs to attack and recognise healthy self-tissue. But if it is under too much pressure, for example, chronic inflammation, this is when the immune system can turn on the host body, attacking self cells and creating autoimmune disease.

Removal of dysfunctional, dead and dying tissue cells is also part of autophagy (literally, self-eating). This process can be seen as a spring clean of the body and may be important in protection from cancer (2)  and also involves both specific and non-specific immunity and can be made more efficient by exercise and fasting with the overall effect of cell regeneration and recycling cellular nutrients (3).

The process of autophagy has been shown to be optimised by a diet low in refined starch and sugar and high in omega-3 fatty acids (4,5).

Herbs and nutrition directly affect the immune system, but all body systems are vital here, so any attempt to improve the health of the immune system must also look at the whole. Emotional health also affects the immune system, hence the field of psychoneuroimmunology. Stress or social isolation will weaken immune function, whereas a relaxed nervous system creates a strong immune system. This connection has been demonstrated many times in studies (6,7,8).

Echinacea (Echinacea angustifolia)
Echinacea (Echinacea angustifolia)

Lack of sleep is strongly linked with a weak immune system and a much-increased risk of cancer. A study involving sleep restriction in healthy young men where sleep was only allowed between ten in the evening and three in the morning resulted in a seventy per cent reduction of natural killer cells plus reduced cellular immune response – both vital in a normal immune system which amongst other things also protects us from cancer.

After one night of recovery sleep, only part of the immune system returned to normal – the conclusion was that even a modest disturbance of sleep reduces the natural immune response (9).

A good and varied diet is important for a healthy immune system. Particularly important vitamins and minerals include vitamins D and C and zinc and selenium. Good sources of vitamin C include most fresh fruit and vegetables; vitamin D is best obtained from sunlight exposure or a supplement. Food sources of vitamin D include oily fish, mushrooms and eggs. Zinc is found in red meat, shellfish, legumes, nuts and seeds. Selenium is found in brazil nuts, fish, poultry and sunflower seeds.

The gut microbiome needs to be healthy for a strong immune system, so fermented foods such as sauerkraut or kefir are helpful. These must be unpasteurized so that the beneficial bacteria are still present.

Short term fasting will have a stimulant effect on the immune system, just as will raising the body’s temperature in a sauna or steam room. This type of stimulation is useful when an immediate effect is needed for an acute situation.

Herbs that affect the immune system can be subdivided into immune modulators or tonics – these are slower acting and can be used long term to improve immune function in those with chronic infection, autoimmune disease or lowered immunity; and herbal antimicrobials that practically attack and kill invading microorganisms.

Immune modulating herbs include echinacea (Echinacea purpurea and E. angustifolia), astragalus (Astragalus membranaceus), marigold (Calendula officinalis), wild indigo (Baptisia tinctoria), Siberian ginseng (Eleutherococcus senticosus), ginseng (Panax ginseng), ashwagandha (Withania somnifera), and all the medicinal fungi including (Trametes versicolour) and reishi (Ganoderma lucidum). Many immune-modulating herbs are also adaptogens, so they will support the endocrine and nervous systems, supporting immunity.

A herb that strengthens connective tissue, hence reinforcing the immune system’s barrier function, is horsetail (Equisetum arvense); this plant contains very high amounts of silicic acid or silica, which is water-soluble and required by all connective tissue (10).

Lymphatic herbs may also have a role to play in promoting autophagy. These might include cleavers (Galium aparine), heartsease (Viola tricolour), and figwort (Scrophularia nodosa).

Herbal antimicrobials include garlic (Allium sativum), thyme (Thymus spp), oregano (Origanum majorana), sage (Salvia officinalis) and walnut (Juglans nigra).

Woman with liver problems

The digestive tract’s general health depends on the health of the gut, its microbiome, and the liver. Any treatment of inflammation anywhere in the body requires that the gut and the liver are healthy and functioning well.

There is a three-way interaction between the microbiome present in the digestive system, bile acids produced by the liver, and the immune system, which results in an inflammatory response, healthy or otherwise.

Bile acids are the main component of bile, produced by the liver and secreted into the small intestine via the gallbladder, where its main function is to digest fats and oils from the diet. However, they also have an important role in the inflammatory process.

After bile acids have processed fats, they travel down the digestive tract, where they are modified into immune regulating molecules by gut bacteria. One type of immune regulating molecule will activate effector helper T cells (Th17) which are pro-inflammatory. For example, when an infection needs dealing with, another type activates regulatory T cells (Tregs) that are anti-inflammatory and necessary when the infecting pathogen has been killed. These should balance each other out to maintain good intestinal health.

Low levels of Tregs have been seen in those with inflammatory bowel disease and are linked with low bile acids (11).

Cholestasis is where there is a decrease in bile flow and is associated with impaired immunity and ability to fight infection and increased inflammation. (12)

Improving the liver’s health will improve bile acid function, and most people will benefit from improving liver health.

Burdock (Arctium lappa)
Burdock (Arctium lappa)

Remove anything causing harm to the liver, such as alcohol or toxic chemicals. Medication may also be causing a problem, and if it cannot be removed, then work with diet to ameliorate the problem as much as possible.

Diet should be organically grown foods as much as possible in order to ensure minimal chemical residues. The Pesticide Action Network UK’s website an idea of how many pesticides and herbicides are used on many types of fruit and vegetables; therefore, it is possible to decide which foods should be bought as organic.

Some foods are good at supporting the liver; these include lemon and lime; bitter salad leaves such as dandelion, chicory and endive; dark green leafy vegetables, particularly the brassica family; olive oil and olives. Coffee is also a useful liver herb, if not overindulged.

The hepatic herbs for the liver need to be chosen carefully to support whatever is going on. If someone has an overactive, hot liver and is given liver stimulant herbs, they will become hot, flushed and emotional.

These people need calming and cooling liver tonics such as agrimony (Agrimonia eupatoria), burdock (Arctium lappa), chamomile (Matricaria chamomilla), dandelion (Taraxacum officinale), vervain (Verbena officinalis) or yarrow (Achillea millefolium). And those with a cold, stagnant liver need the more stimulating liver herbs such as angelica (Angelica archangelica), artichoke (Cynara scolymus), barberry (Berberis vulgaris), marigold (Calendula officinalis), milk thistle (Silybum marianum), or yellow dock (Rumex crispus).

The gut wall lining from mouth to anus is made up of many layers. The inner layer is the mucosa, in which there are mucous secreting cells and epithelial cells. This lining is permeable but very selectively, allowing only a few small molecules to pass through once digested and made safe to enter the bloodstream. The body secretes a protein called zonulin which increases intestinal permeability because sometimes this is required, but this is a controlled and immediately reversible permeability. But zonulin is also secreted when there is inflammation in the gut from food sensitivities, diet, infections, etc.

When this wall is subjected to prolonged inflammatory damage, the tight junctions between cells can widen, allowing larger molecules to pass through, creating more inflammation due to the activation of the immune system and more food sensitivities. So food sensitivities are a cause of, and a result of, increased intestinal permeability.

The increased intestinal permeability is termed leaky gut and is a major player in chronic inflammation and may also be a key process in the development of autoimmune diseases (13).

When the gut lining becomes less efficient and the digestive secretions of the stomach decrease due to poor health or ageing, the ability of the digestive tract to digest food and obtain nutrients will decrease. In this case, symptoms such as bloating, reflux, gas and feelings of fullness will appear, and food intolerances start to increase. These symptoms may also be due to eating the wrong foods. Still, they often indicate that digestive capability has been compromised, which, in turn, will impact the microbiome, the liver, and nutrient availability for the immune system. All of these have an impact on overall inflammation in the body.

Bacterial endotoxin is a lipopolysaccharide LPS found in the cell walls of gram-negative bacteria, which are found in large numbers in the gut, the gums, and other tissue when there is bacterial infection or dysbiosis. When they remain in the intestines, they don’t cause a problem, but when the bacteria die off and there is a degree of gut leakiness, then the released LPS can move through the intestinal wall and into the bloodstream, where they will initiate inflammation. Evidence shows that this process is important in the development of inflammation linked with obesity and diabetes and may be a major cause overall of chronic inflammation (14) and of brain microglial activation, which promotes neurodegeneration of the brain (15).

A diet high in trans fats or constant snacking can also cause a dysbiosis that increases LPS production (16), and a diet high in fructose causes LPS-induced inflammation (17).17 It has been shown that celery (Apium graveolens) contains aglycones which show potent inhibitory activity against LPS-induced nitric oxide production in macrophages.

Cardamom significantly decreases the secretion of inflammatory mediators secreted by lipopolysaccharide-stimulated macrophages.

Leaky gut and digestive ability are closely linked; once the correct diet for the individual has been found, the rest will follow. Healing a leaky gut must commence with a good diet with no inflammatory foods.

Removing processed foods and replacing them with healthy food can turn around an inflamed digestive system within a couple of months. Bone broths, when long-cooked, release collagen peptides that support the repair of the intestinal wall. Gum acacia is another supplement that appears to be able to heal damaged tissue, possibly by supporting that part of the microbiome that improves tight junctions in the intestinal lining (20). Herbs can help repair the gut wall, and those containing mucilaginous polysaccharides such as Aloe vera (Aloe barbadensis), marshmallow root (Althaea officinalis), and slippery elm (Ulmus fulva), and also many seaweeds are often used to improve mucosal health.

Plantain (Plantago major)
Plantain (Plantago major)

These herbs are easiest to take as powders in tablespoonful doses and can be mixed with stewed apples (peel and all), which contain large amounts of pectin, which is also a good gut healer.

Marigold (Calendula officinalis) and plantain (Plantago spp.) are both inflammation-mediating herbs excellent at wound healing. Simmering the dried or fresh herbs for 20–30 minutes makes a strong decoction. Ideally, this would be drunk on an empty stomach after at least a 12 hour fast. Make it the night before and drink the next morning. A dose of a handful of the dried herb in about 250ml of water daily would be fine.

Improving digestive function requires the involvement of bitter herbs and aromatic digestive herbs. These should be chosen to suit the person, making distinctions between warming and cooling bitters (see liver herbs above).

Most culinary herbs and spices such as black pepper, mustard, ginger, coriander and cumin will help digestion and can be taken before eating, with food or afterwards if needed.

If these are not enough, bitter herbs can be used, ideally before a meal but also useful afterwards. I have a formula for a digestive bitters tonic, which has been the most popular formula I have ever made, and hundreds of people have found it useful. The mix contains warming and cooling bitter herbs and aromatic herbs, which together really help digestion:

  • 3 parts artichoke (Cynara scolymus)
  • 2 parts (Angelica archangelica)
  • 2 parts blessed thistle (Carbenia benedicta)
  • 1 part fennel seed (Foeniculum vulgare)
  • 1 part gentian (Gentiana lutea)
  • 1 part bitter orange peel (Citrus aurantium fr.)
  • 1 part ginger (Zingiber officinale)
  • 1 part centaury (Centaurium erythraea)

Take anything from twenty drops to a teaspoonful of tincture in a bit of water as needed.

The combination works best as a tincture as it becomes quite unpleasant as tea. As a tincture, it is pleasant to take if a little bitter to those who are not used to bitter tastes. Everyone gets used to it after a few days.

The human body is an ecosystem, part of which includes a vast number of different microbial organisms which play a vital role in the proper function of our bodies. The role of the gut microbiome is well recognised in the inflammatory process, and the inflammatory process has been shown to have deleterious effects on the microbiome (21).

It has also been well recognised that pre-industrial peoples have a similar microbiome wherever they live in the world. Those living in industrialised areas have a very different, less healthy microbiome due to three main reasons: the presence of antibiotics, a diet of processed food, and a much more sanitised environment.

However, there is no such thing as a “normal” microbiome; it is always individual, so testing to determine a microbiome to see if it is “healthy” is not that useful. A microbiome will contain not only bacteria but also viruses, fungi and parasites, and its makeup will be affected by everything from conception onwards. It is considered that the most influence comes from the first one thousand days of life, including time in utero. However, it can be improved and repaired at all stages of life.

One hundred years ago, the killer diseases worldwide were pneumonia, tuberculosis and infectious gut diseases. Nowadays, these have been supplanted in the richer, western world by the killer inflammatory diseases – cardiovascular disease, cancer and diabetes. So as a population, we have learned how to manage bacteria but overmanaged them so that we killed all micro-organisms, beneficial and pathogenic, without the understanding that we actually needed the beneficial ones

For example, a study has shown that the presence of a bacterium Blautia obeum in the gut can protect against cholera by a number of different mechanisms, including its interaction with bile salts. The study found that B. obeum was prevalent in the microbiome of people studied in Bangladesh. Those from Bangladesh had a much more diverse microbiome than a similar number of people from the USA (22).

The functions of these beneficial microbiotas are numerous and very important to our health. Our understanding of the functions and health of the microbiota has only really developed in recent years, and more and more connections have been drawn between this new industrial microbiota and chronic inflammatory diseases. We still don’t know the full story yet, but it is developing (23).

There is evidence that dysbiosis weakens the immune defences “thereby predisposing to more severe SARSCoV-2 infection and contributing to ‘long COVID.’” (24).

The factor with the most effect on the microbiome is diet, and we need a good variety of foods to feed a large variety of microorganisms. The average modern western diet contains a tiny variety of different plant foods, in some cases less than ten. In contrast, the diet of older generations may well have contained at least one hundred different plant foods.

It is now understood that if we eat at least thirty different plant foods in a week, we will have a much healthier microbiome than if we only ate ten different ones. It’s actually not that difficult to eat such a variety, as plant foods include all grains, nuts, seeds, fruit and vegetables.

One important change in diet from the less developed to the developed world was the reduction of both soluble and insoluble plant fibre based complex carbohydrates found in plants such as legumes, whole grains and vegetables. These were replaced by simple carbohydrates, the refined and processed grains and sugar that make up the modern diet, which is much less useful to the microbiome and shown to have altered its structure and function, resulting in dysbiosis (defined as unnatural changes in the composition of the microbiome) and leading to chronic inflammatory disease.

Stress can also have a significant impact on the microbiome this can be physical or mental stress and can include overworking, sleep deprivation, pollution, local climate change and lack of exercise. Social interaction and physical activity also have an impact on gut and body health (25).

There are several ways to improve the microbiome, but it is most important first to improve the gut’s health, i.e. improve the terrain. If there is a leaky gut, then this needs dealing with first.

Slippery elm (Ulmus rubra)
Slippery elm (Ulmus rubra)

The bacteria in the gut microbiome need prebiotics to feed on for their health. The breakdown products of this digestion are short-chain fatty acids released into the blood circulation, which have beneficial effects on the whole body (26).

They are a particular kind of dietary fibre that the gut microbiota selectively uses and are vital to the microbiome’s health. Good prebiotic fibre containing foods include Jerusalem artichokes, apples, bananas, asparagus, leeks, onions, oats, barley, and linseeds. Acacia gum and slippery elm (Ulmus fulva) are also excellent prebiotic sources.

Probiotics, the bacteria that can support the microbiome and be ingested in capsules or drinks, are useful but are only temporary residents of the gut and only serve a purpose while they are being taken. In order to encourage the microbiome to flourish, the terrain needs to be right, so prebiotics, a healthy diet and a healthy gut wall are most important.

Garlic (Allium sativum) is useful as it is a prebiotic and antimicrobial to pathogenic microorganisms. Fermented foods and drinks such as sauerkraut, kimchi, kombucha and kefir are most useful here too, and as they are food and drink can be taken daily at a much lower cost than probiotic supplements. However, if these are purchased rather than homemade, it is important that they are unpasteurized so that the beneficial bacteria are still present. Eating avocados also seems to support healthy gut flora.

The nervous system comprises two main parts, the central nervous system, which includes the brain and spinal cord, and the peripheral nervous system, which includes nerves branching off from the spinal cord and extending to all parts of the body.

These nerves carry messages or information in their nerve cells or neurons between the brain and the body, which control every action.

There is a strong bi-directional connection between the brain and the gut via the cranial and the vagus nerves and the entire peripheral nervous system. So anything that affects the gut will affect the brain and vice versa. When there is an inflammatory state in the gut, it will affect the brain – this is apparent in patients with inflammatory bowel diseases such as coeliac disease, where there is also a high incidence of brain inflammation visible on an MRI scan (27).

Nervous system health: An Ayurvedic perspective

Or, if the gut is on fire, then the brain will also be on fire.

The action of the vagus nerve is very linked with inflammatory states in the body. The vagus nerve, so-called because it wanders through the body like a vagabond – originates in the brain, travels down the neck, through the chest, to the abdomen creating an interconnected network between the brain, digestive system, lungs, heart, liver and kidneys.

Its principal function is to send messages to the brain from the organs, so the brain is aware of how they are functioning. The vagus is also able to assess immune function too.

The vagus nerve controls the parasympathetic nervous system – so it is vital in winding down from any sympathetic nervous system activity. The sympathetic nervous system is activated by increased cortisol in the fight or flight response created by a stressful situation.

Keeping this balance between parasympathetic and sympathetic is vital for health. It was a matter of life or death to have that sympathetic response when we were out hunting or being hunted back in the stone age. Still, those who don’t deal well with stress and anxiety find themselves in the sympathetic mode more or less constantly and unable to revert to relax mode, which is parasympathetic dominance.

The sympathetic response releases hormones such as adrenalin and cortisol, resulting in a raised heart rate, tense muscles (ready to run), sweating, slowed digestion and a feeling of increased energy due to gluconeogenesis (the generation of new glucose by the liver). It also releases the hormone renin from the kidneys, increasing blood pressure and metabolism.

Understanding the stress response is simple if we consider the domestic cat – they are masters of relaxation (parasympathetic dominance). Still, when necessary, they can spring into fast action to hunt or to run from a dog (sympathetic dominance) and then straight back to sleep again afterwards as though nothing had happened.

Generally, the parasympathetic response is anti-inflammatory, and the sympathetic response is pro-inflammatory, especially if out of control. So chronic stress is a major cause of inflammation.

Stress results in the release of inflammatory cytokines through the effect on sympathetic and parasympathetic nervous system pathways. These cytokines have been found to interact with neurotransmitter metabolism and neuroendocrine function. Poor sleep results in lowered vagal tone, increased inflammation, and inflammation results in poor sleep.

Pro-inflammatory cytokines IL-6 and TNF alpha daytime secretion are increased in insomniacs which causes more inflammation and contributes to the chronic inflammatory diseases so common today – type two diabetes, cancer, osteoarthritis and cardiovascular disease.

Improving vagal tone will help the body to relax better after any stress. There are several methods of improving the tone, and the results will reduce inflammation. These need doing long term and daily for several weeks to get results:

Skullcap (Scutellaria lateriflora)
Skullcap (Scutellaria lateriflora)
  • Cold exposure will activate the vagus nerve, and regular cold exposure can lower the sympathetic response and increase parasympathetic activity via the vagus nerve: cold showers, or at least cold face wash.
  • Deep and slow breathing activates the vagus nerve, reduces anxiety and increases parasympathetic response. Aim at six breaths a minute as diaphragmatic breathing with the expansion of the stomach.
  • Singing, humming, chanting, and gargling activate the throat muscles and stimulate the vagus nerve.
  • Probiotics – healthy gut bacteria improve brain function by affecting the vagus nerve.
  • Meditation – can increase vagal tone.
  • Eye exercises – without moving the head facing forward, look to the right for one minute, then to the centre, then left for one minute, breathing slowly as you do it. This exercise can be done sitting or lying down (28).
  • Omega-3 fatty acids – increase vagal tone and vagal activity. For example, oily fish, flaxseed oil, and walnuts.
  • Exercise – stimulates the vagus nerve.
  • Massage can stimulate the vagus nerve – also reflexology and the Bowen technique.
  • Socialising and laughing stimulate the vagus – and stimulating the vagus often causes laughter.

Anything that causes inflammation in the gut will affect the brain, so in order to protect the brain and nervous system, it is vital to follow an anti-inflammatory diet. There are suggestions that non-coeliac gluten sensitivity may be of prime importance here, but all pro-inflammatory foods should be avoided (29).

Plastics, in particular the plasticisers bisphenol A BPA, and bisphenol S BPS, are also implicated in causing inflammatory damage to nerve cells, so avoiding all plastic wraps and bottles is a good move (30).

Herbs to improve nervous system health will be nervine tonics, nervine relaxants and adaptogens. Many of these double up as inflammation mediating herbs, and notable herbs which do this are chamomile (Matricaria recutita), lemon balm (Melissa officinalis), linden flower (Tilia europaea), St John’s wort (Hypericum perforatum), skullcap (Scutellaria lateriflora), ashwagandha (Withania somnifera), rose root (Rhodiola rosea) and schisandra (Schisandra chinensis).

Endothelial cell health is another important factor in the inflammatory process.

Endothelial cells form the lining of all blood and lymph vessels in the body. They are there to act as a barrier between blood and lymph and the rest of the body tissues. They are also selectively permeable to some chemicals to move into body tissues and permeable to carbon dioxide to move into the bloodstream from tissues. This permeability is a very important function that, among many other things, maintains the blood-brain barrier, which protects the brain from toxic chemicals.

Another main function of endothelial cells is maintaining the elasticity of blood vessels to allow them to constrict and dilate – vasoconstriction and vasodilation in order to control blood flow and blood pressure. Endothelial cells synthesise nitric oxide (NO), which acts as a vasodilator, and also catecholamines which act as vasoconstrictors.

Reduced NO production and/or bioavailability is considered the central mechanism responsible for endothelial dysfunction (31). NO also acts as an anticoagulant to prevent anything from sticking to the endothelial cell wall.

The endothelium also has a role to play in wound healing – controlling platelet aggregation and a clotting factor to prevent further bleeding, but also they are involved in fibrinolysis, which dissolves clots and prevents thrombosis.

If there is a chronic inflammatory process, then damage to the endothelium will result in a loss of elasticity, resulting in poor vasodilation, which results in hypertension; it also results in increased coagulation incidences as it tries to heal itself. This process results in thrombosis, heart and kidney disease, neurological disease and pulmonary disease. Insulin resistance and diabetes are inflammatory and will also damage the endothelium, hence the link between diabetes and cardiovascular disease. With age, diabetes, hypertension, smoking, and inactivity, endothelial cells lose function.

A recent study looking at mRNA COVID vaccines concluded that the mRNA vaccines dramatically increase inflammation on the endothelium and T cell infiltration of cardiac muscle and may account for the observations of increased thrombosis, cardiomyopathy, and other vascular events following vaccination (31).

Cinnamon (Cinnamomum spp)
Cinnamon (Cinnamomum spp)
  • Avoid smoking, inactivity, obesity, sugar and refined carbohydrates.
  • Eat more plants, especially whole grains, nuts and seeds, herb teas, green tea, cocoa, and dark chocolate, which all increase endothelial nitric oxide, one of the most helpful ways of supporting the endothelium.
  • Spices improve endothelial function – turmeric, ginger, cinnamon and black pepper. Foods to improve microcirculation include chocolate, berries, garlic, beetroot and green tea.

Often the heroic methods of modern medicine – the surgery and medications – are required when heart disease becomes severe, but in the earlier stages, or when things are stabilised, there are plenty of herbal interventions that can help.

The main mechanisms of action of the most commonly used hypertension medications are calcium channel blockade, beta-adrenergic blockade and angiotensin-converting enzyme inhibition. Herbs have been shown to act by all of these mechanisms as well.

Herbs that will support endothelial function include ginkgo (Ginkgo biloba), hawthorn (Crataegus oxyacantha), red sage (Salvia miltiorrhiza), rose hips (Rosa canina), reishi (Ganoderma lucidum), ginger (Zingiber officinale). Gentian (Gentiana lutea) has been shown to prevent endothelial inflammation (32).

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Essential oils and sustainability: Challenges, opportunities, solutions https://www.herbalreality.com/herbalism/sustainability-social-welfare/essential-oils-sustainability-challenges-opportunities-solutions/ https://www.herbalreality.com/herbalism/sustainability-social-welfare/essential-oils-sustainability-challenges-opportunities-solutions/#comments Wed, 18 May 2022 17:57:56 +0000 https://www.herbalreality.com/?p=6979 Aromatherapist Ellen Rowland explores problems in the supply chain of essential oils, and potential solutions.

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Aromatherapist Ellen Rowland explores problems in the supply chain of essential oils, and potential solutions.

Essential oils and sustainability: Challenges, opportunities, solutions

With the rising popularity of essential oils in recent years, increasing biodiversity losses worldwide, and the very real impacts of climate change becoming ever clearer and more urgent, talk within the aromatherapy community has turned towards the sustainability of essential oils.

There are questions to be asked surrounding the environmental and social impacts of using these precious medicines. How sustainable actually is this natural form of medicine? Are there steps we can take to mitigate the impacts of essential oil use? Are there other factors at play that influence sustainability?

First, it’s important to put this into context. Of around 350,000 scientifically-known and documented vascular plants (1), those that are known to be medicinal represent roughly 25,790 and of those, around 1500 are aromatic, which is approximately 6% of all known plants. About four hundred species of aromatic medicinal plants are commonly traded for aromatherapy purposes worldwide, which includes essential oils, absolutes, and hydrosols (2).

The State of the World’s Plants and Fungi (SOTWPF) report published by the Royal Botanic Gardens, Kew in 2020 states that two in five plants are threatened with extinction. This means 40% of all recorded plant species, and should ring alarm bells for everyone, as human-led practices such as agriculture, climate change and biological resource use are amongst the primary reasons for this threat (3).

10% of aromatic plants are currently listed as threatened according to The International Union for Conservation of Nature (IUCN) (4). Practices such as deforestation, clearing and using plants with no or unsustainable plant regeneration practices, monocropping and overharvesting wild species all contribute to the unsustainable production and use of essential oils, and therefore increase the likelihood of more species being added to the red list of endangered species.

Simultaneously, these practices damage the biodiverse ecosystems which support the growth of our aromatic plants in the first place. The approach of destroying whole areas of forest to harvest just one aromatic tree does not make sense from a biodiversity standpoint, but there are adaptations we can implement in farming and production of essential oils which can reduce and mitigate the harmful effects of these practices.

Rosemary essential oil (Rosmarinus officinalis)
Rosemary essential oil (Rosmarinus officinalis)

Demand for medicinal and aromatic plants is undoubtedly on the rise. The world has seen “a threefold increase in global trade in medicinal and aromatic plants since 1999” (5) which is largely due to the growing popularity of spas, natural cosmetics, pharmaceuticals, and aromatherapy.

According to The Business Research Company’s 2022 report, the global essential oils market size is expected to grow from $12.36 billion in 2021 to $13.58 billion in 2022 at a compound annual growth rate (CAGR) of 9.90%.

The global essential oils market share is expected to grow to $21.85 billion in 2026 at a CAGR of 12.62% (6). This projected growth brings with it concern surrounding the profitability of the essential oil and aromatherapy sector for large companies that hold a large market share, many of whom have come under scrutiny for promoting dubious practices.

The 2020 Netflix documentary series “(Un)well” shed light on controversial practices within the essential oil industry (7), and should perhaps make us consider the lengths certain companies will go to in order to profit. It is unclear which, if any, environmental sustainability protocols are taken into account or adhered to by big players in the sector, and as such, extra care should be taken and due diligence carried out on any essential oil suppliers.

This, however, requires knowing which questions to ask them, what documentation or records should be available, and how to choose oils to minimise our impact as individual consumers or therapists.

The IUCN labels species as “critically endangered”, “endangered” or “vulnerable”, and as such, a good place to start when sourcing essential oils is to avoid any that come from plants which feature on this list. Agar wood (Oud) Aquilaria malaccensis , Spikenard Nardostachys jatamansi, Sandalwood Santalum album, Palo Santo Bursera graveolens, Atlas Cedar Cedrus atlantica and Rosewood Dalbergia sissoo are all examples of threatened species which should be avoided due to their precarious existence.

In general, harvesting essential oils such as those listed above, which are taken from the heartwood of the tree, has a particularly negative impact on habitats since the whole tree needs to be cut down in order to access the essential oil.

Frankincense (Boswellia carterii) is an extremely popular essential oil, yet its popularity, coupled with the effects of climate change, mean that this once-abundant oil is now in short supply (8). Boswellia forests aren’t able to regenerate fast enough to keep up with the current demand, and so due to over-harvesting, many have disappeared.

Unsustainable harvesting methods include “making a higher number of cuts per tree to extract as much sap as possible and tapping the trees all year round rather than seasonally” (9) which doesn’t allow sufficient time for trees to recover. Furthermore, these intensive practices “weaken the trees, impeding their regrowth and ultimately killing them” (10).

Also take a look at our article on the sustainability of frankincense.

Frankincense (Boswellia serrata)
Frankincense (Boswellia serrata)

Sustainability isn’t just an environmental concern, however. Frankincense comes primarily from Somalia, Africa, India, Oman, and Yemen (11) where climate change will hit hardest (12), and where harvesting is often one of the main livelihoods for local populations.

There are increasing reports of frankincense resin tappers risking their lives “by climbing up cliffs to find new sources”(13) of frankincense, and there have been “reports of people suffering injuries including breaking legs and in some cases death” (14).

Unfortunately, frankincense may quickly be becoming one of the most unethical and unsustainable essential oils available.

It is clear that wider socioeconomic factors such as safety, and the longevity of local livelihoods merit serious consideration as well as the adoption of more sustainable practices when it comes to the production and consumption of essential oils.

Initiatives such as the ‘Adapting Agriculture to Climate Change’ programme, led by the Crop Trust in partnership with Kew and others, will be key in addressing the environmental, social and economic changes which will be caused by global warming.

Essential oil production has a high mass-to-yield ratio, since in order to produce essential oil, large quantities of aromatic plants are required.

For example, 10,000 lbs of rose petals, 250 lbs of lavender, 6,000 lbs of melissa, or 1,500 lbs of lemons respectively are required to produce just one 1 lb of essential oil (15).

In terms of yield, this is extremely low, and so the question of whether the process and extraction of essential oils is wasteful warrants consideration.

Calendula (Calendula officinalis)
Calendula (Calendula officinalis)

Despite Calendula’s popularity in the cosmetic and pharmaceutical industries, a 2020 Colombian study of a supply chain for Calendula officinalis essential oil production found that “high amounts of exhausted biomass (more than 95% w/w) are produced and wasted” (16) in the course of its production.

However, the research revealed several key touchpoints within the supply chain where opportunity exists to reduce emissions (changing how the oils are distilled, for example) and also to contribute to the “social development of farmers” (17) in Colombia through using the exhausted biomass leftover from the plant matter as a “potential high-value “non-conventional agro-industrial feedstock” (18).

More research into using aromatic plants as feedstock for agriculture is needed, yet this does seem to represent a possible solution to one of the issues associated with essential oil production and waste.

Another study focused on the opportunity to use waste from the food industry to produce essential oils, namely citrus peel leftover from juicing (19). Whilst several extraction methods including steam distillation, cold-press and solvent extraction, were tested, solvent-free microwave extraction was identified as the most effective in this study.

This method would probably produce resulting essential oils which would be unsuitable for therapeutic use, but the trials do represent an interesting experiment and opportunity to close the gaps in food production cycles through potentially bridging industries and creating a more circular economy.

FairWild are also a fantastic initiative, and their mission is “to enable transformation of resource management and business practices to be ecologically, socially, and economically sustainable throughout the supply chain of wild-collected products. These include plants, fungi, and lichen – wild resources under enormous pressure worldwide.”

Using essential oils with respect is one way we can minimise our consumption of essential oils and therefore our impact on the environment. For most aromatherapy products we make at home, we only need to use very small amounts of essential oils. Despite their comparatively low yield of plant matter to essential oil, they are extremely concentrated plant extracts, so little is needed to produce excellent therapeutic and aromatic effects. If stored in an airtight bottle away from light and heat, they have a good shelf life – several years, in fact, which makes them a good investment.

Chamomile (Matricaria chamomilla)
Chamomile (Matricaria chamomilla)

Since essential oils can be used to make home-made cosmetics, therapeutic herbal remedies and cleaning products, they can be harnessed in this way to reduce the number of products we buy in single-use plastics from large corporations. This has a positive environmental impact in an indirect way, since by making our own products in reusable glass bottles, for example, we’re creating less waste from other sources.

Finding alternatives to endangered species is also a key way we can reduce our impact when using essential oils. In the podcast An Aromatic Life, during episode #13, Conservation and Sustainability of Aromatic Medicinal Plants, guest Dr. Kelly Ablard advises that we should look at the chemical composition of vulnerable aromatic plants, as well as their therapeutic and energetic factors.

She suggests that instead of buying essential oils from vulnerable plants, this information will allow us to choose a chemically, therapeutically and energetically similar essential oil to ensure we are not contributing to the precarity of vulnerable species. For example, Ho Leaf Cinnamomum camphora (Linalool ct.) is suggested as an alternative to Rosewood, Dalbergia sissoo, and even practices like choosing an oil which is taken from the leaf or branch of a tree as opposed to the heartwood, which requires cutting down the whole tree, would be preferable (20).

One of the very best ways to increase our understanding of how the use of essential oils affects sustainability is through education. Learning about our local aromatic plant species, and plants in general, is key to understanding the ecosystem of which we are a part, and therefore respecting it as a diverse network of intersecting factors that deserves respect. Rather than placing ourselves at the centre of the ecosystem, biocentrism (21) takes the view that humans are just one part of this system, yet it is clear that despite this, we have a great deal of power to influence the whole network substantially, for better or worse, through our choices on both an individual and collective level.

Plantain (Plantago major)
Plantain (Plantago major)

Below are some tips to help you ensure that your essential oil purchases are as informed as possible.

Organic vs non-organic: Which way to go?

Using organic essential oils is recommended, both for therapeutic and environmental reasons. Minimising the amount of harmful pesticides we are putting on our land and onto our bodies is key to public and planetary health. The Soil Association lists lower emissions, lower levels of pollution, and more stored carbon as just three key reasons that organic farming is beneficial (22).

Purchasing power: Know your facts

Asking your supplier the right questions is key to understanding where your oils come from, and how they are produced. A good supplier will often know their farmers and distillers personally, understand and be able to provide you with information on the farming and production practices, and take great care to make it clear exactly how they source essential oils sustainably. Beware of woolly, vague or contradictory information, and essential oils that seem cheap. If it looks too good to be true, chances are it is.

The COSMOS-standard has also been created as a criteria for sustainable cosmetics. Many large businesses subscribe to this, although more need to still.

Whilst individual consumers and therapists are not the main culprits when it comes to harmful essential oil production practices, by making small changes and demanding a level of accountability from our suppliers, we can effect positive change within the essential oil market.

Purchasing oils in small quantities, as needed, and choosing high quality, organic ingredients sourced from trusted suppliers is a good rule of thumb. Checking the IUCN red list before buying, and eliminating use of vulnerable species will also help.

There is no need to stop using essential oils, they are wonderful for physical, mental, and spiritual health – but do stay informed so you can use them responsibly.

  1. Antonelli, A.*et al (2020). State of the World’s Plants and Fungi 2020. Royal Botanic Gardens, Kew. DOI: <https://doi.org/10.34885/172>
  2. Galia, F. (2021). #13: Conservation and Sustainability of Aromatic Medicinal Plants with Dr. Kelly Ablard. [podcast] An Aromatic Life. Available at: <https://open.spotify.com/episode/4HBsd3PDhwJTzFZHkD7KJe> [Accessed 12th May 2022].
  3. Antonelli, A.*et al (2020). State of the World’s Plants and Fungi 2020. Royal Botanic Gardens, Kew, p.14. DOI: https://doi.org/10.34885/172
  4. Galia, F. (2021). #13: Conservation and Sustainability of Aromatic Medicinal Plants with Dr. Kelly Ablard. [podcast] An Aromatic Life. Available at: <https://open.spotify.com/episode/4HBsd3PDhwJTzFZHkD7KJe> [Accessed 12th May 2022].
  5. Unknown. Cites.org. 2022. Medicinal and aromatic plants | CITES. [online] Available at: <https://cites.org/eng/prog/medplants> [Accessed 12 May 2022].
  6. Unknown. 2022. With The Growing Spa Industry, The Essential Oils Market Is Set To Reach $21 Billion By 2026 As Per The Business Research Company’s Essential Oils Global Market Report 2022. [online] GlobeNewswire News Room. Available at: <https://www.globenewswire.com/news-release/2022/03/30/2413070/0/en/With-The-Growing-Spa-Industry-The-Essential-Oils-Market-Is-Set-To-Reach-21-Billion-By-2026-As-Per-The-Business-Research-Company-s-Essential-Oils-Global-Market-Report-2022.html> [Accessed 12 May 2022].
  7. The Guardian. 2022. The dark side of wellness: behind a Netflix series on a murky industry. [online] Available at: <https://www.theguardian.com/tv-and-radio/2020/aug/12/unwell-netflix-series-dark-side-of-wellness-industry> [Accessed 12 May 2022].
  8. Fobar, R. 2019. Frankincense trees—of biblical lore—are being tapped out for essential oils. [online] Available at: <https://www.nationalgeographic.com/animals/article/frankincense-trees-declining-overtapping> [Accessed 12 May 2022].
  9. Unknown. 2019. Essence + Alchemy. Essential Oils – Ethical + Sustainability Issues — Essence + Alchemy. [online] Available at: <https://www.essenceandalchemy.co.uk/lab-notes/ethical-and-sustainability-issues-of-sourcing-essential-oils> [Accessed 12 May 2022].
  10. Unknown. 2019. Essence + Alchemy. Essential Oils – Ethical + Sustainability Issues — Essence + Alchemy. [online] Available at: <https://www.essenceandalchemy.co.uk/lab-notes/ethical-and-sustainability-issues-of-sourcing-essential-oils> [Accessed 12 May 2022].
  11. Fobar, R. 2019. Frankincense trees—of biblical lore—are being tapped out for essential oils. [online] Available at: <https://www.nationalgeographic.com/animals/article/frankincense-trees-declining-overtapping> [Accessed 12 May 2022].
  12. Law, T. Time. 2019. Climate Change Will Impact the Entire World. But These Six Places Will Face Extreme Threats. [online] Available at: <https://time.com/5687470/cities-countries-most-affected-by-climate-change/> [Accessed 12 May 2022].
  13. Unknown. 2019. Essence + Alchemy. Essential Oils – Ethical + Sustainability Issues — Essence + Alchemy. [online] Available at: <https://www.essenceandalchemy.co.uk/lab-notes/ethical-and-sustainability-issues-of-sourcing-essential-oils> [Accessed 12 May 2022].
  14. Unknown. 2019. Essence + Alchemy. Essential Oils – Ethical + Sustainability Issues — Essence + Alchemy. [online] Available at: <https://www.essenceandalchemy.co.uk/lab-notes/ethical-and-sustainability-issues-of-sourcing-essential-oils> [Accessed 12 May 2022].
  15. Yeager, N. 2017. Earth Island Journal. The Environmental Impact of Essential Oils. [online] Available at: <https://www.earthisland.org/journal/index.php/articles/entry/the_environmental_impact_of_essential_oils/> [Accessed 12 May 2022].
  16. González-Aguirre, J.A., Solarte-Toro, J.C, Cardona Alzate, C.A, 2020. Supply chain and environmental assessment of the essential oil production using Calendula (Calendula officinalis) as raw material  [online] Heliyon, Volume 6, Issue 11, 2020, e05606, ISSN 2405-8440, https://doi.org/10.1016/j.heliyon.2020.e05606. Available at <https://www.sciencedirect.com/science/article/pii/S240584402032449X> [Accessed 12 May 2022].
  17. González-Aguirre, J.A., Solarte-Toro, J.C, Cardona Alzate, C.A, 2020. Supply chain and environmental assessment of the essential oil production using Calendula (Calendula officinalis) as raw material  [online] Heliyon, Volume 6, Issue 11, 2020, e05606, ISSN 2405-8440, https://doi.org/10.1016/j.heliyon.2020.e05606. Available at <https://www.sciencedirect.com/science/article/pii/S240584402032449X> [Accessed 12 May 2022].
  18. González-Aguirre, J.A., Solarte-Toro, J.C, Cardona Alzate, C.A, 2020. Supply chain and environmental assessment of the essential oil production using Calendula (Calendula officinalis) as raw material  [online] Heliyon, Volume 6, Issue 11, 2020, e05606, ISSN 2405-8440, https://doi.org/10.1016/j.heliyon.2020.e05606. Available at <https://www.sciencedirect.com/science/article/pii/S240584402032449X> [Accessed 12 May 2022].
  19. Teigiserova, D., Tiruta-Barna, L., Ahmadi, A., Hamelin, L. and Thomsen, M., 2021. A step closer to circular bioeconomy for citrus peel waste: A review of yields and technologies for sustainable management of essential oils. Journal of Environmental Management, [online] 280, p.111832. Available at: <https://www.sciencedirect.com/science/article/pii/S0301479720317576?via%3Dihub> [Accessed 12 May 2022].
  20. Galia, F. (2021). #13: Conservation and Sustainability of Aromatic Medicinal Plants with Dr. Kelly Ablard. [podcast] An Aromatic Life. Available at: <https://open.spotify.com/episode/4HBsd3PDhwJTzFZHkD7KJe> [Accessed 12th May 2022].
  21. Pediaa.Com. 2022. What is the Difference Between Anthropocentrism Biocentrism and Ecocentrism – Pediaa.Com. [online] Available at: <https://pediaa.com/what-is-the-difference-between-anthropocentrism-biocentrism-and-ecocentrism/#:~:text=Biocentrism%20and%20Ecocentrism-,Definition,the%20ecosystem%20as%20a%20whole> [Accessed 12 May 2022].
  22. Unknown. Soilassociation.org. 2022. Organic is Better for the Planet | Soil Association. [online] Available at: <https://www.soilassociation.org/take-action/organic-living/why-organic/better-for-the-planet/#:~:text=There%20are%20multiple%20benefits%20of,Capture%20and%20store%20more%20carbon> [Accessed 12 May 2022].

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Chaga (Inonotus obliquus): A mushroom with many medicinal properties https://www.herbalreality.com/herbalism/western-herbal-medicine/chaga-mushroom-medicinal-properties/ https://www.herbalreality.com/herbalism/western-herbal-medicine/chaga-mushroom-medicinal-properties/#comments Thu, 21 Apr 2022 18:16:04 +0000 https://www.herbalreality.com/?p=6732 Medicinal fungi like chaga have boomed in popularity in recent years. Matthew Clark shares some of the potential ways it can support our health.

The post Chaga (Inonotus obliquus): A mushroom with many medicinal properties appeared first on Herbal Reality.

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Medicinal fungi like chaga have boomed in popularity in recent years. This article shares some of the potential ways it can support our health.

Chaga (Inonotus obliquus) is a black, parasitic mushroom, which looks on the outside like a lump of burnt, craggy charcoal; it belongs to the Hymenochaetacea family of fungi. The genus Inonotus is widespread is widespread in North America, Asia and Europe and comprises around 100 species, represented in Europe by four species, one of which is Inonotus obliquus.

Chaga (Inonotus obliquus): A mushroom with many medicinal properties
Chaga (Inonotus obliquus)

The term ‘chaga’ most probably derives from Russian; chaga is also known as birch conk (a woody growth), clinker polypore, cinder conk and black mass, and may usually be found on the boles of birch trees, (1) though occasionally on other trees: on alder, ash, beech, chestnut, hornbeam, plane-tree, poplar, maple, rowan, oak, walnut, and willow. However, reports on the growth of chaga on trees besides beech are often unreliable as the fungus growing on the other kinds of tree are similar and often confused with chaga. (2)

Chaga grows externally on the bark of the host tree, be it living, dead, standing or fallen. Under the black surface, the chaga mycelium is an orange/brown colour. It causes the decomposition of live boles and usually grows to around between 25-40 centimetres; it dries to a consistency similar to that of hard cork. Chaga usually infects trees that are 30-40 years old through wounds in the bark and can continue to grow on the bole for another 30-80 years. On old trees the growth of chaga can exceed 50 cm in diameter. (3)

Low in calories, high in fibre, and rich in minerals and vitamins, chaga has been used as a traditional medicine in various cultures since time immemorial, particularly in Russia, China, Poland (4) and the Baltic countries. It is also used for food in China. (5) Chaga is used to treat diabetes, parasites, tuberculosis, inflammation, gastro-intestinal problems, heart disease and several kinds of cancer. (6)

Perhaps the oldest reference to the use of chaga as a medicine is by Hippocrates (c. 460–370 BCE) in his Corpus Hippocraticum, in which is described the use of infusions of chaga to wash wounds. (7)

For medicinal treatments chaga is usually ground to a fine powder and made into a tea, which tastes like mushrooms. It is also available in capsule form as a supplement, sometimes in combination with other mushrooms, such as cordyceps.

However, many commercial products are simply unprocessed powdered chaga without having been extracted. This means the active compounds are not bioavailable and so one must be careful when buying a product that the quality is good and that the preparation process is clearly explained if it is simply a powder and not an extract.

Chaga (Inonotus obliquus)
Chaga (Inonotus obliquus)

The chaga mushroom has been the subject of many scientific investigations to explore its medicinal properties, particularly by researchers in South Korea. (8) Chaga has been shown to be effective in reducing cancerous tumours, thereby suppressing the progression of cancer, through promoting energy metabolism. (9)

In the semi-autobiographical novel Cancer Ward by Aleksandr Solzhenitsyn, set in Russia and first published in 1968, cancer patients are prescribed chaga tea.

Several studies on mice and on human cells in vitro have demonstrated the effectiveness of chaga as an anti-tumour agent, effective in the treatment of several kinds of cancers, including cancer in the colon, (10) liver, (11) prostate, breast, (12) lung, stomach, and cervix. (13)

Compounds known as triterpenes/triterpenoids have been extracted from chaga and found to be effective in killing breast cancer cells. (14)

The chaga fungus contains inotodiol (a lanostane triterpenoid), which has anti-tumour properties. (15) Inotodiol and betulin (another triterpenoid with a lupane structure) are found almost exclusively in the fungus growing on birch trees. (16)

Betulin forms up to 30% of the dry weight of silver birch bark; it is found in large amounts in chaga and has anti-cancer properties. (17) It is currently believed that the anti-cancer potential of the mushroom is primarily due to the high content of polysaccharides (18) in the mushroom. (19)

Chaga has the full spectrum of immune-stimulating phytochemicals found in other mushrooms, such as in maitake and shitake, (21) which are widely consumedin Japan. It has been found that the compounds in mushrooms in general that inhibit tumour growth do so mostly by stimulating the immune system. (22)

Chaga may be useful as an immune enhancer in people with either suppressed or compromised immune systems, who may develop auto-immune diseases such as psoriasis, rheumatoid arthritis or type 1 (auto-immune) diabetes. Chaga is a potent immune modulator and could also be used to treat people whose bone marrow has been damaged by chemotherapy. (23)

Many studies have confirmed chaga’s anti-inflammatory properties. (23) One study (24) concluded that chaga could be useful to treat inflammation, notably in bowel disease. It has now evident that inflammation is implicated in numerous health issues, including anxiety, unipolar and bipolar depression, schizophrenia, post-traumatic stress disorder, asthma, rheumatoid arthritis, cardiovascular disease, obesity, diabetes, osteoporosis, Alzheimer’s disease, certain cancers and stroke.

Eight out of ten of the leading causes of death in the USA involve inflammation. (25) More research is needed for specific inflammatory processes and conditions, however it would be a viable investigation route to see how chaga can effect illnesses where inflammation is involved.

Chaga (Inonotus obliquus)
Chaga (Inonotus obliquus)

Besides being anti-inflammatory, chaga is also rich in anti-oxidants, (26) the main anti-oxidants being polyphenols and triterpenoids. As noted above, triterpenoids are effective against some forms of cancer. Antioxidants can prevent or reverse damage to cells caused by aging, the environment or lifestyle.

Polyphenols can help manage both blood pressure and blood sugar levels, and reduce chronic inflammation. There are around 8,000 kinds of polyphenols, which are in many kinds of foods in greater or lesser quantities. Some of the commonly consumed polyphenols include flavonoids, such as quercetin and catechins, which are in fruits; capsaicinoids, in chili peppers; lignans and stilbenes, in vegetables and whole grains; resveratrol in red wine; and ellagic acid in berries.

High levels of anti-oxidants are in chokeberries, elderberries and blueberries. (27) However, several surveys indicate that the highest levels, by far, of anti-oxidants in plant sources are in chaga. (28)

Chaga is particularly rich in the antioxidant known as superoxide dismutase (SOD), which has been shown to reduce free radical damage, preventing wrinkles and having an anti-cancer effect. (29) Several extracts from chaga, including polysaccharides, have also been shown to have neuroprotective effects in degenerative diseases such as Alzheimer’s and Parkinson’s. (30)

Studies on the effect of particular compounds in chaga have indicated that after four weeks they can significantly reduce the body weight, blood glucose levels, and plasma insulin levels of mice with diabetes. (31) It has been shown that the polysaccharides in chaga have hypoglycaemic activity, reducing blood sugar levels. (32)

Other studies, (33) also on rats and mice, confirm that chaga is antioxidant, can reduce blood sugar, and provided further indications that chaga would most probably be effective against diabetes in humans.

Chaga (Inonotus obliquus)
Chaga (Inonotus obliquus)

Two studies suggest the anti-bacterial and probiotic effect of chaga; another study indicates the anti-parasitic properties of polysaccharides in extracts from chaga. (34) The betulin in chaga can easily be converted to betulinic acid, which has been shown to have antiviral activity against HIV and malaria. (35)

Polysaccharides extracted from chaga have been shown to be effective against other viral infections, including herpes, feline influenza (and other feline viral infections), and hepatitis C. (36)

It has been found that chaga modulates immune responses through secretion of cytokines in immune cells, and regulates antigen-specific antibody production. Chaga can increase serum levels of chemoprotective cytokines, (37) which are proteins that regulate the immune system and stimulate white blood cells, which protect against harmful bacteria and viruses.

Cytokines are also implicated in SARS-Covid infection, which causes illness through a cytokine ‘storm’. The triterpenoid inotodiol found in chaga, mentioned above, has been found to induce the proliferation of T-cells, which act against viral infection. (38) So, it may be that chaga can protect against the SARS-Covid virus.

Besides its other effects, chaga has also been shown to be able to reduce levels of total cholesterol in rats, (39) high levels of some forms of cholesterol being a factor in heart disease. It seems that it is the antioxidant effect of chaga that reduces cholesterol.

It has also been found that the polysaccharides in chaga increase in mice the production of sperm and testosterone, and ameliorate impaired reproductive function. (40)

Birch (Betula alba)
Birch (Betula alba)

Birch trees are native to northern latitudes of the world: to Russia, Siberia, northern Europe, Canada, Alaska, northern China and Korea. There are far more birch trees in Scotland than in England. The ancient Balts, Slavs and Finns regarded the birch as a sacred tree.

In pre-Christian Ireland, birch was considered as one of seven sacred trees. (41) The name ‘birch’ derives from the Proto-Indo-European (PIE) root *bher∂g, which means ‘shine’/’brilliance’/’white’, reflected in names such as Albert, Herbert and Robert. (42)

The Celts saw in the birch the deity Brigit/Brigid, whose name derives from the same root, *bher∂g. Brigit was the muse of healers and bards in pre-Christian Ireland, where smitten boys would place fresh, green birch twigs in front of the house of the one they were courting. (43)

Birch twigs used to be used in Europe for the beating of bounds and the flogging of delinquents – and formerly lunatics – to expel evil spirits. In Scandinavia the first leaves of birch mark the beginning of the agricultural year. The witches’ broom used to be made from birch and ash. (44)

In India, the birch tree is called bhūrja in Sanskrit. In north India, texts used to be inscribed on birch bark, which is used by North American Ojibwa Indians for many other purposes, such as for tools, mats, canoes and baskets. (45) The sap of birch trees is used to make a sugar substitute, known as xylitol. Birch sap has less sugar than maple and is used as a syrup by Lithuanians. (46)

In herbal medicine the sap of birch is believed to stimulate urine and bile, purify the blood, and strengthen the urinary tract. (47) Tea made from the leaves of white birch is used for dissolving kidney stones and as a laxative. Twigs and leaves are added to bath water as a treatment for itchy skin and hair loss, while the inner bark is simmered for fever. (48)

Chaga (Inonotus obliquus)
Chaga (Inonotus obliquus)

In the last couple of decades, numerous scientific studies have indicated the potential for chaga to treat several common diseases, including cancer and diabetes, as an immune-system booster, as an antioxidant, and against harmful viruses.

Although the scientific tests so far have been almost exclusively conducted on rats and mice, and many of these studies lack in-depth experiments, (49) it seems highly likely that such effects would be replicated at least to some degree in humans. It should, however, be cautioned that chaga can prevent blood clotting, (50) so it should not be used by anyone using blood-thinning medication.

As mentioned above, the birch tree is revered in several cultures, notably by the Balts, Slavs and Finns. It has been suggested by some commentators (51) that this reverence for the birch tree may derive from the fact that one of the main places where the red, spotted, fly-agaric mushroom (Amanita muscaria) may be found is beneath birch trees.

Fly-agaric has psychedelic effects and is used for shamanic purposes in some cultures in Siberia and North America. (52) It was famously, though incorrectly, (53) identified in the late 1960s by R. Gordon Wasson – one of the great mycologists of the 20th century – as the ‘nectar of immortality’, the ritual drink known as soma, (54) which is revered by the Brahmins of India. However, leaving this suggestion aside, perhaps, as a speculation, reverence for the birch tree has, instead, practical roots in the ancient use of chaga as a wondrous medicine.

  1. Betula fontinalis, Betula lenta, Betula lutea, Betula papyrifera, Betula pendula (silver birch), Betula pubescens/alba (white birch).
  2. Szychowski et al. (2021:293).
  3. Szychowski et al. (2021:293).
  4. Inonotus obliquus is a partially protected species in Poland (Szychowski 2021:293).
  5. Ma et al. (2013.
  6. Kim (2005).
  7. Szychowski et al. (2021:294).
  8. For a recent, comprehensive review of the scientific literature on research into the medical potential of chaga, see Szychowski (2021).
  9. Arata et al. (2016).
  10. Lee et al. (2015).
  11. Youn et al. (2008).
  12. Ma et al. (2013).
  13. Chung et al. (2010).
  14. Zhao et al. (2016).
  15. Chung et al. (2010).
  16. Phillips (2006:310). Betulin is also found in red alder (Alakurtti et al. 2006) and a few other plants (Moghaddam (2012).
  17. Alakurtti et al. (2006).
  18. Three important polysaccharides – starch, glycogen and cellulose – are composed of glucose.
  19. Szychowski et al. (2021:299).
  20. Kim (2005).
  21. Borchers et al. (2008:259).
  22. Kim (2005).
  23. Ma et al. (2013).
  24. Mishra et al. (2012).
  25. Slavich (2015).
  26. Cui et al. (2005); Liang et al. (2009).
  27. In one survey (WebMD 2020) it is reported that the foods with the highest levels of antioxidants are (per half-cup serving) chokeberries (1,123 mgs), elderberries (870 mgs), blueberries (535 mgs) and blackcurrants (485 mgs). Blackberries, raspberries and strawberries have around 160 mgs. Per ounce, cloves contain 542 mgs, and peppermint 427 mgs. Dark chocolate has 249 mgs per tablespoon (milk chocolate has just 35 mgs). Of all nuts, the most polyphenols are in chestnuts, with 347 mgs per ounce. Other sources of polyphenols include flax seeds (229 mgs per tablespoon); a small artichoke has around 260 mgs; a small red onion has around 170 mgs; an olive has around 20–25 mgs; and a cup of coffee has about 35 mgs of polyphenols.
  28. Acai berries reportedly contain 165 oxygen radical absorbent capacity (ORAC) units, pomegranates 105, and blueberries 24; chaga contains 1,104 (Chichaga 2015; Wild Kingdom 2022).
  29. Younus (2018).
  30. Szychowski et al. (2021: 295).
  31. Wang et al. (2017).
  32. Szychowski et al. (2021:299).
  33. Cha et al. (2006); Diao et al. (2014); Sun et al. (2015); Wang et al. (2017).
  34. Szychowski et al. (2021:296).
  35. Alakurtti et al. (2006); Moghaddam et al. (2012).
  36. Szychowski et al. (2021:294, 296).
  37. Kim (2005); Ko et al. (2011).
  38. Maza et al. (2021).
  39. Sun et al. (2015).
  40. Ding et al. (2020).
  41. Graves (1977:253).
  42. Online Etymological Dictionary (2022).
  43. Müller-Ebeling et al. (2003:8).
  44. Graves (1977:166, 173).
  45. Nyholm (2022).
  46. Chepaitis (2016).
  47. Müller-Ebeling et al. (2003:7).
  48. Hopman (1995:187).
  49. Szychowski et al. (2021:298).
  50. Hyun et al. (2006).
  51. For example: Müller-Ebeling et al. (2003:10).
  52. Morgan (1995:106–110).
  53. See Clark (2020).
  54. See Wasson (1969).

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A beginner’s guide to growing medicinal herbs https://www.herbalreality.com/herbalism/western-herbal-medicine/beginner-guide-growing-medicinal-herbs/ https://www.herbalreality.com/herbalism/western-herbal-medicine/beginner-guide-growing-medicinal-herbs/#comments Thu, 21 Apr 2022 17:50:56 +0000 https://www.herbalreality.com/?p=6725 Ben Heron gives you top tips for when you are starting your medicinal herb garden.

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A beginner’s guide to growing medicinal herbs

Growing herbal medicines is a very enriching practise, which supports our wellbeing in its own way. This article gives you top tips for when you are starting your medicinal herb garden.

Growing medicinal herbs is one of those rare things we can do in life that is truly wholesome and beneficial. It is good for the land, it is good for the birds and the bees, and it is good for our health and spirits.

And the great thing is that for all that they give, they ask for relatively little in return. Most medicinal herbs are easy to grow and so long as you follow a few key principles, you can create a stunning herb garden in no time.

This article explores some of the main themes to think about when starting a medicinal herb garden for the first time. It is by no means a comprehensive guide but will hopefully give you some ideas to go away and explore in more detail.

A thriving herb garden full of healing potential
A thriving herb garden full of healing potential

With so many options to choose from, how do you choose which herbs to grow? A good starting point is to do some research into which herbs are best suited for the climate and growing space you have and to consider which medicinal herbs you may want or need in your life.

Is your garden sunny or shady? Is there a specific condition you would like to treat? Or are there specific herbs you feel drawn to? You’ll normally find there are a few key herbs that are perfectly suited for both you and your garden.

It may be that you are someone who suffers from nervous tension and happen to have a shady garden – a perfect opportunity to grow skullcap, lemon balm and St. John’s wort. Or perhaps you have rich, loamy soil in a sunny garden and just want herbs that can be harvested for herbal teas, in which case you can’t go wrong with the likes of chamomile, fennel and catnip.

Or do you just love bright colours and aren’t so bothered about its uses; if so, fill your garden and brighten your life with the oranges and yellows of calendula, California poppy and meadow arnica.

Marshmallow root (Althaea officinalis)
Marshmallow root (Althaea officinalis)

It always helps to have some knowledge of a plant’s natural habitat and – where possible – to make those plants feel at home by mimicking or matching some of those conditions in your garden.

Obviously, the easiest approach is to grow native plants that are already very much at home in our own climate. The likes of marshmallow and meadowsweet, for example, will cope just fine with the wettest and frostiest of British winters.

But if you are growing medicinal herbs such as lavender, thyme or sage, which are native to the Mediterranean, it helps to grow them in a warm, sheltered spot, and maybe even add some sand into your soil to improve drainage and prevent waterlogging.

South-facing walls of a house can create remarkably warm micro-climates that can be perfect for sun-loving herbs.

Some herbs grow in very specific environments. Gentians, for example, are most commonly found growing in high mountain pastures. Obviously, it’s hard to replicate mountain conditions in an English garden, but you can mimic some of the mountain environment by creating a rock garden and growing your gentians somewhere that is shaded from the heat of the midday sun.

Similarly, there are quite a few woodlands herbs that naturally grow in the shade of trees in rich, loamy soil that is the result of many years of rotting autumn leaves. Goldenseal, Himalayan valerian and black cohosh are examples of herbs that thrive when they are grown in shaded areas with compost made from leaf litter.

Herbs come in all shapes and sizes. From the tiny Lily of the Valley to the majestic 8 foot Angelica, your choice of medicinal herbs will always be influenced by the size of your growing area.

Allow each plant sufficient space to grow into and don’t forget that – if you have a small garden – you can use vertical space as well.

Codonopsis and passion flower are two beautiful climbers that can be trained up a trellis, and there are many shade-loving herbs, such as sweet woodruff and Tibetan gentian that can happily grow in their shade.

California poppy (Eschscholzia californica)
California poppy (Eschscholzia californica)

When choosing medicinal herbs to grow it helps to know the difference between annual, biennial and perennial plants. The majority of medicinal plants are perennial. In other words, they live for many years; their foliage usually dies back in the winter and grows back in the spring.

Perennials can be slow growing and need plenty of care when they are young, but once established they require little maintenance other than occasional weeding, watering and cutting back.

Annual plants complete their life cycle in one growing season. They are reliant on seeds for their survival, and as a result they tend to be prolific self-seeders. So, although annual herbs such as German chamomile, calendula and California poppy only live for one season, they can easily be encouraged to return year after year simply by allowing the seeds to mature and fall onto the beds where they have grown.

Biennials are plants that take two growing seasons to complete their life cycle. Angelica, mullein and burdock are examples of biennial plants; they usually produce a rosette of leaves in the first year and flower in the second. Like the annuals, you’ll need to sow fresh seed every year if you want your favourite biennials to be in flower every summer.

High altitude lavender growing in the French Alps
High altitude lavender growing in the French Alps

There are many ways to prepare land for growing medicinal plants – too many to cover here, but in essence the main principle is to encourage natural soil health through organic practices such as using a mulch or cover crop and adding compost where appropriate.

The no-dig method, as taught by Charles Dowding, is a favourite of ours – partly because it doesn’t disturb the ecology of the soil, and also because it can significantly reduce the amount of time spent on weeding.

But before you order a trailer of rotted manure to pour over your lawn (a common no-dig practice), it is important to consider the effect of soil nutrition on the medicinal properties of the plants. Many of the healing compounds found in medicinal herbs are produced in response to environmental stress or external threats.

For example, lavender grown at a high altitude in more nutrient depleted soil has higher levels of essential oils – most likely a result of having to tolerate greater solar-radiation and nutrient stress. So it’s not always best to grow herbs in rich, loamy soils as we would with our vegetables; plants that are grown in poor soils may be smaller in size but can produce much higher quality herbal medicines.

Interestingly, research has shown that herbs grown using organic practices (i.e. without artificial fertilisers), contain higher levels of secondary plant phytonutrients such as the protective polyphenols and flavonoids. The same applies to herbs grown in wild settings. So when it comes to preparing your land, sometimes less is more.

Chamomile (Matricaria chamomilla)
Chamomile (Matricaria chamomilla)

Once you’ve chosen your medicinal herbs and prepared your land, it is time to introduce the plants. Essentially, you have three main options; you can start by sowing seed, you can take cuttings from existing plants, or you can buy new plants (either potted of bareroot).

There is something very satisfying about raising plants from seed; it helps create a stronger relationship with the plants that can add another layer of potency if and when you use them to prepare herbal medicines.

Looking after your seedlings requires patience and care, and most herb growers will agree that the more you give to the plants, the more you receive in return.

There are of course some disadvantages when growing from seed; not everyone has suitable indoor growing space, and it takes longer to reach maturity. Many perennial herbs, such as echinacea, wild bergamot and St John’s wort, will only start to produce flowers in their second year. So, if you prefer not to wait that long and are willing to spend more money, then buying mature plants may be the best solution.

Ladybird larvae eating aphids on a valerian plant
Ladybird larvae eating aphids on a valerian plant

Having raised your seedlings or purchased your plants and planted them in a suitable location in your garden, ensuring that tender plants are protected from late frosts, all you really need to do is keep on the top of the weeds, water them when needed, and protect them from potential pests.

Most herbs are quite resilient and suffer few problems with pests and diseases, but there are a few potential issues to keep an eye on. Seeds waiting to germinate can be a tasty snack for birds and mice; young seedlings can be susceptible to slugs and aphids; and herbs of all sizes can attract hungry rabbits and deer.

Protecting the plants with some kind of physical barrier (traps, mesh cages or fencing) is an effective way to keep larger creatures away. And there are many organic practices for dealing with smaller critters; aphids, for example, can easily be controlled by releasing ladybird or lacewing larvae – both available from Dragonflii.

If you do experience repeated issues from certain pests, you can normally find herbs that are resistant to the pest in question. For example, slugs appear to have no interest in valerian, licorice mint and sweet woodruff. And both deer and rabbits have no interest in lovage, thyme or mullein.

But if you are growing mullein, keep an eye out for the brightly coloured ‘mullein moth caterpillars’, which – as the name suggests – are big fans of the mullein’s soft, juicy leaves. Left to their own devices they can decimate a plant in no time.

Ginseng (Panax ginseng)
Ginseng (Panax ginseng)

The interval between sowing and harvest can vary enormously. Annuals, by their very nature, are quick to grow and can only be harvested in the first year. German chamomile, for example, starts producing flowers in less than 3 months from sowing. But some perennials take a lot longer; Panax ginseng, for example, should be grown for 6 years before its roots are ready for harvest.

The harvest time and frequency will of course depend on the part of the plant that is harvested. Leaves, flowers and seeds can be harvested repeatedly without any serious detriment to the plant; harvesting roots on the other hand is less sustainable, usually requiring the whole plant to be uprooted and new plants grown in its place.

That said, it is possible, for example, to dig around the base of a marshmallow plant to harvest some of the surface roots without killing the plant. And if you only have a few precious echinacea plants, you don’t need to use the roots – their seeds are also packed with the same immune-boosting tingly alkylamides, and when ground up into a powder make a surprisingly delicious tea.

Once harvested, there are many ways to process them into different herbal preparations, but this is a big topic – one that we will look at in more detail later in the year as it is a special skill to harness all the healing vitality of medicinal herbs.

Until then, happy growing!

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Mental health and men: A herbalist’s perspective https://www.herbalreality.com/herbalism/western-herbal-medicine/mental-health-men-herbalist-perspective/ https://www.herbalreality.com/herbalism/western-herbal-medicine/mental-health-men-herbalist-perspective/#comments Wed, 30 Mar 2022 20:14:38 +0000 https://www.herbalreality.com/?p=6646 How herbal medicine can support resilience, healing and transformation.

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Mental health and men: A herbalist’s perspective

Herbalist Jonny Woodall discusses how herbal medicine can support resilience, healing and transformation.

“The mass of men lead lives of quiet desperation” – Henry David Thoreau

Men in the developed western world are struggling. Spiralling rates of depression, suicide and poor mental health increase year on year in most western countries. The statistics paint a woeful picture (1):

  • Nearly 75% of adults who are reported missing are men
  • 87% of rough sleepers are men
  • Three times as many men as women die by suicide
  • Men report lower levels of life satisfaction than women
  • The vast majority of the prison population are men
  • Men are more likely to be detained under the mental health act
  • Men are three times more likely to be drug and alcohol dependent than women
  • Suicide is the leading cause of death for adult men under the age of 50
  • Approximately 75% of the 6,000 recorded suicides in the UK in 2017 were male

It is difficult to point at one solid piece of data or theory as to why men are in the situation we find ourselves today.

In my work with men, I believe the underlying themes point towards a number of different reasons:

  • Lack of purpose or meaning in life
  • The addiction to short term gratification – Food, material positions, sex, gambling etc.
  • Poor male mentoring influence – No father in the childhood home or strong, well rounded male figures in the patient’s life
  • The glorification of violence, money and tyrannical power as a pursuit to meaning
  • Trauma
  • Adverse childhood events (2)
  • A society that values academic pursuits instead of a well-rounded, meaningful spiritual pursuit towards discovering truth and purpose
  • Poor boundaries and a lack of assertiveness
  • Lacking healthy morals

In my clinic I work with mostly young men aged 20-35. Many are what I consider to be “lost”. Lacking meaningful careers, healthy relationships, filled with anxiety, depression and substance abuse.

The focus of understanding the male patient first comes with detailing physiological complaints but often turns into uncovering the life plan or life pattern that the individual is stagnant in, stuck in or struggling to break. It is therefore crucial to help the man see his body is deeply connected to what he surrounds himself with or ingests.

Poor dietary choices and substance misuse are critical to discuss as they often underpin a self-medication process that many men are sucked into in order to cope. This is linked to lacking internal resources and the lack of action on the areas of their life that need attention.

Younger male patients are often unaware of how their behaviours are intricately linked with short term gratification (3). Preferring to engage in behaviours that offer very short term relief through dopaminergic activity (drugs, food, gambling, pornography, spending excessive amounts of money etc). However, this can be a problem that affects men at any age.

Older men tend to live more meaningful lives in terms of family commitments, children and job/career. They are more dominant in manifesting a stronger sense of purpose, responsibility and meaning. But the juggling of such responsibilities can become overwhelming and as such promote a background feeling of instability that men can find difficult to comprehend.

This follows the theory of the ‘U-shaped happiness curve’ (4) which shows data from across the world pointing towards life satisfaction dropping in the age range of 40-50. These also happen to be the years with peak responsibilities when it comes to jobs, finances, children and hobbies. Exhaustion and stress become entrenched within the man who struggles with his demanding work/life balance. Selye’s general adaptation syndrome (5) provides key parts to how the stress response can become overloaded and middle-aged men living a manifested life are easily overburdened around this age.

The “mid-life crisis” plays into this phenomenon of men being unsatisfied in their mid-forties, and seeking other pursuits to alleviate the burden.

At all ages it would seem men have many areas of their life that they consciously or unconsciously do not speak about for reasons such as fear of judgement, ridicule or a general lack of awareness that they need attention.

Humans are innately gifted at using things in their environment to bring about a change. Abuse and/or misuse of foods, medicine and drugs will often feature in a male patient seeking help for mental health problems. It is an important subject to understand here in that the patient is merely seeking a change in their experience of reality by using foods and substances to cope with, change or repress a human sensation or emotion they are struggling to comprehend.

I find that substances play differing roles for men, mainly dependant upon age. Younger men tend to use substances in more social settings as a means to engage with the group. This is predominantly the “party” scene. Large gatherings of people help the individual find more meaning, but they often include substance abuse as a social dynamic.

Solitary substance use tends to be more Cannabis in the younger generation of men. Cannabis is often used for anxiety and insomnia in the home, with stimulants such as cocaine and amphetamine being more favoured when in a group setting. In this case the substances are not necessarily stress related, or due to such a lack of responsibilities, but more associated with escapism.

Substances easily creep in with older men to cope with the increasing demands of a responsible life filled with a mortgage, marriage and children. Excessive Coffee often features in the morning due to poor cortisol awakening response (6), sugary foods during the day due to glucose needs impacted by stress, and alcohol in the evening to switch off and sleep.

Whilst every man is unique in presentation the following protocol is one I use with the most success:

  • Detailed analysis and discussion of childhood experiences, family life, living situation, diet, substance misuse and physiological complaints.
  • Introduction of agreements surrounding action that needs to be worked upon to become more of the man they wish to be.
  • Agreements on changing diet and reducing substance misuse.
  • The withdrawal of substances needs to be aligned with the practitioner attempting to understand what the male patient is using them for (repression of emotions, escapism, social connection, physical pain etc).
  • Herbal treatment should be initially aimed at balancing the autonomic nervous system, fortifying the man’s energy reserves and reducing inflammation. This is often done with tonics, adaptogens, relaxants and anxiolytics.
  • Younger men in their 20’s tend to be needing help to manifest more of the life they want by accepting the meaningful pursuit of responsibility. Herbs that change blood dynamics are more helpful here to break internal stagnancy which will be reflected in their external reality.
  • Older men over 40 tend to need more help with finding calm, peace and a restructuring of the overburdening of responsibilities. Herbs that help reduce inflammation and calm the nervous system tend to be more relevant in this age group.
  • Subsequent treatment should be aimed at working alongside new found goals, visions or thoughts towards a particular challenge, block and project they find meaning in. Nootropics are useful here.
  • In all stages of treatment the consultations should encourage a significant amount of time towards facilitating the man to understand his life is more within his control than what he initially realises. Talking therapy, coaching and herbs are supporting him to become more manifested as a well-rounded and balanced individual.
  • Men are likely to hold onto emotions for fear of judgement. When information is shared or released it is to be celebrated and encouraged by operating through a safe container in which information is received, discussed openly and new perspectives offered. This encourages trust and recognition that the male patient learns is not just acceptable but needed to unburden himself of the psychological weight that carrying around shame, guilt, anger, fear and resentments can bring upon the body.
  • Nootropics are more likely to produce desired affects once inflammation, autonomic nervous system function, gut health and blood pressure have all found a more regulatory nature. I find that giving nootropics too early into treatment will lack the desired outcome.
  • As treatment progresses, remember that the practitioner will produce lasting change by focusing on the life plan resolution and transformation rather than the disease. If you focus solely on the disease and treat only at the physiological level of illness you may not induce the psyco-spiritual changes that assist men to learn how they can master more control of their internal and external reality.

The following herbs are ones I use continuously with my male patients.

Gotu kola (Hydrocotyle asiatica)

  • Actions: Nootropic, anti-inflammatory, brain tonic, warming
  • Used for: Balancing the autonomic nervous system (ANS). Prolonged stress will cause a dysregulation that is perpetuated even at rest. Gotu Kola help stabilise and module the ANS. Helpful for anxiety.
Tulsi (Ocimum tenuiflorum)
Tulsi (Ocimum tenuiflorum)

Tulsi (Ocimum sanctum)

  • Actions: Lung tonic, antidepressant, aromatic, stress relieving, adaptogen
  • Used for: Stagnation in mind and body. It is a highly aromatic herb that focuses on expelling mucus in the lungs and digestion. Perfect for supporting a male patient who is a chronic smoker and/or substance user addicted to behavioural patterns that have caused stagnation.

He shou wu (Polygonum multiflorum radix)

  • Actions: Adaptogen, blood tonic, kidney tonic, alterative, rejuvenative, nervine
  • Used for: Exhaustion and depletion associated with chronic stress. Pain and weakness in the lower back, knees and tendons. A tonic for the adrenals, liver and pancreas.

Maca root (Lepedium meyenii radix)

  • Actions: Boosts fertility, rejuvenative, aphrodisiac, sexual tonic
  • Used for: A native to the high Andean mountains of Peru. It was supposedly eaten by Inca warriors before going into battle as well as being given as a gift to newly married couples (7). Useful for men of any age who are exhausted, suffering with low libido and a general feeling they are severely lacking physiological power.

Damiana leaf (Turnera diffusa folia)

  • Actions: Antidepressant, aphrodisiac, anxiolytic, relieving stress
  • Used for: Improving decision making associated with fear of the unknown. Relaxing the mind and stimulating change.

Wu wei zi (Schisandra chinensis fructus)

  • Actions: Adaptogen, aphrodisiac, nervine, astringent, antidepressant
  • Used for: Originally used by Siberian hunters to improve eyesight, strength and resilience during challenging pursuits. Wu Wei Zi is an adaptogen that has affinity for improving the health of the liver and the vitality of the kidneys. I often use it with male patients who have a lot of repressed anger that needs to be expressed and integrated.

Borage (Borago officinalis)

  • Actions: Adrenal tonic, anti-inflammatory, diuretic
  • Used for: Improving adrenal vitality and regulation. A hyperactive fight or flight response will tax energy levels and Borage is often supportive of improving energy levels, giving the man more resources (energy) with which to take action to bring about further resolution and change.

Rosemary (Rosmarinus officinalis)

  • Actions: Nootropic, antidepressant, stimulates circulation and improves blood flow
  • Used for: Young male patients who are often lazy, lacking motivation and need to create momentum. Rosemary improves blood dynamics which are often stagnant in young men, reflecting a much needed change in behavioural patterns towards creating the life they want.

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How to become a Herbalist https://www.herbalreality.com/herbalism/western-herbal-medicine/how-to-become-herbalist/ https://www.herbalreality.com/herbalism/western-herbal-medicine/how-to-become-herbalist/#comments Wed, 30 Mar 2022 19:17:45 +0000 https://www.herbalreality.com/?p=6636 There are many things to think about when training in herbalism.

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There are many things to think about when training in herbalism, and this article guides you on what to look for to make sure you get the most out of your training.

How to become a Herbalist

There is a growing interest in herbs, herbalism and plant medicine in general. More and more articles appear in the media and on social media, including some ads that pop up claiming to fully train herbalists from £50.00 and in alarmingly short periods of time. It takes time to become a herbalist and even when the training is completed, it is a continuing process of life long discovery and learning.

A plant science professor friend said to me that herbalists are rather unique since we have cross disciplinary learning covering plant sciences, human , clinical knowledge as well as understanding the philosophy of healing. We are a quite unusual people in these times of reductionist and specialist trainings. The interdisciplinary art and science of herbalism gives a worldview that is most valuable for the times we live in.

In this article we will explore the journey to becoming a herbalist practitioner.

“There are people and plants who form part of the  herbal network or web as the mycorrhizal network underpinning the world of plant medicine, and the clinical professional herbalists are like the fruiting bodies that pop up and help to spread and extend the web.” – Andrew Flower

The herbal network includes growers, wildcrafters, manufacturers, educators, historians, researchers, chefs and cooks, scientists, lifelong enthusiasts and also the practitioners. Without the mycelium and supporting biome, the practitioners would not come into being.

With such a diverse ecosystem, there are many ways to be part of it and many paths to be explored and some people decide they do indeed want to become practitioners.

Each person’s journey to becoming a herbal practitioner is highly personal and may be influenced in various ways:

  • Family or community
  • Successful treatment of a condition by a practitioner or someone in the community
  • Reading
  • Botanical gardens or places in nature
  • An enthusiastic teacher at primary or secondary school
  • Workshops
  • Introductory training leading to more in-depth studies
  • Apprenticing to a practitioner

These are some of the things that may kindle an interest in pursuing this vocation.

Anyone who starts to explore the rich ecosystem of herbal healing  will at some point decide whether they are a lay enthusiast or wish to take their learning to a deeper level to become a professional/vocational herbalist.

Many people start with a foundation or introductory course to see if this path is indeed for them and there are some excellent ones such as:

This list of foundation trainings is not exhaustive, there are others of excellent quality and it really depends on what kind of course, teaching methodology and teachers appeal to you. There are also quite a few herbalists running short introductory taster courses in domestic herbalism, gathering or growing herbs.

You can find a list of herbal practitioner schools and courses on our Study herbalism page.

In order to become a herbalist one needs to decide on one’s pathway, although this may evolve and change of time and as one studies.

When choosing where to train, it is important for a person to identify the best fit for them.

Some people like a more reductive biomedical or scientific approach and some prefer a more experiential and relational approach.  It is important to explore the approaches taken by the various training establishments before making a choice.

One also needs to decide on the style of practice and the energetic system they wish to learn-TCM, Ayurveda, Western traditions, ethnic energetics from one’s own cultural background, Biomedical, Psycho-emotional, Relational for example. Some trainings are multifaceted, combining several approaches. There is no single way to practise herbalism so it is important to find what feels right for you.

There are also the practicalities of time available and finding a course structure that fits into your life commitments.

Then there is whether you prefer more online or in person learning, although most of the courses combine a mixture of the two as an adaptation to the times we live in.

Finally, there is the element of  cost.

 Thankfully, these days there is a breadth of training available and many of the schools are now working together to ensure inclusivity, diversity and mutual support between schools to open up student centred learning which helps the student become the kind of herbalist they wish to be and excel at it. It is exciting to see many of the schools collaborating to build a student centred approach with the possibilities of exchanges and decentralisation of learning but with the mentorship and guidance of the chosen ‘home’ school there to support and evaluate progress.

The purpose of undertaking a training is to gain the core competencies needed to be a herbalist of quality and of practitioner capacities.

The core competencies needed to become a proficient herbalist include most, if not all, of the following:

  1. Safety (herbal safety, red flags, drug herb interactions , posology or dosage facts)
  2. Professionalism-legal and ethical practice. Understanding the scope and limit of practice
  3. A knowledge of materia medica, the herbs used in one’s tradition, and sources of sustainable supply of herbs
  4. The capacity to study and integrate evidence from different knowledge sources  including traditional, creative, and scientific. Both literary sources and direct experience
  5. The capacity to assess and diagnose
  6. A knowledge of medicine making, pharmacy, pharmacognosy and dispensing.
  7. Nurturing diversity and inclusivity and developing a culturally appropriate paradigm, including an understanding of the history and politics of plant medicine ( removing erasure, colonialism, commodification and appropriation)
  8. Patient-centred care-integrative and holistic. Acknowledging the importance of physical, emotional, mental and spiritual aspects of wellness. The capacity to offer advice on diet, lifestyle and other factors contributing to health and wellness in an achievable manner taking account of financial, cultural and other factors.
  9. Reflective practice
  10. Practice-based learning
  11. Sustainability-ecological, social and economic
  12. Communication skills
Ashwagandha sustainability (Withania somnifera)

For a person training to be a herbalist there are 2 main options as regards the evaluation of competencies gained.

Most people attend their school/college of choice and work through the programme gaining competencies until they reach their final assessments and graduate.

Other people may have gained competencies in another country or in several locations and therefore their experiential learning needs to be evaluated to ensure they have gained the required competencies.

In the latter case some of the schools offer a bridging training whereby any gaps in studies and competencies are filled rather than having to undertake a complete programme. Alternatively, several of the professional associations offer a grandparenting process to enable those who have not undertaken an accredited course to identify any gaps and give advice on how to fill these to achieve the required level of competencies needed. These processes are often honed to make them more user friendly in many instances.

Along the journey to becoming a herbalist there may be many influences and detours, explorations and experimentations. And when one gets the piece of paper the learning and development does not stop- it is more of a starting point again since there is so much to learn and explore. This is the evolution of the practitioner. It truly is a lifelong journey. Continuing professional development and reflective practice are a valuable and necessary part of the practitioner’s work.

It is also important to check if one can get insurance as a herbalist with the course they choose to embark on. Check if schools are accredited with a verified regulating body and call the school, and insurance companies to be sure. This applies if you plan to take on patients as a practitioner.

Once a person has become a practitioner the next step is to decide how they are going to use their skills and this may change over time. It may also be influenced by how they came to decide to be a herbalist in the first place.

Herbalist Clinical Examinations

Some people choose to have a consulting practice working in a clinic one to one with patients as their entire work.

Others may decide to use their skills in developing products and supplying these OTC either in a shop setting or over the internet.

Some may decide they wish to work with the plants-growing harvesting and processing.

Some go into research whether historical, lab based, ethnobotanical and traditional herbal practice or one of the other fascinating areas of this discipline.

Some go into a more artistic way of working- story telling and writing, drawing, painting, dyeing, fabricating, performance art.

Then there are those who wish to use their knowledge to share information and skills with those who wish to use herbs for the health of themselves, their family and community.  They may run workshops and short course about plant identification, wild crafting, growing herbs, simple medicine making or other skills. They help people learn how to safely harvest and prepare their own domestic remedies from the plants growing around them and also from kitchen materials and ingredients like ginger, cabbage, cinnamon, salt and many more.

Practitioners may work with in their local communities with special interest groups, schools, community gardens, active retirement groups and many other groups to educate and teach safe community herbalism.

By broadening the concept of what a herbalist is from purely a consulting practitioner we see how those who have trained can use their expertise and knowledge to further promote and educate people about the value of our medicine so that we can work towards once again having a herbalist in every community and communities where herbal medicine is seen as a first choice in health care and a vibrant and valuable part of keeping ourselves well and treating disease. All this helps to shift the societal culture forwards to a place where this potentially most sustainable form of medicine is once again central in our culture. This is the way it is for over 60% of the world’s population.

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The rise of herbalism: Why people are turning to nature for medicines https://www.herbalreality.com/herbalism/western-herbal-medicine/rise-herbalism-why-people-turning-to-nature-medicines/ https://www.herbalreality.com/herbalism/western-herbal-medicine/rise-herbalism-why-people-turning-to-nature-medicines/#comments Sun, 06 Mar 2022 16:29:19 +0000 https://www.herbalreality.com/?p=6570 Medicinal plant scientist Rebecca Lazarou dives into why herbal medicines are fast gaining popularity.

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Medicinal plant scientist Rebecca Lazarou dives into why herbalism is fast gaining popularity.

Herbal medicines are fast gaining popularity – but why? Here, medicinal plant scientist Rebecca Lazarou dives into what is causing this shift in paradigm.

The rise of herbalism: Why people are turning to nature for medicines

More and more so in the past couple of decades people have been turning towards natural medicines for their healthcare (1). Herbal medicines generally fall into the “alternative” or “complementary” healthcare sectors.

However these terms can be misleading as for an increasing number of people herbal medicines are their primary form of healthcare. The terms “alternative” or “complementary” are imposed from a hegemonic medical system, in which anything that deviates is implied as lesser than or simply an add-on.  

Anecdotal evidence from herbalism schools shows that the number of applicants to train as herbalists has risen to levels never seen before.

One might even say that plant-based medicines are becoming more and more normalised in society. However it must also be noted that university courses have slowly been closing down over the years, and efforts are needed to reinstate them so that herbal research and longevity can be assured.

There has not been much recent academic research conducted on the general populations use of herbalism during the pandemic, however market research shows use has risen exponentially. Herbal medicine markets global sales are expected to grow from $83 billion in 2019, to a staggering $550 Billion by 2030 (2). Unfortunately this money is not generally falling into herbalists hands, rather it is being generated by often less scrupulous supplement companies. The point here though is that the peak in interest from the public is undeniable and rising rapidly.

Lucy Reed is a PhD candidate researching the use of herbal medicines at Reading University. When asked why herbal medicine use is on the rise she replied

 “Various factors seem to be implicated, for example, television programmes and social media making the field more visible, along with higher incomes to invest in health products and an increase in the training of therapists. In recent (COVID-19) times, lack of access to conventional medicine and a more pressing interest into how we can promote a healthy immune system have also been contributing factors.”

The reasons for the rise in herbalism use are multifaceted. Factors that predict participants’ use of CAM in Western countries include poorer health, specifically chronic health conditions, higher education (3), a life-changing experience that impacted on a person’s world view, spirituality, a commitment to the environment, personal growth, and interestingly, feminism (4).

It has been postulated that the rise in CAM is due to increased anxiety about health across society (4). A national survey conducted in the USA showed that the most significant predictor of CAM use were higher education status followed by overall health status (3). Other reasons include a changing (and more sceptical) perspective of pharmaceuticals and people wanting to use medicines with fewer side effects. Also preventative healthcare is becoming a higher priority for people, and herbal medicines can help massively with this.

There has been an increase in media exposure on the topic of overmedication, with programmes such as “The Doctor Who Gave Up Medicine”, and prominent public figures who are pro “de-medication” such as Dr. Ranjan Chaterjee who advocate “lifestyle prescriptions” (rather than immediately seeking pharmaceutical prescriptions) frequenting popular BBC programmes and popular tabloids. It is well known that there is some public angst around this topic (5) both in informal interviews and on the surveys (6).

Case studies such as the opioid crisis (7) linked to aggressive marketing from certain pharmaceutical companies, have also made people more skeptical of using pharmaceuticals as a first call of action.

A survey shows that people generally prefer to use herbal medicines for illness over pharmaceuticals, in particular for illnesses that are not dangerous (1). However there is a limitation in surveys in that those who are already interested in a topic are more likely to answer, creating a source of bias. 

Shockingly, the third leading cause of death after heart disease and cancer is the side effects of pharmaceuticals. Some of the largest corporate fines in history have been to pharmaceutical companies and corruption has been exposed time and time again. Less than favourable results from research are repeatedly covered up, and data is manipulated for favourable marketing. The results of this have been catastrophic, nonetheless it is legal.

Books such as “Deadly Medicines and Organised Crime: How Big Pharma Has Corrupted Healthcare” by Peter Gotzsche, “Bad Pharma: How Medicine is Broken, and How We Can Fix It” by Ben Goldacre and “Death by Medicine” by Dr Gary Null, go into depth exposing how the industry works. With knowledge like this becoming more commonplace, it is understandable why people are seeking different options for healthcare.

Other factors that may contribute to this trend include the rise in cannabis-based medicines. Products like CBD oil are gracing many shelves on the high street, and perhaps the cannabis industry is a gateway to exploring how plants can affect your wellbeing.

The efficacy of these natural medicines has now become common knowledge to many people, potentially shifting the perspectives of the previously plant-avert.

Plenty of research in this industry has shown the benefits of using extracts which have a multitude of molecules in them, rather than isolated compounds. This is something called the synergy effect, which increases efficacy and safety of a formula.

The industry are marvelling at this exciting new thing to market, as traditionally they focus on one molecule with pharmacological effect. Synergy or the “entourage effect” is heralded at conferences and by brands as a phenomena that is key to quality medicine – ironically this is something herbalists have been shouting about for years! Perhaps the acceptance of this in the scientific community, and by consumers has allowed the door to herbalism to be opened a little wider. Afterall this is how plant medicines work- they all have entourage effects.

Amazingly the psychedelics industry is set to overtake the booming cannabis industry. Fungi such as psilocybin mushrooms (8), and plant formulas such as the Ayahuasca brew are at the forefront of psychiatry and scientific research now. There are countless trials being conducted in the UK, and globally with researcher’s hopeful that such medicines will be available on the NHS in the coming years. Slowly people’s perspectives are shifting from the traditionally dogmatic view that pharmaceuticals best. Perceptions are changing, and therefore so are people’s behaviours and spending habits.

It is important to note that there is no data to support the notion that cannabis and psychedelics are gateways to herbal medicines. However, one thing is clear- people’s perspectives are changing and herbalism, cannabis and psychedelics are paving the way for a shift in the wellbeing paradigm. As well as a need for people to address pervasive mental health issues, there is a growing yearning for people to search for meaning in life.

Whilst it is wonderful that people are turning towards plants for healing, there are many problems this causes too.

“The natural products and herbal supplements field is vast and most people probably still don’t question (let alone know) where the plants in their medicine come from. Many harvesting practices are still unsustainable but it’s often difficult to trace where plants originated. So, while there is a movement towards growing awareness of these issues there are many challenges ahead. “ Lucy Reed

Unsustainable harvesting practises can leave plants near extinct. Rapid booms in a species popularity can lead to very poor quality products, and also the exploitation of workers is a massive issue within the industry. Learn more about some fantastic sustainability initiatives with the United Plant Savers and other articles on Herbal Reality particularly under the Sustainability and Social Welfare section. Other initiatives to protect workers include the Fair Wild foundation, and buying organic is one of the best ways to ensure traceability.

The popularity of herbal medicine is almost certain to continue to rise. Hopefully more holistic healthcare options such as social prescriptions become more commonplace too. Chronic disease is rising, and hberbalism can play a fundamental part in improving people’s quality of life. They can work brilliantly, and are safe- it is understandable why they are gaining popularity. More education is needed amongst the public, doctors, scientists and regulators in order to raise awareness for herbal medicines and increase quality standards.  

When asked about the future of herbal medicines, Lucy replied “I think many people are becoming more aware of sustainability and responsible sourcing as they relate to herbal medicine, and the benefits of using locally harvested plants, as highlighted in publications such as the Business of Botanicals by Ann Armbrecht and the Self Sufficient Herbalist by Lucy Jones. I hope that herbalism can become a truly integrated and sustainable field.

On a global scale, conserving cultural knowledge and skills and at the same time making supply chains more transparent and accountable. Here in the UK I hope that more people who wish to are empowered to grow and/or forage their own medicinal plants – it’s great to see the creation of so many community herb gardens in this respect.”

A sentiment we wholeheartedly agree with!

  1. Lazarou R, Heinrich M. Herbal medicine: Who cares? The changing views on medicinal plants and their roles in British lifestyle. Phytotherapy Research. 2019;33(9):2409-2420. doi:10.1002/ptr.6431
  2. Slice I. Herbal Medicine Market Global Sales Are Expected To Reach US$ 550 Billion by 2030, as stated by insightSLICE. GlobeNewswire News Room. https://www.globenewswire.com/news-release/2021/02/16/2176036/0/en/Herbal-Medicine-Market-Global-Sales-Are-Expected-To-Reach-US-550-Billion-by-2030-as-stated-by-insightSLICE.html. Published 2022. Accessed February 10, 2022.
  3. ASTIN J. Why Patients Use Alternative Medicine: Results of a National Study. Survey of Anesthesiology. 1999;43(3):181-182. doi:10.1097/00132586-199906000-00061
  4. Ritchie M. Use of herbal supplements and nutritional supplements in the UK: what do we know about their pattern of usage?. Proceedings of the Nutrition Society. 2007;66(4):479-482. doi:10.1017/s0029665107005794
  5. Cohen D. How our reliance on opioids may be doing more harm than good. Standard.co.uk. https://www.standard.co.uk/news/uk/the-opioid-timebomb-special-evening-standard-investigation-into-the-overuse-of-prescription-painkillers-a3791051.html. Published 2022. Accessed February 10, 2022.
  6. Hawkes N. Public’s distrust of medicines needs urgent action, says academy. BMJ. 2017:j2974. doi:10.1136/bmj.j2974
  7. Times F. Judge overturns $4.5bn opioid-related settlement in Purdue Pharma bankruptcy. Ft.com. https://www.ft.com/content/9f94d55b-0656-4234-adf5-7a76b3730fc0. Published 2022. Accessed February 10, 2022.
  8. College K. Psilocybin Trials. Kcl.ac.uk. https://www.kcl.ac.uk/research/psilocybin-trials. Published 2022. Accessed February 10, 2022.

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Keeping your lungs healthy https://www.herbalreality.com/herbalism/western-herbal-medicine/keeping-your-lungs-healthy/ https://www.herbalreality.com/herbalism/western-herbal-medicine/keeping-your-lungs-healthy/#comments Sun, 30 Jan 2022 10:13:20 +0000 https://www.herbalreality.com/?p=6308 Shaylee Grant explores what we need to keep our lungs healthy.

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Shaylee Grant explores what we need to keep our lungs healthy.

“For breath is life, so if you breathe well you will live long on earth.” – Sanskrit Proverb

The breath is revered across cultures as a grounding force which ultimately connects us with life, and that marks the beginning and end of life.  We can go for days without water, weeks without food but only minutes without air.

Keeping your lungs healthy

 In Chinese medicine it is where circulating qi is generated, in Ayurveda it is where prana is received. Both of these terms essentially describe our life force. In TCM the lungs are the source of our vitality, and they extract qi from the atmosphere (“heavens”). You can read more about the TCM perspective on respiratory health here, and more about the Ayurvedic perspective on respiratory health here.  

“Heaven’s Qi flows freely to the Lungs”

“The Lungs are the root of Qi” (10 p69)

Every single system in our body relies on oxygen, the breath and therefore our lungs. Effective breathing can have remarkable effects for mental wellbeing, and there are even studies being conducted for using breathwork to deal with PTSD.

It can also help us sleep better, improve immunity and digestion. It is key for regulating our nervous systems, which are vital for mental health and clarity. A healthy respiratory system is key for processing oxygen in our body, as well as removing carbon dioxide and our lungs are the main organ responsible for this. 

“When the breath is unsteady, all is unsteady; when the breath is still; all is still. Control the breath carefully. Inhalation gives strength and a controlled body; retention gives steadiness of mind and longevity; exhalation purifies body and spirit.” – Goraksasathakam

Optimising our breath and respiratory system is critically important for restoring the body and minds harmony. Ayurveda offers practices such as pranayama, and TCM offers Qigong as a way to work with the breath. Breathwork is increasingly popular across Western cultures now too.

The lungs are known as the main organs of the act of breathing. They control the entry of air, without which the body would quickly die. Thus, their function is of great importance to overall health and quality of life.

Beta blockers? 10 herbs to consider

The two lungs sit in the upper third of the thorax. The left lung has two lobes and is slightly larger than the right, which has three lobes. When breathing, the movement between the lungs and the chest wall is facilitated by the pleura.

The lungs contain bronchi (airways) which branch into smaller airways, alveoli, blood vessels, lymph vessels, connective tissue, and nerves. The bronchi not only transport the air, but they also warm and humidify it, while removing particulates. The alveoli are the site of gaseous exchange with the blood.

The natural defences of the lungs include both the innate and the adaptive immune systems. In the upper airway, airborne particles are captured by either the nasal hairs or the mucosa. These particles are either expelled through sneezing, blowing one’s nose, or the mucus is swallowed into the digestive tract.

The particles captured in the lower airways by the mucus there are expelled by the mucociliary escalator, where the small hairs of the respiratory tract beat together to bring mucus up the tract to be coughed or swallowed. The airways also contain a number of anti-microbial chemicals and immune cells to help deal with pathogens.

The lungs have their own closed circulation with the heart, and thus any issue with their health will immediately impact upon the circulatory system. The lungs are also an organ of elimination, as they excrete gaseous acidic waste on the exhalation. Other organs that share eliminatory function are the bowels, kidneys, and skin. If there is a lack of functionality in the lungs, these other systems will experience strain.

Some problems with respiratory health include asthma, COPD, cystic fibrosis, tuberculosis, bronchitis, pneumonia, emphysema and lung cancer. Also pollution effects the lungs, so some extra nourishment can be very helpful for people living in cities.

Food for heart health

It is clear that good nutrition is essential for overall health, and the lungs are no exception. The development of the lungs starts in the third week after conception, and continues until the age of 22. While in development, the foetus must receive sufficient nutrition and oxygen in order to properly develop the lungs.

Otherwise, structural changes occur in the airways that present limited recovery potential (1). In children, the Mediterranean diet with little processed food has been associated with a reduced risk of developing asthma, while the Western diet has been linked to an increased risk (2).

There are a variety of nutrients that support the function of the lungs. Foods such as fruit and vegetables that are high in vitamin C and beta-carotene have been shown to support lung function, as well as fish which is high in omega-3 fatty acids. Additionally, vitamin C, beta-carotene and vitamin E have been shown to reduce phlegm production in the respiratory tract, the over-production of which is involved in a number of respiratory pathologies (3).

Flavonoids, which are found in fruits, vegetables, dark chocolate, wine, nuts, seeds, and most herbs, have been shown to reduce symptoms of asthma. Magnesium may improve the condition of the smooth muscle in the bronchioles, promoting relaxation instead of over-constriction. Vitamin D may also be useful, as a deficiency may lead to a reduced ability to fight off infection (3).

There are environmental factors that contribute to the health of the lungs that must be considered. Air contamination is a concern, especially to those who may have weakened immune systems, children or the elderly. This contamination may come in several forms, such as fungi/mould, dust, smoke, chemical fumes or toxic particles.

Exposure to these contaminants may depend on one’s occupation, lifestyle and/or living situation. These may be linked to the increased urbanisation of the world, and climate change. For instance, ozone is one example of environmental detriments to lung health. Ground level ozone is created when engine gasses and sunlight interact.

This is a phenomenon in urbanised areas and is linked to hospital admissions (4).  The impact of the increasing prevalence of dust storms in the wake of climate change is also being linked to declining respiratory heath (5).

Examples of disease caused by occupational exposure to toxic particulates are silicosis and asbestosis. Silicosis is caused by silicon-containing compounds that people who work in quarrying, mining, stone masonry, glass working, and pottery are commonly exposed to. Silicosis can lead to the development of tuberculosis which leads to further complications. Asbestosis is caused by inhaling the fibres of asbestos, and is found in asbestos miners as well as construction workers who were involved in building works with the material. Asbestos gradually destroys lung tissue (6).

Exercise is supportive of lung health. Exercise is broadly defined, as it can be sport or gardening or cleaning. The general recommendation is to take 30 minutes of exercise.

Exercise strengthens the muscles. If their function is made more efficient, the require less oxygen and produce less carbon dioxide, which reduces the load on the circulatory and respiratory system transporting and excreting these two gasses. Exercise also strengthens the heart, which is in close relationship to the lungs and so benefits pulmonary circulation (9).

Smoking has extremely detrimental effects to lung health. Apart from depositing dangerous tar residues it increases mucus production in the airways, and inhibits the tiny hairs, or cilia, that are key to the function of the mucociliary escalator (7).

This all makes the lungs much more prone to developing breathing difficulties, chronic disease and infection. Smoking is also the cause of most lung cancers and cases of COPD (which encompasses both chronic bronchitis and emphysema) (8).

There are a variety of herbs that can support the lungs, depending on the presenting issue. As most herbs have multiple actions, the following classifications are made for the sake of simplicity, and this is certainly not an exhaustive list. Always consult a medical professional and herbalist if you are experiencing challenges with your lung health.

Elecampane (Inula helenium)
Elecampane (Inula helenium)

Tonics

These support the overall function of the lungs.

  • Elecampane (Inula helenium) has a spasmolytic on the bronchioles and has a long tradition of use in asthma, bronchitis, whooping cough, tuberculosis and pleurisy. 
  • Horsetail (Equisetum arvense)

Expectorant herbs aid the body in excreting excess mucus that may be building up in the respiratory tract. They are divided into warming, relaxing and stimulating.

Warming expectorants

These are used when the lungs are congested and suffering from cold and damp:

  • Ginger (Zingiber officinalis): The classic remedy
  • Cinnamon (Cinnamonum spp): Most often combined with ginger
  • Fennel (Foeniculum vulgare)
  • Aniseed (Pimpinella anisum)

Relaxing or antispasmodic expectorants

Useful where the lungs are tight, wheezing and any cough is dry:

  • Thyme (Thymus vulgaris): Particularly effective at relieving spasmodic coughing though may also help where there are excess levels of mucus
  • Coltsfoot (Tussilago farfara): Generally avoided due to pyrrolizidine content
  • Ma huang (Ephedra sinica): Not available in the USA and restricted in the UK to practitioners
  • Hyssop (Hyssopus officinalis)

Stimulating expectorants

Typically emetics are used in low doses for helping to move stubborn congestion in the base of the lungs:

  • Lobelia (Lobelia inflata): In the UK restricted to practitioners, with additional relaxing properties to provide a rounded effect on the lungs
  • Squills (Scilla spp): A strong emetic mostly used in a syrup
  • White horehound (Marrubium vulgare)
  • Liquorice (Glycyrrhiza spp): Combining a gentle stimulating with demulcent action for a range of lung and cough conditions – a true lung amphoteric!

Demulcents

These herbs help to soothe the respiratory tract in conditions that feel dry and scratchy.

  • Marshmallow (Althea officinalis): For irritated and dry conditions of the airways with unproductive and tickly coughs. Marshmallow can help provide long-term relief in lung infections by allowing time for the inflamed and infected mucosa to heal.
  • Mullein (Verbascum thapsus): Mullein is a wonderfully soothing remedy for the lungs, used to good effect in irritating, hacking coughs with bronchial congestion (flowers have additional stimulating properties)
  • Iceland moss (Cetraria islandica)

Antitussives

Remedies that can suppress a cough – usually because they contain cyanide-producing constituents.

Anticatarral

These herbs help reduce the amount of mucus being produced from the airways.

Immunomodulatory and anti-allergic

These herbs moderate immune function to an appropriate level, if the respiratory tract is being affected by pathogens or hypersensitivity.

Echinacea (Echinacea purpurea)
Echinacea (Echinacea purpurea)
  • Elderberry (Sambucus nigra): Have a specific action in preventing an enzymes produced by the flu virus from attaching to the cilia in the mucosal membranes of the lungs so can be helpful for viral respiratory infections
  • Echinacea (Echinacea angustifolia or purpurea): A useful preventative if you are prone to upper respiratory problems like frequent colds, sore throats, sinuses, middle ear pain, or viral infections like flu
  • Baical Skullcap (Scutellaria baicalensis): Commonly used for asthmatic conditions (especially when associated with secondary bronchitis), hypersensitivity conditions like hayfever and allergic rhinitis. It has a reputation in China of being effective also in acute viral infections of the airways. 
  • Nettle (Urtica dioica): Particularly for allergies that target the respiratory system.
  • Reishi (Ganoderma lucidum): Together with Cordyceps sinensis, G. lucidum has the most extensive range of indications and combines well with it in treatment of lung and liver conditions, as well as to provide all-round adaptogenic support.
  • Cordyceps
  • Black seed (Nigella Sativa): Has been shown to be useful for asthma, allergic rhinitis and other respiratory conditions as it has anti-inflammatory and bronchodilatory effects

Other commonly used herbs:

  • Andrographis: For reducing symptoms in viral respiratory infections including the common cold, flu and sore throat
  • Ashwagandha
  • Astragalus
  • Bibhitaki has astringing and strengthening action on the mucus membranes throughout the body, especially in the lungs
  • Catnip
  • Haritaki
  • Horseradish is also effective against conditions that are characterised by the presence of an obstruction, commonly within the respiratory system. The pungency of horseradish will help to eliminate obstructions and expel them from the body by coughing up
  • Trikatu (Zingiber officinale, Piper longum and Piper nigrum): It is a heating combination that dries mucous secretions and excess phlegm whilst also rejuvenating the lungs.
  • Tusli (Ocimum tenuiflorum): When used as a hot tea, tulsi clears kapha and mucus from the lungs and upper respiratory tract. It is of value in respiratory infections and fever where it reduces temperature by encouraging sweating whilst its penetrating nature clears dampness and toxins.
  •  Vasaka

Most of these herbs can be made into a tea or decoction, except for those restricted to practitioners. They can be used acutely, however the immunomodulatory herbs are often used prophylactically as well. Aromatic herbs may also be used as part of a steam inhalation to bring their antimicrobial benefits into the airways directly, while adding moisture.

There are many types of breath practices that can help with building control over the breath as well as calming the system, which allows for more efficient breathing. There are physiotherapists who specialise in breathing. There are also other practices such as Butyeko, Wim Hoff, pranayama, and Inspirational breathing. Two of our favorite breathwork practitioners are Georgie Lawlor and James from Breathe With James.

  1. Arigliani M, Spinelli AM, Liguoro I, Cogo P. Nutrition and Lung Growth. Nutrients. 2018;10(7):919. Published 2018 Jul 18. doi:10.3390/nu10070919
  2. Berthon BS, Wood LG. Nutrition and respiratory health–feature review. Nutrients. 2015;7(3):1618-1643. Published 2015 Mar 5. doi:10.3390/nu70316184.
  3. Kelly Y, Sacker A, Marmot M. Nutrition and respiratory health in adults: findings from the Health Survey for Scotland. European Respiratory Journal. 2003;21(4):664-671. doi:10.1183/09031936.03.000557026.
  4. Hoffmann D. Medical Herbalism. Rochester: Inner Traditions; 2003.
  5. Schweitzer MD, Calzadilla AS, Salamo O, et al. Lung health in era of climate change and dust storms. Environ Res. 2018;163:36-42. doi:10.1016/j.envres.2018.02.001
  6. Wilson K, Waugh A. Ross And Wilson Anatomy And Physiology In Health And Illness. New York: Churchill Livingstone; 2010
  7. Walker B, Colledge N, Penman I, Ralston S. Davidson’s Principles And Practice Of Medicine. London: Elsevier Saunders; 2014.
  8. Health Effects of Cigarette Smoking. Centers for Disease Control and Prevention. Published 2021. Accessed December 30, 2021.
  9. Your lungs and exercise. Breathe (Sheff). 2016;12(1):97-100. doi:10.1183/20734735.ELF121

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The 3 types of echinacea: A comparison of medicinal actions https://www.herbalreality.com/herbalism/western-herbal-medicine/3-types-echinacea-comparison-medicinal-actions/ https://www.herbalreality.com/herbalism/western-herbal-medicine/3-types-echinacea-comparison-medicinal-actions/#comments Mon, 24 Jan 2022 17:28:07 +0000 https://www.herbalreality.com/?p=6267 Ruth Weaver explores the 3 types of echinacea and their different medicinal actions.

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Echinacea is one of the most popular plants sold over the counter, as it supports the immune system for all sorts of ailments. However there are 3 different species commonly used, all with different properties.

This article explains the difference between them and when it is best to use them.

Echinacea is one of the most widely used and well researched Herbal Medicines today. Most popular for its use in treatment of respiratory infections, such as the common cold, influenza, laryngitis and tonsillitis. It also has a reputation as an immune stimulant, often being used to treat viral symptoms and acute infections by enhancing the immune function (1, 2).

Echinacea (Echinacea purpurea)
Echinacea (Echinacea purpurea)

There are in fact several species of Echinacea, for most of which there has been little to no chemical or pharmacological research, meaning there is very little known about their medicinal potential scientifically. There are three main species of Echinacea used in Herbal Medicine today. Often referenced together in modern herbal literature as ‘Echinacea spp’.

Echinacea is often used by Herbalists in allergic and autoimmune conditions and in management of infections (4, 5). The Echinaceas are sometimes described, maybe more accurately as immune ‘modulators’ rather than ‘stimulators’. An example of what is often seen in herbal medicine – a moderating effect created by a synergy of the active chemistry rather than a singular mechanism created by one isolated compound.

These most well known members of the Daisy (Asteraceae) family are all commonly named under ‘purple coneflower’. These include; Echinacea purpurea (broad leaved or common purple coneflower), E. angustifolia (narrow leaved purple coneflower) and E. pallida (pale purple coneflower).

The most easily cultivated of the three is E. purpurea making it the most widely used today, it is also popular because all parts of the plant can be used (leaf, flower, seed and root). Most preparations of the Echinaceas are made from the roots of the plant.

The Echinaceas are often referenced together with their actions and applications listed in summary under the heading of ‘Echinacea spp’, which would suggest that they can all be used interchangeably. However, this seems possibly to overlook the variations among them that could, under comparison, suggest otherwise.

There are very few reviews available that compare the actions of Echinacea spp, this article hopes to assess the available literature and summarise the known information, in hope to either defining how each of these plants could be best applied or confirming the assumption that they are medicinally interchangeable. First of all, let’s take a look at the basic photochemistry to investigate any possible variations in their chemical composition.

A number of active compounds have been isolated in all three species (1,2,3,4,5). Among all three species there is a unanimous presence of the following compounds;

  • Essential oils, which lend to Echinaceas distinct (and slightly varied) aromatic qualities.
  • Polysaccharides (compounds commonly found to have an effect on the immune system).
  • Sesquiterpenes (common constituents found in the Asteracea or Daisy family that effect the immune system and protect against oxidative stress).
  • Glycosides
  • Inulin
  • Resins
  • Betaine

The three Echinaceas all have phytochemical (biologically active compounds found in plants) similarities as listed above however there are notable variations, particularly around the identity and concentration of some of the key constituents. The table below shows the variation in presence of some of the more notable compounds present in each species;

 E. purpureaE. angustifoliaE. pallida
Alkylamides*******  (largely absent)
Glycosides (Echinacoside) ****
Chicoric acid***  
Cynarin *** 
Polyacetylenes (EO – essential oil)  *** (a distinctive series)
Phytosterols***  
Polysaccharides (Echinacin)*******
Isobutylalkylamines (incl echinacein)*****
Fatty acids (oleic, carotid, linoleic, palmitic).**  

*** strong concentration                                      ** moderate concentration                       *mild concentration

There is a clear variation in presence and concentration of a number of the key active compounds in the Echinacea spp. With this in mind, we can start to gain some understanding of the possible diversity in their effects and medicinal applications by exploring the actions of each of these compounds.

  • Glycosides (echinacoside) were found to be in the highest concentration in E. angustifolia and E. pallida, largely absent in E. purpurea these compounds display antibiotic and anti-microbial activity (4, 5).
  • Alkyladmides, (the compound that produces the tingling in the mouth sensation) are key in Echinaceas immunological activity. These are only present in E. purpurea and E. angustifolia. Alkylamides exhibit immunomodulatory activity (8), an in vivo study found this effect to be seemingly most pronounced in the lungs (9). Many herbalists will say that the presence of the tingling sensation in Echinacea is the sign of a potent and effective medicine.
  • Polysaccharides are present in all three Echinaceas, the highest concentration of them however is found in E. purpurea. Polysaccharides are known for their actions in reducing the ability for pathogens (such as bacteria’s and viruses) to penetrate the tissues. Research shows that Polysaccharide compounds work in a number of ways, enhancing virus specific immune function. The polysaccharide fraction present in all three Echinaceas will therefore play a role in Echinaceas ability to reduce viral replication in early stages of a virus (4, 5).
  • Polyacetylenes (volatile oils) however are only present in E. Pallida, these compounds are powerfully antibacterial and antifungal (4). Research has also found these compounds to exhibit cytotoxic activity (cytotoxic- an agent that may stop cancer cells from dividing and growing and may cause tumors to shrink in size) (6). The Polyacetylenes are also found to have significant anti-inflammatory effects (7).
  • The compound that produces the sharp taste, also responsible for a mild analgesic effect is Isobutylalkylamines (Echinacein), which is shown to be in highest concentration in E. purpurea (4).

In view of the diverse and varied chemical concentrations in each of the three Echinaceas we can see that some unique strengths are held by these plants individually. Chemically E. purpurea and E. angustifolia are most similar, with minor differences in potency and some unique higher concentrations of certain compounds.

By view of the chemistry it may seem that E. pallida is be best applied for infections and inflammations, with a higher presence of antibacterial and anti-fungal compounds. Let’s take a look at what is being said about these three individual plants in the modern and traditional herbal literature.

E. purpurea and E. angustifolia are the most widely available over the counter Echinaceas commercially. Both are widely available in dried or tincture form.

Many herbalists use a combination of E. purpurea and E. angustifolia. This is readily available from herbal suppliers as a 50/50 mix, understandably to benefit from their chemical similarity’s, whilst drawing on their unique strengths, adding more potency to the medicine overall.

Both are also readily available separately, however E. pallida is less available overall. Certainly E. pallida is rarely stocked by herbalist suppliers nor commercially in the West.

It is clear that all three are more than valid in a modern herbalist’s dispensary and certainly in a home apothecary. Perhaps it is that the former two Echinaceas came into the limelight at an earlier point in time, creating a focus on a number of the compounds that they have in common, as there is also significantly less available literature and research on E. pallida.

E. purpurea

Echinacea (Echinacea purpurea)
Echinacea (Echinacea purpurea)

E. purpurea is mildly sweet and sour in taste and is energetically neutralising (both displaying warming and cooling actions). Cooling could be explained by the removal of toxicity (inflammation- heat) from the blood, yet warming by its energetic nature in allowing balanced regulation of blood temperature (2).

Whole plant preparations were shown to be effective in treatment of allergies (4) also modulating the immune function in autoimmunity (5).

E. purpurea is traditionally referred to as a potent blood tonic, both acting on detoxification of the blood and the liver. Enhancing the liver function to remove waste and toxicity, also raises the liver metabolism which enables balanced regulation of blood temperature whilst reducing inflammation in the body (2).

E. angustifolia

With a moderate pungency and mildly bitter tones, E. angustifolia exhibits a cooling effect, much the same as E. purpurea, by its action to detoxify the blood and lymphatic systems (10).

Traditionally E. angustifolia is held in high esteem for use as a blood tonic, specifically in treatment of toxic conditions of the blood. Both elevating the natural defence immunity in the circulation and aiding in the removal of toxins from the blood and lymphatic systems (5, 8, 10).

Applied for both internal and external, viral and bacterial infections, preventing the spread of infection and aiding in repair of tissue damaged by infection (5).

Specific for use in treatment of the common cold, influenza particularly where the lungs are indicated (3), 8).

E. pallida

It seems less common where the Echinaceas are discussed within modern herbals to find separate information about E. pallida, although it is almost always included under the generalised information about the Echinacea spp. In cases where the Echinaceas are discussed in separate monographs, often the focus seems to set either upon E. purpurea or E. angustifolia, but rarely E. pallida alone.

However, in the limited information available E. pallida is often referred to as most specific in supportive treatment for influenza and the common cold (11). Reducing the symptoms and lessening  the duration of upper respiratory tract infections (12). In view of the chemical composition as listed above, it was also seem E. pallida could hold some value in supportive treatment of cellular abnormalities and cancer, in an integrated approach with other treatments, and also in bacterial and fungal infections (6).

Echinacea is safe for most people, including those with immune problems, though it is wise to avoid if on strong immunosuppressive prescriptions. 

Echinacea is in the Asteraceae plant family, and occasionally people exhibit allergic reactions to plants in this family (including daisies and chamomile). If a child has a known allergy to this plant then it is best to avoid giving them echinacea. 

In 2012 a warning was issued by the MHRA that as a precautionary measure the remedy echinacea should not be given to children under 12 years old, due to a small risk of a severe allergic reaction which outweighed any benefits (5). 

However, since this time, there has been research demonstrating the significant benefits of echinacea for children in reducing RTI’s and subsequent antibiotic use with minimal allergic reactions within the study group (6). This was based on a specific extract of echinacea, but suggests that unless there is a specific known allergy to this plant family then echinacea can have many benefits to children’s immunity.

Many herbalists use a combination of E. purpurea and E. angustifolia. Seemingly the combination of these two plants in a medicine creates a good balance of the most desirable compounds, at least in terms of immunological activity. Creating a medicine with potent anti microbial and antiviral action, that can be used broadly.

All three Echinaceas clearly hold great value in treatment of respiratory tract infections. Perhaps E. purpurea and E. angustifolia more specifically for their immunomoduatory effects, blood conditions and infections.

Where E. pallida is possibly most appropriate for management of milder respiratory tract infections, and fungal infections. There could also be a case, given the chemical similarities of E. angustifolia  and E. pallida for combining the two to access higher overall concentrations of antibiotic compounds, creating a higher potency for the treatment of bacterial and fungal infections.

On review of the available pharmacological and traditional data on each plant, it is not entirely possible to conclude on separate applications for these medicines, however it is clear that they are all highly valuable medicines for treatment of infections. Perhaps they can all lend to each other in combination where required, adding to their strengths to create a more potent overall effect. Many herbal medicines are enhanced or altered by combining with other plants and it seems clear that the Echinaceas are no stranger to this notion.

As ever when working one to one with a patient, a herbalist will create a tailored approach, where the full picture of health and imbalance can be addressed, combining herbs that best suit the constitution and circumstances of the individual to create a lasting resolution. Check out our page where to find a herbalist.

If nothing else, the differences in chemical concentrations among the Echinaceas may suggest a case for an enhancing companionship between them, on the basis of what is being addressed in the individual case, selecting herbs that harmonise to best support the specific presentation of the patient.

  1. Bone, K. and Mills, S. (2013). Principles and practice of Phytotherapy modern Herbal Medicine. 2nd ed. Edinburgh Churchill Livingstone, Elsevier.
  2. Kenner, D. and Yves Requena (2001). Botanical medicine : a European professional perspective. Brookline, Mass.: Paradigm Publications.
  3. Spelman, K. (n.d.). Echinacea spp.: A Monograph & What’s New. [online] Available at: https://www.americanherbalistsguild.com/sites/default/files/spelman_kevin_-_echinacea_update.pdf.
  4. Mills, S.Y. (1993). The Essential Book of Herbal Medicine. Editorial: Penguin.
  5. Hoffmann, D. (2003). Medical Herbalism – principles and practices. Inner Traditions Bear And Comp.
  6. Chicca, A. et al (2008). Cytotoxic activity of polyacetylenes and polyenes isolated from roots of Echinacea pallida. British Journal of Pharmacology, [online] issue 153(5). Available at: https://pubmed.ncbi.nlm.nih.gov/18193076/ [Accessed 18 Jan. 2022].
  7. Feizlmayr, E. et al. (2009). Polyacetylenes and polyenes from Echinacea pallida and their anti-inflammatory activity in vitro. Planta Medica. Issue 75. volume 9.
  8. Cech, N. et al. (2006). Liver Enzyme-Mediated Oxidation of Echinacea purpurea Alkylamides: Production of Novel Metabolites and Changes in Immunomodulatory Activity. Planta Medica, issue 72. Volume 15.
  9. Goel, V. et al. (2002). Alkylamides of Echinacea purpurea stimulate alveolar macrophage function in normal rats. International Immunopharmacology,  Volume 2. Issue 2-3).
  10. Frawley, D. and Vasant Lad (2016). The yoga of herbs : an Ayurvedic guide to herbal medicine. Delhi: Motilal Banarsidass.
  11. British Herbal Medicine Association. Scientific Committee (2003). A guide to traditional herbal medicines : a sourcebook of accepted traditional uses of medicinal plants within Europe. London: British Herbal Medicine Association.
  12. Government of Canada, H.C. (2004). Monograph. [online] webprod.hc-sc.gc.ca. Available at: http://webprod.hc-sc.gc.ca/nhpid-bdipsn/monoReq.do?id=79&lang=eng.
  13. 13. Pizzorno J, Murray M, Joiner-Bey H, The Clinician’s Handbook of Natural Medicine. 2nd ed. St Loius, Missouri: Churchill Livingstone Elsevier; 2008. 
  14. 14. F, Paparo L, Nocerino R. et al. Specific gut microbiome signatures and the associated pro-inflamatory functions are linked to pediatric allergy and acquisition of immune tolerance. Nat Commun, 12:5958;2021. https://doi.org/10.1038/s41467-021-26266-z 

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The history of ephedra: A powerful lung medicine from China https://www.herbalreality.com/herbalism/history/history-ephedra-powerful-long-medicine-from-china/ https://www.herbalreality.com/herbalism/history/history-ephedra-powerful-long-medicine-from-china/#comments Thu, 06 Jan 2022 16:46:53 +0000 https://www.herbalreality.com/?p=5999 Ethnobotanist Jason Irving explores ephedra's use as a treatment for asthma.

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Ephedra is a powerful plant used to support lung health. Molecules from it have been the basis for pharmaceuticals, and the plant is now only legally allowed to be prescribed by herbalists. This article explains the fascinating history behind the plant and its medicinal use.  

Ma Huang is a plant used in Traditional Chinese Medicine (TCM) for a wide range of conditions and is most famous today as a treatment for asthma. The plant drug consists of the aerial parts – leaves, stems, flowers – of several species of Ephedra, particularly Ephedra sinica.

The isolated chemical ephedrine is popular as a drug to enhance athletic performance, promote weight loss, and relieve colds and flu. When it was first discovered its main use in pharmacy was as a bronchodilator to open up the airways of asthma sufferers.

The use of Ma Huang to suppress cough can be traced back to the oldest written record of Chinese medicinal plants. This article explores the history of the use of ephedrine and Ma Huang as a bronchodilator, and how the effects can be understood through both the lenses of chemistry and physiology, and traditional Chinese philosophies of healing.

The history of ephedra: A powerful lung medicine from China

Ephedra species have been found in the fossil record going back 125 million years, when dinosaurs still walked the earth (1).There are around 71 species of ephedra recognised by current taxonomy, with a wide distribution through most of Asia and Europe, North Africa and the Horn of Africa, and the Western sides of South and North America (2). It is the only genus in the family Ephedraceae.

The botanical classification of this group of plants has been particularly difficult there are many close similarities in appearance between species. Ephedra species mostly grow as shrubs, consisting of long slender green stems that can photosynthesise. Their leaves appear as small scales on the stem and often turn brown and drop off.

Ephedra spp. have been confused with very ancient group of plants, the horsetails (Equisetum spp.) both historically and more recently in the herbal medicine trade (3).Market surveys today have found several species of Ephedra are sold as Ma Huang, sometimes differentiated as varieties of Ma Huang, but not always (4).

Ephedra sinica is the species most widely used for its medicinal properties. This species is found growing wild in Mongolia, Southern eastern provinces of Russia and in Northeastern China (5). While ephedrine is the most well known constituent, it contains 6 other structurally similar alkaloids in lesser concentrations with similar effects. Not all Ephedra species contain ephedrine type alkaloids (6).

The drug Ma Huanghas always been defined in Chinese Materia Medica texts as the aerial parts of several species of Ephedra. The less commonly used root of Ephedra spp. is known as Ma Huang Gen, which has long been seen as acting in opposition to the aerial parts; for example being prescribed “for checking excessive perspiration of a weak patient” (7). This traditional understanding has been corroborated by studies showing that chemicals that cause blood pressure to lower are only found in the root (8).

Ma Huang has been traded from China to Japan from at least the 16th century, where it was incorporated into Japanese herbal medicine as a treatment for colds and flu in a combination with four to six other herbs known as Maoto, based on the Chinese formulation Ma Huang Tang (9).

Ephedra berries

The active chemicals of Ma Huangwere first isolated in 1887 by a professor at Tokyo University, Nagajosi Nagai. Of particular interest was a new chemical that was named after the plant as ephedrine.

However, it was not until 1923 that researchers at Peking Union Medical College, K.K. Chen and Carl Schmidt, began investigating in detail how it could be used as a drug (10). They found that ephedrine acted in a very similar way to adrenaline, though with a milder, but longer lasting, effect (11).

Adrenaline, also known as epinephrine, is a hormone produced in the adrenal glands above the kidneys that acts as an essential messenger in the fight or flight response – this is how the body prepares itself to deal with a potentially dangerous situation.

Adrenaline helps stimulate a range of changes including increased heart and breathing rate, slowing down digestion, releasing energy sources into the blood, dilation of blood vessels to the muscles, constriction of peripheral blood vessels, central nervous stimulation and bronchodilation. This response is coordinated by the sympathetic nervous system, that is why ephedrine is classed as a ‘sympathomimetic’ as it mimics the body’s natural messenger chemicals to activate receptors of this system.

Because of this effect ephedrine has become a popular drug for athletes to improve performance. It has also been used as a weight loss drug because it suppresses appetite and increases the rate that fat tissue uses and releases energy. It is also widely used in combination with caffeine in over the counter cold and flu remedies for opening nasal passages to relieve sinusitis (12).

However, care should be taken in dosage and duration of use, especially if taking any other medications that produce similar effects. It can lead to anxiety, restlessness, insomnia and a tolerance develops, and in extreme cases of improper use has caused heart attack and stroke. (13)

Both Ephedra spp. and ephedrine should not be taken by people with hypertension, diabetes, hyperthyroidism orglaucoma (14). Because of these concerns there have been bans imposed on the use of ephedrine in sports and weight loss supplements by various regulatory bodies around the world.

Ephedra berry
Ephedra berry

Of particular interest for respiratory health is the bronchodilatory effect of ephedrine (15).When you breathe in air enters through the mouth and down the trachea, which divides into the left and right bronchi to enter the lungs, the bronchi further divide into many bronchioles, which then divide to join the many alveoli where gas exchange takes place.

People suffering from asthma experience a tightening of the bronchioles causing coughing, wheezing and shortness of breath. The bronchi and bronchioles are lined with smooth muscle, which relaxes and opens up in response to adrenaline and ephedrine, this bronchodilatory effect relieves the symptoms of asthma.

While adrenaline had been used for treating asthma it had significant issues: it had to be injected, its effects were short lived, and it was chemically unstable.

Ephedrine solved all these problems, leading to excitement amongst physicians in Europe and the USA, where it was widely adopted for treating asthma from 1926 the 1950s (16). Work on adrenaline led to the synthesis in the laboratory of several similar chemicals, one of which was salbutamol which became the next main treatment for asthma.

When used as an asthma treatment, and for Chronic Obstructive Pulmonary Disorder (COPD), ephedrine was commonly combined with two weaker bronchodilators: caffeine and theopylline, chemicals which were also isolated from a Chinese herbal medicine: tea (Camellia sinensis) (17).

The History of Ma Huang
Figure 1: Shen Nung seated on a rock, wearing simple garments fashioned from leaves, holding a small plant; a selection of roots and plants are also shown on a ledge by his side. Watercolour, China, 1920. (21)

According to legend, the mythological Chinese ruler Shennong (神农) discovered the medicinal effects of tea when tea leaves from the twigs in his fire were carried up the hot air into his pot of boiling water.  This was just one of the hundreds of herbs he tested on himself to identify their properties and taught people their uses, along with the practice of agriculture.

He is credited with writing The Shen Nong Ben Cao Jing (神农本草经), the oldest surviving written record of Chinese materia medica, thought to have been compiled in the 1st or 2nd Century CE. It is variously translated to English as The Divine Farmer’s Materia Medica, The Herbal Classic of the Divine Farmer, or Divine Husbandman’s Classic of the Materia Medica (18,19,20).

This text has been continously referred to in texts on Chinese materia medica ever since, and many of the uses of herbs it describes are still employed today(22). It covers 365 herbs in total, corresponding to the natural cycle of days in a year, that are divided into three scrolls:

“120 ‘upper’ (shang) herbs, which can be taken daily to lengthen the lifespan; 120 ‘middle’ (zhong) herbs, which can be taken to prevent and hold back illness; and 125 ‘lower’ (xia) herbs which treat illness, are mostly toxic and should not be taken for a long time(23)”.

Ma Huang appears on the ‘middle grade’ scroll, which would match with the use of Ephedra spp. today – the use of ephedrine for acute infections only, and not longer term use for general health such as athletic training and weight loss.

The text describes Ma Huang as:

“bitter and warm. It is nontoxic, treating mainly wind stroke cold damage, headache, and warm malaria. It effuses the exterior [through] sweating, eliminates evil heat qi, suppresses cough and counterflow qi ascent, eliminates cold and heat, and breaks concretions and hardness, accumulations and gatherings. Its other name is Long Sha (Dragon Sand). It grows in rivers and valleys.”

Figure 2: Print from the 1833 text ‘Theory of diseases treated with ephedra decoction’ (29)

The translator notes that a renowned scholar, known as ‘Chancellor in the Mountains’, Tao Hong-jing (452-536 CE) later wrote, “Ephedra is the first choice in treating cold damage and resolving the muscles” and that, combined with “Sinnamon Twig, Armeniaca, and Licorice” it “may effect the cure of a tai yang pattern of wind cold in the exterior with pain and stiffness in the head and back of the neck, fever, generalized joint pain, a floating, tight pulse, absence of sweating, chest fullness, and panting”(24).

This is perhaps the first description of the Ma Huang Tangformulation that became so poular for respiratory infections, consisting of: Ma Huang (aerial parts of Ephedra spp.), Gui Zhi (twig of Cinnamomum spp.), Xing Ren (kernel of fruit of Prunus armeniaca) Can Gao (root of Glycyrrhiza spp.).

Writing 1,000 years after Tao Hong-jing, Li Shizhen (25) compiled a Compendium of Materia Medica, the Pents’ao Kang Mu, including 1,900 substances and referencing 900 previous works, critiquing them where necessary. Like his father and grandfather before him he travelled the countryside as a physician, both treating people and learning remedies from them.

Ephedra is described and recommended for stimulating circulation, as a diaphoretic (to induce sweating) and antipyretic (to prevent or reduce fever). According to contemporary TCM herbalists Chen and Chen in the text “It was also believed to be useful in the treatment of cough and as a result the stem became an important ingredient of many antitussive preparations.” (26).

Which they do themselves in their indications for Ma Huang: “Relieves Wheezing and Dyspnea, Stops Cough Wind-cold constriction of the Lung leading to Lung qi reversal: Ma Huang ventilates Lung qi and is useful in treatment of wheezing, dyspnea and cough characterized by wind-cold attacking the exterior that leads to abnornormal rising of Lung qi.” (27).

Ephedra
Ephedra

As is so often the case, exploring the history of this herbal medicine indicates it has been used for a range of conditions on its own and in combination with other herbs, and that fully understanding these uses requires detailed knowledge of philosophies of healing of the time.

Seen through a contemporary biomedical lens, some connections can be made between these texts and the studied effects of ephedrine. The focus on sweating and treating cold and resolving the muscles can be linked to the increased blood flow to the muscles caused by ephedrine.

From the mention of ‘suppressing cough’ and curing ‘chest fullness and panting’ in the The Herbal Classic of the Divine Farmer (Ben Cao Jing) we can assume it was used for treating conditions that we today would classify as asthma. This indication can be found throughout the history of writing on the materia medica of TCM, though it is important to note that it is normally accompanied by a detailed discussion of the cause of the disease and the particular manifestation in specific patients.

A full understanding of these aspects requires a detailed knowledge of the healing principles of TCM, from the concept of the flow Qi, generally translated as ‘life force’, the elements and their relation to the organs, and the importance of the tastes of herbs, and how these combine. Asthma, cough and shortness of breath have many manifestations that will be caused by the interplay of environmental, internal, physical and emotional causes.

Based on research on ephedrine, a standard European reference on herbal medicines understands Ma Huang in biomedical terms as vasoconstricting, bronchodilating, and central [nervous system] stimulating properties (28).

However, like many herbal medicines the chemical constituents of the whole herb are not fully characterised or understood, and these may also aid in managing asthma, coughs and colds. For example research on Ephedra sinica shows it contains chemicals that have anti-inflammatory, anti-bacterial, anti-fungal, antioxidant and anti influenza effects that could explain other ways the herb extracts can work in treating respiratory infections (29,30).

Ephedra is just one example of a medicinal plant with rich history, that’s traditional uses can now partially be explained by modern science. This plant can only be prepared and prescribed by licensed herbalists, due to its potential side effects. We really recommend seeing a herbalist for a personalised treatment plan for all sorts from respiratory health to other ailments. You can find one on our resources page here.

  1. Ickert-Bond, S.M., Rydin, C. and Renner, S.S., 2009. A fossil‐calibrated relaxed clock for Ephedra indicates an Oligocene age for the divergence of Asian and New World clades and Miocene dispersal into South America. Journal of Systematics and Evolution, 47(5), pp.444-456.
  2.  Plants of the World Online. Facilitated by the Royal Botanic Gardens, Kew. Published on the Internet; https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:328160-2 Retrieved 02 Jan 2022.
  3. Yoshizawa, C., Kitade, M. and Mikage, M., 2005. Herbological studies on Chinese crude drug Ma-huang. Part 1-On the botanical origin of Ma-huang in ancient China and the origin of Japanese Ma-huang. Yakushigaku zasshi, 40(2), pp.107-116.
  4. Hu, S.Y., 1969. Ephedra (Ma-huang) in the new Chinese materia medica. Economic Botany, pp.346-351.
  5. Plants of the World Online. Facilitated by the Royal Botanic Gardens, Kew. Published on the Internet; https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:383460-1 Retrieved 02 Jan 2022
  6. Abourashed, E.A., El‐Alfy, A.T., Khan, I.A. and Walker, L., 2003. Ephedra in perspective–a current review. Phytotherapy research, 17(7), pp.703-712.
  7. Hu, S.Y., 1969. Ephedra (Ma-huang) in the new Chinese materia medica. Economic Botany, pp.346-351
  8. Tamada M, Endo K, Hikino H, Kabuto C. 1979. Structure of Ephedradine A, a hypotensive principle of Ephedra roots. Tetrahedron Lett 10: 873–876.
  9. Yoshino, T., Arita, R., Horiba, Y. and Watanabe, K., 2019. The use of maoto (Ma-Huang-Tang), a traditional Japanese Kampo medicine, to alleviate flu symptoms: a systematic review and meta-analysis. BMC complementary and alternative medicine, 19(1), pp.1-11.
  10. Lee, M.R., 2011. The history of Ephedra (ma-huang). JR Coll Physicians Edinb, 41(1), pp.78-84.
  11. Chen, K.K. and Schmidt, C.F., 1926. The action and clinical use of ephedrine: an alkaloid isolated from the Chinese drug Ma Huang. Journal of the American Medical Association, 87(11), pp.836-842.
  12. Abourashed, E.A., El‐Alfy, A.T., Khan, I.A. and Walker, L., 2003. Ephedra in perspective–a current review. Phytotherapy research, 17(7), pp.703-712.
  13. Lee, M.R., 2011. The history of Ephedra (ma-huang). JR Coll Physicians Edinb, 41(1), pp.78-84.
  14. Abourashed, E.A., El‐Alfy, A.T., Khan, I.A. and Walker, L., 2003. Ephedra in perspective–a current review. Phytotherapy research, 17(7), pp.703-712; Chen, J.K., Chen, T.T. and Crampton, L., 2004. Chinese medical herbology and pharmacology (Vol. 1267). City of Industry, CA: Art of Medicine Press.
  15. Barnes, J., Anderson, L.A. and Phillipson, J.D., 2003. Herbal medicines: a guide for healthcare professionals (No. Ed. 2). pharmaceutical press. p.244
  16. Lee, M.R., 2011. The history of Ephedra (ma-huang). JR Coll Physicians Edinb, 41(1), pp.78-84.
  17. Schultze‐Werninghaus, G. and Meier‐Sydow, J., 1982. The clinical and pharmacological history of theophylline: first report on the bronchospasmolytic action in man by SR Hirsch in Frankfurt (Main) 1922. Clinical & Experimental Allergy, 12(2), pp.211-215
  18. Daniel, Gillian, 2015. The Legend of the Divine Farmer. Public Domain Review. Published 03 Nov 2015. Retrieved 02 Jan 2022 https://publicdomainreview.org/essay/the-legend-of-the-divine-farmer
  19. Nugent-Head, J., 2014. The First Materia Medica: The Shen Nong Ben Cao Jing. Journal of Chinese Medicine, (104).
  20. Evans, L., 2017. Reading of the Divine Farmer’s Classic of Materia Medica: Shen Nong Ben Cao Jing Du. The Journal of Chinese Medicine, (114), pp.64-65.
  21. Shen Nung seated on a rock, wearing simple garments fashioned from leaves, holding a small plant; a selection of roots and plants are also shown on a ledge by his side. Watercolour, China, 1920?. Wellcome Collection. https://wellcomecollection.org/works/z5w9zzbf/images?id=z9szdx4b . Published 1920. Accessed January 6, 2022.
  22. Chen, J.K., Chen, T.T. and Crampton, L., 2004. Chinese medical herbology and pharmacology (Vol. 1267). City of Industry, CA: Art of Medicine Press.
  23. Nugent-Head, J., 2014. The First Materia Medica: The Shen Nong Ben Cao Jing. Journal of Chinese Medicine, (104). p.24
  24. Yang, S., 1998. The divine farmer’s materia medica: a translation of the Shen Nong Ben Cao Jing. Blue Poppy Enterprises, Inc.. pp.51-52.
  25. Li, M. and Liang, Y., 2015. Li Shizhen and The Grand Compendium of Materia Medica. Journal of traditional Chinese Medical Sciences, 2, pp.215-216.
  26. Chen, J.K., Chen, T.T. and Crampton, L., 2004. Chinese medical herbology and pharmacology (Vol. 1267). City of Industry, CA: Art of Medicine Press. p.14
  27. Chen, J.K., Chen, T.T. and Crampton, L., 2004. Chinese medical herbology and pharmacology (Vol. 1267). City of Industry, CA: Art of Medicine Press. p.36
  28. Barnes, J., Anderson, L.A. and Phillipson, J.D., 2003. Herbal medicines: a guide for healthcare professionals (No. Ed. 2). pharmaceutical press.
  29. Theory of diseases treated with ephedra decoction, Chinese. Wellcome Collection. https://wellcomecollection.org/works/pxhq48mb . Published 1833. Accessed January 6, 2022.

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Winter warmers: Aromatherapy for respiratory health in cold and flu season https://www.herbalreality.com/herbalism/western-herbal-medicine/winter-warmers-aromatherapy-for-respiratory-health-cold-flu-season/ https://www.herbalreality.com/herbalism/western-herbal-medicine/winter-warmers-aromatherapy-for-respiratory-health-cold-flu-season/#comments Sat, 11 Dec 2021 16:23:30 +0000 https://www.herbalreality.com/?p=5925 Aromatherapist Ellen Rowland explores how essential oils directly affect the respiratory system.

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Aromatherapist Ellen Rowland explores how essential oils directly affect the respiratory system.

Winter warmers: Aromatherapy for respiratory health in cold and flu season

The winter months often present a challenge for our respiratory health, whether there’s a pandemic happening or not. Viral illnesses such as colds and flu, as well as their accompanying bacterial infections, can cause blocked noses, chest infections and difficulty breathing. All this can make these darker, chillier months even less pleasant to bear than usual!

What’s to blame?

Whilst colder temperatures are not the sole cause of our common winter illnesses, they can play a contributing role.

However, in the northern hemisphere, it’s generally accepted by health professionals that the lack of sunlight we experience during winter, and the subsequent reduction in Vitamin D that this can cause, is a primary cause.

Lack of Vitamin D can significantly reduce our body’s immunity, and therefore our resistance to diseases (1).  Couple this with more time spent indoors and colder, drier air which might make it easier for viruses to survive, and there you have it – the perfect cocktail of conditions for the transmission of coughs, colds and flu, and their associated pathogens (2).

Whilst we can’t avoid acute respiratory illnesses such as colds and flu 100% of the time, there are actions we can take to make sure that we’re best placed to fight off the germs come winter and prevent longer-term, chronic respiratory conditions. The American Lung Association (27) and Harvard Health (28) recommend these tips for optimum lung health:

  • Don’t smoke: Avoiding smoking helps us minimise the risk of developing chronic lung conditions such as COPD,  and also helps us protect against the risk of developing chronic inflammation which can lead to chronic bronchitis.
  • Where possible, avoid exposure to pollutants, indoors and out. Pollutants can damage lung tissue and make us more vulnerable to disease.
  • Take steps to prevent infection: The COVID-19 pandemic has taught most of us the importance of protecting ourselves and others from infection. Simple things like ventilating indoor spaces, regular hand-washing with soap and water, or using a 70% alcohol-based sanitiser, are excellent ways to prevent infection.
  • Regular exercise: This helps keep our lungs healthy and can strengthen our immune system, too.
  • Get some sleep: Those who sleep less than 7hrs per night are up to three times more likely to become infected with rhinovirus (the common cold)! (29) So make sure you’re getting enough and your chances of becoming infected will be significantly reduced.

Unfortunately, even the best prevention strategies aren’t always fool-proof at preventing infection. Stress, lack of sleep, and coming into contact with others who might be infected aren’t always avoidable. Whilst there are plenty of over-the-counter pharmaceuticals to choose from, it’s clear that Aromatherapy has a large part to play in supporting our respiratory health.

Essential oils, when applied topically via lotions, ointments or balms, enter the body via the skin, then the bloodstream. They also reach the brain indirectly, via the olfactory system. The respiratory system, in contrast, is directly influenced by essential oils.

The volatile nature of the aromatic phytocompounds found in essential oils means that they are easily inhaled, and can reach both the upper and lower respiratory tracts, which means that aromatherapy by inhalation has a particularly powerful effect on the respiratory system. It is one of the safest and most effective ways to use essential oils for respiratory health (3).

Aromatherapists use a wide range of tools, oils and treatments to help support their clients with respiratory health over the winter, but firstly it helps to understand a little more about some common respiratory illnesses so that we can make sure to choose the most appropriate and effective treatment for the condition in question. Whilst there are a whole host of respiratory pathogens to explore, these acute conditions are typically the most common in winter in the northern hemisphere.

The common cold

An infection of the nose, throat and sometimes ears, this viral upper respiratory tract infection is probably familiar to most of us. Symptoms can include sneezing, coughing, a runny nose, sore throat, body aches, and fatigue (4). Recovery time can range from a few days to more than a week, and whilst there isn’t a cure for a cold, there are several aromatherapeutic interventions that we can use to ease symptoms and alleviate discomfort and pain.

Influenza (flu)

Another virus which most of us will be familiar with. Like the common cold, this virus infects the ears, nose and throat, but also the mouth and lungs – so affects the lower respiratory tract, too. Symptoms can be much more severe and can last for several weeks. Body aches, a fever, headaches, sore throat, a cough and even vomiting or diarrhoea can accompany flu (5).

Bronchitis

A potentially severe bacterial infection, often triggered by cold or flu viruses. Smokers and those with sinusitis, allergies, enlarged tonsils or adenoids are particularly prone to bronchitis. The main symptom is an ongoing cough, which is often mucous-producing. Sufferers may also experience body aches, a headache, shortness of breath and wheezing (6).

Before approaching treatment, it’s important to consider that each essential oil is made up of hundreds of different phytochemicals, all with different effects on the body (7). Whilst some aromatherapists may group these compounds into broad chemical groups with different properties and benefits in each, it is generally considered best practice not to apply a “one size fit all” approach when considering an essential oil’s uses, or treating an individual.

After all, as in many schools of herbal medicine, the aim is to treat the whole person, and not just the symptoms. Depending on the unique circumstances surrounding the illness, along with other lifestyle factors and tendencies unique to the person, the treatment, and oils used, will change.

Equally, considering an essential oil holistically, instead of reducing it to its individual compounds, is recommended. It’s worth noting that some essential oils work synergistically together (8), with altogether more powerful effects on the body, and therefore we should consider choosing oils in combination with each other for maximum benefit.

Physical actions

A single essential oil can have a wide range of properties and actions, depending on the balance of its numerous active compounds. Depending on the condition, it may be helpful to choose oils that have a combination of the following actions on the body and mind, so they can work synergistically to address common winter illnesses. Most of the oils detailed below are recommended for inhalation blends, though where topical application is recommended, this is noted.

Mint (Mentha x piperita)
Mint (Mentha x piperita)

Antispasmodics, antitussives

Essential oils with antispasmodic or antitussive actions will help to address muscle spasms, for example, those resulting from persistent coughs, and may help to reduce symptoms. Peppermint (Mentha piperita) essential oil, for example, has been shown to have antispasmodic actions in the trachea of rats. (9)

Antibacterial

Inhaling oils that are antibacterial can support recovery from bacterial infection, such as bronchitis. Antibacterial oils include Peppermint (Mentha piperita) (see safety note above), Thyme (Thymus vulgaris), Pine (Pinus sylvestris) (12,13).

Antiviral

Antiviral oils, when inhaled, can help protect against and aid recovery from some viral infections. Powerful antiviral essential oils include Eucalyptus (Eucalyptus globulous), Ginger (Zingiber officinalis) and Black Pepper (Piper nigrum) (14,15).

Anti-inflammatory

Herbs that are anti-inflammatory in nature can help to calm swelling and redness, for example, in the case of a sore throat caused by infection or repeated coughing. Anti-inflammatory herbs include Lavender (Lavandula angustifolia) and Chamomile (Matricaria recutita). Whilst ingesting essential oils is not advised, taking an anti-inflammatory, aromatic herbal tea blend (if safe to do so) can be a brilliant way to support an aromatherapeutic inhalation treatment that focuses on other symptoms. 

Lavender (Lavandula angustifolia) and Chamomile (Matricaria recutita) are both excellent anti-inflammatory herbs that make great infusions and may be accompanied with a demulcent (soothes mucous membranes) herb such as Marshmallow root (Malva sylvestris) to help relieve a sore or irritated throat (16).

Decongestant, expectorant and mucolytic

Using expectorant (expels mucous), decongestant (clears airways) and mucolytic (breaks down mucous) essential oils in an inhalation blend can be an effective way to break down and expel excess mucous and relieve blocked noses and chesty coughs. Oils with these properties include rosemary (Salvia rosmarinus) and Spanish marjoram (Thymus mastichina).

Febrifuge

Oils that can help to bring down a high temperature with their ‘cooling’ and anti-inflammatory actions are known as febrifuge and include Palmarosa (Cymbopogon martinii), a sweet, rosy-lemon scented oil, peppermint (Mentha piperita), and chamomile (Matricaria recutita).

These oils can be included in a weak, topical blend with an appropriate carrier oil, such as sweet almond (Prunus dulcis) and applied via a cool, damp flannel or via an ointment to the chest and neck area, and the forehead (steer clear of the eye area if using peppermint, and make sure the dilution is -1%). You can ask your aromatherapist to make an ointment, cream or lotion for you (21,22).

Chamomile (Matricaria chamomilla)
Chamomile (Matricaria chamomilla)

Analgesic

Headaches, as well as body aches and pains, can really add salt to the wound when a cold or the ‘flu takes hold. Oils which are pain-relieving such as Lavender (Lavandula angustifolia) and Peppermint (Mentha piperita) are particularly useful for relieving pain when applied via an ointment or oil blend to the forehead or body at a safe dilution (23,24).

Emotional actions

It can be really helpful to bolster the oils used for treating the various physical symptoms listed above with those that work on the nervous system, and provide soothing, clarifying or uplifting effects. Most of us will have experienced a dip in mood or foggy-headedness which can often accompany a nasty cold or virus, and so treating these emotional symptoms alongside the physical ones is key to aiding recovery.

Sedative, nervine

It can often be helpful to include a nervine (calming) oil in a respiratory blend, or even better, make up a separate blend for bedtime which contains oils that are less stimulating than many of those mentioned above. Chamomile (Matricaria recutita), Lavender (Lavandula angustifolia) and Frankincense (Boswellia carterii) are all soothing in their actions and will help promote calm and a restful night’s sleep. Lavender in particular is sedative, so will encourage sleep. Chamomile is often recommended for insomnia and stress, and Frankincense is used for anxiety and depression, so these would also be lovely additions to a pre-sleep blend (25).

Clarifying, uplifting

In the morning, another approach is needed. Poor sleep, a stuffy nose and a headache can all lead to a feeling of “fuzziness” and a lack of clarity of thought. Therefore, oils such as pine (Pinus sylvestris), lemon (Citrus limonum), and bergamot (Citrus bergamia) are recommended in the morning. Their ability to clarify the mind and uplift the spirits make them ideal for feeling fresh and clear-headed (26).

You’ll notice that some of the oils above appear multiple times; this is because they have a whole host of actions on the body and mind. Some of the most accessible and multi-functional oils have been included, but it’s always wise to do your own research and experiment (safely) with blending oils in a way that works for you. To help you get started, below are some suggested blends for two common winter bugs.

Rosemary essential oil (Rosmarinus officinalis)
Rosemary essential oil (Rosmarinus officinalis)

Cold & chesty cough blend (daytime)

For inhalation in a room diffuser, or steam inhalation via a bowl of steaming hot water with a towel covering the head and bowl

Ingredients

  • 3 x drops rosemary essential oil (Salvia rosmarinus)
  • 3 x drops eucalyptus essential oil (Eucalyptus globulous)
  • 3 x drops pine essential oil (Pinus sylvestris)

How to make a chesty cough essential oil

  • Set a room diffuser for 30mins (don’t inhale directly), or inhale steam for 5-10mins via the steam-bowl method detailed above, taking regular breaks.
  • This is a great blend to inhale throughout the day to aid with symptoms of the common cold such as a blocked nose, chesty cough or foggy head.

Flu and fever blend (evening)

This blend is for a massage oil.

Ingredients

  • 20 ml sweet almond oil (Prunus dulcis) or other suitable carrier oil.*
  • 2 x drops chamomile essential oil (Matricaria recutita)
  • 2 x drops palmarosa essential oil (Cymbopogon martinii)
  • 2 x drops lavender essential oil (Lavandula angustifolia)

How to make a flu and fever essential oil

  • Blend the essential oils into the carrier and stir for 30sec. Massage gently into the chest and neck area 30mins before sleep.
  • This analgesic (pain-relieving) febrifugal, cooling and calming blend makes a lovely massage oil. The massage itself will have additional soothing effects on the nervous system, and the oils will work synergistically to cool and calm the fever.

There are endless combinations of essential oils to choose from, but we hope that the guide and resources here will provide a foundation that will support you in deciding which oils, blends and methods of application will best support you with your respiratory health over the winter.

  1. Unknown. The Reason for the Season: why flu strikes in winter. Science in the News. Published 2021. [online] Accessed: 26 November 2021. Available from: https://sitn.hms.harvard.edu/flash/2014/the-reason-for-the-season-why-flu-strikes-in-winter/
  2. Smith H, Sweet C. Cooperation between Viral and Bacterial Pathogens in Causing Human Respiratory Disease. In: Brogden KA, Guthmiller JM, editors. Polymicrobial Diseases. Washington (DC): ASM Press. Published 2002. Chapter 11. Available from: https://www.ncbi.nlm.nih.gov/books/NBK2479/
  3. Martin, I. Aromatherapy For Massage Practitioners. (1st ed.). Baltimore: Lippincott Williams & Wilkins. 2007. p265.
  4. Albert M, Dy N, M.D. Feeser S, Winter Illness Guide. , at Johns Hopkins Community Physicians, Johns Hopkins Medicine. Published 2021. [online] Accessed 26 November 2021. Available from: https://www.hopkinsmedicine.org/health/conditions-and-diseases/winter-illness-guide
  5. Albert M, Dy N, M.D. Feeser S, Winter Illness Guide. , at Johns Hopkins Community Physicians, Johns Hopkins Medicine. Published 2021. [online] Accessed 26 November 2021. Available from: https://www.hopkinsmedicine.org/health/conditions-and-diseases/winter-illness-guide
  6. Albert M, Dy N, M.D. Feeser S, Winter Illness Guide. , at Johns Hopkins Community Physicians, Johns Hopkins Medicine. Published 2021. [online] Accessed 26 November 2021. Available from: https://www.hopkinsmedicine.org/health/conditions-and-diseases/winter-illness-guide
  7. Caddy, R. Essential oils in colour (2nd ed.). Amberwood Publishing. 1997.
  8. Shute, J. Synergism in essential oils and aromatherapy. Published 2021. Accessed 26 November 2021. Available from: https://aromaticstudies.com/synergism-in-essential-oils-and-aromatherapy/
  9. Peppermint (Mentha Xpiperita). Taylor & Francis. https://www.tandfonline.com/doi/abs/10.1080/J157v07n02_07?journalCode=iher20. Published 2009. Accessed December 10, 2021.
  10. Caddy, R. Essential oils in colour (2nd ed.). Amberwood Publishing. 1997.
  11. Martin, I. Aromatherapy For Massage Practitioners. (1st ed.). Baltimore: Lippincott Williams & Wilkins. 2007. P267.
  12. Caddy, R. Essential oils in colour (2nd ed.). Amberwood Publishing. 1997.
  13. Martin, I. Aromatherapy For Massage Practitioners. (1st ed.). Baltimore: Lippincott Williams & Wilkins. 2007. p267.
  14. Caddy, R. Essential oils in colour (2nd ed.). Amberwood Publishing. 1997.
  15. Martin, I. Aromatherapy For Massage Practitioners. (1st ed.). Baltimore: Lippincott Williams & Wilkins. 2007. p.267.
  16. Hoffmann, D. The holistic herbal (3rd ed.). Thorsons, Harper Collins Publishers. 2002. p.37.
  17. Caddy, R. Essential oils in colour (2nd ed.). Amberwood Publishing. 1997.
  18. Martin, I. Aromatherapy For Massage Practitioners. (1st ed.). Baltimore: Lippincott Williams & Wilkins. 2007. p.267.
  19. Caddy, R. Essential oils in colour (2nd ed.). Amberwood Publishing. 1997.
  20. Martin, I. Aromatherapy For Massage Practitioners. (1st ed.). Baltimore: Lippincott Williams & Wilkins. 2007. P.267.
  21. Caddy, R. Essential oils in colour (2nd ed.). Amberwood Publishing. 1997.
  22. Martin, I. Aromatherapy For Massage Practitioners. (1st ed.). Baltimore: Lippincott Williams & Wilkins. 2007. P.267.
  23. Caddy, R. Essential oils in colour (2nd ed.). Amberwood Publishing. 1997.
  24. Martin, I. Aromatherapy For Massage Practitioners. (1st ed.). Baltimore: Lippincott Williams & Wilkins. 2007. p.267.
  25. Mojay, G. Aromatherapy for healing the spirit. London: Gaia. 2005. pp. 60, 74, 90.
  26. Mojay, G. Aromatherapy for healing the spirit. London: Gaia. 2005. Pp. 52, 92, 110.
  27. Unknown. Tips to Keep Your Lungs Healthy. Updated 6 October 2021. Accessed 29 November 2021. Available from: https://www.lung.org/lung-health-diseases/wellness/protecting-your-lungs
  28. Unknown. How to boost your immune system – Harvard Health. Published 2021. Accessed 29 November 2021. Available from: https://www.health.harvard.edu/staying-healthy/how-to-boost-your-immune-system
  29. 29. Walker, M. How sleep can improve your immunity. Published August 2020. Accessed 29 November 2021. Available from: https://www.ted.com/talks/matt_walker_how_sleep_can_improve_your_immunity?language=en

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Essential oils for treating inflammation: An aromatherapist’s perspective https://www.herbalreality.com/herbalism/western-herbal-medicine/essential-oils-for-treating-inflammation-aromatherapist-perspective/ https://www.herbalreality.com/herbalism/western-herbal-medicine/essential-oils-for-treating-inflammation-aromatherapist-perspective/#comments Thu, 02 Dec 2021 19:09:45 +0000 https://www.herbalreality.com/?p=5867 Aromatherapist Ellen Rowland takes a look at treatment strategies of inflammation with essential oils.

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Aromatherapist Ellen Rowland takes a look at treatment strategies of inflammation with essential oils.

What is inflammation, and should I worry about it?

Inflammation has received a significant amount of negative press in recent years, with numerous scientific studies citing it as the biggest health threat facing humans (1) and as the “most significant cause of death in the world today” (2). But science also teaches us that inflammation is the body’s normal immune response to trauma(3,4)infection or injury, and a helpful ally in the fight against infection and disease. So which is it, friend or foe?

Essential oils for treating inflammation: An aromatherapist’s perspective
Hyssop (Hyssopus officinalis)

Acute or chronic?

The answer may not be so straightforward as we first hoped, but thankfully research that can clarify the muddied waters of inflammation and health does exist. Key to determining whether inflammation may be harmful or helpful to us is understanding the difference between acute and chronic inflammation. Acute inflammation is a natural bodily immune response to invading pathogens, injury or disease.

There are a number of visual clues (known as the five ‘cardinal signs’ in ancient times (5)) which can help us detect whether the inflammatory process is happening in our bodies. These signs, which were coined by the ancient Romans and Greeks, are redness, swelling, heat, pain and loss of function (6).

Most of us will be familiar with these signs – on cutting a knee, twisting an ankle or even breaking a bone, within minutes, our body – when functioning correctly – triggers them by sending blood to the injured site along with numerous cells such as macrophages which repair and protect the damaged tissue (7), and others which fight off disease, like neutrophils (8).

When inflammation gets out of hand

But what happens when inflammation becomes chronic? Recent research has shown that there are a number of environmental, social and lifestyle factors that can actually increase the likelihood of developing systemic chronic inflammation (SCI) (9).

Whilst inflammation in and of itself does not necessarily pose a problem, when ongoing, it can lead to a number of diseases that “collectively represent the leading causes of disability and mortality worldwide” (10).These diseases include type 2 diabetes, hypertension, cardiovascular disease, different types of cancer, neurodegenerative and autoimmune diseases, osteoporosis and even mental health conditions like depression (11).

The wider factors at play

Chronic inflammation has a number of possible causes, including immune disorders, ongoing infection, auto-inflammatory disorders caused by cell defects and exposure to irritants, to name a few (12). However, our modern, urban environments, sedentary lifestyles, nutrient-poor diets and increasing lack of physical activity can all play a role in contributing to chronic inflammation (13) and sending the body’s immune response into overdrive, which in turn may create a “chicken-and-egg” (13) cycle of inflammation-disease-inflammation.

What can we do about inflammation?

But whilst the long lists of risk factors and diseases can seem extensive and scary, there are a number of lifestyle changes we can make as individuals which can help to reduce the likelihood of developing chronic inflammation and its associated conditions. Where appropriate, making some changes to our diet, such as eating more nutrient-dense foods, increasing physical activity (within our ability), avoiding chemical irritants and environmental pollutants and maintaining good sleep hygiene can all help to prevent inflammation (14,15).

However, it bears acknowledging that some communities and individuals are much better equipped to tackle public health issues such as SCI than others. Health (in)equity is an urgent worldwide concern, and social factors such as economic status have proven to have a significant influence on variations in population health and mortality rates (16).

Aromatic approaches to treating inflammation

Whilst it cannot legitimately be suggested that aromatherapy alone can cure diseases associated with chronic inflammation, it’s clear that herbal and holistic health disciplines such as aromatherapy have a key role to play in supporting us on an individual level with both chronic and acute inflammation and ultimately increasing quality of life. Increasing quality of life is something we believe should be at the forefront of healthcare priorities.

Let’s take Osteoarthritis (OA) and Rheumatoid arthritis (RA) as examples. Whilst RA is an auto-immune disease, and OA is a degenerative joint disease (17), it’s thought that it is possible for both to be hereditary, too (18,19). This would suggest that sufferers might be in a position where they are managing the effects of inflammation, rather than eliminating it completely. You can read about arthritis and herbalism here, as well as the Ayurvedic perspective.

Indeed it may not be possible, or desirable, for everyone suffering from forms of Arthritis to eliminate the symptoms; constantly striving to do so may cause emotional distress. It is in the short-term ‘flare-up’ treatment (acute) and the management of ongoing (chronic) conditions that aromatherapy can play a part. There are a number of essential and carrier (base) oils that can be used in topical and inhalation blends to treat both forms of Arthritis as well as numerous other inflammatory conditions.

Treating acute flare-ups vs. chronic inflammation

During Rheumatoid arthritic flare-ups, for example,  joints can become tender, swollen, and even deviate, becoming deformed (20). These symptoms can appear suddenly, causing intense pain and heat in the joint. In Osteoarthritis, inflammation tends to appear in the later stages of the disease (21), and as such, the Aromatherapist’s focus will tend to be on pain management and joint mobility.

Which method should I choose?

Aromatherapists work with many methods of application in their practice. Typically, preparations can range from inhalers to oil blends, creams to balms, aromatic soaks to sprays. It’s important to choose the most appropriate method of application to ensure the treatment is targeted to the condition, pleasant and easy to use since this will ensure effective outcomes for the patient or client.

In both cases of Arthritis mentioned above, a Clinical Aromatherapist would likely decide to prepare a product for the client to use topically (on the joint itself) such as a balm, cream or ointment made from a mixture of essential and base oils. This method of application allows the active constituents in the oils to permeate the skin barrier and target the affected site quickly, whilst providing some immediate relief (for more acute conditions) through the gentle application of a soothing ointment.

An ointment is an excellent choice in this case for practical reasons, too – it’s easy to apply morning and night, and can be carried in a bag or pocket when the patient is out and about. For other inflammatory conditions such as coughs and colds, another method such as inhalation might be more suitable.

Chamomile (Matricaria chamomilla)
Chamomile (Matricaria chamomilla)

Essential oils for inflammation

There are several oils that can be a useful addition to any budding aromatherapist’s natural first-aid kit. For acute inflammatory blends, specific oils indicated include those which are strongly analgesic (pain-relieving) and anti-inflammatory. German chamomile (Matricaria recutita), lavender (Lavandula angustifolia) and turmeric (Curcuma longa) all have strong anti-inflammatory properties (23) and can be useful additions to ointments targeting acute inflammation.

For more chronic conditions, either pain-relieving (analgesic) ‘cooling’ oils such as peppermint (Mentha piperita), or indeed ‘warming’ oils like ginger (Zingiber officinalis) and Black Pepper (Piper nigrum) can also be combined in a blend to provide relief.

Carrier oils: Therapeutic in their own right

Base oils (carrier oils) are also important additions since they both serve to dilute and blend the essential oils safely, whilst having therapeutic properties of their own. They can also aid absorption of the essential oils, which are the primary active ingredient in the product.

Carriers such as almond (Prunus amygdalis), apricot (Prunus armeniaca) and jojoba (Simmondsia chinensis) oil are particularly useful here. Almond oil is slow-absorbing, allowing for application of the ointment over a long period of time, which is ideal for chronic conditions. Apricot, on the other hand, is light and easily-absorbed, so ideal for fast-acting ointments. Jojoba, which is actually a wax, mimics the chemical structure of skin’s sebum, so is easily tolerated and helps balance the skin’s moisture levels (23). 

Carrier oils infused with a herb (macerations) are also extremely useful additions, adding another layer of therapeutic intervention to products. Particularly indicated for topical application for inflammatory conditions is St John’s wort (Hypericum perforatum) infused oil, which has a beautiful deep-red colour.

Blending for synergy: Working holistically

Aside from targeting solely the physical symptoms which are presenting, the Aromatherapist may also consider including an oil in an anti-inflammatory blend that assists with any emotional aspects of suffering with inflammatory conditions. Both sweet orange (Citrus aurantium var. dulcis) and cardamom (Elettaria cardamomum) are good anti-depressive oils, for example, and can help to uplift the spirits of the patient or client if they are suffering from stress or low mood as a result of their physical condition.

This synergistic approach to treatment is one that all good Aromatherapists will take, since aromatherapy, like herbalism, tends to focus on the person and their unique situation first and foremost, and not on the presenting symptoms alone.

Ultimately, if we try to look at inflammation not as a villain or harbinger of bad news and disease, but as a messenger with something important to tell us, our fear of inflammation may subside. Usually, inflammation is a sign that our body is doing its job to protect us from disease, and knowing this, we can perhaps begin to tune in to its signals and warning signs.

We might decide to make changes to our lifestyle that support us with our long-term health, preventing inflammation from becoming chronic and problematic, whilst enlisting our herbal and aromatic allies to address and calm acute and chronic conditions as and when they arise.

  1. Pahwa R, Goyal A, Bansal P, et al. Chronic Inflammation. [Updated 2021 Sep 28]. In: StatPearls [online]. Treasure Island (FL): StatPearls Publishing; 2021 Jan. Available from: https://www.ncbi.nlm.nih.gov/books/NBK493173/
  2. Furman D, Campisi J, Verdin E et al. Chronic inflammation in the etiology of disease across the life span. Nat Med. 2019;25(12):1822-1832. doi:10.1038/s41591-019-0675-0. Available from: https://www.nature.com/articles/s41591-019-0675-0
  3. Oxford University Hospitals NHS Foundation Trust. Inflammatory diseases. [online]. https://www.ouh.nhs.uk/oxparc/information/diagnoses/inflammatory-diseases.aspx. Published 2021. Accessed October 21, 2021.
  4. Fighting Inflammation. Harvard Health. [online]. https://www.health.harvard.edu/staying-healthy/understanding-inflammation. Published 2021. Accessed October 21, 2021.
  5. Punchard N, Whelan C, Adcock I. J Inflamm. 2004;1(1):1. doi:10.1186/1476-9255-1-1 Available from: https://journal-inflammation.biomedcentral.com/articles/10.1186/1476-9255-1-1
  6. Punchard N, Whelan C, Adcock I. J Inflamm. 2004;1(1):1. doi:10.1186/1476-9255-1-1 Available from: https://journal-inflammation.biomedcentral.com/articles/10.1186/1476-9255-1-1
  7. Actor J. K, 2 – Cells and Organs of the Immune System, Editor(s): Actor, J.K. Elsevier’s Integrated Review Immunology and Microbiology (Second Edition), W.B. Saunders, 2012, Pages 7-16. ISBN 9780323074476, doi: 10.1016/B978-0-323-07447-6.00002-8 Available from: https://www.sciencedirect.com/science/article/pii/B9780323074476000028
  8. Ali O. A, Mooney D. J. 31 – Converging Cell Therapy with Biomaterials, Editor(s): Craig Halberstadt, Dwaine Emerich. Cellular Transplantation, Academic Press, 2007. ISBN 9780123694157, doi: 10.1016/B978-012369415-7/50032-6. Available from: https://www.sciencedirect.com/science/article/pii/B9780123694157500326?via%3Dihub
  9. Furman D, Campisi J, Verdin E et al. Chronic inflammation in the etiology of disease across the life span. Nat Med. 2019;25(12):1822-1832. doi:10.1038/s41591-019-0675-0. Available from: https://www.nature.com/articles/s41591-019-0675-0
  10. Furman D, Campisi J, Verdin E et al. Chronic inflammation in the etiology of disease across the life span. Nat Med. 2019;25(12):1822-1832. doi:10.1038/s41591-019-0675-0. Available from: https://www.nature.com/articles/s41591-019-0675-0
  11. Furman D, Campisi J, Verdin E et al. Chronic inflammation in the etiology of disease across the life span. Nat Med. 2019;25(12):1822-1832. doi:10.1038/s41591-019-0675-0. Available from: https://www.nature.com/articles/s41591-019-0675-0
  12. Pahwa R, Goyal A, Bansal P, et al. Chronic Inflammation. [Updated 2021 Sep 28]. In: StatPearls [online]. Treasure Island (FL): StatPearls Publishing; 2021 Jan. Available from: https://www.ncbi.nlm.nih.gov/books/NBK493173/
  13. Unknown. Understanding acute and chronic inflammation. Harvard Health. [online] https://www.health.harvard.edu/staying-healthy/understanding-acute-and-chronic-inflammation. Published 2020. Accessed October 21, 2021.
  14. Unknown. Understanding acute and chronic inflammation. Harvard Health. [online] https://www.health.harvard.edu/staying-healthy/understanding-acute-and-chronic-inflammation. Published 2020. Accessed October 21, 2021.
  15. Furman D, Campisi J, Verdin E et al. Chronic inflammation in the etiology of disease across the life span. Nat Med. 2019;25(12):1822-1832. doi:10.1038/s41591-019-0675-0. Available from: https://www.nature.com/articles/s41591-019-0675-0
  16. Mackenbach J, Kunst A. Measuring the magnitude of socio-economic inequalities in health: An overview of available measures illustrated with two examples from Europe. Soc Sci Med. 1997;44(6):757-771. doi:10.1016/s0277-9536(96)00073-1. Available from: https://pubmed.ncbi.nlm.nih.gov/9080560/
  17. Martin, I. Aromatherapy For Massage Practitioners. 1st ed. Baltimore: Lippincott Williams & Wilkins; 2007:212-213.
  18. Chen D, Shen J, Zhao W et al. Osteoarthritis: toward a comprehensive understanding of pathological mechanism. Bone Res. 2017;5(1). doi:10.1038/boneres.2016.44 Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5240031/
  19. Bullock J, Rizvi S, Saleh A et al. Rheumatoid Arthritis: A Brief Overview of the Treatment. Medical Principles and Practice. 2018;27(6):501-507. doi:10.1159/000493390 Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6422329/
  20. Martin, I. Aromatherapy For Massage Practitioners. 1st ed. Baltimore: Lippincott Williams & Wilkins; 2007: 211-213.
  21. Martin, I. Aromatherapy For Massage Practitioners. 1st ed. Baltimore: Lippincott Williams & Wilkins; 2007: 211-213.
  22. Martin, I. Aromatherapy For Massage Practitioners. 1st ed. Baltimore: Lippincott Williams & Wilkins; 2007: 211-213.
  23. Martin, I. Aromatherapy For Massage Practitioners. 1st ed. Baltimore: Lippincott Williams & Wilkins; 2007: 150-157
  24. Wölfle U, Seelinger G, Schempp C. Topical Application of St. Johnʼs Wort (Hypericum perforatum). Planta Med. 2013;80(02/03):109-120. doi:10.1055/s-0033-1351019 Available from: https://pubmed.ncbi.nlm.nih.gov/24214835/

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Endangered plants and women’s health: Fertility herbs at risk https://www.herbalreality.com/herbalism/western-herbal-medicine/endangered-plants-women-health-fertility-herbs-risk/ https://www.herbalreality.com/herbalism/western-herbal-medicine/endangered-plants-women-health-fertility-herbs-risk/#comments Fri, 29 Oct 2021 15:22:24 +0000 https://www.herbalreality.com/?p=4825 Susan Leopold discusses why plants used for women's health are at risk and how to avoid them for herbal formulations.

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Endangered plants and women's health: Fertility herbs at risk

Susan Leopold discusses why plants used for women’s health are at risk and how to avoid endangered fertility herbs for herbal formulations.

It was early spring when visiting a friend in southern Virginia that I came across a rare encounter with a small colony of just emerging false unicorn root (Chamaelirium luteum). This sacred fertility herb was thriving in the woods nestled throughout a graveyard of rusty old farm equipment.

Hiding in plain site along a winding creek there were about 20 or so plants spread out in small clusters with the trickling sound of a winding creek. I was in awe of these divine forest beings. A part of me deeply hoped that the digger’s hand would never find this population and that the rusty old farm equipment would be a deterrent, a strategic decoy.

We don’t yet understand how to successfully cultivate this plant. It can be germinated from seed, but it takes years to grow. It needs a certain type of soil to thrive, and it produces both male and female flowers, which complicates its ability to reproduce under cultivated circumstances. So, ironically, we do not know how to propagate and cultivate a plant that is highly desired for women’s reproductive health. If there were one plant that I feel strongly about taking out of commerce in Appalachia, this is the plant I would choose.

Agnus Castus (Vitex agnus-castus L.)
Agnus castus (Vitex agnus-castus L.)

In the last decade I have been the director of United Plant Savers. With boots on the ground I have met with landowners, diggers, dealers, growers, suppliers and herbal formulators, so my experience comes from a humble perspective and my inquisitive nature. False Unicorn root is the most valuable root for a digger to sell along with wild American ginseng.

The difference is that ginseng is a plant that people have been planting the seeds of for many decades. It’s a plant that has been tended by rural people for generations to ensure its future. Only a few dedicated growers of native plants have tried to germinate false Unicorn root, and its future is in serious decline.

The herb trade in the US is completely unregulated and very much an underground secretive trade. It’s important to know that we have little data on what is going on except for the prices advertised on digger and dealer pages on Facebook and prices of herbal formulas that are being sold online.

Current price for dried root on Etsy (2021) is 40.00 dollars for one gram, or 161.00 dollars for 4 oz (butterfly express) that amounts to around 2,500.00 a pound, and lastly an 8 oz tincture sells for 100.00 dollars (Vita Living). A digger would likely get around 100/200 dollars a pound, and that is roughly around 75 plants or many more depending on the size and if the roots are dried. The roots themselves are like a small carrot and lose around 1/3 of their weight when dried.

United Plant Savers publishes the Journal of Medicinal Plant Conservation, and on our website the Journal, along with all kinds of resources are there for free to download and explore. Dalene Barton-Schuster, CH. Doula wrote an article “Saving a Sacred Fertility Herb, False Unicorn Root.” In this article, she discusses the medicinal properties of false unicorn and within that framework she also suggests similar herbs such as tribulus (Tribulus terrestris), vitex or chaste tree berry (Vitex agnus-castus) and dong quai (Angelica sinensis).

There are some examples of fertility herbs with similar actions to false Unicorn aiding in the increase in estrogen and helping with fertility. As for aiding in prevention of recurrent miscarriage, partridge berry (Mitchella repens) is a great alternative.” United Plant Savers promotes herbalists to consider using analogues to “At-Risk” plants when possible. On our website is a wonderful list of analogues provided by Herbalist Jane Bothwell.

I often try to convey that there is a bounty of herbs that are not “At-Risk” and that companies can quickly reformulate, but once a plant is in decline and especially when its habitat is diminishing, nature cannot so easily reformulate. Certain plants can take decades to repopulate, and, in some cases, they are dependent on relationships we don’t even understand or know how to replicate.

United Plant Savers created the “At-Risk” Tool, a simple list of questions based on five categories; the life cycle of the plant, the part that is harvested, the habitat, threats, and demand. These questions can help guide the user to determine for themselves the ethical impact on plant biodiversity. A critical aspect to herbalism is getting to know the plant, understanding where it grows, its life cycle and the part of the plant being harvested.

In Appalachia many of the herbs in trade are roots of long living perennial native plants that grow in only healthy forests. In Eastern Europe, many of the herbs in trade are leaves, berries and flowers, so there are different challenges from maintaining healthy ecosystems to sustaining healthy harvesting of plant populations.

There are also social implications regarding who is harvesting the plants and how they are treated and compensated. These are all important questions to ask suppliers and herbal product companies when making informed decisions.

Ecological herbalism is an awakening to the deep connection between the health of the planet and human health. I cringe at the thought of plants in peril in an herbal formula, and I am also in awe at the amazing diversity of plants that support women’s health, so choose wisely.

False unicorn (Chamaelirium luteum)
False unicorn (Chamaelirium luteum)

Another plant that I strongly discourage for use in herbal formulas is trillium. This woodland spring ephemeral, also known as beth root, is a slow growing spring ephemeral that takes decades to establish. Its seed produces what is called an elaisome, which is a fatty white substance that attracts ants that then disperse the seeds. It can take two years before this seed might germinate, and when the bulb is harvested, that plant’s life is over. Each bulb harvested could be a plant that has lived in the forest for 20-30 years.

There is more to this story. There are 43 species of trillium worldwide, with 38 species in N. America and 5 found in Asia. Trilliums are often dug in early spring before they flower as they have distinctive three leaves. The epicenter of diversity is found in southern Appalachia where the most digging takes place. Many of these species are endangered and face all kinds of pressures such as deer predation, loss of habitat and increase in invasive species.

I wrote an article on “How we protect Trillium” that details the diversity of trilliums in N. America, and I worked on a committee with the IUCN on red listing the N. American Trillium species. The IUCN has just started the process over the two years to evaluate medicinal plants in N. America, which is good news but also frustrating that this important work is still lingering and underfunded. As I have mentioned, the herb trade in the US is very secretive.

Diggers are often on private and public lands, so they want to remain anonymous, and dealers are often trading cash or drugs for plants, so it is challenging to ensure that the correct plant is being harvested and/or harvested in a sustainable way and that people who are harvesting are also paid and treated fairly and that private land and public lands are being respected. There are no regulations in the underground plant trade of Appalachia, and in general the United States is very much a plant blind society that dedicates very few resources to the study or protection of plants.

Information we have on plant populations is often decades outdated if we have data at all. Certainly, trilliums could be cultivated for herbal formulas, but currently all trilliums in the herbal supply chain are wild harvested. A very interesting article in the last journal covers efforts in Pakistan to grow the native Trillium govanianum due to overharvesting pressure. United Plant Savers takes a strong stand on trilliums being removed from herbal products unless they come from a cultivated source.

Black cohosh according to the 2019 market report produced by the American Botanical Council was number 15 on the list of the topmost traded herbs generating 28,078,996.24 dollars in sales and its almost all wild harvested. The issue with black cohosh beyond the sustainability of tons of root being harvested each year is that there are several similar species and adulteration in herbal products is an issue.

Therefore a few companies have dropped cohosh from its product or have switched to growing black cohosh since it can be propagated to ensure that that the roots are indeed black cohosh. In our Annual Journal we published an article on the look alike cohoshes and a simple guide for how to distinguish these species.

United Plant Savers strongly encourages conservation through cultivation, and therefore we launched the forest grown program to support forest farmers of botanicals. The FGV program provides important growing and life cycle information on five plants: ginseng, goldenseal, cohosh, bloodroot, and ramps. We hope to expand this program to other native forest herbs that we have solid information on how to cultivate such as Solomon’s seal, and wild yam.

Women’s herbs of Appalachia are a pharmacopeia of phyto rich alkaloids and saponins that reduce inflammation and support the female reproductive system through the many stages of life. These roots are understudied in their potential and undervalued in how the forests are managed.

This article has not covered the in-depth use of these plants in herbal practice, but that information is abundant on many websites and books. What is lacking is balancing that information with transparency in the supply chain and the ecological understanding of what these plants need from us to survive the pressures of today’s rapidly growing marketplace. These are challenging times, and as herbalists we must advocate and speak for the herbs as an integral part of our practice.

We must ask difficult questions about the supply chain and try to understand the reproductive challenges for plants to survive. As we seek support from plants to help us navigate the challenges of women’s health, we must find ways we can reciprocate this gift.

I encourage you to sign-up to plantsavers.org and to take advantage of our online International Herb Symposium learning platform with over 100 classes and a full 18 months to enjoy them. Your membership and enrollment in the International Herb Symposium not only elevate the work of United Plant Savers it offers the opportunity to deepen your knowledge of the herbal realities of the plant kingdom.

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Botanical drugs and supplements that may be safe and useful in COVID-19 https://www.herbalreality.com/herbalism/western-herbal-medicine/botanical-drugs-supplements-may-be-safe-useful-covid19/ https://www.herbalreality.com/herbalism/western-herbal-medicine/botanical-drugs-supplements-may-be-safe-useful-covid19/#comments Fri, 29 Oct 2021 15:22:19 +0000 https://www.herbalreality.com/?p=4597 Mark Blumenthal explores the misapprehensions surrounding the safety and efficacy of herbal ingredients to help guide clinical use.

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Botanical drugs and supplements that may be safe and useful in COVID-19

Mark Blumenthal explores the misapprehensions surrounding the safety and efficacy of herbal ingredients to help guide clinical use.

First identified in China in December 2019, a novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus disease 2019 (COVID-19) quickly caused a pandemic. While scientific information about the virus has accumulated, a definitive cure remains elusive.

Botanical supplements have been recommended in the context of COVID-19, but practically no clinical studies have been performed. This raised concerns over whether botanical supplements are safe and effective for prevention, as adjuvant therapy, or after exposure to SARS-CoV-2. This review addresses the misapprehensions surrounding the safety and efficacy of herbal ingredients to help guide clinical use.

The 3 types of Echinacea: A comparison of medicinal actions
Echinacea (Echinacea purpurea)

Echinacea (Echinacea spp., Asteraceae)

Preparations made from aerial and root parts of echinacea, mainly E. angustifolia and E. purpurea, are popular and scientifically supported options for the prevention and treatment of the common cold. Echinacea extracts contain a mixture of compounds with cytokine-suppressing and -inducing effects, suggesting that echinacea extracts and alkaloids may be useful for treating allergic and inflammatory responses.

Echinacea extracts have also demonstrated immunosuppressive effects, which may be beneficial in COVID-19 patients where the inflammatory response is exacerbated. The risk of herb-drug interactions with echinacea is deemed low.

Elderberry (Sambucus nigra, Adoxaceae)

Elderberry juice has long been used as a diaphoretic in the treatment of the common cold. It also has immunomodulatory properties. Elderberry extracts have shown antiviral effects against influenza virus A and B in vitro and in human clinical trials. Despite these promising results, they cannot be extrapolated to suggest a positive effect in patients with COVID-19 as there are no scientific data available. The available evidence suggests there is a low risk of adverse effects when using elderberry before SARS-CoV-2 infection or in the early stages of infection.

South African geranium (SAG; Pelargonium sidoides, Geraniaceae)

SAG roots and rhizomes possess immunostimulant activity as assessed in several in vitro models. More than 30 clinical trials have been conducted with an SAG extract (Eps 7630®; Umckaloabo®; Dr. Willmar Schwabe GmbH & Co. KG; Karlsruhe, Germany) in the treatment of acute respiratory tract infections. The promising antiviral effects and strong safety profile of the extract warrant further clinical investigation.

Medicinal mushrooms and fungal preparations

Medicinal fungi are an expanding area of research, with oyster mushroom (Pleurotus ostreatus, Pleurotaceae); Ganoderma spp. (Ganodermataceae), chaga (Inonotus obliquus, Hymenochaetaceae); caterpillar fungus (Ophiocordyceps sinensis, Ophiocordycipitaceae); and maitake (hen-of-the-woods; Grifola frondosa, Meripilaceae) drawing the most interest.

Other mushrooms have been clinically studied with focuses on the treatment of cancers, immunological diseases, and immune-adjuvant therapy. Clinical and animal studies have demonstrated that the bioactive polysaccharides or polysaccharide-protein complex from medicinal fungi enhance innate and cell-mediated immune responses. Data with chemically well-defined fungal ingredients in COVID-19 patients are needed to evaluate whether specific fungi could be beneficial.

Ashwagandha (Withania somnifera)
Ashwagandha (Withania somnifera)

Adaptogens are natural compounds that increase the body’s adaptability, resilience, and survival in nonspecific ways. While more than 100 medicinal plants have been identified to possess apoptogenic activity, only a few have been shown to exhibit multitarget effects on the neuroendocrine-immune system.

These include andrographis (Andrographis paniculata, Acanthaceae), eleuthero (Eleutherococcus senticosus, Araliaceae), ginseng (Panax spp., Zingiberaceae), rhodiola (Rhodiola rosea, Crassulaceae), schisandra (Schisandra chinensis, Schisandraceae) and ashwagandha (Withania somnifera, Solanaceae).

In addition to affecting the immune response, the ability of these adaptogens to alleviate stress-induced mental and behavioral disorders is relevant as these conditions have increased due to the COVID-19 pandemic.

Licorice (Glycyrrhiza spp., Fabaceae)

Licorice spp., primarily Glycyrrhiza glabra, G. inflata, and G. uralensis, root contains bioactive compounds that possess anti-inflammatory and antiviral effects. β-Glycyrrhetinic acid, a metabolite of one of these components, may enhance the activity of hydrocortisone, suggesting that the coadministration may have a therapeutic effect in inflammatory lung diseases. More studies are needed to gain new insights on the potential role of licorice or its components in the treatment of COVID-19.

Turmeric (Curcuma longa, Zingiberaceae)

Curcumin, the main bioactive component of turmeric, has demonstrated activity against a variety of viruses by interfering with critical steps of the viral replication cycle. Curcumin also blocks cytokine release, which has translated to clinical improvements in animal models of diseases where a cytokine storm affects morbidity and mortality outcomes. Taken together, curcumin may theoretically be of benefit in COVID-19 pathophysiology and clinical manifestations.

Frankincense (Boswellia spp., Burseraceae)

Frankincense inhibits inflammation through the cyclooxygenase (COX) pathway. Most studies have reported moderate anti-inflammatory efficacy with frankincense as a mono-product and in combinations with other herbs, suggesting its use as a promising approach for the treatment of COVID-19-related inflammatory complications.

Salicylate drugs of botanical origin

A range of herbs contain salicylic acid derivatives. These include 

  • Willow spp. Salicaceae
  • meadowsweet (Filipendula ulmaria, Rosaceae)
  • Birch (Betula spp., esp. Betula lenta, Betulaceae)
  • Wintergreen (Gaultheria procumbens, Ericaceae) oil

While preparations derived from these botanicals are often used externally, there is no evidence for negative side effects in the context of COVID-19.

There exists no evidence that the immunomodulating herbs discussed here would exacerbate a cytokine storm, and herb-drug interactions are not expected.

Botanical drugs and supplements continue to gain interest from researchers as potential therapeutic agents for SARS-CoV-2 drug development. Still, research exploring the mechanisms of action and efficacy of these herbs in the content of SARS-CoV-2 exposure is needed. In either case, despite the lack of strong clinical data to support active recommendations, the current evidence suggests these botanicals are safe enough to permit use by the public with the appropriate caution.

The authors declare no conflicts of interest.

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The metabolic crisis and what we can do about it https://www.herbalreality.com/herbalism/western-herbal-medicine/metabolic-crisis-what-we-can-do-about-it/ https://www.herbalreality.com/herbalism/western-herbal-medicine/metabolic-crisis-what-we-can-do-about-it/#comments Fri, 29 Oct 2021 15:22:18 +0000 https://www.herbalreality.com/?p=4460 Robert Verkerk discusses key factors associated with metabolic disease and treatment approaches.

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Robert Verkerk discusses key factors associated with metabolic crisis and disease and important treatment approaches.

The metabolic disease crisis afflicts a large part of the global population, particularly those in higher-income and emerging industrialised countries, and represents the single largest preventable, non-communicable disease burden in these countries (1).

The covid-19 pandemic has shone a spotlight on how a single viral pathogen can exploit comorbidities that are the result of metabolic dysfunction, creating havoc in its wake. It is surely also a reminder of the urgent need to address the underlying metabolic crisis, especially among younger members of society who will otherwise become extremely vulnerable both to chronic and infectious diseases.

Obesity, type 2 diabetes and ischaemic heart disease are three of the most pronounced downstream manifestations of the metabolic crisis.

However, increasingly, many types of cancer are considered to have a metabolic basis (2), while the rapid rise in prevalence of Alzheimer’s and dementia in industrialised countries is also thought to be, at least partially, mediated by metabolic disturbance, hence the increasingly common reference to type 3 diabetes (3).

There is overwhelming evidence that the causes are both variable, between individuals, yet are also multi-factorial, being a consequence of our poor adaptation to modern lifestyle and dietary patterns.

The Global Burden of Disease Study (2015) (4) identified four metabolic risk factors that are widely associated with the dysregulated metabolism that is typically associated with diet and lifestyle mediated metabolic diseases, these being:

  1. Raised systolic blood pressure
  2. Overweight and especially obesity
  3. Hyperglycemia (high fasting blood glucose levels), and
  4. Hyperlipidemia (high levels of fat in the blood).

These physiological risk factors are in turn associated with other physiological factors, as well as a broad array of social, environmental and genetic contributory factors. Given huge differences in the response both by individuals and different population groups to these multiple determinants of metabolic disease, there is little scientific consensus over which are the most important combination of factors for particularly diseases or population groups.  

This uncertainty is compounded by the common lack of clarity around the causality of non-communicable and metabolic diseases, that is much harder to ascertain than is the case of infectious (communicable) diseases.

Among the plethora of factors associated with the increased or reduced risk of metabolic diseases that contribute to many of the leading causes of preventable and premature deaths, notably ischemic heart disease, stroke, some cancers (breast, prostate, colorectal), obesity, type 2 diabetes and low bone mineral density, are the following:

  • Dysregulated energy and glucose metabolism (5)
  • Excessive and overly-frequent intake of sugars and refined carbohydrates, in association with reduced fibre intake, that contribute to chronically raised blood sugar (hyperglycaemia) and subsequently insulin resistance (6)
  • Dysregulated lipid metabolism, in particular the inability to beta-oxidise (burn) fatty acids in adipose tissue and the development of non-alcoholic fatty liver (7)
  • Dysregulated ‘cross-talk’ between adipocytes in adipose tissue (subcutaneous fat), macrophages (immune system) and neurons (nervous system) (8)
  • Hormonal dysregulation of appetite, a complex process involving multiple hormones including grehlin (hunger), leptin (satiation) and adiponectin (fat burning). Apart from involving the endocrine system, it also involves the gut and its microbiome, the brain, the central and autonomic nervous systems, the immune system, adipose tissue and a large number of signalling compounds and nutrient-sensing systems such mTOR and AMPK (9)
  • Low bone mineral density caused by disturbances to metabolism of calcium, other minerals and low circulating vitamin D status (10)
  • Low grade, chronic systemic inflammation and oxidative stress (11)
  • Chronic stress and inadequate quantity and quality of sleep (12)
  • Exposure to air pollution and environmental toxins (13)
  • The bidirectional relationship between physical inactivity and obesity (14)
  • The prevalence of obesogenic environments and ‘anthropogens’ (human-made environments, their by-products and/or lifestyles encouraged by these, some of which may be detrimental to human health) (15)
  • Social determinants of metabolic disease including socio-economic status, structural and cultural factors (16)
  • The interplay of genetics and epigenetics in gene expression (17)

Not only are these associated factors both multiple and highly variable, very few have been identified as direct, causal factors. Several years ago, when metabolically-triggered low-grade systemic inflammation (sometimes referred to as ‘metainflammation’) was linked to obesity and chronic diseases like type 2 diabetes and ischaemic heart disease, there was hope that resolving inflammation alone would resolve these two great burdens of disease (18). 

More recently it has been found that metainflammation may or may not be associated with obesity while it is consistently connected with a range of lifestyle-related and environmental factors such as diet, inactivity, smoking, sleep, chronic stress and pollution exposure (19).

Leading Australian obesity and metabolic disease clinicians and researchers, Drs Garry Egger and John Dixon, accordingly suggested that “obesity may often be just an accomplice to, as much as a perpetrator of, many metabolic diseases” and that solutions should be directed to trying to reduce citizen exposure to anthropogens and obesogenic environments (20).

The same authors also provide a framework that can be used to help better understand the hierarchy of determinants. These can be classified as ‘downstream’ (i.e. cause), ‘midstream’ (i.e. cause of the cause) or ‘upstream’ (i.e. cause of the cause of the cause) (Figure 1).

Figure 1. A hierarchy of determinants and risk factors/markers in chronic (including metabolic) disease aetiology (From Eggers & Dixon, 2014 (20)).

Eggers & Dixon also tabulate, using the acronym NASTIE ODOURS, a wide range of determinants (Box 1) of chronic disease along with evidence of how specific factors may increase or decrease risk, or act as moderators (mediators).

BOX 1 – Lifestyle & environmental determinants (‘anthropogens’) of metabolic disease

N = Nutrition (lack of diversity, inadequate plant foods/phytonutrients, poor eating patterns, excess intake of refined carbohydrates
A = In(Activity) (e.g. sedentary behaviour/work, lack of stretching/dynamic movement)
S = Stress, anxiety and depression
T = Technology-induced pathology (e.g. screens, machinery, highly processed foods)
I = Inadequate sleep (quantity and quality)
E = Environment (political/economic, recreation and green spaces, pollution)
O = Occupation (e.g. social justics, work equality, security)
D = Drugs, smoking and alcohol
O and U = Over- and Under-exposure (e.g. sunlight, radiation, asbestos)
R = Relationships (e.g. companionship, peer support, love)
S = Social factors (e.g. poverty socio-economic status, education, security)

Adapted from Eggers & Dixon (2014) (20)

Despite the obvious difficulties in modifying some of the determinants of metabolic disease, such as underlying genetic predisposition or an individual’s place of residence or work, there are a very large number of factors that can be altered in ways that can, sometimes dramatically, improve health outcomes. Even an individual’s genetic predisposition can be altered by changing the inner and outer environment to which the individual is exposed, which in turn changes the pattern of gene expression (i.e. epigenetics) (21).

Four over-arching priorities are identified below. These are open to modification, optimal outcomes often being realised when interventions or protocols are personalised, following guidance by the individual’s health practitioner, around the specific needs, capacities and environments experienced by the individual.

For the purposes of this article, examples of possible interventions are drawn mainly from the fields of nutrition and herbal medicine. These interventions are of particular value given the multi-target, and often, multi-system actions, of nutrients and synergistic plant compounds.

Metabolic flexibility refers to the adaptive ability to have “a clear capacity to utilize lipid and carbohydrate fuels and to transition between them.” (22) When this capacity is lost, i.e. metabolic inflexibility occurs, an individual is usually primarily reliant on burning carbohydrates to produce adenosine triphosphate (ATP) via the mitochondria.

This inflexibility is associated with ‘metabolic syndrome’ that afflicts obese and type 2 diabetic individuals which is characterised by:

  1. Excessive insulin response to elevated blood sugar.
  2. A failure of skeletal muscle tissue to transition from using fatty acids (lipid) as an energy source during the fasting state and carbohydrate in the insulin-stimulated prandial state.
  3. A tendency to store excess energy as fat (23).

Blood sugar spikes can be greatly reduced by eliminating or reducing consumption of sugars, refined carbohydrates (e.g. bread, rice, pasta), as well as starchy vegetables.  Moreover, extending the fasting intervals (e.g. at least 5 hours between eating intervals, 12-16 hour overnight fasts, or 8-hour time-restricted feeding) can help to re-educate the neuro-endocrine system to beta-oxidise fatty acids.

This adaptive process, that may take several weeks or even months, culminates in the liver-generating ketone bodies that can be used as an energy source, the process being referred to as ‘keto-adaptation’ (24). It is always non-existent in cases of non-alcoholic fatty liver disease (25).

Extremely helpful in supporting this process of keto-adaptation are herbal products that are able to blunt blood sugar responses following carbohydrate-containing meals. In this regard cinnamon has been intensively studied and used clinically, often used both as an infusion in tea or in powdered form in capsules. Not only has it been found to be able to reduce post-prandial blood-glucose spikes, it can also increase insulin sensitivity and reduce fat accumulation in the liver (26,27,28).

Trial data tends to be highly variable, this likely being the result of different profiles and concentrations of key bioactive constituents, such as chalcones, flavonoids, tannins and coumarins, these also varying between Cinnamomum species. Commonly used species include Cinnamomum zeylanicum (Ceylon cinnamon), aka Cinnamomum verum (true cinnamon), and Cinnamomum cassia (Saigon cinnamon), the latter often containing coumarins which may, at high intake levels, be of concern for those with variations of the CYP2A6 gene that impact coumarin metabolism (29).

With a wealth of historical use and trial data behind it, is triphala, the Ayurvedic combination of three fruits, namely amla (Emblica officanalis), haritaki (Terminalia chebula)and bibhitaki (Terminalia bellirica). The formula has been shown to act as a powerful antioxidant, anti-inflammatory and blood-sugar regulator (30). Another widely used combination is fruit extracts from haritaki, and the oleoresin of guggul (Commiphora wightii [formerly C. mukul]) and myrrh (Commiphora myrrha), widely available in a daily preparation of 200 mg of each (31).

Public health messaging often advises citizens to exercise more or be more active without underlying consideration of their metabolism and physiology. Many people who are inactive have sub-optimal energy yielding pathways and benefit from cofactors that facilitate function. These include a full array of bioactive, naturally-occurring forms of B vitamins as well as coenzyme Q10, all of these being cofactors in mitochondrial respiration via the Kreb’s cycle.

In addition to these micronutrients, research is increasingly pointing to an ever more diverse array of phytonutrients facilitating mitochondrial function and ATP generation. These phytonutrients are generally absent or very limited in simplified Western, processed food-based diets and an array were reviewed by Tao et al (2019) (32), as follows:

  • Homoisoflavanone-1: a natural compound in the Chinese herbal medicine, Polygonatum odoratum
  • Myricetin: a flavonol compound found in multiple herbs
  • Esculetin: a natural coumarin compound found in traditional medicinal herbs
  • Curcumin: the principle component of Curcuma longa rhizome/root
  • [6]-Gingerol: the key bioactive component of ginger
  • Triptolide: a natural product from Tripterygium wilfordii
  • Thymoquinone: an active constituent of Nigella sativa seeds
  • Epigallocatechin gallate (EGCG): a polyphenol from green tea
  • Artepillin C: a bioactive component of Brazilian green propolis
  • Allicin: predominant component of freshly crushed garlic
  • Ganoderma atrum polysaccharide
  • Ginsenosides: a major pharmacologically active ingredients of ginseng
  • Jolkinolide B: a diterpenoid from Euphorbia fischeriana
  • Withaferin A: a steroidal lactone of Withania somnifera (ashwagandha)
  • Cucurbitacin B: a bioactive compound from Pedicellus melo.

There is increasing recognition in the scientific community that food serves much more than being a source of energy or calories for the body. Rather is provides the body with information – and critical to this is the diversity of nutrients provided by diverse, nutrient-dense diets, along with culinary and medicinal herbs. Furthermore, evidence is accumulating that suggests nutrition in the first 1000 days of lives is an important contributor to long-term healthspan (33).

Nutrient-density and dietary diversity have been shown to relate directly to the anti-inflammatory nature of diets (34).

Anti-inflammatory diets have been widely studied and tend to be plant-based, rich in polyphenols and fibre, while being lower in omega-6 fatty acids, sugars and refined or processed foods compared with conventional diets (35).

Given that every eating event triggers an inflammatory response in the body, anti-inflammatory dietary patterns are also generally associated with intermittent fasting or time-restricted feeding.

The damaging effects of stress are caused by the response to stress, rather than the stressor itself. Stress-modulating herbs, especially adaptogens (36), have been shown to be invaluable to help improve the stress response under conditions of persistent, chronic stress that are all too common in modern day lives.

Well studied and clinically-proven adaptogens include:

  • Rhodiola rosea, root (37)
  • Withania somnifera (ashwagandha), root (38)
  • Panax quniquefolius, root (39)
  • Schisandra chinensis, fruits, seeds (39)
  • Eleutherococcus senticosus (Siberian ginseng), root (36)

Research since the 1980s has revealed ever more about the critical role of the endocannabinoid system (ECS) in maintaining balanced mood and a resilient stress response (40). This includes evidence of the deleterious role of chronic, psychoemotional stress on cannabinoid receptors in the brain and central nervous system (41). This provides good clinical justification for use of high quality, full spectrum CBD-standardised that cannabinoid receptors to help modulate the response of cannabinoid receptors in those exposed to such ongoing chronic stressors (42).

Additionally, several herbal medicines have been conclusively demonstrated to facilitate sleep duration and quality. These include:

It is clear that top-down public health measures have had little impact on curtailing the spiral of metabolic disease that is running rampant through the majority of the industrialised world. The impact caused by SARS-CoV-2 is a reminder of how pathogens can interact with unhealthy, imbalanced body systems and cause severe disease and societal disruption.

While it may seem that proven solutions to the metabolic crisis are still wanting, there is copious clinical evidence of successes in reversing metabolic diseases, although little of this is adequately documented or published in peer reviewed journals. Adding to this difficulty is that the disease-centric nature of prevailing medical systems means that very little effort is expended studying dietary and lifestyle patterns associated with the healthiest populations, the research on the world’s ‘blue zones’ of exceptional longevity being an exception (46).

Self-care and practitioner-guided self-care, the democratisation and even digitisation of health are key elements of any solution to the crisis, as recognised by the Lancet Global Health Commission of 2018 (47) and others.

Central to this will be multi-factorial, whole system-focused approaches and interventions that include at their heart the diversification of natural, plant-based diets. Additionally, such strategies should include increased intake of sustainably produced phytonutrients and herbal medicines which are increasingly being shown to be capable of restoring homeostatic balance in those suffering the effects of metabolic disturbance or dysfunction.

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  21. Abdul QA, Yu BP, Chung HY, et al. Epigenetic modifications of gene expression by lifestyle and environment. Arch. Pharm. Res. 2017; 40: 1219–1237. [Link: https://link.springer.com/article/10.1007/s12272-017-0973-3#citeas]
  22. Kelley DE, He J, Menshikova EV, Ritov VB. Dysfunction of mitochondria in human skeletal muscle in type 2 diabetes. Diabetes. 2002; 51: 2944–2950.[Link: https://diabetes.diabetesjournals.org/content/51/10/2944.short].
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  24. Freese J, Klement RJ, Ruiz-Núñez B, et al.  The sedentary (r)evolution: Have we lost our metabolic flexibility? Version 2. F1000Res. 2017; 6: 1787. [Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5710317/]
  25. Shao M, Ye Z, Qin Y, et al. Abnormal metabolic processes involved in the pathogenesis of non-alcoholic fatty liver disease (Review). Exp Ther Med. 2020; 20(5): 26. [Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7471863/]
  26. Allen RW, Schwartzman E, Baker WL, et al. Cinnamon use in type 2 diabetes: an updated systematic review and meta-analysis. Ann Fam Med. 2013; 11(5): 452-9. [Link: https://pubmed.ncbi.nlm.nih.gov/24019277/]
  27. Deyno S, Eneyew K, Seyfe S, et al. Efficacy and safety of cinnamon in type 2 diabetes mellitus and pre-diabetes patients: A meta-analysis and meta-regression. Diabetes Res Clin Pract. 2019; 156: 107815. [Link: https://pubmed.ncbi.nlm.nih.gov/31425768/]
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  29. Uno T, Obe Y, Ogura C, et al. Metabolism of 7-ethoxycoumarin, safrole, flavanone and hydroxyflavanone by cytochrome P450 2A6 variants. Biopharm Drug Dispos. 2013; 34(2): 87-97. [https://pubmed.ncbi.nlm.nih.gov/23112005/]
  30. Zhang Y, Xiang R, Fang S, et al. Experimental Study on the Effect of Tibetan Medicine Triphala on the Proliferation and Apoptosis of Pancreatic Islet β Cells through Incretin-cAMP Signaling Pathway. Biol Pharm Bull. 2020 Feb 1;43(2):289-295. [Link: https://pubmed.ncbi.nlm.nih.gov/31813891/]
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  37. Anghelescu IG, Edwards D, Seifritz E, et al. Stress management and the role of Rhodiola rosea: a review. Int J Psychiatry Clin Pract. 2018; 22(4): 242-252. [Link: https://pubmed.ncbi.nlm.nih.gov/29325481/]
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How to search for herbal science research: Top tips and techniques https://www.herbalreality.com/herbalism/western-herbal-medicine/how-to-search-for-herbal-science-research-top-tips-techniques/ https://www.herbalreality.com/herbalism/western-herbal-medicine/how-to-search-for-herbal-science-research-top-tips-techniques/#comments Fri, 29 Oct 2021 15:22:17 +0000 https://www.herbalreality.com/?p=4430 Viv Rolfe explains where to look for good quality herbal research, and how to search for what is up and coming.

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Viv Rolfe explains where to look for good quality herbal science research, and how to search for what is up and coming.

How to search for herbal science research: Top tips and techniques

The weaving together of scientific herbal evidence and the extensive back-catalogue of traditional knowledge and practitioner experiences, is a recognised goal within the herbal community (1).

Often, knowing where to look for good quality herbal research, and how to search for what is up and coming, can be quite a challenge. Online tools can be used to help search for clinical information, and there are a number of different types of article that are useful.

The aim of this article is to provide a brief explanation of what these are, and how to search for them.

The best way of gathering evidence in a consistent manner regarding the effects (good and bad) of a herbal remedy on a group of people is through doing a clinical trial. To achieve a good quality trial, many methods need to be in place including randomisation, blinding, placebo-controlled (best summarised here (2)). People reading a clinical trial paper can look out for these buzz-words as a starting point for sifting out the higher quality papers from lower quality papers.

When several clinical trials have been completed on a subject, (for example with  herbs such as Turmeric or Ginseng where there is an abundance), researchers might choose to pool the data and summarise the results from them in a systematic review. In essence a systematic review summarises evidence from a variety of experiments researching a common topic, in order to more accurately assess an outcome with as much evidence as possible.

As with trials, these must follow a precise methodology to minimise the author’s bias from the process (best summarised here (3). Again, buzz-words for selecting the best reviews would be those that have used a specialist organisation (e.g. Cochrane Organisation, Joanna Brigg’s Institute), and those that have used validated tools to produce a high quality report (e.g. AMSTAR, PRISMA) or evaluated the trials that they have selected in a robust way (for example looking for risk of bias tools and other factors that signify the quality of a study).

These are some simple pointers, and as the reader gets more familiar with clinical trials and systematic reviews, you will begin to understand the finer nuances.

So how to get started and search for stuff?

As the numbers of systematic reviews continues to grow, authors are As the numbers of systematic reviews continues to grow, authors are recommended to share their intended protocols on PROSPERO (4). Sadly this doesn’t stop many similar reviews being published, but it is a fun place to search for work that is ongoing. In the search box, a simple phrase like “Herb OR Botanical OR Plant” can yield a number of ongoing reviews.

For example, there is an interesting study underway looking at the role plant compounds can play in suppressing sweet taste receptors in the mouth, and the protocol is clearly outlining the research question, searches and methods that the review will use (5).

If a review is complete and published, it should say so on PROSPERO, or you can search for the authors names in a second online database PubMed. This is a free tool from the US National Library of Medicine and it is a hub to search for scientific papers from around the world. Of course, of importance to the world of herbal research is the use of Asian journals, and a number of these are well represented. (Additional searches can also be done to retrieve more localised information (6).

The simplest way to use PubMed is to use the ‘clinical queries’ search (7). On this page you can search for any herb and you’ll see articles relating to COVID-19 (a recent addition) alongside a list of other clinical studies; these studies include clinical trials and systematic reviews, although occasionally there is a stray article that has crept through the search strategy, but on the whole, it is pretty precise.

Another important thing to remember is that plant nomenclature is complex and everchanging. Thankfully the Medicinal Plant Naming Service (MPNS) at Kew Gardens fixes this problem. Here you can type in the name of a medicinal plant, and it will show you the synonyms and homonyms of this species including both common names and Latin binomials.

A fantastic feature that it has, is that you can search scientific databases for research without having to manually type in all of the different names of a plant. Sometimes plants have over 50 names so this saves a tremendous amount of time.

The steps are as follows using the example of chamomile:

Once you start searching you’ll find there is a wealth of information out there. It is important to recognise that the assessment of herbs and preparations through these methods established by western medicine is problematic, where iOnce you start searching you’ll find there is a wealth of information out there.

It is important to recognise that the assessment of herbs and preparations through these methods established by western medicine is problematic, where individualised natural preparations intended as a holistic approach are squeezed through the mechanics of looking at single ingredients for one biological target.

However both scientific and clinical research methods are advancing to allow for more complexity through ‘omic technologies and use of big data. So it is likely in the future that these methods will reflect more of the spirit of herbal medicines to help with further integration and ultimately wider choices for the public regarding their health.

  1. Roy Upton (2021) Can We Integrate Traditional Knowledge and Modern Science? (Part 7). Available: https://www.herbalreality.com/integrate-traditional-knowledge-modern-science/
  2. Trish Greenhalgh (1997) How to read a paper: Papers that report drug trials BMJ 1997; 315 :480 doi:10.1136/bmj.315.7106.480
  3. Trish Greenhalgh (1997) How to read a paper: Papers that summarise other papers (systematic reviews and meta-analyses) BMJ 1997; 315 :672 doi:10.1136/bmj.315.7109.672
  4. PROSPERO (2021) International prospective register of systematic reviews. Available: https://www.crd.york.ac.uk/prospero/
  5. Antonio Segura-Carretero et al (2021) Plant-derived compounds and suppression of sweet-related responses. PROSPERO 2021 CRD42021248971 Available: https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42021248971
  6. Madhur Aggithaya et al (2015) Literature searches on Ayurveda: An update. Ayu. 2015;36(3):238-253. doi:10.4103/0974-8520.182754
  7. PubMed Clinical Queries (2021) Available: https://pubmed.ncbi.nlm.nih.gov/clinical/

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Too many pills, not enough roots https://www.herbalreality.com/herbalism/western-herbal-medicine/too-many-pills-not-enough-roots/ https://www.herbalreality.com/herbalism/western-herbal-medicine/too-many-pills-not-enough-roots/#comments Fri, 29 Oct 2021 15:22:16 +0000 https://www.herbalreality.com/?p=4422 Herbalist Edward Thompson discusses the role of herbal medicine in patient self-care and reducing medication.

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Herbalist Edward Thompson discusses the role of herbal medicine in patient self-care and reducing medication, including pills.

Too many pills, Not enough roots

There is no doubt that over the past 80 years many drugs have been introduced which have had profoundly beneficial and life-saving effects on our health. This includes the use of antibiotics such as penicillins in acute infections, insulin in type 1 diabetes, thyroxine in hypothyroidism and calcium channel blockers to reduce severe raised blood pressure.

In the last decade however there has been an increased use of medication to reduce risk of and treat illnesses which have a major lifestyle component such as type two diabetes, obesity, high cholesterol and hypertension, with the NHS drugs bill in 2016 totalling £9,204.9 million (1).

The use of risk scores and in particular the Q risk score in patients in the UK and the reduction to 10% as the trigger for treatment has meant that many more healthy patients are being prescribed preventative medication such as statins and blood pressure medication. At the same time mental health problems are increasing and the prevalence of obesity which is a risk factor for type two diabetes is also rising dramatically. It is creating a perfect storm for patients being on multiple drugs.

Herbal medicine has an important part to play in calming the multiple medication storm, especially when combined with lifestyle change.

Polypharmacy, which can be defined as a patient being on 5 or more medicines is becoming increasingly common, especially amongst those who are 65 or older. This has arisen due to the increased use of preventative medication, and the increasing burden of chronic disease due to both longevity and the western lifestyle.

Research and guidelines have focused on single diseases resulting in patients with more than one illness being started on multiple medications, all individually indicated but in combination resulting in polypharmacy.

Some patients are prescribed 10 or even 15 medications and often experience marked side effects such as dizziness, indigestion, bowel problems, fatigue and falls. These patients have their symptoms controlled but they often do not have a good quality of life and don’t feel well.

In the UK between 2008 and 2015 the number of hospital admissions directly related to drug side effects increased by 53.4%, from 60,055 in 2008-2009 to 92,114 in 2014-2015. Every year in Europe an estimated 8.6 million unplanned hospital admissions occur as a result of drug side effects and in the US the harm resulting from medication errors is estimated at $42 billion dollars per annum (2).

Herbal medicines have an important role to play in reducing the drug burden of the population, especially when used alongside lifestyle changes, and the deprescribing of unnecessary medication. The targeted use of herbal medicines may also help to reduce the drugs bill, adverse drug reactions and encourage self-help.

Herbal medicine and humanity have enjoyed a close symbiotic relationship for millennium and today there are approximately 21,000 different plants used worldwide.

Some plant medicines are very potent with their therapeutic action coming from a relatively small number of powerful phytochemicals and have often formed the basis for drug development for example foxglove (Digitalis pupurea) and digitalis for heart failure and heart rate control, and belladonna (Atropa belladonna) and associated alkaloids as inhalers in chronic obstructive pulmonary disease.

However, many plant medicines represent a more complex range of actions containing 100s of potentially active principles which work in synergy, with it often being difficult to reliably isolate the “active” ingredient. These herbal medicines are well suited to the management of more complex illnesses as they are themselves inherently complex, whilst at the same time being biologically close to us, having evolved within the natural world. Herbal medicines at this end of the spectrum have a low side effect profile, and provided they are of good quality and attention is given to potential drug herb interactions are safe.

The evidence base for herbal medicine varies from Level I evidence where a plant has had enough research to allow for a systematic review of randomised controlled trials to Level IV evidence where the knowledge of the plant is based on experience and expert consensus (3). The majority of herbal medicine evidence is empirical being at Level IV, which is seen conventionally as having a lower level of validity when compared with Level I evidence.

However, the empirical basis of herbal medicine is particularly powerful as it spans centuries as opposed to decades and is also often cross cultural. A significant number of national guidelines such as NICE guidelines are partially based on Level IV expert consensus and so this can be considered an acceptable level of evidence, especially considering the low side effect profile of most plant medicines.

Diabetes and in particular Type 2 Diabetes mellitus is becoming a major health issue with an 80.1% increase in the prescribing of diabetic medication in the UK in the decade leading up to 2017, the overall cost of diabetes medication in 2016-17 being £983.7 million (4).

Herbal medicine has a role to play in diabetes with there being 400 herbal medicines which are believed to help diabetes (5).  

Plant medicines which have demonstrated an effect on diabetes in human clinical trials are Gymnema (Gymnema sylvestre) a herbal medicine used traditionally in Ayurvedic medicine (6), fenugreek (Trigonella Foenun-graecum) which has been used in the Middle East and India (7) and cinnamon (Cinnamomum zeylanicum) (8), all of which have beneficial effects on blood glucose levels.

Recent research into type 2 diabetes has also shown that a calorie restricted diet of 800 calories a day for a period of 3-5 months reversed diabetes in 46% (9), and it is likely that the addition of herbal medicines such as Gymnema, Fenugreek and Cinnamon would potentiate the effectiveness of diet in the treatment of type 2 diabetes.

Viral upper respiratory tract infections such as coughs, colds and ear infections are a common reason for patients to attend general practice, with time and patient pressures sometimes leading to unnecessary antibiotic prescribing. This increases the risk of antimicrobial resistance with there being a direct link between the amount of antibiotics prescribed in a community and antibiotic resistance.

It has been estimated that increasing antibiotic resistance could lead to 10 million deaths a year worldwide by 2050, with an estimated 25,000 people dying in Europe each year as a result of antibiotic resistant infections such as MRSA and E. Coli. (10).

The increased education of the public, GPs and Nurse Prescribers in the use of herbal medicines for the self-care of viral infections could lead to reduced antibiotic prescribing, with the use of herbal medicines such as Elderberry (Sambucus nigra fructus) in the treatment of viral upper respiratory tract symptoms including fever, nasal congestion, and headache (11).

In addition, there is evidence that Echinacea (Echinacea angustifolia/purpurea) can be used in the treatment and prevention of colds (12) and Andrographis (Andrographis paniculata) in reducing the symptoms of upper respiratory tract infections (13).

St. John's Wort (Hypericum perforatum)
St. John’s wort (Hypericum perforatum)

Mental health problems are increasingly prevalent in the UK population with antidepressants representing the biggest increase in prescription items in 2016. 64.7 million prescriptions for antidepressants were issued in 2015-16, with 3.7 million more anti-depressants being dispensed in 2016 than the previous year, and in 2015 anti-depressants cost the NHS £780,000 a day (1).

Herbal medicines have been used for mental health problems for centuries and can play an important role along with lifestyle changes, and psychological therapies in mild and moderate depression.

St John’s wort (Hypericum perforatum) has a high level of evidence (Level 1) with one meta-analysis of 29 trials showing it to be as effective as antidepressants in mild and moderate depression, and more effective than placebo in major depression, with fewer side effects than conventional antidepressants (14).

A 2017 meta-analysis of 27 clinical trials came to similar conclusions when comparing St John’s wort to Selective Serotonin Reuptake Inhibitors (SSRIs) such as citalopram (15). St John’s Wort however does need to be used with attention to the other medication which the patient is taking due to its potential interaction with medications such as the contraceptive pill and warfarin.

Rhodiola (Rhodiola rosea) has also been shown to effect depression (16) and is thought to have adaptogenic effects helping the immune and endocrine system to adjust to stress. Herbal medicines can also be helpful in anxiety with 21 plants having human clinical trial evidence of efficacy such as chamomile (Matricaria recutita), skullcap (Scutellaria lateriflora), passionflower (Passiflora incarnata), and ashwagandha (Withania somnifera) (17).

Ashwagandha has been shown to improve anxiety and stress compared to placebo (18) and the potential for adaptogenic herbal medicines such as ashwagandha and rhodiola along with others such as reishi (Ganoderma lucidum) to help reduce the adverse effects of stress is unique to herbal medicine and highly significant considering the prevalence of stress in the community. The humble chamomile tea (Matricaria recutita) is available from most food stores has been shown to reduce anxiety scores and is a good example of a readily available herbal medicine with significant self-care potential (19).

There can be no doubt that herbal medicines alongside the use of lifestyle medicine and the deprescribing of medications which are no longer indicated can play a critical role in healthcare and reducing a patient’s medication burden. Plant medicines can also play an important part in patient self-care, and the management of stress and mental health problems, as well as in preventative medicine.

There is an urgent need for better education of both the public and frontline health care professionals into the possible benefits of plant medicines, as well as more appropriate research into the use of herbal medicines, especially those which are commonly used by practitioners with good empirical effect but which have not attracted research.

  1. NHS Digital, Prescriptions Dispensed in the Community – Statistics for England, 2006-2016, June 2017
  2. WHO, Medication Without Harm, WHO Global Patient Safety Challenge, 2017
  3. National Health and Medical Research Council (NHMRC). A Guide to the Development and Evaluation of Clinical Practice Guidelines. Commonwealth of Australia, Canberra, 1999.
  4. NHS Digital, Prescribing for Diabetes in England – 2006/07 to 2016/17, Aug 2017
  5. Kumar S. Mittal A. Babu D. Mittal A. Herbal Medicines for Diabetes Management and its Secondary Complications. Current Diabetes Reviews, 2021, 17, 437-456
  6. Baskaran K. Ahamath K, Shanmugasundaram K. Antidiabetic Effect of a Leaf Extract from Gymnema Sylvestre In Non-Insulin-Dependent Diabetes Mellitus Patients Journal of Ethnopharmacology, 30 (1990) 295 – 305
  7. Narsingh V. Usman K. Patel N. Arvind J. Sudhir D. et al. A multicenter clinical study to determine the efficacy of a novel fenugreek seed (Trigonella foenum-graecum) extract (FenfuroTM) in patients with type 2 diabetes. Food and Nutrition Research. Octo 2016 Vol.60 (1) p.32382-32382
  8. Zare R. Nadjarzadeh A. Zarshenas MM.  Shams M. , Heydari MG,  Efficacy of cinnamon in patients with type II diabetes mellitus: A randomized controlled clinical trial. Clinical nutrition (Edinburgh, Scotland), 2019-04, Vol.38 (2), p.549-556
  9. Lena ME. et al. Primary Care-led management for remission of type 2 diabetes (DiRECT): an open label cluster randomised trial. Lancet. Feb 2018 10;391 (10120):541-551
  10. Public Health England, Health matters: antimicrobial resistance. Dec 2015. Health matters: antimicrobial resistance – GOV.UK (www.gov.uk)
  11. Harnetta J. Oakes K. Carèa J. Leache M. Brown D.  Cramerg H et al. The effects of Sambucus nigra berry on acute respiratory viral infections: A rapid review of clinical studies. Advances in integrative medicine, 2020-12, Vol.7 (4), p.240-246
  12. Jawad M. Schoop R. Suter A. Klein P.  Eccles R. Wahner-Roedler D. Safety and Efficacy Profile of Echinacea purpurea to Prevent Common Cold Episodes: A Randomized, Double-Blind, Placebo-Controlled Trial. Evidence-based complementary and alternative medicine, 2012-09-16, Vol.2012, p.841315-841315
  13. Panel RC. Saxenaa R. Singh BP. Kumarc SC. Yadavc MPS. et al. A randomized double blind placebo controlled clinical evaluation of extract of Andrographis paniculata (KalmCold™) in patients with uncomplicated upper respiratory tract infection. Phytomedicine Volume 17, Issues 3–4, March 2010, Pages 178-185
  14. Linde K. Berner MM. Kriston L. St John’s Wort for Major Depression. 2008 Cochrane Database of Systematic Reviews, Issue 4.
  15. Ng QX. Ventakatarayana N. et al. Clinical use of Hypericum perforatum (St John’s wort) in depression: A meta-analysis. Journal of Affective Disorders 1 March 2017, Vol 2010. Pages 211-221
  16. Sarris J. Panossian A. Schweitzer I. Stough C. Scholey A. Herbal medicine for depression, anxiety and insomnia: A review of psychopharmacology and clinical evidence. European neuropsychopharmacology, 2011, Vol.21 (12), p.841-860
  17. Sarris J. McIntyre E. Camfield DA. Plant-Based Medicines for Anxiety Disorders, Part 2: A Review of Clinical Studies with Supporting Preclinical Evidence. CNS drugs, 2013-08-01, Vol.27 (8), p.675-675
  18. Pratt MA, Nanavati KB. et al. An alternative treatment for anxiety: a systematic review of human trial results reported for the Ayurvedic herb ashwagandha (Withania somnifera). Journal of Alternative and Complementary Medicine 2014 Dec;20(12):901-8
  19. Keefe JR. Mao JJ. Soeller I. Li QS. Amsterdam JD. Short-term open-label chamomile (Matricaria chamomilla L.) therapy of moderate to severe generalized anxiety disorder. Phytomedicine (Stuttgart), 2016-12-15, Vol.23 (14), p.1699-1705

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The art and science of herbal formulation: Western herbal medicine https://www.herbalreality.com/herbalism/western-herbal-medicine/art-science-herbal-formulation-western-herbal-medicine/ https://www.herbalreality.com/herbalism/western-herbal-medicine/art-science-herbal-formulation-western-herbal-medicine/#comments Fri, 29 Oct 2021 15:22:15 +0000 https://www.herbalreality.com/?p=4404 We explore how formulations and medicine making of traditional medicine in the west has changed over time.

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We explore how formulations and medicine making of traditional medicine in the West, also known as Western herbal medicine, has changed over time.

Traditional medicine in the west did things rather differently. If we go back to Galen the acknowledged authority from Roman times, we see that in his world view the ‘power’ of the individual medicine (or ‘drug’) was foremost. Galen set out what was in effect a ‘research agenda’ for ‘proving’ these powers, based on eight conditions:

  1. The drug must be of good unadulterated quality
  2. The illness must be simple, not complex
  3. The illness must be appropriate to the action of the drug
  4. The drug must be more powerful than the illness
  5. One should make careful note of the course of illness and treatment
  6. One must ensure that the effect of the drug is the same for everybody at every time
  7. One must see that the effect of the drug is specific for human beings
  8. One must distinguish the effect of drugs (working by their qualities) from foods (working by their substance)
The Art & Science of Herbal Formulation: Western Herbal Medicine

In effect the physician’s role was to ‘prove’ the individual effect of each drug by direct experience. The fundamental principle in Galen’s work was that nature was an active dynamic force. Treatments engaged these forces, either in the case of drugs through their own dynamic ‘qualities’, or in the case of foods by the qualities of their substance.

In classifying the dynamic qualities of medicines, Galen refined the widely established view that they had ‘temperaments’ reflecting well-understood climatic influences: hot, cold, dampness and dryness, each formed of paired combinations of the four elements that made up nature: earth, water, fire and air (heat is generated by fire and air, cold by earth and water and so on).

The elements were associated with four fluids or ‘humours’ in the body, black bile, phlegm, yellow bile and blood, with their associated personality types, the melancholic, phlegmatic, choleric and sanguine. The humours were the cornerstone of therapy and physicians moved to counteract excess (plethora) or deficiency (kenos) in any of them.

For excess or toxic conditions remedies were antidota, primarily heating, cooling, drying and moistening as necessary, in degrees, with remedies in the ‘first degree’ milder than those in the third or fourth (which became increasingly dangerous). In deficiency conditions physic remedies were replenishing or supportive.

Galen

This focus on the quality of each remedy was elaborated in the second flowering of Galenic medicine in the 9th-11th centuries, still widely practised throughout the Islamic world as Unani/Tibb (‘unani’ is the Arabic word for Greek).  Islamic medicine also pays more respect to the qualities of individual herbs than to formulations, Physicians are expected to understand intimately the nature of each remedy, its natural habitat, its specific energy pattern, actions, indications, specific relationships to the organs, duration of action, toxicity and contraindications, types of preparation, dosage, administration and antidotes.

Interestingly the settler traditions of North America in the 19th century rediscovered Galenic principles themselves. The pioneer Samuel Thomson credited his espousal of heating remedies in fever management not only to native American traditions like the sweat lodge and use of cayenne, but to earlier Greek-Roman concepts. In his widely popular 1835 book ‘New guide to health; or the botanic family physician’ Thomson also espoused vitalistic principles similar to those of Ayurveda and also naturopathy.

  1. Health follows from obeying natural laws
  2. Disease is an obstruction or diminution of vital energy
  3. Disease is caused by violation of natural laws such as:
    • hereditary (violation by forefathers)
    • lack or excess of exercise
    • sudden temperature changes
    • wrong diet and over-eating
    • poisons and pollutants
    • injury
  4. Symptoms, such as fever, are due to the effect of the disease and are not the disease itself
  5. Disease has only one basic type of cure – to remove obstructions or restore vital energy using substances that act in harmony with natural laws and the vital energy
  6. In doing so one or more of the following effects should be accomplished:
    • relaxation
    • contraction
    • stimulation
    • soothing
    • nourishing
    • neutralisation

However neither Thomson, nor his more sophisticated successors in the North American Eclectic and Physiomedical traditions, developed substantial formulation protocols. They did develop deep insights into the vital actions of each herb and so produced the most elaborate materia medicas of the modern age, but like Galen and the Islamic physicians before them clearly kept their focus on the individual remedy. There are formulae in all their books, but it seems these were less important than their role in eastern classic texts.

So discussing Western herbal formulation is much more difficult than the relatively clear descriptions in Chinese and Ayurvedic medicine. Over the course of the last few centuries, largely due to the meteoric rise of allopathic medicine along with various forms of discrimination against Herbal Medicine, much of the traditional language has morphed into modern scientific terminology.

The closing of Eclectic schools in America in the early 20th Century, and the removal of Physiomedicalism from herbal education in the UK in the late 1970s, shut the doors on the more formal inclusion of vitalism in herbal training. In the face of various legal threats to practice and coupled with the pressure to ‘modernise’ the profession and promote ‘phytotherapy’ as the modus operandi, much of the framework and language of vitalistic thinking has been obscured.

In spite of its modern appearance phytotherapy can still be seen as the end of a cultural line through western history. The benefits of the phytotherapeutic approach to our understanding as herbalists are of course priceless, however an innate lure to the naturalistic means this cultural void has been filled by a somewhat disconnected approach to herbal pharmacology; some phytochemistry, some science, part Galenical, part Physiomedicalist, part Thomsonian, part Eclectic and probably ‘part’ a few other things depending on the herbalist’s training and experience.

This over-emphasis on molecular herbalism risks leading western practitioners away from differential prescription based on a comprehensively clear set of principles. How do we decide on using Melissa or Scutellaria or Taraxacum or Arctium in a clearly logical and vitalistic manner without a common diagnostic framework that is appropriate to how herbs work? In modern times we have been forced down the anti-inflammatory, antispasmodic, generally-anti route and in doing so diminished our collective autonomy.

Do we borrow from Asian traditions, tap into our Celtic past, use our intuition, or justify it all based on 1 out of the 1000s of the chemicals in the plant?

On a more positive note however, if Western practitioners follow the Galenic ideal they formulate from scratch with each patient, starting with a clean sheet of paper and building up an individual blend from a deep insight into the personality of each remedy and their assessment of the needs to the patient in front of them.

There has been much work by eminent herbalists and schools to develop the principles of our herbal traditions into a more cohesive form; Michael Tierra, Anne McIntyre, Graeme Tobyn, Thomas Garran, Jim McDonald to just mention a few have all written useful work integrating different modalities of Western, Ayurvedic, Chinese traditions.

Whether its using the Eclectic’s focus on tissue states (hot-cold/wet-dry/tense-relaxed), or re-birthing Galenical energetics, even some education on the levels of strength of each herb a la Culpepper, there is reflection across the community as to how we answer this cultural question about our identity in a world dominated by a primarily reductionist approach. We would do well to hold close Hippocrates’s advice that “Its more important to understand what sort of person has a disease than what disease a person has.”

That being said, the inherent functionality of the plants, and the very practical approach taken by the Western herbal tradition, means a wealth of information about each species is known. Out of all the herbal traditions, Western Herbal Medicine has perhaps most successfully coupled historical knowledge with phyto- and biochemical approaches, leading to a respected place in many communities and some healthcare systems.

Although some may debate whether the use of a single plant solely based on a disease name is really ‘herbal medicine’, nonetheless, in Germany for example, phytomedicine is widely dispensed alongside allopathic medicines. And the vast increase in high quality research made possible because of this understanding of phyto- and biochemistry is taking the profession to new heights of interaction with the forefront of medicine.

Generally speaking, like its Galenic, Islamic and North American precedents, modern Western Herbal Medicine categorises therapeutic groups of plants by effects on physiology. Often these ‘actions’ are related not only to the system they influence (e.g. expectorants, nervines) but also the class of phytochemical constituents they contain (e.g mucilages, tannins).

Whilst the contribution of Western herbalism to understanding how plants work cannot be underestimated – and new research into the interaction of herbs and the microbiome is revealing startling new insights – this action orientated approach is useful for categorising herbs but it takes you away from seeing the quality with which that activity may work. What a herb ‘does’ is not who that herb ‘is’.

To understand ‘how’ a herb initiates change in a given person you need to understand the character of the person and the herb; Valerian (Valeriana officinalis) and Skullcap (Scutellaria lateriflora) are two very different type of nervines and only knowledge of the traditional uses and doses, the guidance of a good teacher, knowing the vitalistic qualities and direct experience can really help to differentiate.

As the fortunate recipients of the wisdom of our ancestors, much of the differential selection of the best herbs for certain conditions has already been done. Of course, all herbs have more than one ‘action’ and experience has distilled these into their main activity (often described as primary and secondary actions). Further to the active nature of the herb, herbs are designated effective differentiators; Aromatic, Astringent, Bitters, Demulcents, Relaxants, Stimulants. So you can have aromatic nervines, bitter nervines etc. Today, secondary activities are often medicalised terms; anti-bacterial, anti-inflammatory etc.

Excellent summaries by Simon Mills & Kerry Bone, David Hoffman, Jill Stansbury are worth exploring further. Also take a look at the References and Biography further down.

Taking Ulcerative Colitis as an example and drawing from David Hoffman’s Medical Herbalism text as an example of a formula for IBS:

  • Bayberry (Myrica cerifera) – 2 parts
  • Mugwort (Artemisia vulgaris) – 1 part
  • Chamomile (Matricaria recutica) – 1 part
  • Wild Yam (Dioscorea villosa) – 1 part
  • Peppermint (Mentha piperita) – 1 part
  • Valerian (Valeriana officinalis) – 1 part

5ml of a tincture 3x/day. A carminative tea also prescribed.

ActionHerbFunction
AstringentBayberry (Myrica cerifera)Stops diarrhoea, reduces mucus
BitterMugwort (Artemisia vulgaris), Chamomile (Matricaria recutica)Stimulates digestive secretions
Anti-inflammatoryWild Yam (Dioscorea villosa), Chamomile (Matricaria recutica)Reduce localised inflammation
CarminativeChamomile (Matricaria recutica), Peppermint (Mentha piperita)Smooth transition of gas
Anti-spasmodicWild Yam (Dioscorea villosa), Chamomile (Matricaria recutica), Peppermint (Mentha piperita)Stop cramping
VulneraryChamomile (Matricaria recutica)Stops bleeding, damage to intestinal lining
NervineValerian (Valeriana officinalis)Treats underlying stress and stress from diarrhoea

Adaptogens are strengthening herbs that help us adapt to stress by interacting with the endocrine system. They help normalise metabolism and nourish the tissues. Examples include Licorice (Glycyrrhiza glabra), Ashwagandha root (Withania somnifera), Rhodiola root (Rhodiola rosea) and Ginseng root (Panax ginseng)

Alteratives are herbs that ‘alter’ the condition in a tissue by eliminating metabolic waste via the liver, large intestine, lungs, lymphatic system, skin and kidneys. Examples include Burdock root (Arctium lappa), Dandelion root (Taraxacum officinalis), Cleavers (Galium aparine), Poke (Phytolacca decandra) and Nettle leaf (Urtica dioica).

Burdock (Arctium lappa)
Burdock (Arctium lappa)

Amphoterics are herbs that bring balance to different organs, tissues and systems by regulating hyper and hypo functioning. Amphoterics create harmony. Examples include Licorice root (Glycyrrhiza glabra), Oatstraw flowering tops (Avena sativa), Hawthorn berry (Crataegus oxycanthoides).

Analgesic: These are medications that are applied internally or externally to reduce pain, Many of them work by depressing the functions of the central nervous system, Examples of effective analgesics include Jamaican Dogwood (Piscidia erythrina), Pasqueflower (Anenome pulsatilla), California Poppy (Eschscholzia californica), Corydalis (Corydalis yanghusuo) and Wild Lettuce (Lactuca virosa). Topically, Aconite (Aconitum napellus) and Cayenne (Capsicum minimum) are powerful anodynes.

Antimicrobials are herbs that interfere with the proliferation and life-cycle of microbes; bacteria, fungi, and viruses. Examples include Thyme leaf (Thymus vulgaris), Echinacea (Echinacea species), Elderberry (Sambucus nigra).

Aphrodisiac herbs are those that nourish, build and stimulate sexual desire and potency. Examples include Saffron (Crocus sativa) and Ashwagandha root (Withania somnifera).

Astringents: This group of herbs contain tannins that act to precipitate proteins and draw tissues together, tightening and toning them to reduce secretions and discharge. Astringents also tend to stop bleeding and can act on tissues with which there is no direct contact. Examples include Raspberry leaf (Rubus ideaus), Lady’s Mantle leaf (Alchemilla vulgaris), Agrimony leaf (Agrimonia eupatoria), Shepherd’s Purse leaf (Capsella bursa-pastoris), Witch Hazel leaf (Hamamelis virginiana) and Yarrow leaf (Achillea millefolium).

Bitters stimulate digestion by enhancing digestive secretion and peristaltic movements of the gut. They act via a reflex from the taste buds to the brain then through the vagus nerve to whole digestive system. Often these herbs are combined with warming digestives to balance the cold nature of bitters. Examples include Artichoke leaf (Cynara scolymus), Gentian root (Gentiana lutea), Wormwood leaf (Artemisia absinthium), Oregon Grape root (Mahonia aquifolium), Goldenseal root (Hydrastis canadensis)

Limeflower (Tilia x europaea)
Limeflower (Tilia x europaea)

Cardiotonics: These are herbs that bring order and strength to the cardiovascular system. speed up or slow down the heart as needed. Examples include Hawthorn berry and leaf (Crataegus oxycanthoides), Motherwort leaf (Leonurus cardiaca), Lily of the Valley leaf (Convalleria majalis), Garlic bulb (Allium sativum), Lime flower (Tilia platyphyllos), Mistletoe leaf and berry (Viscum album).

Carminative herbs are high in essential oils and help ease digestion by relieving gas, spasms and cramps. Examples include Aniseed (Pimpinella anisum), Fennel seed (Foeniculum vulgare) and Peppermint leaf (Mentha piperita).

Cholagogues and choleretics: Cholagogues promote the production of bile in the liver. A cholereticis a type of cholagogue that promotes the release of bile from the gall bladder into the duodenum. Cholagogues have an alterative and laxative effect. Cholagogues are contra-indicated if there is acute liver failure, obstructive jaundice, painful gallstones or cholecystitis. Examples include Celandine leaf (Chelidonium majus), Barberry root (Berberis vulgaris), Dandelion root and leaf (Taraxacum officinalis root), and Blue Flag root (Iris versicolor).

Demulcents are soothing mucilaginous and silky herbs that can be taken internally to soothe and protect damaged or inflamed tissue. Examples include Slippery elm bark (Ulmus rubra), Marshmallow root (Althea officinalis) and Limeflower (Tilia cordata).

Diaphoretics are herbs that cause sweating by increasing circulation in the periphary of the body. Usually used to help to relieve fevers some examples are Yarrow aerial parts (Achillea millefolium), Elder flowers (Sambucus niger), Ginger root (Zingiber officinalis).

Diuretics are herbs that stimulate the flow of urine, and help remove fluids from the body. Common examples are Dandelion leaf (Taraxacum officinalis), Burdock root (Arctium lappa) and Corn silk (Zea mays).

Emmenagogues are herbs that stimulate and promote menstruation. Examples include Marigold flowers (Calendula officinalis) and Chaste Tree fruits (Vitex agnus-castus), Turmeric root (Curcuma longa).

Expectorants are herbs that assist the body in expelling mucus from the upper respiratory tract. Examples include Licorice root (Glycyrrhiza glabra), Elecampane root (Inula helenium) and Thyme leaf (Thymus vulgaris).

Thyme (Thymus vulgaris)
Thyme (Thymus vulgaris)

Galactagogues are herbs that encourage the flow of breastmilk. Examples include Fennel seed (Foeniculum vulgare), Celery seed (Apium graveolens) and Shatavari root (Asparagus racemosus).

Hepatics are herbs that generally support liver function by decongesting as well as supporting bile flow. Examples include Dandelion root (Taraxacum officinalis), Yellowdock root (Rumex crispus), Turmeric root (Curcuma longa).

Hypnotics and sedatives: These are medications that promote a deep and relaxing sleep. They may work through muscle relaxant properties, through the action of volatile oils on the limbic system, or through the presence of alkaloids that affect the central nervous system. Chamomile flowers (Matricaria recutita), Lime flower (Tilia platyphyllos), Lemon balm leaf (Melissa officinalis), Wood Betony aerial parts (Stachys betonica), Skullcap leaf (Scutelleria lateriflora), Wild Lettuce leaf (Lactuca virosa), Passionflower aerial parts (Passiflora incarnata), Ashwagandha root  (Withania somnifera) Valerian root (Valeriana officinalis), Corydalis root (Corydalis yanhusuo), California Poppy aerial parts (Eschscholzia californica).

Hypolipidemics: These herbs mildly reduce serum lipids, including triglycerides and cholesterol. Examples include Hawthorn berry and leaf (Crataegus oxycanthoides), Turmeric root (Curcuma longa), Guggulu resin (Commiphora mukul), Garlic bulb (Allium sativum), and Cayenne fruit (Capsicum annuum).

Hypotensives: These herbs act to reduce a high blood pressure by relaxing muscles or through a calming effect upon the central nervous system. Examples include Hawthorn berry and leaf (Crataegus oxycanthoides), Garlic bulb (Allium sativum), Lime flower (Tilia platyphyllos), Cramp bark (Viburnum opulus), Valerian root (Valeriana officinalis), Motherwort  leaf (Leonorus cardiaca) and Mistletoe leaf and berry (Viscum album).

Immunomodulants: These herbs restore balance to a dysfunctional immune system. These are often used in chronic autoimmunity. such as Crohn’s and multiple sclerosis. Many immunomodulants are adaptogens, and vice versa. Examples include Reishi mushroom (Ganoderma lucidum), Astragalus root (Astragalus membranaceus), Licorice root (Glycyrrhiza glabra), Siberian Ginseng root (Eleuthrococcus senticosus), Ashwagandha root (Withania somnifera) and Cordyceps (Cordyceps sinensis).

Immunostimulants: These herbs stimulate the immune system protecting against infection, including non-specific mechanisms, and the specific mechanisms of humoral and cell-mediated immunity. Many immunostimulants are antimicrobials and vice versa, and are used in both acute and chronic infection. Examples include Echinacea root and leaf (Echinacea spp.), Garlic bulb (Allium sativum), Myrrh resin (Commiphora myrrha), Thyme (Thymus vulgaris, Andrographis leaf (Andrographis paniculata),) and Wild Indigo (Baptisia tinctoria).

Laxative herbs are those that stimulate or promote bowel movements. There are different types of herbs; gentle aperients, like Dandelion root (taraxacum officinalis), that have a mild effect; bulk-forming laxatives, like Flaxseed (Linum usitatissimum), that increase the water and bulk of the stool; stimulant laxatives is Senna leaf (Senna alexandria) that invigorate the muscles of the lower bowel to create a stronger motion. 

Nervines are herbs that soothe the nervous system and have a calming effect on the emotions. Examples include Oatstraw flowering tops (Avena sativa), passionflower (Passiflora incarnata), Lavender (Lavandula officinalis), St. John’s Wort (Hypericum perforatum), Rosemary leaf (Rosmarinus officinalis), and Gotu Kola leaf (Centella asiatica).

Fresh rosemary (Rosmarinus officinalis)
Fresh rosemary (Rosmarinus officinalis)

Rubefacients: When applied externally these herbs cause a mild local irritation and draw blood to the area through capillary dilation. Rubefacients are used to enhance blood supply to localized areas to remove congestion and promote healing. Examples include Cayenne fruit (Capsicum minimum), Mustard seed (Brassica spp.), Ginger root (Zingiber officinalis), and Peppermint leaf (Mentha piperita oil)

Sialogogues: These are medications that stimulate production of saliva to treat dry mouth, poor digestion, receding gums and infection including Prickly Ash bark (Zanthoxylum americanum), Echinacea root (Echinacea spp) and Spilanthes flower (Spilanthes acmella).

Tonics is a slightly controversial term as it seems to apply to herbs that bring tone to an organ or tissue. It is also used to refer to herbs that help the whole system to function better acting as general energy boosters. Examples of herbs that bvring tone to the tissues are the astringent Goldenseal (Hydrastis canadensis) and Ground Ivy (Glechoma hederacea). Those that bring energy are Cacao (Theobroma cacao), Oatstraw flowering tops (Avena sativa) and Ashwagandha root (Withania somnifera).

Vulneraries: These are wound-healing herbs used internally and externally. Astringent herbs such as Witch Hazel (Hamamelis virginiana) and Shepherd’s Purse leaf (Capsella bursa-pastoris) directly stop bleeding and promote the formation of an eschar (scab). Mucilaginous herbs such as Plantain leaf (Plantago lanceolata) and Selfheal leaf (Prunella vulgaris) soothe inflammation. Some vulneraries are used internally to speed tissue healing, including Marigold flower (Calendula officinalis), Plantain leaf (Plantago lanceolata), Selfheal leaf (Prunella vulgaris), and Marshmallow root (Althaea officinalis).

And Western Herbalists and phytochemists have taken the chemical insights to whole new levels of expertise, allowing for deeply scientific view of the inner workings of how the herbs behave in and act on the body. This has led to a specific understanding of how some species work, greater safety and improved quality standards.

The Monographs in The British Pharmacopoeia (and Indian, Chinese, European, USA etc) list the levels of marker compounds denoting medicinal grade. A pharmacopoeia (a word from the Greek for ‘knowing medicines’) is an official reference text containing a collection of standards to assure the quality of the medicines you can get from a doctor or pharmacy. Many herbs are used as medicines and their medicinal standards are published in the pharmacopoeias:

Herb nameFood grade
ISO 6571/1984
European Pharamocopoeia
Chamomile flowersMin. 0.2% essential oil0.4% essential oil
Apigenin min. 0.25%
Fennel seed (sweet)Min. 1% essential oilMin. 2% essential oil (specifying that 80% of this must be anethole with a maximum of 10% estragole and 7.5% fenchone)
Peppermint leafMin. 0.6% essential oilCut leaf min. 0.9% essential oil
Whole leaf min. 1.2% essential oil

The attention to safety with regards contaminants (microbiological, heavy metals, pesticides, pollutants, extraneous materials) as well as quality in terms of upper and lower limits of important compounds) has brought the practice of clinical herbalism into the highest standard of safe and effective healthcare.

Prescribing regulations

Please note that there are specific dispensary standards for blending herbs for individual use that must be followed by practitioners in the UK as a part of our commitment to safe and effective practice through self-regulation. Please refer to your Practitioner Association for the specifics.

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The art and science of herbal formulation: Ayurvedic formulation https://www.herbalreality.com/herbalism/western-herbal-medicine/art-science-herbal-formulation-ayurvedic-formulation/ https://www.herbalreality.com/herbalism/western-herbal-medicine/art-science-herbal-formulation-ayurvedic-formulation/#comments Fri, 29 Oct 2021 15:22:14 +0000 https://www.herbalreality.com/?p=4386 Herbalist Sebastian Pole explores the creation of Ayurvedic formulas which is based on some fundamental herbal pharmacological principles.

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Herbalist Sebastian Pole explores the creation of Ayurvedic formulas which is based on some fundamental herbal pharmacological principles.

“There is nothing in the world which does not have therapeutic utility when applied in appropriate conditions and situations.” – Charaka Samhita Sutrasthana

The creation of Ayurvedic formulas is based on some fundamental herbal pharmacological principles that are all grouped together in what is known as the dravyaguna shastra – the treatise on the qualities of medicinal substances.

Over 6,000 species have been described in Ayurveda, though perhaps around 600 are in common use today. At its heart is a very simple idea that opposites balance each other (samanya-vishesha). And that the opposite is also true that ‘like increases like’.

Essentially it promotes the idea that substances with like qualities increase each other proportionally:

  • Cinnamon and ginger = double spicy, very heating
  • Neem and andrographis = double bitter, very cooling
  • Those with opposing qualities balance each other: Cooling diets, lifestyles or herbs such as aloe vera remove hot inflammation, whilst heavy herbs like Ashwagandha balance lightness.

Below is a list of the different criteria that are used in Ayurveda to differentiate the potency of each herb that need to be considered when combining herbs:

  • Taste (rasa): Sweet, sour, salty, pungent, bitter, astringent (Find more about tastes in our article The Six Tastes of Ayurveda)
  • Effect on the metabolic thermal body (virya): Hot, cold and neutral; this category clarifies whether herbs warm you up or cool you down, if they stimulate or reduce the digestive fire, whether they are expansive or contractile by nature, whether they increase circulation or reduce it.

The quantity of impact is graded into degrees:

Degree of heatHeating flavours
hot in the third degree (hottest)Pungent (katu)
hot in the second degreeSour (amla)
hot in the first degreeSalty (lavana)
Degree of coldCooling flavours
cold in the third degree (coldest)Bitter (tikta)
cold in the second degreeSweet (madhura)
cold in the first degreeAstringent (kashaya)
  • Post-digestive effect (vipaka): How the taste of a natural substance changes after digestion and cooking, hence how it influences the doshas and physiology in the long-term. This rather unique interpretation primarily refers to the long-term effects on the fluids of the body and their impact on the bowels and fertility. Drying bitter and pungent herbs, like neem for example, are considered to reduce fertility if used long-term as they ‘dry’ the reproductive fluids.
  • Effect on the digestion, fluid system and tissues in the body (guna): The herbs have qualities of light, heavy, unctuous, drying, penetrating and soft; e.g. Mint is light, shatavari is heavy, aloe vera is unctuous, cinnamon is drying.
  • The unique properties of the plant (prabhava): This describes what the plant’s unique activities are above and beyond their energetics. For example, tulsi (Ocimum tenuiflorum) is classified as heating but it therapeutically helps to clear heat and reduce fever through diaphoresis. This means that whatever the causes of the fever Tulsi is indicated, along with other appropriate herbs, and this is its prabhava; jwarahara– the fever destroyer.
  • Tropism (satmya): The affinity a plant has for a certain organ, tissue or channel (ashaya/dhatu/srotas); e.g. Garlic for the lungs, turmeric for the liver, brahmi for the brain.
  • Constitutional (dosha): The effect of the herb on the constitution; i.e. whether it increases, decreases or balances the doshas.

These energetic descriptions of the herbs are all based on the different qualities of nature. To use an artistic metaphor, the theory of energetic pharmacology is the canvas; this is the basis. The herbs are the paints that the artist uses to paint a picture full of texture, depth, colour and clarity.

How the colours of the paints are blended depends on the artist’s interpretation of the scene in front of them, just as the energetic qualities of the herbs are merely guides along the path to finding the perfect formula for the patient. They are not absolutes. This is the stroke of the brush that gives the picture its unique quality. The interpretations of herbal energetics are flexible and depend on who is taking how much, of what and when.

As beauty is in the eye of the beholder, so herbal energetics are in the senses of the experiencer. The skill of the herbalist lies in uniting the theoretical framework of energetic pharmacology (dravyaguna), with the reality of the balanced or imbalanced physiological state of the patient (dosha prakriti and dosha vikriti). 

“Drugs act by virtue of their own nature and qualities at the proper time, in a given place, in appropriate conditions and situations; the effect produced is considered to be their action (karma); the factor responsible for the effect is their energy (virya); where they act is the place (adhisthan); when they act is the time (kala), how they act is the mode of action (upaya); what they accomplish is the achievement (phalam).” – Charaka Samhita Sutrasthana

Ashwagandha (Withania somnifera)
Ashwagandha (Withania somnifera)

Having arrived at an accurate Ayurvedic diagnosis the next step is to define the treatment plan. Treatment focuses on clearing out excess doshas, ama and malas and strengthening deficient dhatus, agni, prana, tejas and ojas. Ayurveda uses six main techniques to treat disease and create health:

  • Reducing (langhana) where there is an excess. Purification (shodhana) or palliation (shamana) are prescribed for reducing any excess pathologies.
  • Tonifying (brimhana) where there is deficiency. Sweet and nourishing tonics (rasayana) are given for building strength.
  • Drying (rukshana) therapy is used to alleviate any excess fluids in the system. Herbs that are diuretic or remove mucus dry the system.
  • Oleating (snehana) treatments moisturise dryness and give unctuousness to the tissues by using oily and demulcent substances.
  • Sweating (svedana) therapy reduces coldness, heaviness, stiffness, ama and trapped heat in the body by using steam and diaphoretic herbs.
  • Astringing (stambhana) therapy is used to slow the excessive flow of bodily fluids with tannin rich herbs.

When making a formula based on these techniques, you always focus on:

  • Disease specific treatment (vyadhi pratyanika):– focus on mitigating the disease
  • Dosa specific (dosa pratyanika):– focus on regulating predominant doshic pattern
  • Dhatu specific (dhatu pratyanika):– focus on predominant tissue imbalance
  • Digestionspecific (agni):– focus on digestive energy
  • Clearing toxins (ama):– focus on cleansing with bitter and pungent herbs

And you may include solutions for:

  • Removing obstacles: low digestive fire (mandaagni), blocked channels (srotorodha), undigested wastes/toxins (ama), inflammation (raktapitta, shotha), palliation (shamana), deep cleansing (shodhana)
  • Increase mental clarity (sattvavajaya), nourishing the intellect (medhya varga)
  • Increase circulation (rakta pravritti)
  • Rejuvenate inherited strength (ojas), inner metabolic fire (tejas), life-force (prana), general tonic rejuvenation (rasayana)

Carrier herbs (anupana)

This is the idea that certain substances either act as catalysts or messengers to the main active herb and help carry them to certain parts of the body. The carriers are either mixed with or taken alongside the medicine. Known as an anupana they are the medium that carries the herbs to their intended destination and enhances or moderates their effect. Water (hot or cold), milk, ghee, oil, herb juices, sugar, salt and honey are all used as vehicles.

Shatavari (Asparagus racemosus)
Shatavari (Asparagus racemosus)
  • Water when hot encourages digestive agni, clears toxic ama and reduces vata and kapha;
  • Water when cold reduces pitta;
  • Milk counteracts pitta and also encourages the nourishing effect of Ashwagandha (Withania somnifera) or Shatavari (Asparagus racemosus);
  • Ghee carries the herbs deep into the tissues, nourishes the nervous and reproductive systems and it also has a catalytic (yogavahi) effect on the herbs that helps to potentise them;
  • Aloe vera (Aloe barbadensis) carries herbs to all the tissues with a special affinity for the plasma, blood and reproductive tissues;
  • Honey clears kapha due to its warming astringency and is often used with herbs that treat the lungs and congested mucus conditions. It stimulates the appetite and prevents excessive excretions. It acts as a catalytic yogavahi substance that enhances the activity of the herbs taken with it

The herbs ride on these carriers like the scent on the wind. Using an anupana can enhance the potency of a preparation as well as facilitating its journey to the intended destination.

Famous Ayurvedic formula such as Triphala, Trikatu and Kaishor guggul incorporate these principles. Kaishor Guggul is a classic preparation including Triphala, Trikatu and a range of other herbs for reducing pain and inflammation, with a focus on arthritis, gout and skin problems.

Preparing Kaishor Guggul

Dose: 2 pills 2-3x/day with warm water

Each 250mg pill contains:

Common nameLatin nameDose
HaritakiTerminnalia chebula7.75mg
BibhitakiTerminalia bellirica23.26mg
AmalakiPhyllanthus officinalis7.75mg
GuduchiTinospora cardifolia11.63mg
ShunthiZinigber officinale5.81mg
MarichPiper nigrum5.81mg
PippaliPiper longum5.81mg
VidangaEmbelia ribes5.81mg
JaypalaCroton tiglium0.73mg
TrivrutOperculina turpenthum0.73mg
GugguluCommiphora mukul (purified)186.05mg
Source Reference: Sharangadhara Samhita and Bhaishajya Ratnavali.
Guggulu Shodhana (purification) reference: Bharat Bhaisajya Ratnakara
Triphala (Terminalia chebula, Terminala belerica & Emblica officinalis)
Triphala (Terminalia chebula, Terminala belerica & Emblica officinalis)

Triturated with the decoction of: Haritaki (Terminalia chebula), Bibhitaki (Terminalia bellirica), Amalaki (Phylanthus officinalis), Guduchi (Tinospora cordifolia)

  • Guduchi has a powerful pitta reducing action that penetrates deeply into the tissues.
  • Guggulu scrapes the pitta and vata toxins from the plasma, blood and muscle tissues.
  • Triphala, vidanga and trivrut combine to clear inflammatory toxins and ama.
  • Trikatu digests the toxins in the tissues and enkindles the tissue agni.

‘Kaishor’ indicates ‘youth’, hence it is used to prevent ageing and keep youth intact.

For the best results the Sarangadhara Samhita recommends that when using guggulu preparations one should avoid sour foods, penetrating foods, indigestion, excessive exercise, hot sun, alcohol and anger.

By learning the basic language of herbs, getting to know the herbs and, overtime, developing your intuition you can take these principles and mould them with your expertise using base formulae as building blocks and adjusting as appropriate for each individual case.

Also read “The Ayurvedic approach to digestive health and nutrition“.

Medicinal substances are classified according to groups that have different physiological actions. The Charaka Samhita lists 50 groups of ten herbs and the Bhavaprakasha Samhita has 24 such categories. These Ayurvedic pharmacological concepts offer deep insight into how herbs work to balance the doshas, dhatus, and malas. They tie together the concepts of taste (rasa), energetics (virya) and post-digestive effect (vipaka) as well as incorporating prabhava so that we can have a clear understanding of the primary action of the herb. The list below contains some of the most popular categories listed throughout the Ayurvedic literature.

  • Abhishyandi: These substances block the channels and cause heaviness. The flow of rasa is hindered and stagnation occurs when too much of these substances are used. They are mainly unctuous and heavy in nature; eg. yoghurt obstructs the flow in the channels.
  • Anuloma: These herbs help vayu to move in its appropriate direction. They are often mild aperients and help with flatulence and constipation. They are usually aromatic and carminative herbs, commonly from the Umbelliferacea family, such as Fennel seed (Foeniculum vulgare) or Ajmoda (Apium graveolens).
  • Arsoghna: There are anti-haemorrhoidal remedies such as Chitrak (Plumbago zeylanicum) or Ginger (Zingiber officinale).
  • Artava janana: Herbs promoting the menstrual flow such as Myrrh (Commiphora myrrha).
  • Balya: This means strengthening and these herbs are tonics. They are usually heavy and filled with the earth element, like Bala (Sida cordifolia) or Ashwagandha (Withania somniferum).
  • Bhedaniya: These are purgative herbs that forcibly expel the solid and liquid parts of faeces. Kutki (Picorrhiza kurroa) has this effect at a high dose.
  • Brmhaniya: These are nourishing herbs that are full of the water element; e.g. Shatavari (Asparagus racemosus).
  • Chaksushya: These herbs improve eyesight; e.g. Amalaki (Phyllanthus officinalis).
  • Chhardi nigrahana: These are anti-emetic herbs such as fresh Ginger (Zingiber officinale recens), Pomegranate juice (Punica granatum) or Cardamom (Elettaria cardamomum).
  • Chedana: These herbs actively draw out toxins by scratching them from the tissues; Guggul (Commiphora mukul), Shilajit (Asphaltum) and Black Pepper (Piper nigrum) all help to detoxify the deeper tissues.
  • Daha prasamana: These herbs alleviate burning sensations in the body, such as Sandalwood (Santalum album) or Coriander (Coriandrum sativum).
  • Dipaniya: These herbs enkindle the digestive fire. They indirectly digest ama. They are usually pungent, hot and dry; for example Long Pepper (Piper longum), Black Pepper (Piper nigrum) and Chitraka (Plumbago zeylanicum).
  • Garbashaya: These herbs have an affinity for the uterus, such as Ashoka (Saraca indica) and Roses (Rosa centifolia).
  • Grahi: These herbs dry the moisture of the body and of the wastes; Ginger (Zingiber officinale), Cumin (Cuminum cyminum).
  • Hikka nigrahana: These herbs are anti-hiccough such as Clove (Syzygium aromaticum).
  • Hridaya: These herbs have a tonic effect on the heart; Arjuna (Terminalia arjuna) and Ashwagandha (Withania somnifera).
  • Jeevaniya: These herbs are life-giving and rejuvenative herbs such as Amalaki (Phyllanthus officinalis).
  • Jwarahara: These are anti-pyretic herbs for stopping fevers including Musta (Cyperus rotundus) and Kalmegh (Andrographis paniculata).
  • Kandughna: These are anti-pruritic herbs such as Peppermint (Mentha piperita), Turmeric (Curcuma longa) and Musta (Cyperus rotundus).
  • Kanthya: These herbs are renowned for their affinity for the throat; for example Licorice (Glycyrrhiza glabra), Long Pepper (Piper longum).
  • Kasahara: These are anti-tussive herbs such as Vasaka (Adhatoda vasaka) or Long Pepper (Piper longum).
  • Krumighna: These herbs are specifically for removing parasites and worms; for example Neem (Azadiracta indica) or Kalmegh (Andrographis paniculata).
  • Kushtaghna: These are herbs that treat skin diseases such as Neem (Azadiracta indica) or Manjishta (Rubia cordifolia).
  • Lekhaniya: These herbs ‘scrape’ the waste residues out of the body by a drying action. They are usually bitter and pungent in flavour; for example Guggul (Commiphora mukul), Myrrh (Commiphora myrrha), Vacha (Acorus calamus), Turmeric (Curcuma longa), Triphala, Barley and Honey.
  • Madakari: These are substances that cause intoxication, such as alcohol.
  • Mutra sangrahaniya: These herbs reduce the flow of urine such as Bhallataka (Semecarpus anarcadium)
  • Mutravirechana: These herbs are diuretics that increase the flow of urine, such as Gokshura (Tribulus terrestris) and Coriander (Coriandrum sativum).
  • Nidrajnana: These herbs promote sound sleep; eg Tagarah (Valeriana wallichi), Ashwagandha (Withania somnifera)
  • Pachana: These herbs directly ‘digest’ ama.  They do not necessarily stimulate digestion as well; e.g. Triphala.
  • Praja sthapana: These herbs prevent miscarriage such as Ashoka (Saraca indica).
  • Pramathi: These herbs remove the accumulated doshas from the dhatusand cells; e.g. Vacha (Acorus calamus) and Black Pepper (Piper nigrum).
  • Purisha sangrahaniya: These are intestinal astringents that stop diarrhoea such as Bilva (Aegle marmelos).
  • Rakta shodhana (rakta prasadana): These herbs specifically clean the blood and ‘alter’ its chemistry so that it does not cause inflammatory problems; for example Manjishta (Rubia cordifolia).
  • Rechana: These herbs are cathartics. They forcibly expel faeces as semi-solid diarrhoea; e.g. Castor oil (Ricinis communis) or Rhubarb root (Rheum palmatum).
  • Rasayani: These herbs rejuvenate the cells and extend life. They are anti-oxidants and also remove diseases; e.g. Guduchi (Tinospora cordifolia), Amalaki (Phyllanthus officinalis) and Haritaki (Terminalia chebula).
  • Samjanasthapana: These herbs are used to restore consciousness; eg Vacha (Acorus calamus).
  • Sandhaniya: These herbs heal broken bones and hasten the repair of broken bone tissue. Guggul (Commiphora mukul) is famous for this. Resins have a significant role here because resins in general are considered to relate to the blood part of plants just as the bark of trees is said to relate to bone tissue. The analogy is that just as resin heals the bark so it heals the bone. They also encourage circulation to flow to the wounded part of the body and hasten healing.
  • Shamana: These are herbs that reduce the pathogenic level of a dosha to a more healthful level. The dosha is not expelled from the body, it is calmed. These are ‘palliative’ herbs; e.g. Guduchi (Tinospora cordifolia).
  • Shirovirechan: These are herbs that clear the orifices of the head, also known as errhines. Such herbs are Vacha (Acorus calamus) or Cloves (Syzygium aromaticum).
  • Shodhana: These herbs actually clear the excess doshas out of the body; e.g. Triphala, Castor oil (Ricinus communis) or Manjishta (Rubia cordifolia).
  • Shonita sthapana: These are haemostatic herbs such as Manjishta (Rubia cordifolia).
  • Shramshana: Herbs that are laxatives and clear faeces before complete digestion is complete; e.g. Trivrut (Operculina turpethum).
  • Shula prasamana: These are anti-colic herbs that prevent intestinal spasms; for example Hingu (Ferula asafoetida) or Cumin (Cuminum cyminum).
  • Shukrala: Herbs that increase semen and/or give force to its ejaculation; e.g. Amalaki (Phyllanthus officinalis), Aswagandha (Withania somnifera) and Shatavari (Asparagus racemosus).
  • Shukra janana: These are sperm increasing herbs; for example Ashwagandha (Withania somnifera) and Safed Musali (Asparagus adcendens).
  • Shukra shodhana: These herbs purify the sperm such as Gokshura (Tribulus terrestris).
  • Snehopaga: These are moistening herbs such as Castor oil (Ricinis communis) or Tila/Sesame (Sesamum indicum).
  • Stambhana: These are astringent herbs that are constipating, stop bleeding and are drying. They have the properties of vata and so increase it. Manjishta (Rubia cordifolia) is a renowned astringent that stops bleeding diseases.
  • Stanya janana: These herbs can increase lactation; for example Fennel (Foeniculum vulgare) and Shatavari (Asparagus racemosus).
  • Stanya shodhana: These herbs purify the breast milk such as Fennel (Foeniculum vulgare) and Musta (Cyperus rotundus).
  • Sukshma: These herbs are penetrating herbs that can travel through the minutest channels, such as Salt, Neem oil (Azadiracta indica) and Gotu Kola (Hydrocotyle asiatica).
  • Swasahara: These herbs prevent breathing difficulties such as Somalata (Ephedra vulgaris) and Vasaka (Adhatoda vasaka).
  • Swedopaga: Herbs that induce sweating such as Vasaka (Adhatoda vasaka).
  • Triptighna: These herbs are thirst quenching such as Amalaki (Phyllanthus officinalis).
  • Udara prasamana: These are allergy treating herbs such as Pit shirish (Albizzia lebbek).
  • Vajikarana: These are aphrodisiacs that increase sexual desire, strengthen the reproductive system and nourish shukra dhatu; for exampleKapikacchu (Mucuna pruriens), Ashwagandha (Withania somnifera).
  • Vamana: These are emetic herbs. They work specifically on pitta and kapha that have accumulated in the stomach. They move upwards and outwards. High doses of Licorice (Glycyrrhiza glabra) are emetic as is Madanphala (Randia dumentorium).
  • Varnya: These herbs benefit the complexion and skin lustre. Aloe vera (Aloe barbadensis), Sandalwood (Santalum album) or Rose water (Rosa centifolia).
  • Vedana sthapana: These are analgesic herbs such as Cloves (Syzygium aromaticum) or Ashoka (Saraca indica).
  • Vikasi: These herbs destroy the tone of the joints by loosening the ligaments; e.g. Betel nut (Areca catechu).
  • Virechana: These herbs are purgatives that move downwards. They dissolve undigested foods and expel them; e.g. Haritaki (Terminalia chebula).
  • Vishaghna: These are anti-toxin herbs that destroy ‘poison’ in the system; e.g. Neem (Azadiracta indica), Kutki (Picrorrhiza kurroa) and Sariva (Hemidismus indica).
  • Vyavayi: These herbs spread everywhere in the body and are then digested; e.g. Ganja (Cannabis sativum) and Opium (Papaver somniferum).
  • Yogavahi: These are catalyst herbs. When they are mixed with another herb they enhance its action; e.g. Ginger (Zingiber officinale), Honey and Ghee.

You can find all Ayurveda articles on our Insights page

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Cannabis: A folk remedy in Europe https://www.herbalreality.com/herbalism/western-herbal-medicine/cannabis-folk-remedy-europe/ https://www.herbalreality.com/herbalism/western-herbal-medicine/cannabis-folk-remedy-europe/#comments Fri, 29 Oct 2021 15:22:12 +0000 https://www.herbalreality.com/?p=4320 Matthew Clark takes a look at the discovery of cannabis, its botanical classification, and its historical use as a medicine in Europe.

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Matthew Clark takes a look at the discovery of cannabis, its botanical classification, and its historical use as a medicine in Europe.

The cannabis plant is extraordinarily versatile: it can be used for textiles, oil, food, rope, building materials, medicine and inebriation. During several millennia, particular varieties have been selectively bred by humans for either fibre, seed or psychoactive properties. This has resulted in numerous different kinds of cannabis plant.

In this article we will be looking at the discovery of cannabis, its botanical classification, and its historical use as a medicine in Europe.

Cannabis A folk remedy in Europe

The earliest evidence of what may be the cannabis plant has been found in pollen samples found in Lake Baikal in Southern Russia, dating to around 130,000 years ago; though these traces in pollen may instead be of Humulus (the hop family) (1). 

The cannabis plant probably first disseminated before the last Ice Age (c.13000 BCE) in at least two regions: Central Asia and Eastern Europe.

The earliest evidence of humans using cannabis comes from recent research conducted at the Okinoshima (on the Boso peninsular) site in Japan, which indicates the use of cannabis (adhering to pottery of the Jomon culture) in 8200 BCE. Cultivation of the plant appears to begin in the Copper Age (c.3500–2300 BCE), increasing in the Bronze Age (c.3500–1600 BCE) (2). 

Historically, cannabis has been one the most widely cultivated plant in human history (Schultes et al. 1975:22) (3). Due to travel, cultivation, selective breeding, trade and global seafaring, numerous varieties of the cannabis plant grow on all continents; cannabis finally arrived on the continent of South America in the 15th century (4).

Cannabis (Cannabis sativa)
Cannabis (Cannabis sativa)

There is abundant evidence for the use of cannabis in Europe for fibre, rope and textiles that dates back several millennia;(5) there is also archaeological evidence from Eastern Europe (in Bulgaria) and Central Asia dating from the 5th millennium BCE which has revealed that in antiquity cannabis was smoked for inebriation. Buds would be placed on hot stones or a brazier inside a simple, tent-like structure made of felt, which then became filled with smoke (6).

Amongst other similar discoveries, cannabis material, almost certainly used for inebriation, has been found at sites in Xinjiang Province in western China,(7) dated to the mid-first millennium BCE, and in Israel at the Judahite shrine at Arad, dated to the 8th century BCE (8).

The earliest, extant report in the West of the effects of cannabis, which is well known, is by the Greek historian Herodotus in his Histories,(9) who around 450 BCE described militant, wild, horse-riding Scythians in a region near the Black Sea inhaling cannabis smoke in felt tents and “howling with laughter.”

Despite the report of the psychoactive properties of cannabis by Herodotus and later accounts from the world of radical Qalandar Sūfīs in the Middle-East and Central and South Asia from the 12th century onwards,(10) and although known as a medicine in the classical Greco-Roman world, the psychoactive effects of cannabis were hardly known about in Europe until the mid-nineteenth century.

As mentioned above, research suggests that the cannabis plant may have originated in at least two regions, in Eastern Europe and Central Asia, resulting in at least two main varieties, which may have resulted from early human selection and cultivation.

Carolus Linnaeus

The botanical classification of cannabis plant species began in 1542 with the identification and image of Cannabis sativa (“cultivated” Cannabis) in a work on plants (De historia stirpum commentarii insignes) by the German physician and botanist Leonhart Fuchs (11).

More than 200 years later, Carolus Linnaeus, the Swedish “father” of modern botanical classification, also identified Cannabis sativa from specimens growing in Holland and Sweden (12) in his 1753 compendium Species Plantarum. The variety grown in Europe, and subsequently in North America, which was psychoactively weak, was generally known as “hemp.”

The classification of the cannabis into Cannabis indica (“Indian cannabis”)and Cannabis sativa began with the Frenchman Jean-Baptiste Lamarck in his Encyclopédie méthodique, publishedin 1785 (13). Lamarck was of the opinion that the indica variety was the kind native to India and Persia.

Cannabis ruderalis (“roadside Cannabis”), a small (two feet high), dark green, weedy variety found primarily in parts of Russia, was subsequently added to the classification in 1924(14), making a tripartite classification of the naturally growing cannabis plant. It was, however, only in the 1960s that botanists became fully persuaded that cannabis is not a monotypic plant but is, rather, polytypic (15). 

The current, general consensus is that Cannabis sativa strains have thinner leaves, are taller, spindlier, have less dense branch formations, and are generally reputed to have a proportionally higher component of THCs, while Cannabis indica strains have broader leaves, are shorter, and are reputed to be higher in CBDs, with less THCs. The third variety, Cannabis ruderalis, has a low THC and CBD content. (THCs provide the stimulating “high” of cannabis, while CBDs have a generally non-psychoactive, sedating effect.)

Although still adhered to by consumers, growers and suppliers, with the current awareness of the diversity of plant types, referred to above, this three-type classification of cannabis now seems inadequate (16). Based on extensive research, particularly by Karl Hillig at Indiana University, Clarke and Merlin (17) tentatively classify ten historical strains of cannabis originating in Europe and Asia.

Medicinal uses of the cannabis plant were known to the Greeks and Romans. The works of three medical authorities, Pliny, Discorides and Galen, are cited below, as they were perhaps the most influential on the subsequent development of medicine in Europe.

Pliny The Elder

Pliny The Elder

Pliny (the Elder) (23–79 CE), the Roman naturalist and military commander, knew cannabis. He describes it in his work Natural History (17), but not at all as an inebriant, even though he also discusses the inebriating, sleep-inducing properties of opium in this work (20.76), which was written in 77 CE. In Book 20 (“Drugs Obtained from Garden Plants: Hemp, Nine Remedies”), Pliny made the following observations:

Hemp originally grew in the forests, where it is found with a blacker and rougher leaf than in the other kinds. Hempseed, it is said, renders men impotent: the juice of this seed will extract worms from the ears, or any insect which may have entered them, though at the cost of producing head-ache.

The virtues of hemp, it is said, are so great, that an infusion of it in water will cause it to coagulate: hence it is, that if taken in water, it will arrest looseness in beast of burden. A decoction of the root in water, relaxes contractions of the joints, and cures gout and similar maladies. It is applied raw to burns, but it must be frequently changed, so as not to let it dry.

Dioscorides

Dioscorides (40–90 CE), the Greek physician and pharmacist, also knew cannabis. In his five-volume work on herbal medicine (De Materia Medica), he lists two kinds of cannabis, Kannabis emeros and Kannabis agria (19). He observes that Kannabis agria and Kannabis emeros are useful for making ropes, earache, “quenching conception,” inflammation and aching joints:

3–165. Cannabis Emeros

Cannabis is a plant of considerable use in this life for twisting very strong ropes. It bears leaf with a bad scent, similar to the ash; long hollow stalks, and a round seed. Eaten in quantities these quench conception. The herb (juiced while green) is good for earaches. It is also called cannabium, schoenostrophon, or asterion; the Romans call it cannabis.

3–166. Cannabis Agria

Cannabis sylvestris bears little stems similar to those of althea [3­–163] but darker, sharper and smaller. The leaves are similar to the cultivated but sharper and darker. The reddish flowers are similar to lychnis [3–114, 3–115], with the seed and root similar to althea. The root (boiled and applied) is able to lessen inflammation, dissolve oedema, and disperse hardened matter around the joints. The bark of this is suitable for twining ropes. It is also called hydrastina, the Romans call it terminalis, and some, cannabis.

Galen

Galen (Claudius Galenus) (129–c.199–216 CE), the great, Greek medical author and physician to several Roman emperors, briefly discusses cannabis in his De alimentorum facultatibus (34 [550]) (19) He observes that:

[Cannabis] produces headaches and unhealthy humours. Nevertheless some people roast and eat it with other sweetmeats. (Clearly, I am calling things that are eaten after dinner for pleasure while drinking, sweetmeats.). The seeds are quite warming, and consequently when they are taken in quantity over a short period they affect the head, sending up to it a vapour that is both warm and like a drug.

It has been suggested by some scholars that the classification of the cannabis plant into two kinds by Pliny and Dioscorides supports a thesis that they only used Cannabis sativa, which had little or no psychoactive resin, and that the other kinds he referred to were the more psychoactive variety Cannabis indica. However, neither Pliny, Dioscorides or Galen seem to have fully known about the psychoactive effects of any variety of cannabis. It seems more likely that the varieties of cannabis that they were acquainted with were simply those with a low THC content.

Cannabis (Cannabis sativa)
Cannabis (Cannabis sativa)

Perhaps the first reports in any European language about the psychoactive effects of cannabis was by François Rabelais (1490–1553), who had translated the Histories of Herodotus before writing the novel Gargantua and Pantagruel,(21) in which he enthuses about the usefulness of the fibre of cannabis (which he refers to as “Pantagruelion”); he also notes the “perfect jollity” induced by cannabis and some of its medical applications

The first substantial notice in a European language of the medical and psychoactive properties of the plant comes from two doctors stationed on the west coast of India.

Cristoval Acosta, from Burgos in Spain, wrote a treatise on medicine and drugs in 1578; Garcia d’Orta, from Portugal, was the first European to compile a materia medica for India, in 1563, entitled Coloquios dos simples e drogas he cousas medicinais da India, which became a major source of information for Linnaeus. d’Orta observes how his servants are reluctant to work, get hungry and laugh after eating cannabis, and how women are particularly prone to its aphrodisiac effects (22). 

Cannabis was subsequently referred to in several important botanical works, including the voluminous, twelve-volume work in Latin, Hortus Marlabaricus, which was published in Amsterdam between 1678 and 1693 by the Dutchman Hendrik Adriaan van Rheede tot Drakenstein (van Rheede), who became the Dutch Governor of Cochin in 1663 (23) In this work, cannabis is referred to as Kalengi Cansjava (24).

Cannabis continued to be known in Europe as a medical remedy throughout the medieval period (25). Robert Burton, an English clergyman, recommended cannabis for depression in his Anatomy of Melancholy, published in 1621.

Nicholas Culpepper writes in his widely-read Complete Herbal that, (26) “[Hemp] is so widely known to every good housewife in the country, that I shall not need to write any description of it.” Similarly to other physicians of the time, he records its usefulness for jaundice, earache, swelling, cough, worms, and other ailments; but he makes no mention of its inebriating properties.

Nicholas Culpepper

Nicholas Culpepper
Nicholas Culpepper

“It is sown in the very end of March, or beginning of April, and is ripe in August or September. It is a plant of Saturn and good for something else you see, than to make halters only. The seed of Hemp consumes wind, and by too much use thereof disperses it so much that it dries up the natural seed for procreation; yet, being boiled in milk and taken, helps such as have a hot dry cough.

The Dutch make an emulsion out of the seed, and give it with good success to those that have the jaundice, especially in the beginning of the disease, if there be no ague accompanying it, for it opens obstructions of the gall, and causes digestion of choler. The emulsion or decoction of the seed stays lasks and continual fluxes, eases the cholic, and allays the troublesome humours in the bowels, and stays bleeding at the mouth, nose, or other places, some of the leaves being fried with the blood of them that bleed, and so given them to eat.

It is held very good to kill the worms in men or beasts; and the juice dropped into the ears kills worms in them; and draws forth earwigs, or other living creatures gotten into them. The decoction of the root allays inflammations of the head, or any other parts: the herb itself, or the distilled water thereof doth the like.

The decoction of the root eases the pains of the gout, the hard humours of knots in the joints, the pains and shrinking of the sinews, and the pains of the hips. The fresh juice mixed with a little oil and butter, is good for any place that hath been burnt with fire, being thereto applied.“

The New London Dispensary, published in 1682, also includes hempseed decoctions for various ailments (27). 

The first report in English of the inebriating effects of cannabis was around the same time, by Captain Thomas Bowery, who drank bhāṅg on the west coast of India and published a short (and quite hilarious) account of his and his ten friends’ experience of it around 1680 in a Geographical Account of Countries Round the Bay of Bengal. Interestingly, Bowery notes how bhāṅg, “operates accordinge to the thoughts or fancy of the Partie that drinketh thereof.” (28)

The great scientist, architect and polymath Robert Hooke (1635–1703) obtained some cannabis in a coffee shop in London from Robert Knox, an East India Company merchant who had used bhāṅg successfully in India to cure dysentery, after he had escaped from captivity in Sri Lanka (29).

On December 18th 1689, Hooke gave a lecture entitled “An Account of the Plant call’d Bangue” (29) to the Royal Society in London, in which he explained that the drug is used by thousands of people and that the person who introduced it to him had experimented with it many times himself. Hooke reported that the dose of powdered leaves to be eaten was about the quantity that would fill a common tobacco pipe.

He observed that: the patient understandeth not, nor remembereth any Thing that he seeeth. heareth or doth, in that Extasie but becomes, as it were, a mere Natural, being unable to speak a Word of Sense; yet he is merry, and laughs, and sings and speaks Words without any Coherence, not knowing what he saith or doth; yet he is not giddy or drunk, but walks and dances and sheweth many odd Tricks.

He did not consider it at all dangerous, giving “no Cause of Fear, ‘tho possibly there may be laughter”. Hooke (27) also observed that cannabis could: “prove as considerable a Medicine in Drugs, as any brought from the Indies; and may possibly be of considerable Use for Lunaticks, or for other Distempers of the Head and Stomach, for that it seemeth to put a Man into a Dream, or make him asleep, whilst yet he seems to be awake, but at last ends in a profound Sleep, which rectifies all…and in all probability would cure them [lunaticks]”.

In these remarks, Hooke is anticipating by around three hundred years the potential of cannabis for treating particular psychiatric disorders.

William O’Shaughnessy

William O’Shaughnessy
William O’Shaughnessy

Knowledge in modern Europe of the psychoactive effects of cannabis was primarily due to psychological research by French investigators, principally Moreau de Tours (1845). Two other French medical doctors, Raymond Meunier and Pascal Brotteaux also published detailed accounts of the psychological effects of cannabis inebriation, in 1909 and 1934, respectively.

Besides the investigations by French psychiatrists, the person most influential in drawing attention to both the psychoactive effects and potential medical applications of cannabis was the Irish doctor and pioneer cannabis researcher, William O’Shaughnessy, who first reported his research findings in 1839 (32).  

He observed in Bengal first-hand the well-known effects of cannabis inebriation and wrote detailed reports of its various medical applications. He brought cannabis back to England and had a cannabis tincture manufactured by Peter Squire, a well-known pharmacist of Oxford Street in London who produced “Squire’s Extract.”

From the mid-19th century until global prohibition began in 1924, medical preparations that included “Indian hemp” were widely prescribed by western doctors for a range of ailments. Between 1840 and 1900, around a hundred articles on the therapeutic applications of cannabis were published in medical journals.

We have seen how knowledge of the medicinal and psychoactive properties of cannabis had a long gestation period in Europe, stretching back two millennia to Greco-Roman times. Between 1924 and until December 2020, when cannabis was finally rescheduled by the UN as having potential medical applications, global medical research was hampered in various ways for nearly a century by legal restrictions.

In recent years great progress has been made uncovering the potential uses of cannabis for a host of ailments. The full range of the possible medical applications of “soe admirable a herbe” are finally being brought to light, with attention now being focussed on several of the hundreds of molecular components of the plant.

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  31. Mikuriya, Tod H. (ed.) (2007) [1973]. Marijuana: Medical Papers 1839–1972 (vol. 1: Cannabis: Collected Clinical Papers). Nevada City, CA: Symposium Publishing.
  32. Grinspoon, Lester, and James B. Bakalar (1997). Marihuana, the Forbidden Medicine (revised edn.). New Haven/London: Yale University Press.

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The art and science of herbal formulation: An introduction https://www.herbalreality.com/herbalism/western-herbal-medicine/art-science-herbal-formulation-introduction/ https://www.herbalreality.com/herbalism/western-herbal-medicine/art-science-herbal-formulation-introduction/#comments Fri, 29 Oct 2021 15:22:12 +0000 https://www.herbalreality.com/?p=4364 The art and science of herbal formulation is as a pinnacle of clinical herbal medicine. Sebastian Pole explores what's in a herbal formula.

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The art and science of herbal formulation is as a pinnacle of clinical herbal medicine. Sebastian Pole explores what’s in a herbal formula.

The art and science of herbal formulation: An introduction

The art and science of herbal formulation can be viewed as a pinnacle of clinical herbal medicine. And from a societal perspective, a defining factor in human intellectual and medical achievement as well. Every culture in the world has hundreds of species they rely on for their health and well-being; we can define the ability to recognise a few hundred species at every stage of growth, as well as know how to use every part of the plant, as a sign of high cultural intelligence.

Our ability to have sifted through the 250,000 or so flowering plants, (along with numerous fungi, minerals and fauna), to refine a collection of the most therapeutic, and then be able to combine them for maximum efficacy is a wonder of human ingenuity and compassion.

All herbalists know that creating a differentially diagnosed treatment plan develops the building blocks to make a personalised formula that optimise the chances of clinical success. However, there are as many ways to prescribe herbs as there are routes up a mountain, be that as a single herb, in formulas, low-dose, high-dose, as teas, decoctions, tinctures, pills, salves, steams or subjects of contemplation to mention a few.

And beyond the desired efficacy there are many important factors to consider in terms of quality, safety, sustainability, dosage, contraindications, interactions, side-effects, compliance, cost and taste. Its no surprise that the world of herbal pharmacy is complex; its dealing with the very heart of Nature and our interdependent relationship with that complexity.

The oldest recorded evidence of medicinal plant recipes has been found on Sumerian clay slabs from Nippur, dated c2500 BCE. Numerous prescriptions including a range of over 250 plants have been found. Further evidence of our growth in medical knowledge occurs in the Ayurvedic Charaka Samhita c150BCE and early Chinese teachings in the Huang Di Nei Jing (Yellow Emperor’s Inner Classic) and the Shanghan Lun, Treatise on Cold Diseases, from c200CE.

Earlier formulations from around 3BCE have been discovered in China such as the Wu Shi Er Bing Fang (Formulas for Fifty Ailments) but they are more basic constructs lacking names, energetics and differentiation. Collectively, these seminal texts contain the earliest evidence of the first formula classifications based on differential diagnosis.

As knowledge and experience grew the great herbal traditions of Greece, India, China, Japan, Africa, Arabia, and the Americas all developed insight into blending different species to gain more specific and enhanced effects. Whether you call it a blend, prescription, recipe or formula, its at the heart of clinical herbal medicine.

A herbal prescription is a blend of herbs ranging from 1 to over 50 herbs plus, though more commonly from around 6-12 herbs. These formulas are often prescribed as a powder, pill, water (tea or decoction) or alcohol extraction (tincture or extract). Depending on the client, the illness, and the herb(s), the dose can range from low milligram doses to 100g or more a day.

Today we understand this idea of formulation, of how combining species together brings greater efficacy and safety, through the idea of synergy which is another way of saying “The whole is more than the sum of its parts”. Synergy implies a reciprocally beneficial relationship where plants’ nutrients and phytochemicals potentiate and support one another yielding a therapeutically superior result beyond that of their individual effects.  It opens up to the ideas of creative emergence where something can materialise out of the complexity that would not have manifested otherwise.

Given our 10 million or so years of human evolution its no surprise that our human genes respond very well to a wide range of low dose natural phytochemicals. Just think, if there are 1000 compounds in a plant and as we used to sustain our diet from around 150 species of plants (compared with around 20 today) our human eco-system is familiar with around 150,000 plant molecules. In contrast to this, modern medicine’s high-dose, single-molecule medicine has no precedent in our evolutionary history.

Whilst a high dose of a drug may be valuable in an emergency, herbs are the medicines we evolved to use for our everyday health. Tradition and synergy prove they work best when used as whole herbs, or full-spectrum extracts, in blended formulae.

As alluded to above, synergy is coupled with diversity. More diversity leads to greater efficacy and safety.

Synergy is coupled with greater efficacy as a low dose of many compounds work together to enhance their effects; e.g. energetically Ginger and Black pepper when used together are more pungent than when used alone, and phytochemically, Berberine’s bacteria modulating effects are enhanced by Methyoxylated flavonolignans in Mahonia aquafolium, or the multiple compounds in Hypericum perforatum that have been attributed with neurological effects, are more effective taken together than alone.

And safer. Synergy is coupled with safety as it can also ameliorate potential toxicity of some compounds; many herbs, such as aconite or calamus are traditionally prepared with other herbs, such as licorice and/or ginger, to mitigate extremes.

A great summary of synergy in herbal medicine is here by Eric Yarnell : https://restorativemedicine.org/journal/synergy-in-herbal-medicines-part-1/

Also, valuable to read is Lisa Ganora’s Herbal Constituents, Foundations of Phytochemistry.

Whilst there are many insights from different cultures, my experience is rooted in the Ayurvedic, Chinese and Western herbal traditions and so we will explore those approaches to making a herbal formula.

You can find more articles on Herbal Medicine on our Herbalism page.

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  • Dash, B and Sharma, R, Charaka Samhita, Chowkhamba Press, 1996, India
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  • Ganora, L, Herbal Constituents, Foundations of Phytochemistry, 2019, USA
  • Gogte, V, Ayurvedic pharmacology and therapeutic uses of medicinal plants, Bhavan’s Book University, 2000, India
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Why there is such an increase in allergies and what herbalism can do about it https://www.herbalreality.com/herbalism/western-herbal-medicine/why-increase-allergies-what-herbalism-can-do/ https://www.herbalreality.com/herbalism/western-herbal-medicine/why-increase-allergies-what-herbalism-can-do/#comments Fri, 29 Oct 2021 15:22:09 +0000 https://www.herbalreality.com/?p=4231 With rising numbers in allergic reactions, Vilma Matuleviciute explores why there is such an increase and how herbal medicine can help.

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Why there is such an increase in allergies and what herbalism can do about it

With rising numbers in allergic reactions, Vilma Matuleviciute explores why there is such an increase and how herbal medicine can help.

Herbalists are seeing steadily increasing numbers of people presenting with allergies, including food allergies, in their clinical practices.

People are having stronger symptoms and more hypersensitivity reactions. Various allergic diseases such as asthma, hay fever, urticaria, atopic dermatitis and allergic rhinitis are now affecting nearly 20% of the population across the world, and children are more affected than adults. (1)

There seem to be several external and internal factors contributing to this rise in allergies.

The general consensus is, unfortunately, that climate change and environmental factors stemming from it, such as air and chemical pollution, pesticides, insecticides, heavy metals, wildfires, soil quality degradation, longer flowering seasons due to heatwaves (hence longer exposure to pollen), all contribute to the rise seen in allergies in the recent decades. (2, 3, 4) Interestingly, plants growing in polluted areas with higher exposure to carbon dioxide also release more pollen. (4)

Air pollution is implicated in worsening allergic reactions in city dwellers especially, when the grasslands and thus the exposure to grass pollens in the cities are reducing in the last two decades. Cross-reactivity reactions predispose sensitive individuals to pollen and certain food allergies. (5)

Toxicity and oxidative stress

As external factors befall on wide population, it is clear that internal factors play a major and most likely the decisive role in individual susceptibilities in developing various allergies.

Exposure to toxins and allergens creates oxidative stress in the body, immune dysregulation and consequent inflammatory response. (6) For those individuals who have lowered antioxidant status in their tissues (because of lack of nutrients due to poor diet or genetic predisposition in detoxifying chemicals, toxins and heavy metals) this would add to their load of risk factors.

Gut, lungs and skin microbiome disturbances

Herbalists have always paid attention to gut integrity and the latest scientific research confirms the importance of gut microbiome in many inflammatory conditions, including allergies and asthma. (7) The significance of more recently discovered skin and lungs microbiome and its protective effects is also been investigated. (8)

Dysbiosis – a disturbed gut microflora, is the epicentre of immune and inflammatory imbalances leading to allergic reactions. (9) Gut microflora in children can be affected by a variety of components, such as use of antibiotics, the use of probiotics, dietary fats and fibre, and more. The rise in C-section births might be a possible risk factor in some children for developing allergies. (10)

On the other hand, the protective effect of breastfeeding (especially for 6 weeks to 6 months) is also well documented. (11) In adults, the use of antacids (PPIs), antibiotics, NSAIDs and other medications is hugely disruptive to microbiome and the gut lining integrity, leading to dysbiosis and increased permeability of the intestines (‘leaky gut’).  Food allergies are also linked with dysbiosis. (12) The main culprits are peanuts, cow milk, wheat, egg, soy, fish, shellfish and tree nuts.

The importance of healthy mucosal layer and its protective function is well known, but recently its immune function also has been recognised. (13)

Immune dysregulation and inflammation

As previously mentioned, the imbalances in gut microbiome lead to immune dysregulation, which in turn creates inflammation. Allergies are driven by T helper (Th) 2 responses, mast cell activation and the release of numerous inflammatory cytokines, such as  IL-4 and IL-13 and histamine. (14)

Adding fermented foods or probiotics and eating plenty of dietary fibre has a huge protective role in gut health. Prebiotics are also very important. Commensal gut bacteria ferments fibre into short-chain fatty acids (SCFA), which supports gut lining integrity and regulates immune system response via gut-associated lymphatic tissue (GALT). (15, 16) The latest research shows that regulatory T cells (Treg) have an important balancing effect on immune system and can dampen an allergic response triggered by T helper (Th) 2 cells. (17) 

The older concept of “hygiene hypothesis” introduced by David Strachan in 1989 has been explored for several decades and suggests that increased hygiene and smaller families (less siblings) lead to reduced exposure to infections and can predispose children to developing allergies later on. (18)

This partly can be explained by a lack of protective bacteria. Furthermore, research shows that decreased intestinal microbial diversity is an important risk factor for increased susceptibility to allergies. (19)

The newer biodiversity hypothesis has expanded the understanding of various internal and external factors affecting the microbiome. (20)

As the biodiversity in nature surrounding us (our external microbiome) is reducing and changing, so is our inner microbiome becomes diminished, its diversity reduced, and it has to adapt to changes. The immune system (and the nervous system, for sure!) is trying to catch up and this leads to rise in allergies and immune dysregulation.

It is widely recognised that herbal medicine can help to address the above-mentioned complexities and to correct the arising imbalances in the body. To meet and correct the imbalances arising from such above-mentioned complexities the multifaceted approach employing complex herbal medicines is needed.

Obviously, the herbalists look at the individual’s constitution and their presenting symptoms, which will direct their choice of herbs. Here some possible, more general herbal choices used in treating allergies will be discussed. The list of herbs is not complete and other choices can be made as required.

Nettle (Urtica dioica)
Nettle (Urtica dioica)

Allergic rhinitis (AR)

Main signs & symptoms are runny nose with clear mucus, congestion and sneezing. Eyes can also be affected.

In traditional western herbalism, according to Matthew Wood (2004), this energetic picture of AR could be described as a predominantly damp and cold tissue state, with deficiency underneath. The use of warming, aromatic, spicy, clearing, astringent herbs is indicated to reduce catarrh (damp), clear congestion, reduce allergic response, support the mucosal lining.

Nettle (Urtica dioica)

Clinical experiences shared by many herbalists and scientific analyses of the plant, as well as traditional uses across many countries brings nettle into forefront of a group of herbs used for allergies. (22, 23, 24) Sambucus nigra – elderberries and elderflowers are traditionally also used to support immunity, to reduce catarrh, clear congestion, reduce inflammation. (22)

Zingiber officinalis – ginger is a warming, aromatic, pungent spice, which helps to reduce catarrh and nasal congestion. (25) Curcuma longa – turmeric is probably one of the most researched herbs. Traditional and scientific research shows a strong anti-inflammatory effect, useful in allergies and other inflammatory conditions. (26)

  • Urtica dioica folia
  • Sambucus nigra (flos & fructus)
  • Zingiber officinalis
  • Curcuma longa

Vitamin C (citrus, peppers, broccoli, blackcurrants) and quercetin (onions, apples, citrus, green leaves) can be added as supplements or through foods. Black pepper is great to clear runny nose and is traditionally used in Ayurvedic medicine to clear catarrh. Warm aromatic and astringent teas – ginger, cinnamon, green tea, can be very useful.

In chronic AR or prevent recurrent episodes, immune modulating herbs such as Astragalus membranaceus can be added to the mix or used in between the flare ups (27).

Chamomile (Matricaria chamomilla)
Chamomile (Matricaria chamomilla)

Urticaria / hives

Main signs and symptoms are red itchy wheels and rash on the skin

In traditional western herbalism, this energetic picture of urticaria could be described as a predominantly a hot tissue state. The stagnation of the tissues (especially the liver and lymph) might be present. Stress is often a strong aggravator, as well as eating allergenic foods.

The use of cooling, detoxifying herbs, having a traditional ‘alterative’ action on the tissues – cleansing and clearing, to help to reduce inflammation, modulate the immune response, support the integrity of the gut and the function of the liver. Nervous system support is often needed in this condition.

German chamomile (Matricaria recutita)

German chamomile is traditionally used in Europe as a tea for allergies, congestion, to reduce inflammation and pain. It also has an anxiolytic and calming effect (28) Caution- sensitivity to Asteraceae family can cause allergic reactions. Albizzia julibrissin – Albizzia or silk tree is traditionally used in TCM and Ayurvedic medicine to help to reduce allergic reactions and ameliorate symptoms such as itching or wheezing. (29)

It is also has a calming, anxiolytic and antidepressant effect, as indicated in ethnobotanical studies and traditional uses. So it can be very useful in various acute and stressful allergic conditions, including urticaria.

  • Urticaria dioica folia
  • Matricaria recutita
  • Albizzia julibrissin
  • Arctium lappa radix

Externally creams are used in the herbal clinical practice with Stellaria media – chickweed or Aloe vera to help to reduce itchiness and soothe skin irritations. Vitamin C and quercetin supplements could be useful too, as well as pre- & probiotics (if not further causing more histamine release) to support gut microbiome.

Thyme (Thymus vulgaris)
Thyme (Thymus vulgaris)

Asthma

Main symptoms are wheezing, cough, tightness of chest, shortness of breath, which might be aggravated on physical exertion, exposure to cold air, on exposure to allergens or with emotional stress.  

Asthma is a complex inflammatory disease. Depending on the severity of it, whether it is chronic or acute, and on the constitutional individual’s type, in traditional western herbalism the energetic picture of asthma could be described as a deficient and stagnant condition with an accumulation of damp, heat, cold or/and dryness in the tissues.

The use of herbs to help to reduce inflammation (heat), reduce cough, expel mucus (damp),  relax bronchospasm, modulate the immune response, support the integrity of the gut and microbiome. Nervous system support is also often needed in this condition and herbs traditionally called nervines can be very helpful.

Herbs

Herbs to feed gut microbiome, to support biodiversity of microflora and gut health, to support digestion and intestinal absorption, such as Arctium lappa radix and Inula helenium are traditionally used by herbalists. Mucosal membranes and epithelial integrity can be supported by using mucilage – rich herbs such as Althea offcinalis, Aloe vera or Glycyrrhiza glabra.

As allergies always have an inflammatory component, increasing anti-inflammatory unprocessed plant-based foods in the diet is important, as well as feeding the microbiome with plenty of fibre and staying hydrated to support elimination processes.

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  2. Mattila T, Santonen T, Andersen HR, et al., 2021. Scoping Review-The Association between Asthma and Environmental Chemicals. International Journal of Environmental Research and Public Health. 1;18(3):1323.
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  5. D’Amato G, 2007. The UCB Institute of Allergy; Pollen Allergy in Europe.
  6. Schaumann F, Frömke C, Dijkstra D., 2014. Effects of ultrafine particles on the allergic inflammation in the lung of asthmatics: results of a double-blinded randomized cross-over clinical pilot study. Particle and Fibre Toxicology. 1:39
  7. Aguilera, A. C., Dagher, I. A., & Kloepfer, K. M. (2020). Role of the Microbiome in Allergic Disease Development. Current allergy and asthma reports, 20(9): 44.
  8. Ver Heul A, Planer J, Kau AL., 2019. The human microbiota and asthma. Clinical Reviews in Allergy & Immunology. 57(3):350-363.
  9. Yang, L., Fu, J., & Zhou, Y., 2020. Research Progress in Atopic March. Frontiers in Immunology. 11:1907
  10. Kristensen K & Henriksen L., 2016. Cesarean section and disease associated with immune function. Journal of Allergy & Clinical Immunology. 137:587–90
  11. Taylor-Robinson DC, Williams H, Pearce A et al., 2016. Do early life exposures explain why more advantaged children get eczema? Findings from the U.K. Millennium Cohort Study. British Journal of Dermatology. 174:569–578
  12. Suther C, Moore MD, Beigelman A, et al., 2020. The Gut Microbiome and the Big Eight. Nutrients. 12(12):3728
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  14. Galli, S. J., & Tsai, M. (2012). IgE and mast cells in allergic disease. Nature medicine, 18(5), 693–704.
  15. Kim, J. E., & Kim, H. S. (2019). Microbiome of the Skin and Gut in Atopic Dermatitis (AD): Understanding the Pathophysiology and Finding Novel Management Strategies. Journal of clinical medicine, 8(4), 444.
  16. Bunyavanich, S., & Berin, M. C. (2019). Food allergy and the microbiome: Current understandings and future directions. The Journal of Allergy & Clinical Immunology, 144(6), 1468–1477.
  17. Wang W, Wei C, Cheng Z et al., 2020. Aberrant Th2 Immune Responses Are Associated With a Reduced Frequency of IL-35-Induced Regulatory T Cells After Allergen Exposure in Patients With Allergic Asthma. Allergy, Asthma & Immunology Research. 12(6):1029-1045.
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  19. Abrahamsson TR, Jakobsson HE, Andersson AF et al. (2014). Low gut microbiota diversity in early infancy precedes asthma at school age. Clinical and Experimental Allergy. 44:842–50.
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  21. Matthew Wood, 2004. The Practice of Traditional Western Herbalism: Basic Doctrine, Energetics and Classification. North Atlantic Books, Berkeley, California
  22. Sayin, I., Cingi, C., Oghan, F. et al (2013). Complementary therapies in allergic rhinitis. ISRN allergy, 2013: 938751. https://doi.org/10.1155/2013/938751
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  28. Srivastava JK, Shankar E & Gupta S., 2010. Chamomile: A herbal medicine of the past with a bright future (Review). Molecular Medicine Reports. 3: 895-901.
  29. He Y, Wang Q, Ye Y, et al, 2020. The ethnopharmacology, phytochemistry, pharmacology and toxicology of genus Albizia: A review. Journal of Ethnopharmacology. 257:112677
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Can we integrate traditional knowledge and modern science? https://www.herbalreality.com/herbalism/western-herbal-medicine/integrate-traditional-knowledge-modern-science/ https://www.herbalreality.com/herbalism/western-herbal-medicine/integrate-traditional-knowledge-modern-science/#comments Fri, 29 Oct 2021 15:22:08 +0000 https://www.herbalreality.com/?p=4106 Roy Upton explores if, and how, we can integrate the knowledge from traditional herbal medicine with modern science.

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Roy Upton explores if, and how, we can integrate the knowledge from traditional herbal medicine with modern science.

Can we integrate traditional knowledge and modern science?

In most countries, traditional health practitioners such as in Ayurveda, Naturopathy, and TCM are required to be trained in Western anatomy, physiology, and pathology. While many Western medical schools have programs introducing students to traditional healing systems, they are presented as overviews, not as fully developed medical systems, but rather as non-evidenced-based therapies to which patients may be exposed.

While traditional health care practitioners benefit greatly from the integrated traditional-western knowledge and integrate this into patient care to greater or lesser degrees, most western physicians cannot provide any guidance regarding traditional practices except to recommend they not be used.

Similarly, applying western standards of either chemical or pharmacological assessment to traditional herbal medicines can inform and increase our knowledge base of the botanical. However, it should be remembered that one of the reasons traditional herbal medicine is growing in popularity despite ready access to modern medicine is due to the failings of modern medicine. Traditional healing systems offer a different paradigm of understanding health and disease that increases the therapeutic options to those in need.

Thus, attempting to regulate or restrict traditional herbal healing systems because they do not fit into the typical western paradigm is an antithesis to the healing system itself and a great detriment to patients. Froma traditional herbal medicine perspective, preservation, development, and acceptance of morphological and organoleptic assessment skills are critical in preserving traditional medicine practices, while the analytical tools of modern pharmacognosy enriches the knowledge base.

Regarding traditional medicine practice, there is some protection of traditional herbal medicine principles internationally. In most countries that regulate herbal medicines (e.g., much of Asia, the European Union, and India), herbal medicine practitioners are exempt from standard manufacturing GMPs.

This is not the case in the US, where FDA maintains the authority to require practitioners to be in full compliance with standard dietary supplement manufacturing GMPs, an authority that threatens the perpetuation of traditional herbal healing in that country. As recognized by the WHO and European Union, the whole crude plant part is considered to be the active ingredient, not a specific amount of a compound(s) that can be quantified.

Macroscopic and sensory evaluation of herbal ingredients, followed by therapeutic experience, are the sole means by which traditional herbal practitioners can continue practicing their traditional healing systems. Not recognizing traditional herbal assessment principles in formal pharmacopoeia limits the expression and evolution of traditional herbal medicine, and instead, pushes herbal medicines solely into a western pharmaceutical paradigm.

Prior to the advent of modern analytical chemistry, microscopic examination of crude herbal drugs, along with gross morphological and organoleptic assessment as described above, were the primary tools used for crude herb assessment.

European and American pharmacognosists put tremendous emphasis on the ability to identify plants to species microscopically, including those that that are closely related, detect adulterations, and, in some cases, even assess relative quality. According to noted American pharmacognosist Henry Kraemer (1908):

“The microscope furnishes the surest means of determining the identity of a powdered drug at our command…the microscope also furnishes the most reliable means for detecting and determining adulterants in powdered drugs… [and] detecting the presence of worm-eaten drugs or powders of certain classes of drugs which have been exhausted in whole or in part…”

Kraemer went so far as to say that even the time of gathering, method of drying, and length of time for which a botanical had been stored could  “be judged in many instances by the use of the microscope”. Additionally, there is great sensitivity in being able to detect adulterating species.

For example, many years ago there were numerous reports of the Chinese herb stephania (Stephania tetrandra) being mixed up with a different species of plant (Aristolochia fangchi), which contains the renal toxin and potential carcinogen aristolochic acid (AA). This adulteration was responsible for from several hundred to a few thousand deaths. With microscopic examination, the addition of as little as 0.3% of Aristolochia fangchi in a stephania sample can be detected by observation of the differing oxalate crystals that occur within the species (Upton 2006).

Discerning crude drug species microscopically reached a very high level of refinement and is reflected in numerous seminal texts on the subject in the middle 19–20th centuries, most notably Berg (1865) and Meyer (1892) of Germany; Moeller of Austria (1890); Tschirch and Oesterle of Switzerland (1900); and microscopists of the UK and US such as Sayre (1917), Mansfield (1937), Greenish (1904), Kraemer (1920), and Youngken (1930), to name a few.

With advancements and evolution of analytical chemical techniques, first with paper chromatography followed by thin-layer chromatography (TLC) and then more quantitative techniques (liquid chromatography [LC], gas chromatography [GC], and finally molecular technologies (e.g., DNA), microscopy, like morphology and sensory assessment, as a scientifically valid analytical tool was regarded as outdated in the face of these more recent techniques.

However, seldom is one analytical technique inherently superior to another. The superiority or applicability of one analytical method over another is dependent upon the desired analytical endpoint. From this perspective, microscopy is as scientifically valid of an analytical tool as any other technique and is currently enjoying a resurgence in the US where it had fallen into almost complete neglect in previous decades.

The first of the chemical assessment techniques in most pharmacopoeias, Eastern and Western, is thin layer chromatography (TLC), and more recently, high performance TLC (HPTLC), and is primarily used as an identification assay.TLC and HPTLC analysis provide a snapshot of the constituent profile of crude plant drugs and has been a standard entry in pharmacopoeias for decades.

In previous decades, TLC as an analytical technique was very crude, had a limited degree of reproducibility, was cumbersome, and not very GMP-compliant. In more recent decades, the introduction of HPTLC has addressed many of these deficiencies. As a chemical analytical tool, HPTLC is extremely versatile and sensitive for the identification of many crude herbal drugs and is especially useful for the detection of adulterations, often with a very high degree of sensitivity.

However, it must be recognized that any chemical testing is a surrogate for identification as, in contrast to identifying the actual plant material botanically, morphologically, organoleptically, or microscopically; it is the chemical profile that is being identified not the plant. Closely related species of plants may be very similar chemically.

Additionally, the constituent profile of the plant can vary dramatically across the range of commercial materials that may be traded, variations occurring due to growing, harvesting or post-harvesting conditions, age of the plant, or extracting parameters. Identification of plants chemically is therefore limited and is most accurate when coupled with appropriate physical tests. For compliance with pharmacopoeia monographs, TLC/HPTLC or other quantitative assays are conducted in tandem with the physical tests outlined above.

Critical to any chemical testing methodology of medicinal plants is to look at the suite of constituents from the perspective of chromatographic fingerprinting and not only individual markers. The concept of chromatographic fingerprinting was developed primarily by Chinese phytochemists who recognized that the activity of a Chinese herb is in its collection of compounds not just the single active constituent approach typical of modern drugs.

Numerous papers have been published on the subject and provide guidance on appropriate ways to apply modern chemistry to the analysis of traditional herbal drugs (Fan et al. 2006; Liang et al. 2004; Xie et al. 2006, among others).

A critical starting point to chromatographic fingerprinting is to obtain multiple samples of the desired botanical that is grown, harvested, and dried in a manner that is optimal for the plant part. Such criteria are traditionally determined organoleptically by evaluating the color, smell, taste, texture, relative purity, and other physical characteristics of the plant. Optimal picking times can be informed by traditional literature, such as harvesting the flowering tops of St. John’s wort on the eve of St. John’s day (June 24).

While the specificity of a single day may not be required, in most growing areas, St. John’s day reflects a harvest time when the plant is in full bloom, the traditional time to harvest most flowers; roots and barks are typically harvested in the Spring or Fall; leaves, prior to flowering before the energy of the plant goes to flower, seed, and fruit production.

In Chinese herbal medicine, specific herbs must be gathered at a specific age, such as the roots of dang gui (Angelica sinensis) at a minimum of four years of age; or Chinese ginseng (Panax ginseng) at a minimum of five years of age. Optimal harvest times can be greatly informed by chemical analysis. Specifically regarding St. John’s wort, the highest concentration of the suite of St. John’s wort constituents including flavonoids and napthodinathrones are yielded during the budding and flowering stage (during blooming), the concentrations dropping dramatically after flowering and being higher in upper leaves than lower leaves (Tsitsina 1969).

St. John's Wort (Hypericum perforatum)
St. John’s Wort (Hypericum perforatum)

Another critical aspect in developing chromatographic fingerprinting methodologies for medicinal plants is to obtain samples of closely related and potentially adulterating species that may be inadvertently traded for the authentic material.

Having multiple species of the same appropriate quality material, ideally from multiple regions for multiple years, allows the analyst to observe the variation inherent in natural products due to changing environmental conditions. Having closely related or adulterating species helps the analyst know if the chromatographic fingerprint is robust enough to identify the authentic from substitute species.

In recent decades, chromatographic fingerprinting techniques have been coupled with chemometric programs (Mok and Chau 2006, among others). These programs are designed to store and analyze multiple datapoints from multiple samples and provide statistically relevant comparative fingerprints that allow for developing relatively objective criteria for what constitutes an acceptable chromatographic fingerprint. Ideally, such determinations should be made based on the available clinical data that establishes the efficacy of the herbal drug being analyzed; without a clinically relevant correlation, even the chemical fingerprint is only a surrogate marker of quality.

It is important to recognize that much of the basic work in developing appropriate chromatographic fingerprints is best done in academic settings and is a very expensive and time-consuming process that does not allow for the high throughput testing often required by industry. Once done in academia, such testing criteria can then be codified into pharmacopoeia as a way to promote a consistent standard.

In addition to identity tests, most Western pharmacopoeial monographs require quantitative assays, many of which will correlate directly with the pharmacopoeial definition of the botanical drug ingredient and may or may not directly correlate with activity. Quantitative assays are often lacking in Eastern pharmacopoeias (e.g., Ayurvedic Pharmacopoeia; PPRC). In most cases, quantitative assays will quantify a specific compound that is correlated with a known active constituent or class of constituents.

Other compounds assayed are considered surrogate marker compounds for activity, other chosen compounds may reflect a constituent or class of constituents that provide a baseline of “quality” based on harvest or processing practices, which may or may not correlate with activity, and yet others will reflect other measures of “quality”, such as an organoleptic bitterness value for a particular botanical such as gentian root (Gentiana spp.) or a swelling index as discussed previously regarding mucilage content of slippery elm bark or flax seed.

Valerian root (Valeriana officinalis)
Valerian root (Valeriana officinalis)

As noted, very seldom is a single constituent correlated with the total activity of a particular botanical. Rather, the total extract or profile of the crude drug is considered the active ingredient or substance.

This is reflected in WHO documents (WHO 1991) and acknowledged by renowned medicinal plant researchers (e.g. see Mukherhee 2011; Wagner et al. 2009; Xie et al. 2013). For example, valerian root (Valeriana officinalis) is a sedative herb used at least since the 1st century (Pickering 1879). The essential oil was long considered to represent the active fraction.

However, early pharmacological work demonstrated that the essential oil fraction was only associated with approximately 1/3 of the total activity of the extract (Gstirmer and Kind 1951). Later, research demonstrated depressant activity of the dichloromethane extract but activity could not be attributed to either the valepotriates, valerenic acid, valeranone, or the essential oil (Krieglstein and Grusla 1988).

To date, the total activity of valerian has not been fully articulated though its efficacy in reducing the time required to fall asleep and to stay asleep is supported. Today, Western pharmacopoeias require quantitation of the essential oil fraction of valerian as the primary marker of quality.

St. John’s wort (Hypericum perforatum) provides another example of a plant whose efficacy as an antidepressant has been documented over a period of more than 2000 years, but for which the pharmacological mechanisms in humans have yet to be determined (Cott 2005). Thus, quantification of a single marker or group of markers should be viewed as representing only a portion of the activity of the whole plant or extract made therefrom.

Regarding quantitative assays, varying pharmacopoeias take different approaches in determining what compound(s) are to be assayed. For example, the pharmacopoeias of Germany and the US tend towards specificity of compounds favoring relatively sophisticated quantitative technologies such as HPLC in contrast to more generic technologies such as spectrophotometry. Whereas HPLC has greater accuracy in quantifying individual compounds, spectrophotometry groups like compounds together, often resulting in higher quantitative values as compared to HPLC.

Both technologies have strengths and weaknesses. HPLC offers greater accuracy in quantitation; this is its primary advantage. If used appropriately, HPLC can also be used for purposes of identification if the total chromatographic fingerprint of the plant is considered and thus has a greater chance of detecting adulterants. Spectrophotometric techniques, in grouping like compounds, may give a more accurate representation of the totality of the plant or extract, but has the distinct disadvantage of being easily fooled by purposeful admixtures of adulterants.

In the US, there are no requirements to follow any monograph standards for herbal supplements. Analysts and botanical dietary supplement manufacturers often attempt to perform a single test for all or most identity and quality testing, often times choosing the most economically feasible assay, but not always the most appropriate.

Such testing may or may not provide scientifically valid results for the desired analytical endpoint. In the EU, where there is a legal requirement to follow all aspects of the European Pharmacopoeia monographs, there appears to be a greater use of spectrophotometric methods, which are only employed after appropriate identity of the botanical ingredient has been confirmed. In the USP, there appears to be greater utilization of specific methods, requiring multiple analytes, greater time, and greater expense.

Another limitation of current pharmacopoeial works include the fact that many perceived independent standards are based on single proprietary products. In such cases, a sponsor submits analytical data, often of a proprietary extract, and the characterization of that proprietary extract becomes the standard for the botanical generically, but may not be widely applicable to generic products creating a false sense of independent verification.

However, also codification of a commercial proprietary product as a generic standard may provide an unfair advantage to the submitting manufacturer as all competitors then must either submit their own data for consideration of revision of the monograph (a lengthy process) or be encouraged to follow the standards of the their competitor, which they may not be able to do due to the proprietary nature of the original extract used. This is more of an issue in countries where the process is driven more by commercialism than science.

Some Chinese researchers propose a tiered approach to traditional Chinese herbal drug quality control development, recommending “elementary, intensive, and advanced” levels of testing. The “elementary” level reflects current standard requirements of pharmacopoeias that focus on basic identity, qualitative tests, and analysis of a single marker compound.

The “intensive” level includes multiple component analysis, including differentiation between “high” and “low” quality materials based on quantitative assays of a particular compound(s).

The “advanced” level proposes that the multiple component herbal medicine be subjected to formal pharmacological study but acknowledges the inherent lack of Western pharmacological models for assessing traditional Chinese actions of herbs such as to “expel wind” and “nourish kidney” (Xie and Li 2007).

Similarly, it has been proposed that the comparison of a crude herbal drug to a properly made well characterized extract is a more appropriate way to assess the quality of a Chinese herbal drug than to simply assay a single constituent (Xie et al. 2013). While these represent more appropriate ways to ensure the integrity of multi-component ingredients and formulas than the typical Western pharmacopoeial approach, they continue to depend on chemical analysis versus traditional herbal assessment skills and therefore, do not take into consideration the full suite of traditional assessment techniques.

Botanical identification

Botanical identification remains the primary technique for the identification of plants worldwide. While chemotaxonomy and DNA analysis have made great strides in altering the classifications of traditional taxonomy, neither technology has supplanted botany as the primary means of identifying medicinal plants. However, in virtually all official pharmacopoeias, botanical identification is not included as a required test with which to conform. The reason for this is that oftentimes the botanically unique characters of a specific plant are not intact in the crude plant drug.

Willow tree
Willow tree

Historically, different species of a specific genus of plant, and sometimes, different genera of plant, were used as a specific botanical drug. Rather than being referred to by its generic and specific name e.g., Salix purpurea, medicinal plants were described according to their Galenic names e.g., Cortex salicis, the Galenic name referring to the bark of varieties of willow that were historically used interchangeably without differentiation of species.

Such a practice is represented in most pharmacopoeias but is increasingly moving towards greater speciation. For example, in the European Pharmacopoeia, the bark of several species of Salix is allowed as long as the barks conform to the identity tests given and possess a minimum quantity of salicin (1.5%), the primary putative active constituent, and precursor to the development of acetyl salicylic acid (aspirin).

Conversely, in the US, where herbs are predominantly traded as ‘dietary supplements’ not ‘medicines’, for purposes of supplement labeling, the names of botanical ingredients must conform to Herbs of Commerce of the American Herbal Products Association (AHPA). The current edition of this text, rather than recommending use of Galenic or more common names (e.g. “willow bark”), mostly requires speciation such as crack willow (Salix fragilis), purple willow (Salix purpurea), white willow (Salix alba), etc.

Unfortunately, while conformity to the identification tests of pharmacopoeias for these barks can be assured, most of these barks cannot be identified to species when in their crude form as they are morphologically, organoleptically, chemically, and medicinally very similar, the very reason why the multiple species are used interchangeably. Thus, greater levels of specificity are often required for either academic or arbitrary regulatory reasons creating unnecessary impediments, to continued use of traditional herbal medicines.

Daodi (region specificity)

Daodi is a philosophy that is exclusively applied to the development of medicinal substances. Dao is an ancient Chinese unit of measure, which became applied to the development of districts. Di means earth or land and is applied to specific geographical regions.

According to Zhao et al. (2012), daodi medicinal materials are generally defined as medicinal materials produced in specific geographic regions under natural ecological and environmental conditions that are optimum for the growing of the plant, with particular attention to cultivation, harvesting, and processing techniques.

Daodi lead to quality and clinical effects that are considered to surpass those of the same botanical produced in a different region. The concept of daodi was used by early Chinese herbalists and codified by Sun Simiao in his Qian Jin Yi Fang (Supplement to the Formulas of a Thousand Gold Worth). According to Sun:

“When ancient doctors used medicinals they depended on the earth, therefore when the treated ten people they achieved results in nine. Although contemporary doctors understand the pulse and prescriptions, they discard the timing for harvesting medicinals. They are not familiar with the originating land or the freshness, aged nature, emptiness or fullness; therefore they only achieve results in five or six cases out of ten.”

Sun’s teachings underscore the importance of daodi, organoleptic assessment, and a quality control system that integrates the proper harvest time and source of the originating plant material. Furthermore, in the Ben Cao Pin Hui Jing Yao (Essentials of Chinese Materia Medica) of China’s Liu Wentai (1488–1505), specific attention was given to medicinal plant development that encompassed the sprouting of the plant, the land on which it was grown, the timing of planting and harvest, and potential substitutes.

Thus, prior to the development of formalized good manufacturing practices and prior to the adherence to mandatory pharmacopoeial standards, Chinese physicians recognized the need for strict adherence to quality control in ways that ensured the quality of the medicinal plant from the field to the medicine long before the advent of chemical analytical techniques. This care is reflected in the many grades of herbs that can be observed in any Chinese herbal pharmacy today.

Such principles reflect common sense in ensuring the quality of herbal drugs. Similar principles are being applied internationally and in a myriad of Good Agriculture and Collection Practices (GACP) developed by varying national and international bodies. The People’s Republic of China (PPRC) is perhaps most active in establishing good agricultural practices (GAP) for medicinal herbs and integrating them in medicinal plant production.

Similar to Sun’s observation in the Tang Dynasty, modern herbal practitioners are often not aware of the quality control needs of herbal medicines, and rather rely on industry to produce quality medicines, when much of the industry lacks the skills necessary to do so.

Daodi is an important concept to include in the development and selection of herbal medicines and there may be wisdom in codifying such principles in modern pharmacopoeias. According to Zhao et al. (2012), among the 500 most commonly used Chinese medicinal materials, approximately 200 are recognized as having daodi medicinal material specifications.

These 200 medicinal materials account for 80% of the total consumption of medicinal materials in China, making daodi a very important concept in modern herbal medicine GMPs. Today, the source and manner in which the botanical was grown and harvested is seldom considered by industry and regulators.

Molecular identification

In animals, a single barcoding region from the mitochondrial cytochrome c oxidase-1 gene can identify most species. In plants, no single barcoding region has been identified with sufficient resolution to identify most species, therefore a combination of at least two regions (barcodes) is required and use of other techniques in tandem provide greater levels of accuracy. Molecular techniques of medicinal plant identification are not currently included in most pharmacopoeia but some attempts have been made to consider their inclusion.

Ginseng (Panax ginseng)
Ginseng (Panax ginseng)

Like all analytical technologies, molecular analysis has strengths and weaknesses in crude plant identification. First and foremost it is solely a identification tool.

Whereas most all other methods provide both identity and quality assessments, molecular techniques is only for species identification. Among the technique’s strengths are its great sensitivity.

If the unique identifying primers for the particular target species has been appropriately developed, and the technique used is robust enough to filter DNA from non-target organisms (e.g., other plants, non-target plant parts, etc.), then it is an exceptionally powerful tool for identifying plant material to species and beyond, including the same species that have different genetic lineage, such as wild American ginseng (Panax quinquefolium) grown in Kentucky, versus the same species from cultivated root stock in Wisconsin, versus that grown in Canada.

A second advantage of molecular techniques is in detecting admixtures with other species with great sensitivity. A logistical advantage of the technique is that it uses very small amounts of material for analysis.

Among its weaknesses is also the technique’s great sensitivity. Molecular techniques have the ability to detect the presence of trace of insignificant amounts of non-target species, such as rice and pollen or a blade of grass, the results of which can be interpreted as ‘contamination’. In other cases, genetic material of a non-target species can be preferentially amplified over the genetic material of the target species, that can be inaccurately interpreted as an ‘adulteration’.

A significant disadvantage is its inability to discern different plant parts, a requirement of all medicinal plant GMPs. As with chemical analysis, DNA analysis will not detect the presence of non-organic contaminants that are readily detected organoleptically or microscopically.

Perhaps the greatest strength of genetic testing is in forensic analyses of plant material that is difficult to identify with standard testing methodologies or to detect the presence of difficult to find adulterations and contaminations.

Perhaps its greatest weakness, unlike virtually all other standard techniques from sensory assessment to chemistry, is its inability to offer any meaningful data regarding quality. It is purely an identification tool that is limited in its ability to discern plant parts, that works best in intact plant material, where most other techniques provide data points for both identification and quality of a crude plant or extract.

However, its utility in routine quality control is limited as was poignantly highlighted by researchers in Australia who applied various methods of genetic barcoding to various stages of the manufacture of medicinal plant products. The researchers attempted to determine if DNA barcoding was a useful routine test for the quality control of botanicals and genetically analyzed the ingredients throughout the manufacturing process from gathering of botanical vouchers to drying, to pulverizing, to extracting, to preparation of the finished product.

Even for vouchered specimens, a high of only 40% of specimens were able to be identified with DNA using one set of markers and a low of about 18% with another set of markers, determining that substantial degradation of DNA occurred in properly dried materials.

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Environmental sustainability of medicinal plants https://www.herbalreality.com/herbalism/western-herbal-medicine/environmental-sustainability-medicinal-plants/ https://www.herbalreality.com/herbalism/western-herbal-medicine/environmental-sustainability-medicinal-plants/#comments Fri, 29 Oct 2021 15:22:08 +0000 https://www.herbalreality.com/?p=4109 Roy Upton explores how traditional healing systems have developed in developing countries compared to the West.

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Roy Upton explores how traditional healing systems and sustainability have developed in developing countries compared to the West.

Environmental sustainability of medicinal plants

At the heart of most all herbal medicine traditions is a relationship with earth and the natural world. This stems from the inalienable fact that humans are an extension of the natural world, are dependent upon the natural world for their survival, and that what affects the natural world affects human health (e.g., diet, pollution, etc.).

This relationship also extends to cultures, some of whom for generations have either cultivated medicinal plant crops or harvested them from the wild, and forms the basis of countless economies worldwide.

While over-harvesting of medicinal plants can have a negative environmental effect on sustainability, cultivation or wild harvesting of medicinal plants when done according to Good Agriculture and Collection Practices (GACP), international standards for which exist (e.g., WHO 2003; AHPA, among others), creates incentives for land preservation and maintains and fosters environmental stewardship of natural resources, thus ensuring future supplies of medicinal plants. Overwhelmingly, development and loss of land is the primary reason for loss of biodiversity and species.

Juxtaposed against the largely positive environmental impact of medicinal plant trade is the largely negative environmental impact of pharmaceutical medications, which have significant consequences on both human and environmental health. There are two primary sources of pharmaceutical pollution; pharmaceutical production and the pollution generated therefrom through effluence and emissions, as well as the excretion of medications and their metabolites ingested by humans and farm animals.

In the US, a report from the US Geological Survey detected pharmaceutical contaminants in 80% of 139 streams sampled. Contaminants included antibiotics, hypertensive medications, antidepressants, analgesics, reproductive hormones, and other prescription drugs that also affected municipal water (Glassmeyer et al. 2005; NRDC 2009).

The most stark sustainability impact of pharmaceuticals has been from endocrine disruptors, partially due to metabolites excreted in urine from oral contraceptive use. A 2007 study reported that 75% of male smallmouth bass in certain areas of the Potomac River basin (US) had ovarian tissue in their gonads resulting in a feminization of the fish (Blazer et al. 2007).

Other studies report similar negative effects directly associated with oral contraceptives delivered through municipal wastewaters affecting fish populations (e.g., Kidd et al. 2007). In another study, fish exposed to effluent from a cattle feedlot in the US state of Nebraska experienced reproductive abnormalities, including reduced testes size in male fish and a lower level of estrogen in female fish (Orlando et al. 2004).

Other studies link such xenoestrogen exposure to testicular and breast cancer in humans (Wright-Walters and Volz 2007, and references therein). The US Geological Survey (Glassmeyer et al. 2005) reported finding nonprescription pharmaceuticals in more than 40% of the municipal water samples tested; prescription and nonantibiotic pharmaceuticals in more than 30% of samples. Moreover, the ubiquitous overuse of antibiotics, especially in farm animals, bioaccumulate in soil potentially giving rise to antibiotic resistance pathogens (NRDC 2009), that is already a serious international health care crisis.

Lavender (Lavandula angustifolia)
Lavender (Lavandula angustifolia)

Such events are not limited to the US. In Pakistan, the non-steroidal anti-inflammatory (NSAID) diclofenac was linked to widespread die off of vulture populations leading to the listing of three vulture species as endangered (Arnold et al. 2013, and references therein).

Moreover, the same drug increases the risk of heart attack in humans (Kearney et al. 2006). A number of surveys in Germany report that 95% of the pharmaceuticals studied are not readily biodegradable; 15% are persistent in surface water, approximately 50% of veterinary pharmaceuticals studied are persistent in soil, and a large number of pharmaceutical substances and metabolites can be found in wastewater and surface water throughout Europe.

Standard long-term tests conducted with fish, daphnia, and algae as test organisms revealed effects at pharmaceutical concentrations of less than 1 mg/L, while one study described changes in aquatic organisms at much lower concentrations of less than 0.001 mg/L (EEA 2010).

There currently exists little health risk assessment data regarding the potential adverse effects from chronic exposure to the myriad of pharmaceuticals that accumulate in the environment. From a traditional herbal medicine perspective, it is incongruent to have a healing system that, in addition to killing more people than cigarettes and alcohol from gross adverse effects, is so inherently toxic to the environment that it contributes greatly to human disease. Conversely, medicinal plants have co-evolved with the environment for millennia and such negative consequences do not exist in healthy ecosystems.

Tulsi (Ocimum tenuiflorum)
Tulsi (Ocimum tenuiflorum)

Lastly, an often neglected or completely shunned aspect of modern traditional herbal medicine is the role medicinal plants can play in spiritual health. This is largely due to modern medicine’s attempt to be scientific, a paradigm that, when applied in a typical manner, tends to divorce human and material existence from any precept of spirit, whether spirit is defined from a creationist or evolutionary perspective, or from a perspective of humanity’s relationship with each other, and the relation of humans to the larger world or creation.

In many systems of traditional healing, spiritual well-being is the highest ideal to achieve. In a practical sense, this means an attainment of a sense of peace and harmony with self and one’s surrounding world.

In Ayurveda, for example, significant emphasis is placed on mental and emotional well-being through the incorporation of meditative practices, prayer (puja), and therapies such as pancha karma and shirodara, designed to promote a long life of physical, mental, and emotional well-being. Numerous herbs figure into a variety of spiritual practices. In India, the herb tulsi (Ocimum sanctum) is highly revered and by some is considered the wife of god Vishnu (Vishnupriya).

Tulsi is central in Tulsi Vivah, a ceremony marking the end of the monsoon season and beginning of the Hindu wedding season, the rites of which are described in Hindu scripture. Among some regions of India, households grow tulsi plants and perform ceremonies by circling the plant reciting mantra morning and evening. Also in India, the Hindi avatar Dhanvantari is depicted as Lord Vishnu with four hands, holding medical herbs in one hand and a pot containing a rejuvenating nectar called amrita in another. Dhanvantari is also considered the God of Ayurveda.

In Western herbal traditions stemming from ancient Greece, the botanical genus Asclepias (commonly known as milkweed) is named after Asclepias, the Greek God of medicine. Thus, in most all medical traditions, including those in the West, there was an innate relationship between physical and spiritual health that was connected through plant-based medicines.

In TCM, especially in Taoist practices, there was and continues to be great emphasis of aligning one’s life with the spiritual will of heaven. In the five phases (wu xing) theory of TCM, each of the five major organ systems is correlated with a spirit that both serves to guide one to one’s authentic self that can be cultivated through various physical and spiritual practices. In this regard, the use of herbs served to facilitate this cultivation.

In TCM principles, the shen (spirit or mind) is housed in the heart; the hun (ethereal soul) in the liver; the po (corporeal soul) in the lungs; yi (intellect or ideation) in the spleen, and zhi (will) in the kidneys. In turn, the physical manifestations of each of these organ systems affects these various “spirits” (wu shen). According to Chinese medical philosophy, the hun governs one’s nature. It drives and has the ability to nourish one towards their destiny. When in disharmony, the hun wanders aimlessly or perhaps violently, and in either case, cannot direct one to their greater good or expression.

The yi or intellect represents our ability to discern ideas and experiences and to form intent; intent of thought and action. When in disharmony, the judgment of the yi is clouded or misguided. The po most closely reflects human instinct, our inner knowing despite having all the facts; our gut senses, and is inherently limited to expressing our greatest self in one lifetime.

When in disharmony, the po can cause us to act on gross human desires without considering the larger consequences of such actions. The zhi or will, provides, or not, the motivation to accomplish and act on intent. When in disharmony, the ability to act according to what is in the best interest of the five spirits is impaired. Lastly the shen or mind (xin) is regarded as consciousness itself.

On a physical level it is our level of peace of mind, while on a more esoteric level it governs our ability to mobilize all the other shen to their higher purposes, imparting benevolence, compassion, and love when healthy, and muddled or erratic thinking and lack of the aforementioned positive qualities when in disharmony.

The shen, yi, po, zhi, and hun are said to be “housed” in the heart, spleen, lungs, kidneys, and liver, respectively and are therefore influenced either positively or negatively by the physical health or disease of these organ systems. As such, herbs and formula that support the health of these systems support the higher goals of spiritual self, compassion, and love for humanity for which humans are capable.

While some of these concepts may seem archaic and religious, possibly not worthy of inclusion in modern medical thought, in the context of human and social health, the attainment of mental, emotional, and social well-being is a central doctrine to most concepts of health as articulated by the WHO (1946) as:

“Health is a state of complete physical, mental and social well-being and not merely the absence of disease or infirmity.”

Thus, any complete healing system must take into account how an individual can attain, or a practitioner can facilitate the attainment, of higher states of health and healing than simply the removal of symptoms. This is the highest ideal of traditional healing systems that has no foundation or construct in the current Western medical delivery system, pharmaceutical industry, or modern pharmacognosy.

It is only through traditional healing systems that such a level of health and healing can even be considered. Whether one is willing to apply what many consider to be spiritual aspects of healing to modern medicine is a matter of choice. In a more material sense, the recognition of the role pharmacognosy plays in human health was succinctly stated by DiPasquale (1984):

“Pharmacognosy is the science of drugs that originate from living beings and are studied to help other living beings.”

The benefits obtainable through the proper use of herbal medicines are inherently different than those attained through standard use of pharmaceutical medications and Western disease care paradigms. Because of this, a different paradigm for ensuring the integrity of traditional herbal medicines is to apply scientific investigation in a way that fully honors the unique characteristics of traditional healing systems.

First and foremost is, through human investigation, understanding the scientific basis of the theoretical healing principles of our varying healing traditions, pharmacologically, physiologically, and pathologically and with an emphasis on patient outcomes. All other experimentation is abstract and of limited utility. Second, and most importantly regarding herbal medicine, is intensive investigation of what constitutes a “quality” herbal medicine that would then drive the quality control guidelines and requirements of the supply chain so as to ensure appropriate quality of herbal medicines in a manner that is truly independent of commercial influence and has scientific integrity. Such investigation could include a myriad of testing parameters.

First of these would be proper identification of starting plant populations followed by morphological and organoleptic profiling of botanicals growing in their natural habitat and then to codify these characters in pharmacopoeias, GACP guidance documents, and in regulation or practice, as was done historically.

Chemical profiling of the botanicals can allow for making determinations of optimal harvest times, drying, processing, extracting, and storage conditions. Morphological, organoleptic, and chemical characterization can also help determine what species of plants can be used interchangeably, again, in manner that was similarly done historically. In the world of medicinal plant research, focus can be given, not only to Western pharmacological mechanisms but to how those mechanisms correspond, or not, to traditional characteristics such as taste, smell, and sensation of the botanical; or to make a scientific determination of what it really means for an herb to be classified as a ‘yin tonic’ or to ‘pacify vata’.

Clinical investigation could also look at the application of the traditional medicine within the context of the lifestyle recommendations that usually accompany such prescriptions, emphasizing the holistic approach typically employed by traditional healers versus the lack of emphasis regarding lifestyle changes that dominate in Western medical care.

Such investigation can open a world of therapeutic possibilities for health care that is greater than what either traditional or modern systems offer alone. Such inquiry could then more fully inform the practice of both paradigms of medicine, creating new opportunities for research and practitioner training, product development, and environmentally sustainable economies.

While developing countries continue to rely on traditional healing systems for their primary health care needs, there is an ever increasing recognition in developing countries of the value these traditional healing systems have in human health and as a part of modern health care systems. This is a phenomenon occurring internationally.

Herbal medicines serve an integral role in traditional healing systems and there is a need to preserve, promote, and continue to develop the traditional knowledge base needed for ensuring the identity, purity, and quality of botanical ingredients. Pharmacopoeias play a key role in these processes.

However, in most Western countries, pharmacopoeial monograph systems developed as chemistry was overtaking crude botanical medicine and drugs were evolving into pure, isolated, and then synthetic compounds, in contrast to the multiple compounds and broad array of pharmacological activities inherent in herbal medicines.

Because of this, modern pharmacopoeias, and subsequently regulatory systems, attempt to characterize botanical medicines in the same way they do pharmaceutical medications. Lacking in this system is a realization that traditional herbal medicine systems have a distinct way of understanding their materia medica that is vastly different than western pharmacological approaches. Rather, over several millennia, knowledge of plant-based medicines evolved based on the properties inherent in the plant, that includes a plant’s chemistry, and is reflected in the flavor, smell, and qualities as ascertained through sensory evaluation.

More importantly, in traditional; healing systems, botanicals are applied in a manner that is similarly distinctly different from the typical western model whose focus is on disease pathology and symptom suppression in contrast to the improvement of human health and the elimination of the underlying cause of disease. In traditional medical systems, herbs are used to promote health, vitality, and longevity, and treat disease, and ameliorate symptoms.

In conventional western medical practice, there is a single focus on pathology and almost no emphasis on health. Whereas there are hundreds of botanical medicines that are used to promote health, there is not a single pharmaceutical medication designed to promote health and vitality.

Driving the popularity in traditional herbal medicine is a desire on the part of consumers to be healthier. Another significant factor are the many failings of modern medicine in dealing with many diseases, most specifically, chronic degenerative diseases for which pharmaceuticals offer only palliative care, as well as the significant dangers posed by pharmaceutical medications, which are widely recognized as one of the leading causes of preventable deaths. Yet a last, but little recognized driving factor for the popularity of herbal medicine is its potential for environmental sustainability.

Preserving herbal medicine preserves cultural knowledge, cultural integrity, environmental integrity, and the integrity of human health. If herbal medicine is to survive and thrive for future generations it cannot simply be approached using the same models as those used for pharmaceutical medications. Similarly, pharmacopoeias and regulatory systems must evolve to take into consideration the unique philosophies and traditional systems in which herbal medicines are applied and not simply reduce herb quality assessment to a chemical test.

Rather, all aspects of the source of medicinal ingredients from the field to the pharmacy must be taken into consideration as was done historically by herbalists and early pharmacognosists. If modern pharmacopoeias and regulatory systems can evolve to integrate traditional healing knowledge and practices, herbal medicine can thrive and reach its full potential in serving humanity.

If not, it will continue to survive and be utilized by those who are more committed to the promotion of health and minimization of disease, but will continue to be marginalized in modernity that maintains the status quo of disease management to the detriment of individual and societal health.

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Pharmacopoeias in codifying quality of herbal medicines https://www.herbalreality.com/herbalism/western-herbal-medicine/pharmacopoeias-codifying-quality-herbal-medicine/ https://www.herbalreality.com/herbalism/western-herbal-medicine/pharmacopoeias-codifying-quality-herbal-medicine/#comments Fri, 29 Oct 2021 15:22:02 +0000 https://www.herbalreality.com/?p=4103 Roy Upton explores the history of pharmacopoeias and their important role in herbal medicine.

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Roy Upton explores the history of pharmacopoeias and their important role in herbal medicine quality.

Pharmacopoeias In Codifying Quality Of Herbal Medicines

The modern concept of pharmacopeias is defined as containing “pharmaceutical specifications that are intended to secure uniformity in the composition, quality, and therapeutic activity of medicines and that are made obligatory within a political unit by legally effective authority” (Sonnedecker 1993). The term pharmacopoeia is derived from the Greek pharmakon (meaning medicine or charm) and poien (meaning to make).

Any of the earlier works of materia medica, which attempted to codify the preparation of medicinal ingredients or formulae, can be considered the antecedents of today’s pharmacopoeias. In this regard, China’s Shennong Bencao, Egyptian papyri (e.g., Eber’s Papyrus), the Caraka Samhita of India, and the early Greek and Roman works of Theophrastus, Dioscorides, and Galen all represent such works. However, over time, pharmacopoeias evolved as consensus documents generated by groups of physicians or pharmacists, versus individual authors, and were given formal authority by authoritative bodies.

Historians differ as to the earliest of formal works of medical authority, but perhaps the first such consensus standard was Nuovo Receptario Composito, a book of medical ingredient standards commissioned by the guild of physicians of Florence and made official in Florence in 1498 (Gaddum 1946).

Fifty years later in 1548, the actual word pharmacopoeae appeared in Pharmacopoeae Jacobi Sylvii libri tres of French physician Jacques Dubois, but the term was used only in its generic sense. The first officially sanctioned work with the word pharmacopoeia was the Pharmacopoeia Augustana of 1601 (Sonnedecker 1993) and others soon followed establishing the model for official pharmacopoeias.

Early pharmacopoeias (e.g., Pharmacopoeia Augustana 1601; Pharmacopoeia Londinensis 1618) were predominantly books of recipes for extracts, syrups, and oils and provided guidance for relative standardization of medicinal preparations, many of which were Galenical, relatively crudely extracted, herbal preparations.

Over time, pharmacopoeias (e.g., British Pharmacopoeia 1864) introduced standards of identity and quality for individual herbal medicines. Many of these reflected relative generality, sometimes not specifying plant species (e.g., acacia) but notably included information regarding the identifying morphological characters, origin, collection practices, and drying conditions of the drug material, clearly the primary considerations of early herbalists and plant collectors.

Another early pharmacopoeia, the Dispensatorium Lippiacum (Scherf 1792) introduced organoleptic characterizations and the use of magnifiers as part of the assessment criteria for plant medicines. Interestingly, the Dispensatorium Lippiacum was described as “predominantly addressing handcraft savvy pharmacists in small towns” (Friedrich no year), a description that could readily be applied to numerous traditional herbal extract (tincture) manufacturers in the US today.

In addition to being predominantly recipe books of relatively crude herbal preparations, some of the earliest of formal pharmacopoeias (e.g., Augsberg Pharmacopoea 1613), attempted to resist the ever-growing movement to use Paracelsun “chemical” medicines. According to history of pharmacy scholar George Urdang (1882–1960), in a decree of the Augsburg Senate in 1582, the apothecaries (druggists) were “admonished” not to prepare or offer for sale “substances which are known to be detrimental or poisonous, such as Labdanum minerale, the so-called antimony, also Turpethum minerale and other purging mecurials.”

Many of the precepts of the Paracelsun use of powerfully acting drugs, were in direct opposition to the empirical lineages of Galenists and Hippocratists. However, soon after, in 1589, the London College of Physicians proposed that the chemicals, salts, extracts, and metals of Paracelsus be included in the London Pharmacopoeia. This was eventually realized in 1618 with the inclusion of calomel (mercury chloride) among the medications for internal use.

While the juxtaposition of Paracelsun ideologies and those of the Galenists where in great part an attempt of the Paracelsuns to not blindly follow the empirical philosophies of the ancients, and were very much attempting to apply scientific experimentation in medicine, Galenists were alarmed at what they saw as the introduction of highly poisonous substances that had no basis of safety or efficacy into medical practice. As noted, this trend laid the groundwork for modern drug development that predominates today.

Another development marking the distinction between traditional and modern drugs was the introduction of chemical testing methods into pharmacopoeial monographs. Prior to analytical chemistry, the focus of pharmacopoeias and materia medicas was on morphology as the primary identity test and proper harvesting conditions and organoleptic characters as the primary criteria by which herb quality was assessed.

The Pharmacopoea Wirttembergica (1741) was the first pharmacopoeia to introduce chemical testing of drugs, a trend that continued as analytical chemistry advanced and chemically characterized drugs became dominant. Whereas the earliest pharmacopoeias and materia medicas reflected a relatively herbal-botanical approach to the assessment of herbal medicines, later Western pharmacopoeias, persisting to the current day, deferred to chemistry.

Pharmacopoeias codify the standards of identity, purity, quality, and testing for herbal drugs, traditional and modern. Generally speaking, if a pharmacopoeia does not provide a monograph for a specific drug then the drug cannot be traded commercially.

However, in herb-friendly societies, such restrictions do not apply. Most pharmacopoeias worldwide are relatively consistent in the fields of information they provide. The primary principle of pharmacopoeial monographs is to ensure the proper identity of the herbal ingredient to be used in a drug and develop minimal standards of quality and purity, so that when a pharmacopoeial-grade drug ingredient is used it will deliver the intended activity.

Some of these pharmacopoeial monograph standards are consistent with herbal assessment practices employed by traditional herbalists. Others are a result of the ever modernization of herbal medicines including the requirement for chemical testing that often overshadows traditional assessment techniques as discussed below.

Most pharmacopoeias lack information that is essential to procuring a high quality herbal medicine and rather create a minimum standard of acceptance. This influences many product manufacturers to produce products that meet a minimal quality standard rather than an optimal quality standard.

For example, the North American botanical goldenseal root (Hydrastis canadensis) contains from 2.5% to 6% of berberine alkaloids. Most pharmacopoeial standards (e.g. AHP, USP) formally require for the botanical to contain not less than 2.5% berberine alkaloids, the lowest amount the plant contains. In contrast, a traditional herbalist attempts to determine optimal harvest times in order to prepare an optimal medicine.

In most all cases, the interface between the medical practitioner, the classical botanical pharmacognosist, and the resultant pharmacopoeial standard has been largely lost creating a significant disassociation between the manufacture and practice of medicine, a connection that traditionally was much more integrated.

Approximately 74% of countries do not have their own pharmacopoeias. Of these countries lacking their own pharmacopoeia, approximately 56% utilize the monographs of the European Pharmacopoeia (EP) or United States Pharmacopeia (USP); approximately 30% utilize no pharmacopoeia; and, perhaps most telling, 78% of countries do not include herbal medicines in their national drug lists (WHO 2005).

In both developed and developing nations, unless provisions for access to non-official plant drugs are in place, or at the very least not restricted, availability to traditional herbal drugs can be impeded, a situation currently in place in the US where there is no regulatory allowance of traditional herbal medicines.

The following fields of information are contained in the majority of pharmacopoeial monographs worldwide. Different pharmacopoeias give greater or lesser emphasis to certain fields of information over others. Compliance with all aspects of the monograph in developed countries, most represented by the pharmacopoeias of China, the European Union, Iran, and the United States, is required, a requirement that contains redundancy and, in some cases, unnecessary testing, all of which drives the cost of traditional herbal medicines up.

Pharmacopoeial definition

Most monographs begin by defining the medicinal substance. This definition establishes the identity of the material being used and oftentimes, the minimum quality of the ingredient to be used, usually determined by the presence of a specific quantity of a chemical compound as noted in Table 3.

The pharmacopoeial definition is often the first body of information that establishes that a chemical test is required for acceptance of the herbal drug. Chemical testing is especially relevant when most of the activity of the botanical can be assigned to a specific constituent, when there is a narrow therapeutic to safety window of the drug, or when the medicinal qualities of the plant cannot be discerned through sensory analysis.

Generally speaking, and specifically regarding relatively safe herbal drugs, chemical testing has great value as a complement to organoleptic assessment. Chemical assessment is most critical for the more toxic of herbal medicines that possess a narrow therapeutic window.

However, analytical chemistry does not take the place of ensuring optimal times of harvest and proper drying, processing, and storage conditions. Chemistry can more fully inform these practices, but in itself is not sufficient to render analytical techniques such as botany, microscopy, and sensory evaluation obsolete or inferior to other techniques (see Macroscopic and Sensory [Organoleptic] Evaluation below).

PharmacopoeiaDefinition
European Pharmacopoeia (EP)Whole or cut, dried flowering tops of Hypericum
perforatum L., harvested during flowering time.
Content: minimum 0.08 per cent of total hypericins,
expressed as hypericin (C30 H16 O8; Mr  504.4) (dried drug).
United States Pharmacopoeia (USP)St. John’s Wort consists of the dried flowering tops or aerial parts of Hypericum perforatum Linne´ (Fam. Hypericaceae), gathered shortly before or during flowering. It contains not less than 0.04 percent of the combined total of hypericin (C30H16O8) and pseudohypericin (C30H16O9) and not less than 0.6 percent of hyperforin (C35H52O4).
Table: Pharmacopoeial definitions of St. John’s wort (Hypericum perforatum)

Macroscopic and sensory (organoleptic) evaluation

All pharmacopoeia monographs include a morphological description of the plant drug under various descriptive headings such as: Identification in the European Pharmacopoeia; Botanic characteristics in the USP; and Description in the Ayurvedic Pharmacopoeia of India and Pharmacopoeia of the People’s Republic of China.

These sections primarily give the relative form, size, shape, and physical features of the crude plant drug. These were the primary criteria used by traditional herbalists and early pharmacognosists in discerning the authenticity of the plant drug material. Great emphasis was similarly placed on plant morphology in the numerous pharmacognosy works of the 19th and early 20th centuries (e.g., Flückiger and Tschirch in 1887; Mansfield 1926; Sayre 1917; etc.).

Detailed instruction was provided in how an appropriate macroscopic/morphological assessment was to be performed on various plant parts. Today there is a plethora of references (e.g; Applequist 2006; Leon and Lin 2018; Pfaender 1991; Wichtl 2004; Zhao 2009; 2014) on the morphological assessment of crude plant drugs that provide a scientifically valid means for identifying a large number of medicinal plants to determine conformity with pharmacopoeial identification specifications.

Organoleptic assessment was, historically, and among herbalists today, the most important suite of characters for determining the relative quality of a crude plant drug. Organoleptic evaluation of plant material includes an assessment of the flavor, aroma, texture, and sensation experienced by the assessor and requires a specialized skill set akin to those required by food scientists and sommeliers, but to a much lesser degree. From a botanical medicine sense, flavor is broadened to include the sensation of texture and mouth feel.

Flavor arises when chemicals in foods (and herbs) react chemically with receptors on taste buds (gustatory calyculi) on the tongue, mouth, and throat. The tongue is covered with 2000–5000 taste buds, each one containing 50–100 taste receptor cells. In modern food sensory evaluation, five basic flavors are recognized: sweet, sour, salty, bitter, and umami.

This latter umami flavor was defined by the Japanese to describe the “savory” flavor of the commonly used food flavoring monosodium glutamate (MSG). There are relatively few herbs that possess this flavor and so its relevance to organoleptic assessment of botanicals is limited. More relevant are the flavors recognized in traditional herbal medicine systems, namely, sweet, sour, bitter, salty, pungent, and in Ayurveda, astringent, which is more accurately a mouth feel, but never-the-less, regarded as a flavor for purposes of describing herbal actions.

From an evolutionarily perspective, flavors are either aversive or desirable and inform human decisions about what and what not to eat. At a very basic level, the sweet flavor typically identifies high-energy foods; strongly bitter and or strongly acrid flavors are undesirous and may indicate a poison.

Flavors contribute part of the sensation of foods, and are complemented by aroma detected by olfactory epithelium receptors, texture detected mechanically such as through nerves in muscles, temperature through thermoreceptors, and sensations of coolness (peppermint leaves or oil), heat (cayenne, black pepper), and pungency (cloves, ginger root) through chemical sensations detected by skin and mucous membranes (chemesthesis), all of which are referred to by some as the “nature” of the herb.

In some cases, the flavors directly correspond to medicinally active constituents as established in western science, such as menthol from peppermint; capsaicin and piperine from cayenne and black pepper, respectively; and eugenol and gingerol from cloves and ginger root, respectively. Medicinally, menthol is an active constituent in topical analgesics. Menthol triggers cold-sensitive TRPM8 receptors in the skin.

It is through this mechanism that the familiar cooling sensation when inhaled, ingested, or applied topically is experienced (Eccles 1964), while menthol’s analgesic properties are mediated through a selective activation of κ-opioid receptors (Galeottia et al. 2002).

  • The yellow color and bitter taste of the Chinese herb huang lian (Coptis spp.) (Zhao and Chen 2014) and the North American goldenseal root (Hydrastis canadensis) is correlated with berberine content, the herbs’ putative primary active constituent
  • The mucilaginous content of herbs such as slippery elm (Ulmus fulva), flax seed (Linum usitatissimum), and psyllium seed (Plantago ovata), as determined by the swelling index included in most pharmacopoeias, is correlated with the soothing and moistening nature of the herbs
  • The bitter flavor of Ganoderma species is correlated with immuno-modulating triterpenes (Kubota et al. 1982; Nishitoba et al. 1989)
  • The numbing effect of Echinacea angustifolia root experienced when chewed is correlated with isobutylamides, which are among the most biologically and pharmacokinetically relevant of echinacea constituents (Woelkart et al. 2005).

These are only a few examples where there is a clear association between herbal flavors, known active constituents, and pharmacological effects.

Prior to the advent of chemistry, traditional herbal systems developed a very sophisticated system of sensory assessment that formed the didactic basis for understanding the pharmacology of the herbs. These systems also linked sensory qualities found in nature with sensory qualities of pathology and health (hot, cold, moist, dry, etc.), and then correlated those with the sensory quality of plant drugs.

On a philosophical level, Chinese medicine assigns the five specific flavors identified in that system to five organ complexes, respectively; bitter to the heart; sweet-spleen/pancreas; pungent-lungs; salty-kidneys; sour-liver.

Each taste is considered to have specific attributes such as bitter substances are draining and drying; salty substances soften and attract moistness; sweet substances nourish; pungent substances disperse; and sour substances astringe.

Chemically, bitter substances often correspond to alkaloids and certain triterpenes; sweet substances to carbohydrates and complex sugars (e.g. polysaccharides); pungency to volatile oils; salty substances to mineral salts; and sour to flavonoids and plant acids. While these basic flavor-chemistry correspondences are simplistic and not specific to disease complexes from a Western medical approach, they form the basis of pharmacology that is completely unified in the diagnostic system of Ayurvedic and Chinese medicine.

While herbalists historically did not specifically know what compounds were correlated with what activity, they recognized that it was the whole herb and the predominant nature of the herb that was considered active and that the quality of the herbal drug was discerned, and often directly correlated, to its sensory characteristics. These relationships were then either proven or disproven through experience and refined over centuries.

In Ayurveda and TCM, this system of sensory relationship between nature, humans, and medicines, is still actively applied by almost all herbal practitioners and has been integrated somewhat by some western herbalists. It is this very system that uniquely correlates qualities of nature, with qualities possessed in plants, with qualities reflected in anatomy, physiology, and pathology, creating a unified system based on natural principles of human health that is, itself, a microcosm of nature and is the traditional antecedent to individualized medicine.

This is yet another stark differentiator between traditional and modern systems whose diagnostic systems seldom look at the nature of the person but rather defer the understanding of human health and pathology to machines that generate often arbitrary values that reflect symptomatic changes in a statistical norm but says little about the individualistic needs of the human being.

This is one of the very reasons why there is a rapid and increased recognition of traditional herbal systems worldwide. It is not a fad, but a universal need to restore humanistic values to human health. The relationship with the plant itself is reflected in numerous herbal traditions as follows:

“The crude drug is the foundation of the pharmaceutical preparation… the [pharmacognosist] must be able to judge of the intrinsic qualities of drugs. This last is the most important part of the art of pharmacognosy, for while it is easy to learn to identify different drugs it is difficult to obtain the experience necessary to judge of quality shades….The study of crude drugs is most important.” – John Uri Lloyd (1849-1936)

 “Visual inspection provides the simplest and quickest means by which to establish identity, purity and, possibly, quality. If a sample is found to be significantly different, in terms of color, consistency, odor or taste, from the specifications, it is considered as not fulfilling in the requirements.” – WHO (1998)

“The way of using herbs, there is one way, there is no other. That is to master the herb’s nature and flavor, and to understand its yin and yang. Only with this understanding, even if the herbs are many, can you achieve desired results.” – Zhang Jingyue (1563–1640) Jingyue Quanshu (Complete Works of Jingyue)

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Traditional herbal medicines: Centuries of Empiricism https://www.herbalreality.com/herbalism/western-herbal-medicine/traditional-herbal-medicines-centuries-empiricism/ https://www.herbalreality.com/herbalism/western-herbal-medicine/traditional-herbal-medicines-centuries-empiricism/#comments Fri, 29 Oct 2021 15:22:01 +0000 https://www.herbalreality.com/?p=4100 Roy Upton explores how, when it comes to herbal medicine, the thousands of years of empirical experience is completely discounted.

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Traditional herbal medicines: Centuries of Empiricism

Roy Upton explores medicinal empiricism, including how, when it comes to herbal medicine, the thousands of years of empirical experience is completely discounted.

One of the points of demarcation between the basis of evidence by which traditional and modern drugs are differentiated is empirical observation of the former and modern clinical trials of the latter. Interestingly, as in the examples of toxicity and fraud discussed above, it is only when approved drugs get into empirical use are their actual toxicity revealed.

Additionally, in the US, 20% of prescription drugs are used for off-label uses, uses for which they were not specifically approved, including use in pregnancy and in children, uses for which were determined by practitioners empirically and are legally allowed. A 2006 study reported that most all of these off-label uses (73%) had little or no scientific support (Radley et al. 2006).

This is most troubling as one of the primary reasons given worldwide that dissuades physicians and insurance carriers from integrating herbal medicine into national health care plans is a perceived lack of scientific evidence; yet most of what is practiced in Western medicine, including the use of pharmaceuticals and medical procedures (e.g., cesarean sections, hysterectomies, mammography and PSA screening) are not evidenced-based, or are based on very poor evidence.

In other words, as with the vaccines developed against COVID-19, the true level of safety and efficacy is only revealed through empirical observation, yet, when it comes to herbal medicine, the potential veracity of thousands of years of empirical knowledge and experience is completely discounted.

A number of examples of traditional herbal medicines illustrate their value based on modern research supporting historical indications, despite a lack of understanding of the pharmacological mechanisms associated with the activity. St. John’s wort (Hypericum perforatum) is one of the most ancient of herbal remedies in Western civilization and continues to be used today in much the same ways as in ancient times. Dioscorides wrote: a decoction of the fruit (taken as a drink with a pint of honey water) is available for sciatica. It expels much bilious excrement… Smeared on, it is good for burns (Osbaldeston and Wood 2000).

St John's wort (Hypericum perforatum)
St John’s wort (Hypericum perforatum)

Today, St. John’s wort is routinely used topically by modern medical herbalists for burns, scrapes, and neuralgic pain and internally for the treatment of depression, all traditional uses that are scientifically supported (Upton et al. 1997).

While St. John’s wort was introduced into modern Western medical practice by homeopaths, who regarded it as “arnica for the nerves”, a dictum attributed to Paracelsus (Jones 1880) and arnica being a highly regarded healing agent for tissue damage, St. John’s wort became widely accepted by non-homeopaths. St. John’s wort has historically been one of the most relied-upon botanicals for the treatment of wounds. Part of this activity is due to Hypericum’s antimicrobial activity, which modern research attributes to the essential oil, phloroglucinols, and flavonoids.

In a relatively modern study, a St. John’s wort oil, one of the oldest of Galenical St. John’s wort preparations, was shown to facilitate the healing of second and third degree burns (Saljic 1975) and successfully treat infection with Staphylococcus aureus (Negrash and Pochinok 1972) to a degree greater than standard treatment with sulfonilamide (Aizenman 1969). In another study of St. John’s wort, a tincture (1:10) of the herb was studied for its wound-healing properties and compared with calendula, another widely used vulnerary.

The effect of orally administered tincture of St. John’s wort was greater than topical application of Calendula tincture in the healing of incision, excision, and dead space wounds as evidenced by an increase in epithelization and wound-breaking strength (Rao et al. 1991). Another randomized, double blind, placebo-controlled clinical trial demonstrated efficacy for St. John’s wort to facilitate the healing of wounds in women who had undergone Cesarean section.

Significant reductions were observed in scarring, pain, and pruritus (Samadi et al. 2010). In recognition of the ancient use of St. John’s wort as a healing balm, St. John’s wort oil was listed in the Pharmacopoeia Augustana (1612) and in the first Pharmacopoeia Londinensis (1618).

Gerard (1633) wrote that St. John’s wort’s use as a balm for wounds, burns, ulcers and bites was without equal, stating; “for I dare undertake to cure any such Wound as absolutely in each respect, if not sooner and better, as any Man whatsoever shall or may with Natural Balsam”. Linnaeus (1749) in his Materia Medica reported on the use of the flowers and herb of St. John’s wort (Hypericum vulgare) to stop bleeding of the lungs and urinary tract and as a anthelmentic. In total, there are approximately 2000 years of empirical medical observation of the efficacy of St. John’s wort as a vulnerary (wound healing agent) and modern research to support this use.

Today, in much of Europe and the US, St. John’s wort is heavily marketed by phytopharmaceutical companies for depression and “improving mental health”. The Latin name Hypericum was derived from the earlier Greek eikon as recorded in the second century BCE by Nikander (Alexipharmaca V, line 603) and then later by the noted Greek physician Euryphon (upereikon; 5th century BCE) as yperikon, which meant “over an apparition”(Hobbs 1990; Robson 2003).

Paracelsus also recommended St. John’s wort for “phantasmata”, which referred to psychoses and hallucinations, and for “healing of the soul”. In early times, depression was undoubtedly considered a form of possession, and from a humanistic perspective versus medical diagnostic perspective, depression can very much be described as a “disease of the soul”.

Triphala (Terminalia chebula, Terminala belerica & Emblica officinalis)
Triphala (Terminalia chebula, Terminala belerica and Emblica officinalis)

In more modern times, formal clinical trials including meta-analyses, demonstrate St. John’s wort’s efficacy in the treatment of mild to moderate depression (Andreescu et al. 2008; Linde et al. 1996; 2008). In one of a few trials in which significant benefit was not demonstrated with either St. John’s wort or the approved anti-depressant imipramine, the herb performed better than the pharmaceutical both in patient outcome and side effect profile (Davidson 2002).

Thus, even in a study where the herb presumably was not statistically significantly better than placebo, it never the less showed great efficacy than a formally approved pharmaceutical agent. More importantly, there are 1900 years of empirical experience of the use of St. John’s wort and more than 20 years of clinical data, including positive meta-analyses demonstrating efficacy for depression.

Ayurvedic medicine provides us with a particularly poignant example of a traditional herbal drug that has similarly stood the test of time and modern research—the three-fruit combination triphala. Triphala was first written about and used extensively more than 1000 years ago in the seminal text of Ayurveda the Caraka Samhita (~100 BCE).

This formula is a mainstay of the practice of virtually every modern Ayurvedic practitioner today and, for many, it is the first therapy given before any others can be considered effective. Additionally, triphala is regarded as a rasayana, a rejuvenative tonifier used to preserve life (Ponnusankar et al. 2011).

Much of the modern research of the individual herbs in triphala, as well as the combination itself, focuses on cytoprotective, immunomodulating, and antioxidant activity (Jagetia et al. 2004; Naik et al. 2005; Sairam et al. 2002; Srikumar et al. 2005), three pharmacological actions that can be considered to be associated with preserving life.

A last example is provided by a classic Chinese herbal formula known as si wu tang (four substance decoction). The formula was first written about in the Tai Ping Hui Min He Ji Ju Fang (Imperial Grace Formulary of the Tai Ping Era) between 1078–1085 CE. The formula was originally described for its use in menstruation, among other indications.

Regarding menstrual difficulties, Western conventional medicine has few therapeutic options regarding gynecological health and fewer good therapeutic options. In 2003 in the US alone, there were approximately 602,457 hysterectomies performed, 538,722 (~89%) of which were for benign conditions (Wu et al. 2003). Some studies show that many hysterectomies are deemed unnecessary by second opinion or when alternative treatments are offered (BMJ 2014; Tan 2014).

Some experts suggest that up to 90% of hysterectomies are not medically necessary (NWHN 2014). Hysterectomy rates differ between countries, ranging from a high of 5.4 per 1000 women in the US (Farquahr and Steiner 2002); intermediate rates of 3.7 per 1000 in Italy (Materia et al. 2002); and a low of 1.2 per 1000 in Norway (Mepherson et al. 2002). The conditions for which hysterectomies, which are often accompanied by removal of the ovaries as prophylaxis against ovarian cancer (oophorectomy), are performed are predominantly to relieve symptoms of difficult menstruation that generally do not threaten lives.

Current scientific evidence suggests that elective oophorectomy is not advisable for the majority of women as it may lead to a higher risk of death from cardiovascular disease and hip fracture and a higher incidence of dementia and Parkinson’s disease (Rocca et al. 2009). Recently, it has been concluded that preserving ovaries until at least the age of 65 years was associated with higher survival rates.

Conversely, women who had a bilateral oophorectomy had a higher incidence of risk of all-cause death, fatal and nonfatal coronary heart disease, stroke, and lung cancer. Markedly, none of the groups in which oophorectomies were performed showed any correlation with increased survival (Parker et al. 2009) suggesting that alternatives, such as those offered with botanical medicines, such as si wu tang, offer a completely different therapeutic strategy with tremendous potential for reduction of harm and benefit.

And, each of these examples offers clear evidence regarding the lack of evidence of some of the most common of medical procedures, despite Western’s medicine belief of adhering to principles of ‘evidence-based medicine’, even when these procedures cause irreparable harm or are ineffective.

While the botanical medicines discussed provide only a select view of the breadth of herbal medicines used worldwide and that have been supported by scientific study, the list can easily be multiplied by hundreds. More importantly, a review of the scientific literature reveals relatively few new discoveries regarding the uses of herbal medicine. Rather, studies mostly support the medical uses of the herbs that were known historically.

For example, of all the plant-derived products currently available as prescription products, 72% are used in a manner, which parallels their ethnomedical use.

Similarly, bioprospecting in the traditional herbal medical literature for potentially medicinal compounds has been demonstrated to yield more positive findings than random screening (Cordell and Colvard 2005; Tempesta and King 1994). Moreover, noted medicinal plant researcher Geoffrey Cordell (2002), underscores the need for humans to pay close attention to the preservation and investigation of traditional knowledge and natural resources that provide traditional and modern medicines for future generations, a message that should be taken to heart.

Nicholas Culpepper
Nicholas Culpepper

Historically there were two primary arms to the study of traditional herbal healing modalities; therapeutics and materia medica. Therapeutics provides the theoretical framework by which health and disease is understood, the second the medicinal agents used, materia medica. Therapeutics provide the diagnostic principles that form the basis for which materia medica is to be applied.

Today, the majority of herbal medicines are researched in a way that takes little or no consideration into the therapeutic framework in which herbal medicines should be used. Rather, individual herbs (relatively rarely, formulas) are investigated from a western pharmacological perspective for Western disease endpoints, completely removed from any cultural diagnostic context, such as of Ayurveda or TCM.

The primary reason that Chinese medicine offers potentially effective treatments for functional gynecological problems, as discussed above, is due to the theoretical basis of understanding the physiology and pathology of the gynecological system.

In Western medicine there is little understanding of the cause of functional gynecological imbalances. There are metrics with regards to identifying hormonal imbalances, growths, and abnormalities, but little to no understanding of the cause (see Goodman and Gilman).

Conversely, Chinese medicine offers unique perspectives on promoting the health of the gynecological system through a myriad of theories of the causative factors of gynecological imbalances that correspond directly to therapies to address those imbalances.

Whereas Western medicine offers hormonal replacement therapy (HRT) that itself increases mortality, along with palliative medications, surgery, and ablation therapies, TCM offers a host of therapies that include dietetics, baths, exercise, moxabustion, acupuncture, and a myriad of diverse herbal prescriptions, such as si wu tang, some of which have been in continued use for several hundred years.

Many of these therapies have been demonstrated to have high rates of efficacy relative to controls for a wide range of gynecological imbalances including infertility, endometriosis, polycystic ovarian syndrome, dysmenorrhea, and pelvic inflammation, to name only a few (Jue and Fan 2009; Robinson and Wiczyk 2011, among others).

Dioscorides
Dioscorides

Whether we consider evidence from cuneiform medical recipes from 3400 BCE, the birch fungus in the pouch of the Neolithic Oetzi the Iceman (circa 3300 BCE), or the writings of the 1st century physician-herbalist Dioscorides, whose writings remained the medical authority for more than 16 centuries, it is clear that medicinal plants have been the primary medicinal agents used throughout human history. The WHO has a long history of promoting the responsible use of herbal medicines worldwide.

As a non-regulatory body, WHO is in a unique position to offer relatively unbiased guidance for how herbal medicines should be integrated into health care systems, both at the community and national levels, with the express purpose of what is in the best interest of the communities. This is a distinctly different position than national regulatory authorities, which have a myriad of social and economic biases that drive national health care policy.

First and foremost, it is important to recognize that healing is a reflection of cultural belief whether that belief is based in indigenous traditions or modern paradigms. Therefore, the true integration of traditional healing practices, including the use of traditional herbal medicines, must be considered from the perspective of how traditional- and technologically-oriented healing systems differ, as discussed above.

Encompassed in traditional medicine are those practices that are based on indigenous theories, beliefs, and experiences that are passed from generation to generation. These traditions reflect well-established and nationally accepted systems of medicine such as Ayurveda and TCM, as well as more localized practices and philosophies of healing by minority communities such as Native American, South American, and indigenous aboriginal healers in Australia, to name only a few.

In contrast, ‘modern’ or ‘conventional’ medicine is reflected in the concept of Western ‘allopathic’ medicine, a term ironically coined by the founder of homeopathy Samuel Hahnemann (1755–1843), and as generally applied to modern technologically oriented (Western) healing practices.

Traditional herbal medicines are more generally and specifically defined within WHO documents and are categorized into four main groups as follows (WHO 2004):

  • Category 1: Indigenous herbal medicines: These medicines are used by local communities indigenous to a specific region and within a framework of cultural knowledge that may or may not be accessible to those outside of the community. WHO recommends that these medicines be allowed to be used freely by the communities. However, WHO stipulates, rightfully or wrongfully, that if these medicines enter the dominant market or go beyond the community boundaries, then those medicines must meet safety and efficacy requirements established in national regulation.
  • Category 2: Herbal medicines in systems: These medicines have a long history of use within a formalized system of medicine that are accepted by the country(s), for example, traditional Ayurveda, Chinese medicine, Unani-Tibb.
  • Category 3: Modified herbal medicines: These are medicines used in the above-mentioned categories but have been modified in some way that is no longer completely consistent with traditional systems. WHO contends these medicines should comply with national regulatory standards for safety and efficacy.
  • Category 4: Imported products with a herbal medicine base: These medicines represent imported raw materials or finished products that are registered for use in the country of origin. Again, WHO contends that these products have to meet the safety and efficacy requirements of the recipient country.

WHO more specifically defines herbal medicines as follows:

“For the purpose of these guidelines, the Consultation agreed that Herbal Medicines should be regarded as: Finished, labeled medicinal products that contain as active ingredients aerial or underground parts of plants, or other plant material, or combination thereof, whether in the crude state or as plant preparations.

Plant material also includes juices, gums, fatty oils, essential oils, and any other substances of this nature. Herbal medicines may contain excipients in addition to the active ingredients. Medicines containing plant material combined with chemically-defined active substances, including isolated constituents of plants, are not considered to be herbal medicines.“

These categories clearly articulate the basis in which herbal medicines are to be allowed for use by indigenous communities, by practitioners of well-developed healing traditions, or integrated into the fabric of the national health care system.

Moreover, the last definition of herbal medicine makes a clear differentiation between a traditionally prepared herbal medicine, a modern chemical isolate, and the combination of both. This is poignant as an herbal substance such as St. John’s wort has several centuries of accumulated data regarding indications, efficacy, and safety, and numerous modern studies documenting relative safety and efficacy, must be considered differently than the newly developed drug of the year that has no history of ever even existing let alone any data regarding safety and efficacy.

Ephedra (Ephedra sinica)
Ephedra (Ephedra sinica)

While some countries (e.g., Japan, India, People’s Republic of China) have worked diligently to represent traditional healing practices, including herbal medicine, as part of their national health care systems, as of 2005, approximately 60% of WHO member countries had no policy on traditional healing practices (WHO 2005).

Moreover, while it is largely public interest that is driving the desire for greater access to herbal medicines, and thus driving policies, oftentimes, national policies are established with little or no input from the traditional medicine practitioner community.

For example, neither the EU traditional medicines Directive 2001/83/ECnor the Dietary Supplement Health and Education Act (DSHEA), the latter that constitutes the primary access by which traditional herbal agents are allowed in the US, had formal input from the most well established of the traditional medicine practitioners, namely, Ayurvedic, Chinese medicine, or naturopathic practitioners.

Thus, in both the US and the EU, it is industry with vested interests in specific herbal remedies that drive both health care policy and herbal medicine approval. This is a significant impediment to traditional healing practices as the availability of materia medica is often dependent upon the availability of crude herbs or herbal preparations through industry.

The 2006 banning of the Chinese herb ephedra (Ephedra sinica) in the US is a clear example of how the misuse of an herb by industry, and subsequently by consumers, in stimulant and weight loss products led to significant adverse events. This resulted in both perceived and real concerns regarding the herb’s safety that resulted in a complete restriction from public and practitioner use, losing one of the most important articles of both Chinese and Western herbal materia medica, and losing access to an herb that, when properly used, had been used with a high degree of safety for more than 5000 years.

Similarly, national policies regarding herbal medicines tend to focus predominantly on supply and manufacturing issues, with relatively little resources expended on human clinical trials, and fewer resources expended to investigate botanicals medicines in the manner in which they were traditionally used; as part of a multifaceted healing program that included dietary, stress, and behavioural modification.

As begun by Paracelsus, too much emphasis is placed on studying herbal drugs in the same way that conventional drugs are studied, thus, often investigating the herbal drug out of the cultural and medical context in which it was historically used.

“To talk about pharmacognosy is to follow the evolution of man’s knowledge during the various civilizations, i.e. the evolution of mankind from the dawn of time to the present.” – DePasquale (1984)

Historically and until relatively recent times, pharmacognosy, the study of drugs derived from natural products, represented an intersect between traditional herbal medicine, ethnobotany (the traditional and cultural use of plant medicines and textiles), and scientific inquiry.

In ancient times, the predecessors of modern pharmacognosists, represented by early medical scholars such as the Greek physician Dioscorides (1st century CE), were more closely linked with the practice of medicine than their descendents of the 20th century, many of whom were influenced by the chemical revolution taking place at the time and became more aligned with the business of drug development rather than the practice of medicine.

With its formal beginnings in the writings of the Austrian professor of medicine Johann Adam Schmidt (1759–1809), the original focus of pharmacognosy was on ensuring the identity, quality, and purity of plant-based drugs (Schmidt 1811). A principle focus at the time was on the source and quality of the raw material used in the manufacture of herbal drugs.

This was prior to the advent of modern analytical chemistry and so the morphological and organoleptic characters of the crude plant drug, and later, the cellular structures of the plant as observed with a compound microscope, were the primary analytical tools used for quality evaluation. As analytical chemistry and the manufacture of synthetic drugs advanced, the science of pharmacognosy evolved into the field of pharmaceutical biology with an emphasis on natural products chemistry, molecular biology, and biotechnology.

The modern pharmacognosist, rather than applying the skills of classical botanical pharmacognosy to ensure the identity, quality, purity, and integrity of plant drugs, which were being replaced by chemical drugs, were employed to search for novel compounds that could be exploited as drugs for commercial purposes. This change in scientific focus paralleled the changes in the medical profession described previously.

According to a 1941 article in the magazine Science, “The desertion of the study of vegetable drugs soon became almost complete…at the present time researches dealing with plant medicinals are relatively rare and are becoming more so. Today is the heyday for organic synthetic chemicals.” (Griggs 1981).

Evolving medical theories similarly had significant impact on traditional healing modalities. The focus on the germ theory in Western medicine as a primary cause of pathology paralleled earlier medical philosophies of China’s Zhang Ji (Zhang Zhong Jing; ~150–210 CE) in his Shang Han Za Bing Lun (Shang Han Lun; Treatise on Cold Damage Disorders) that recognized pathogenic factors as a cause of epidemics.

Germs and their destruction through the subsequent advent of antibiotics, an incredible life-saving but one-sided facet of disease treatment, became the primary focus of 20th century medicine that employed a militaristic strategy to search and destroy disease, a strategy that has persisted. This is in stark contrast to the vitalistic principles of Chinese and Ayurvedic medicine, whose primary focus was and is on the health of the host.

The earliest text of TCM, the Neijing Suwen (475 BCE–221 CE) records; “Uneducated practitioners behave very aggressively, believing they can launch an attack. Before the old disease has ended, a new disease emerges in addition.” (Unschuld and Tessenow 2011). The myriad of serious negative side effects that are an inherent part of modern iatrogenesis provide ample evidence of the consequences of aggressive treatments.

According to traditional systems of healing, a healthy host, it is reasoned, is less susceptible to external pathogenic influences and has the greatest chance of health restoration, for example, from chronic degenerative diseases, for which modern medical constructs have little to offer.

This realization was articulated in the historical TCM literature of Chinese herbalist and acupuncturist Li Dongyuan (1180–1252 CE). Li broke from the earlier traditions of the Shang Han Lun that focused on external pathogenic factors as the cause of disease and noted that if a person’s core health, as embodied in the health of the spleen and stomach (earth engendering school), is strong they will have resistance from external invasion no matter how strong the pathogen (Yang and Li 2002).

This was a revolutionary concept in medical history that has yet to be practically applied in Western medicine. Most importantly, these two concepts, the Shang Han and Earth Engendering traditions, along with several other principle philosophies (e.g., yin-yang, four levels, seven emotions, and eight principles) reflect a system that embraces a myriad of medical philosophies that are applied according to the needs of an individual patient. This is in stark contrast to the single-minded focus of western medicine on a pathogen.

As modern pharmaceuticals increased in isolation, potency, and pharmacological exactness, herbal medicines largely vanished from use in Western countries. Conversely, Ayurvedic and traditional Chinese medicine remained relatively strong up until the 20th century. There were periods in the history of China and India (e.g., while under British rule) when traditional medical practices were formally discouraged in favor of European medicine.

However, for example, after decades of influence of western medical theories in China, traditional Chinese medicine practitioners began to identify deficiencies in western theories and argued that traditional Chinese medicine had much to offer the totality of medical care and began a process of integrating Western and traditional Chinese medical theories (Chen 1999) that continues today.

Subsequently, as of a 2005 survey conducted by the WHO, 1242 herbal medicines were listed on China’s essential drug list (WHO 2005). Similarly, after the end of British rule in India, Ayurveda once again regained its popularity and today, there are more hospitals of Ayurvedic care than there are conventional Western medical hospitals and the government actively supports the development of Ayurveda, as does the Chinese government for TCM. There are approximately 960 plants species used by the Indian herbal industry (Sahoo et al. 2010).

Herbal medicine in Europe experienced a resurgence for more practical reasons; after World War I, a number of drug patents, such as aspirin and heroin, were lost to the Allied Forces under the Treaty of Versailles (Jeffreys 2005).

Similarly, during World War II, much of the infrastructure for drug development was destroyed in major cities throughout Europe. This forced many, most notably Germans, to once again look at traditional herbal medicines and began a trend of cultural use and research that has persisted to the present day.

While herbal medicine in the US survived in pockets of minority groups (African Americans and Caucasians from the rural south, certain Christian sects, Mormons, Native Americans, etc.), a true resurgence did not occur in the US until the 1960’s with the back to nature ‘hippy’ movements occurring then.

This movement was overlaid with experimental use of a variety of hallucinogens, a number of which were of plant origin (e.g., Psilocybe, Datura, Lophora, Cannabis). At the same time, America was introduced to all the isms of the rest of the world such as Buddhism, Confucianism, Daoism, Hinduism, Shamanism. All of these philosophies emphasize an individual’s relationship within the context of the greater world as well as one’s responsibility to the world.

This was in contrast to the dominant Christian constructs that suggest that “man has dominion over the earth”, a philosophy rejected my many as new thoughts from the east and from Native Americans were introduced.

Regarding traditional medicine, these emerging philosophies partially established the foundation of nature being the primary healer and the recognition or belief that humans and plants have co-evolved and, because of that, plants were the optimal form of medicine for human health; a philosophy firmly held by many herbalists and natural health care practitioners today.

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The most advanced medicine in the world and the worst health statistics to show for it: America https://www.herbalreality.com/herbalism/western-herbal-medicine/most-advanced-medicine-world-worst-health-statistics-america/ https://www.herbalreality.com/herbalism/western-herbal-medicine/most-advanced-medicine-world-worst-health-statistics-america/#comments Fri, 29 Oct 2021 15:21:55 +0000 https://www.herbalreality.com/?p=4096 Roy Upton explores the role of herbal medicine in America's healthcare system.

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Evidence for the failings of a profit-driven medical system is demonstrated in the USA. Roy Upton explores the role of herbal medicine in America’s healthcare system.

The most advanced medicine in the world and the worst health statistics to show for it: America

Evidence for the failings of relying strictly on a research- and profit-driven versus a practitioner driven medical system is no better demonstrated than in the health care statistics of the United States. In 1998, Schuster et al. reported that in almost all aspects of health care, the US is failing.

These failings encompass the spectrum of services from preventive, acute, and chronic care; from infants to the elderly; or the health care delivery system of a single city or the country overall. Patients are either not receiving the care they should be receiving or they are receiving inappropriate care that is related to both under treatment and over treatment, as well as the inappropriate use of pharmaceutical medications. Similar findings were reported by numerous other authors (e.g., McGlynn et al. 2003) and organizations over the past decades, demonstrating these patterns have not changed.

By all measures of individual and social health, America is ranked among the worst of all similarly developed nations (Shellard 2000; WHO 2000; Woolf and Aron 2013). In infant mortality, a general marker of overall societal health, the US ranks an appalling 31 (based on 2008 data; Heisler 2012) in the world behind virtually all similarly industrialized nations. In 2000, the WHO ranked the US a dismal 37th in overall health care systems.

In a similar ranking by the Commonwealth Fund (2011), the US was far behind other nations in terms of healthy lives, quality, access, efficiency, and equity of health care delivery services and 19th of 23 nations surveyed in healthy life expectancy at age 60 (Commonwealth Fund 2008).

Perhaps most importantly, the report noted a “strikingly consistent and pervasive pattern of higher mortality and inferior health in the US, beginning at birth”; that this pattern of poorer health was evident at all stages of life, from infancy to childhood, to adolescence to young adulthood, to middle and old age, and could not be explained by disparities in social demographics.

Those who could afford health care and were financially well off fared little better than those less fortunate. More unfortunate is that some of these findings have been reported for decades (such as the persistent high rates of infant mortality) and yet no meaningful change in the system occurs. The failings of the American system is similarly evidenced by the disproportionate negative impact COVID-19 has had on the American population, where more people have died per capita than any other nation.

Primary care pioneer Barbara Starfield (1932–2011), highlights that the majority of those countries with the best health statistics have a strong primary care infrastructure and that better outcomes are correlated with primary care services (Starfield 2000). Primary care providers can be described as ‘patient centric’. This in contrast to the predominant reliance on specialists in the US, which can be described as more ‘research centric’.

The WHO has a long history of recognizing traditional health care practitioners as primary health care providers, but many countries, like the US, lack acceptance or full integration of traditional healing practitioners into their national health care systems. The advantage of integrating traditional healing practices into a national health care system was highlighted by China’s full integration of traditional Chinese medical practices, and specific codification of herbal formulas for the treatment of SARS in 2003. When herbal medicines were integrated into the treatment of SARS, the death rate due to SARS dramatically declined (Chen and Nakamura 2004; Yang et al. 2020). Similar protocols and use of herbal medicine were fully integrated for various stages of COVID-19.

No improvements in health statistics can occur without a fundamental change in the philosophical basis by which health and healing is approached. As long as the militaristic approach of search and destroy is employed as the primary therapeutic paradigm, big guns represented in powerful pharmaceuticals and high tech interventions will continue to yield the extremely poor health statistics reflected in the American system.

Medical diagnostic technology that leads to a cascade of subsequent treatments is partly responsible for the relatively high rate of iatrogenesis in the US (Starfield 2000). Such diagnostics are predominantly research-driven and represent how lack of a patient-centered focus results in negative health outcomes. This is no more evidenced than in policies regarding prostate-specific antigen (PSA) screening and mammograms.

Knee Pain Inflammation

For almost two decades in the US, annual PSA screening was recommended for healthy men over 50 years of age despite the lack of robust scientific evidence for a benefit (see Albertsem 1996; Woolf 1994). Literally millions of men were screened annually at an annual cost of $447 million to America’s Medicare program alone (2009) (Ma et al. 2014). False positives and detection of slow growing (indolent) tumors resulted in aggressive surgical or radiation treatments that caused serious harm including urinary incontinence, erectile dysfunction, pain, infections, hospital readmission, and death (Moyer 2012).

It has only been more recently that a number of studies specifically looking at the benefit-risk assessment of routine PSA testing over the last 20 years determined that the moderate to high risks of PSA screening and the ensuing cascade of treatments as described by Starfield (2000) far outweighed the low to moderate benefits of PSA screening (Carter et al. 2013).

Annual screening resulted in high levels of false positives that led to unnecessary biopsies that carry a risk of bleeding, infection, pain, urinary symptoms, and hospitalization (Loeb et al. 2012; Nam et al. 2013). Because of this, PSAs are no longer recommended for most of the demographics for which it was previously used. Routine mammograms followed the same trajectory and were, and among many, remain, a research-driven and profit-motivated technology (Epstein et al. 2001).

While early detection with mammograms benefits a small subset of the population, the very act of compressing breasts between two plates and subjecting breast tissue to the cumulative DNA-damaging effects of radiation increases women’s risk of breast cancer; some estimates accounting for up to 20% of breast cancers in the US (Epstein et al. 2001 and references therein).

Despite mounting evidence of questionable benefit (see Miller et al. 2014) and substantial risk of mammograms, as of February 2014, 75% of American women reported having received a mammogram in the past year. In the United States alone, approximately 37 million mammograms are performed annually at a cost of approximately $100 per mammogram. It can be considered that routine PSA and mammography screening are almost identical in their over-diagnosis, over-treatment, marginal benefit, enormous cost, and substantial risk.

Such practices represent medicine at its worst and are a complete antithesis of the common medical dictum of Primum non nocere (first do no harm), often attributed to Hippocrates and still integral, in theory only, to modern medical ethics. More significantly, these examples of research-driven technologies represent an insidious aspect of the modern health care system as every major cancer association as well as local and national government agencies strongly supported the use of the aforementioned screening tools for the majority of the adult population despite a lack of clinical evidence of benefit and despite significant mechanistic and observed evidence for risk.

The negative impact of such research- and economic-driven policies is clear. However, more importantly, these are poignant examples of how much of what is considered technologically advanced medicine is not based in sound clinical science, but rather research-based science.

A primary criticism levied against herbal medicines, and other traditional healing practices, is their lack of scientific proof of efficacy based in modern pharmacological research. However, much of traditional herbal medicines and traditional healing practices in general, are precisely based on human clinical outcomes codified in human experience for hundreds or thousands years.

This is not to say that traditional healing knowledge is complete, safe, effective, and appropriate for all people all of the time, or does not have limitations and knowledge gaps. This merely reflects a different knowledge base that has been a consistently evolving foundation of human healing since the beginning of human existence, and at the very least, should be given the same respect, honor, and use as technologically advanced therapies that only have decades of largely experimental use.

Table 1: US Health care statistics compared to 13 other countries

OutcomeRanking of 13 countries*
Average for all health indicators surveyed12
Low birth-weight %13
Neonatal and infant mortality13
Years of potential life lost13
Postneonatal mortality and life expectancy at one yr old for females11
Postneonatal mortality and life expectancy at 1 yr old for males12
Life expectancy at 15 years of age10
Life expectancy at 40 years of age (males)9
Life expectancy at 40 years of age (females)10
Life expectancy at 65 years of age (females/males)7
Life expectancy at 80 years of age (females/males)3
Age adjusted mortality10
* Japan, Sweden, Canada, France, Australia, Spain, Finland, the Netherlands, the United Kingdom, Denmark, Belgium, United States, Germany.
Source: Starfield B. 2000. Is US health really the best in the world? JAMA 284(4): 483-485.

Table 2:  Mortality due to iatrogenic causes in the US

CauseMortality
Deaths from unnecessary surgery12,0001
Medication errors in hospitals70001
Other hospital errors44,000-98,0002
Deaths from infections contracted in hospitals (annually)80,0001
Deaths from non-error, adverse effects of medications (annually)106,0001
Sources: 1 Starfield B. 2000. Is US health really the best in the world? JAMA 284(4): 483-485.
2 Kohn LT, Corrigan JM, Molla Donaldson S (editors). 2000. To err is human: building a safer health care system. National Academies Press, Institute of Medicine and National Research Council. 287 pp.

In addition to the philosophical differences between traditional and conventional medical practitioners and the economics that drive medical practice, is the problem of having a system that relies predominantly on pharmaceutical medications. There is no doubt that pharmaceuticals save lives, especially in acute crisis.

The advent of antibiotics, while solidifying a search and destroy militaristic philosophy as a primary approach in health care, was responsible for saving tens of millions of lives. Morphine, while representing an inherent split between whole plant-based medicines and active constituents, is an incredibly effective painkiller, that, due to its potential for diversion to opium and heroin, is no longer allowed in the public domain as a plant-based medicine as it once was.

And, the story of pharmaceutical development can easily be written to focus on the positive attributes modern drugs have contributed to human health (e.g. The Inside Story of Medicines) (Higby and Stroud 1997). But despite many great successes in the world of pharmaceuticals, ironically many of which were derived from plants (e.g., aspirin, morphine, and vinca alkaloids), there is a tremendous price that current and future societies pay for their effects.

Firstly, pharmaceutical medications are represented to the public and health care professionals as proven to be safe and effective according to scientific methods. This is not entirely true. In 2009, the pharmaceutical giant Pfizer, plead guilty to a felony charge and agreed to pay $2.3 billion in fines for fraudulently marketing select drugs.

This was the fourth fine levied against Pfizer for similar infractions since 2002 demonstrating that fraud within at least one pharmaceutical giant is a recurring theme. In recent decades, a large number of the most recognized pharmaceutical companies have paid similar fines, most for fraudulent marketing practices and some for violations of good manufacturing practices (GMPs). Such practices reflect relatively gross violations of federal law.

The research and development side of pharmaceutical development is much more nuanced and insidious as has been highlighted in recent writings such as Deadly Medicines and Organised Crime: How Big Pharma Has Corrupted Healthcare. This expose was written by Peter Gøtzsche, a co-founder of the highly prestigious independent evidenced-based Cochrane Collaboration. Another, The Truth About Drug Companies: How They Deceive Us and What To Do About It, was written by medical doctor Marcia Angell, former editor in chief of the New England Journal of Medicine.

Both works, written by long-term editors of arguably two of the most prestigious medical journals in the world provide clear and evidence-based examples of broad-based bias and fraud in the world of medical literature.

These authors demonstrate clearly that published clinical research is positively biased to the sponsoring companies, provide examples of gross fraud by medical writers claiming to conduct trials that were never conducted (reviewed in Gupta 2013), and report that negative findings are often not publicized, allowing for a drug to be released on the market with the mistaken belief that it has been scientifically demonstrated to be safe and effective.

The consequence of poor science and fraud in pharmaceutical drug development is significant. There are numerous examples of heavily marketed drugs that were removed from the market due to serious, sometimes fatal, adverse effects including Oraflex, Propulsid, Rezulin, and perhaps the crowning jewel of this collection, Vioxx, a widely prescribed arthritis drug that was withdrawn from the market after disclosures that the pharmaceutical manufacturer Merck, withheld information from patients and physicians about the potential for Vioxx to increase the risk of heart attacks and stroke.

Vioxx use resulted in between 88,000 and 140,000 cases of serious heart disease. Most significantly, cautions regarding the safety of Vioxx were put forth by epidemiologist David Graham, who at the time was the Associate Director of the Food and Drug Administration’s (FDA) Office of Drug Safety. In formal testimony given before the US Senate Committee on Finance, Dr. Graham provided poignant testimony stating that policies within FDA were insufficient to protect the public from drugs, which carry unacceptable risks, stating;

“I would argue that the FDA, as currently configured, is incapable of protecting America against another Vioxx. We are virtually defenseless… Finally, the scientific standards CDER [Center for Drug Evaluation and Research] applies to drug safety guarantee that unsafe and deadly drugs will remain on the US market.” (Graham 2004).

In a follow-up interview with Dr. Graham, Congressional representatives asked specifically what within FDA needed to be fixed, Dr. Graham replied:

“FDA is inherently biased in favor of the pharmaceutical industry. It views industry as its client, whose interests it must represent and advance. It views its primary mission as approving as many drugs it can, regardless of whether the drugs are safe or needed.” (Carozza 2005).

While such testimony can be viewed as representing only an individual opinion, similar findings were reflected in a US Government Accountability Office (GAO 2006) report that stated:

“FDA lacks a clear and effective process for making decisions about, and providing management oversight of, post market drug safety issues.”

The fallacies of the scientific validity of the US drug approval process is further promoted to the American public in equally infactual ways. In a 2013 article in the Journal of General Internal Medicine, authors Faerber and Kreling, reported that 60% of prescription drug ads and 80% of over the counter drug ads were found to be misleading or false.

The study found 43% of the claims in direct to consumer (DTC) drug ads were “objectively true” while 55% were “potentially misleading” and 2% were “false.” Most DTC prescription drug ads reportedly spend more time on benefits than negative side effects and 84% of regulatory letters sent by the FDA from 1997 to 2006 cited the companies producing those ads for minimizing risks and/or exaggerating effectiveness of drugs.

For example, one study found that although 19% of DTC ads mentioned lifestyle changes as an adjunct to medication, none mentioned them as an alternative to drug treatment (Frosch 2007). Thus, promoting a drug in consumer advertisements as the solution to a specific health problem, rather than emphasizing life-saving lifestyle changes, disincentivized viewers from making healthy lifestyle changes and fostered the belief such changes are ineffective or unnecessary (Shaw 2008).

DTC drug advertisement, which is illegal in most all countries with the exception of the US and New Zealand, rarely focuses on public health messages about diet, exercise, addictions, social issues, and other treatments that may be more cogent to wellness than pharmaceutical interventions (Almasi et al. 2006).

Healthy lifestyle modification can result in fundamental changes in an individual’s health status, is free of side effects, and free of cost. Unfortunately, such practices are very bad for business, which circles back to the economic aspect of American medicine, that it is a business. Unfortunately, what happens in America does not stay in America. The consequences of deceptive drug development and approval practices carries over to other nations.

The relevance of all this to traditional healing practices, especially herbal medicine, is two-fold

  1. First is that research, economic, and regulatory agendas are heavily biased to pharmaceutical development based on research findings that are often flawed at best and fraudulent at worst, versus being patient centric and outcomes oriented.
  2. Second, no single herbal medicine or collective of herbal medicines in the history of the world has resulted in the magnitude of public harm as drugs such as opioids, Vioxx or Rezulin or the collective of pharmaceutical drugs.

Yet, despite hundreds or thousands of years of clinical and empirical data with herbal medicines, their use is often restricted or limited based on claims of their “unknown dangers” simply because modes of action have not been fully articulated according to modern conventional drug standards.

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Economic influences of medical evolution https://www.herbalreality.com/herbalism/western-herbal-medicine/economic-influences-medical-evolution/ https://www.herbalreality.com/herbalism/western-herbal-medicine/economic-influences-medical-evolution/#comments Fri, 29 Oct 2021 15:21:53 +0000 https://www.herbalreality.com/?p=4093 Roy Upton explores why the desire to fit herbal medicines into a modern drug regulatory model is more about economics than health care.

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Roy Upton explores why the desire to fit traditional herbal medicines into a modern regulatory model is more about economics than health.

Economic influences of medical evolution

Generally speaking, herbal raw materials were historically gathered by local herbalists, who either prescribed them directly to patients or delivered them to practitioners. Often the price of an herbal consult and herbal formula was eggs, milk, a chicken, or the consult and treatment were free due to the practitioner being provided for by the larger community, similar to socialized systems of medicine.

While, such practices seem out of place or inapplicable in developed nations, such practices still exist in many undeveloped and developing nations (e.g., rural China, Vietnam) and play a significant role in the affordability factor of traditional herbal medicine. This is no better expressed than in the teachings of China’s Sun Simiao.

Sun left a legacy of some of the most important and poignant lessons of traditional Chinese medicine as well as medical ethics. In his Bei Ji Qian Jin Yao Fang (Essential Prescriptions for Every Emergency Worth a Thousand in Gold) Sun wrote: “physicians should respond to whoever asks for help, not distinguishing between poor and rich, young and old, ugly and elegant, friend or foe, foreigner or native, wise or fool, but should treat them equally as though they were your own relatives, without discrimination” (Li 1983).

A similar philosophy was espoused in the ancient Ayurvedic literature in which payment for services was to be primarily provided by the wealthy and included formal lists of those who should receive free services (Wujastyk 2012). This teaches that providing health care to those in need is considered in these traditions to be more of a responsibility than a business. This is yet another stark contrast to, most notably, the US health care system, which can be characterized as being more of a business than a responsibility.

In a similar fashion, traditional herbal medicines historically were relatively affordable, or in some cases, free for the picking, in traditional communities with intact herb-rich environments.

At the same time that medicines were on the path of chemical development, medical professions in the US, and somewhat worldwide, were on a similar trajectory. The path taken would eventually lead to restrictions and obstacles to the acceptance of traditional herbal medicines. In the US, prior to the development of the American Medical Association (AMA) in 1847, there were multiple schools of medical thought. These disciplines included the Eclectics, Physiomedicalists, and Thomsonian practitioners, all of whom specialized in the use of botanical medicines; homeopaths; and allopaths, also known as “mineral doctors”.

The allopaths followed the path laid down by Paracelsus, and at the time, used bleeding (scarification) and calomel (mercury chloride) preparations as among their primary therapies. The AMA, a organization founded exclusively by the mineral doctors in their first set of bylaws, adopted specific language that excluded from the professional organization, any “irregular” physicians whose “practice is based on exclusive dogma…”, a clause, which at the time was specifically directed at homeopathic physicians who were at the time successfully competing with AMA physicians (Baker et al. 2009).

At the time, while medical science was evolving quickly, medical education had lagged behind. In the US, the Carnegie Foundation commissioned a lawyer named Abraham Flexner to report on the status of medical education in America.

The result of the report published in 1910 was that schools were given specific ratings of A, B, or C according to facilities, laboratories, teaching resources, personnel, etc. Johns Hopkins, a decidedly allopathic oriented school, was considered the model by which all other schools were judged. Flexner was accompanied by the secretary of the AMA’s Council on Medical Education, a decidedly allopathic representative and bias. Recommendations were put forth as to what the standards of education should be, again following allopathic leanings.

By 1936, more than $90 million in funding was directed to a select group of schools that met the criteria subsequently endorsed by the AMA. According to Pulitzer Prize winning author Paul Starr (1982) in his The Social Transformation of American Medicine: The Rise of a Sovereign Profession and the Making of a Vast Industry, while the educational funding boards claimed neutrality in their pursuit to “improve medical education”, they “sought to impose a model of medical education more wedded to research than to medical practice.”

According to Starr, while the policies that ensued from the Flexner report did not determine which institutions would survive, they did greatly influence which would dominate and what ideals would prevail. This greatly ushered in a change that may be ironically described as decidedly un-Paracelsun, in that research-driven findings, not patient outcomes or physician observation, would dictate medical treatments; the practice of medicine became research-based, not patient-based.

This was occurring at the same time as the chemical revolution was resulting in the rise of the pharmaceutical manufacturing industry whose lobbying power led to the integration of their products into the non-nationalized, largely profit driven medical delivery system of the US today. This is somewhat relevant to countries other than the US as most developed nations are wedded to the same pharmaceutical-oriented, research-driven philosophies, though the manner in which those services are paid for differ between nationalized and market-driven systems, as reflected in the European Union and US, respectively.

Astragalus (Astragalus membranaceus)
Astragalus (Astragalus membranaceus)

Economics in the herbal medicines industry today is similarly driving health care policies resulting in either greater or lesser degrees of access or restrictions to herbal medicines. For example, the range of cost in the United Kingdom for getting a traditional herbal medicine approved is between £30,000 and £120,000 (as of 2014). To have the same UK-approved herbal drug approved in other European Union (EU) countries costs an additional £10,000–£15,000 per country registration.

In the EU, the cost of getting a drug approved in 2014 was approximately 100,000 euros (~$137,000 US). To date, 1015botanical drugs have been approved through the EU model, most of which are single ingredient preparations. As most of the drug registrations are duplicative, these represent only a very small proportion of the traditional materia medica.

Another regulatory model that impedes access and affordability to herbal medicines is the Botanical Drug Model established by the Food and Drug Administration in 2004 in the US, a country that does not recognize traditional herbal medicines as a distinct category, and has a modern drug approval process that results in a cost of approximately $750 million (2008 estimates) and several years to bring a drug to market. If no commercial entity has an interest in a particular herbal ingredient then the cost required to meet the regulatory requirements for drug approval will not be pursued and non-approved herbal drugs will either be completely restricted or at least not supported within the regulatory framework.

Few companies would consider astragalus, hawthorn berry, or the 1000-year-old Ayurvedic compound triphala, candidates for this level of investment for items that have been in the public domain for centuries. More poignantly, in the US, there is no regulatory model for the approval of traditional herbal medicines and the use of herbs as “medicines” is technically illegal despite legal recognition of some traditional healing practitioners (e.g., traditional Chinese and naturopathic medicine), as primary care providers.

Similarly, traditional herbal medicines are not reimbursed under any American insurance program. Thus, with regards to either traditional or conventional medicine, in a non-nationalized health care system, economics, more than medical or health needs, drives medical research, practice and regulation.

Triphala (Terminalia chebula, Terminala belerica & Emblica officinalis)
Triphala (Terminalia chebula, Terminala belerica and Emblica officinalis)

Integration of herbal medicines is greatly limited even in nations with nationalized health care systems where profit perhaps is not as great of a motivating factor as it is in the US. This is perhaps best evidenced by the fact that since the enactment of the EU traditional medicines Directive (2001/83/EC)in 2004, not a single traditional Ayurvedic or Chinese herbal formula has been approved throughout the EU and only a single Chinese herb, Dioscorea nipponica,has been approved in Holland.

This is highly significant to the practice of traditional herbal medicine as, in the EU, the presence of non-registered herbal medicines on the market is technically illegal despite the fact that they have been in the public domain for literally hundreds or thousands of years.

Similarly, in the US, only two botanical drugs have been approved through the botanical drug approval process since the regulations were promulgated; Veregen, a patented ointment prepared from green tea (Camellia sinensis) used for the treatment of genital warts; and dragon’s blood (derived from Croton lechleri) as an anti-diarrheal drug for HIV/AIDS patients. These two latter botanical drugs represent novel innovations not traditional uses.

The cost associated with their approval has not been reported. Interestingly, there are no other approved pharmacological agents for these specific indications. It is highly unlikely that approval of a botanical substance through the botanical drug approval process for an indication, for which an already approved pharmaceutical exists, will ever be granted.

Another factor in these discussions that is of particular interest to the US market is the fact that most nations, with the exception of the US, have a long history of socialized health care. Today, reimbursement or coverage of herbal medicines is an integral part of the health care delivery system of many developed countries (e.g., China, France, Germany, Japan, Netherlands, Republic of Korea) to greater or lesser degrees (see Zhang 1998; Zhang 2001) and is key to keeping herbal medicines affordable. Yet, in most Western countries, the herbs and formulas that make up the bulk of the traditional materia medica are not recognized, approved, and in some cases, as in the US, not allowed as medicines.

Today’s quest for modern medicines and the desire to fit traditional herbal medicines into a modern pharmaceutical drug regulatory model is more about the creation of a new highly profitable blockbuster drug than relief of suffering of humankind, a model that affects health care policies worldwide.

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Historical perspectives on traditional herbal medicine https://www.herbalreality.com/herbalism/western-herbal-medicine/historical-perspectives-traditional-herbal-medicine/ https://www.herbalreality.com/herbalism/western-herbal-medicine/historical-perspectives-traditional-herbal-medicine/#comments Fri, 29 Oct 2021 15:21:52 +0000 https://www.herbalreality.com/?p=4088 Roy Upton explores the historical perspectives on traditional herbal medicine.

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Roy Upton explores the historical perspectives on the dynamic relationship between humans, plants, traditional herbal medicine and the environment overall.

Historical Perspectives On Traditional Herbal Medicine

“Esam bhutanam prthivi rasha, prthivya apo raso-pam osadhayo rasa, osadhinam puruso rasah“
[The essence of all beings is Earth. The essence of the Earth is Water. The essence of Water is Plants. The Essence of Plants is the Human Being….] – Chandogya Upanishad, sixth century CE Vedic text

Thus, are the philosophical underpinnings of human existence recorded in the Chandogya Upanishad, a Vedic text dating to the Brahmana period sometime before the sixth century CE that clearly articulates the dynamic relationship that exists between humans, plants, and the environment overall.

Similarly, the philosophy of Vis Medicatrix Naturae (the healing power of nature), as set down by Hippocrates summarizes the basic principles of healing; namely that the body as a living biological organism is always trying to achieve a state of health and balance and that an observed malady is the body’s attempt to reestablish equilibrium (Grube 1954; Hiroshi 1998). This connection between human health and nature is a philosophical underpinning of many traditional healing systems worldwide (Payyappallimana 2010), but is a perspective most often overshadowed or completely lost in attempts to push herbal medicine into a level of acceptance in modernity.

Ancient healers recognized the human organism was made of the same substances that existed in nature and thus is an extension of nature. Therefore, so it was reasoned, that healing was facilitated through nature and substances of nature; namely fresh air, pure water, sunshine, good nutrition, exercise, and herbal medicines, and, including in shamanistic or religious healing practices, invocation of ancestors, saints, spirits, and deities.

Chinese herbal medicine

The practice of herbal medicine, historically followed two paths. The first of these was rooted in relative simplicity; an herbalist gathering plant medicines and attending to the needs of the sick in a system that can be defined as community-based health care. These were, and in many countries today, are, the folk healers, grandmothers and grandfathers learned in the use of medicinal plants.

The second path was that of professional practitioners. In ancient times, some of these were among the most learned of their generation and are well represented from the 1st to 15th centuries CE in works such as De Materia Medica of Dioscorides and the Hippocratic Corpus of Hippocrates, both of Greece, the Charka Samhita of India, and the Shennong Bencao of China, followed a few centuries later by the Canon of Medicine byIbn Sīnā (Avicenna) of Persia and several centuries later by the Renaissance herbal writers such as Fuchs, Gerard, Mattiolis, Parkinsons, and Salmon, and the later Chinese authority Li Shizhen’s Bencao Gangmu, to name only a few.

The use of herbs within these formal medical traditions was integrated with very sophisticated theories of anatomy, physiology, and pathology. Conversely, folk healing traditions predominantly represented an empirical use of herbs passed down through families, community knowledge, and fragments of the more formalized medical practice. While the humoral system of Hippocrates, Galen, and to a great degree, Avicenna, was the ancestor of today’s medical theories, today’s conventional Western medical practitioners have no relationship to these past theories, with a belief of the scientific superiority of current theories.

In contrast, the medical theories of Ayurvedic and Chinese herbal medicine remain intact, continue to evolve, and continue to be practiced according to their same historical foundational principles, and often with correlative understandings informed by western science. Inherent in both Ayurveda and traditional Chinese healing systems is the belief that humans are an extension of nature and therefore, the theoretical principles developed were inherently designed to mimic nature and facilitate healing by adhering to vitalistic principles reflected in nature.

These principles include the tri-doshic and five element (wu xing) systems of Ayurvedic and TCM, respectively, both of which relate human anatomy, physiology, pathology and dietary and herbal therapies to, in Ayurveda, vata (air), pitta (fire), and kapha (water) (which themselves consist of earth, water, fire, wind, and ether); and in TCM huo (fire), tu (earth), jin (metal), shui (water), and mu (wood).

In contrast, current western medical traditions possess no principles that inherently link human health with the living biological principles of nature, and only tangentially as an after thought, attempt to link health to behavior or lifestyle. Traditional healing systems inherently seek to bring human beings into a healthful balance with self in relation to their environment. In contrast, the focal point of Western medicine is symptom suppression, inhibiting the very healing response meant to restore homeostasis to the organism.

Louis Pasteur
Louis Pasteur

Traditional healing systems are commonly regarded as vitalistic or holistic, while Western medical philosophy is often described as mechanistic, reductionist, or rationalistic (Coulter 1975). This latter rationalistic perspective is based on the perception that development of modern medical theory and drug development was founded on rational scientific principles, implying that traditional herbal medicine knowledge lacked a rational basis, a premise countered by noted medical historian John Riddle (Riddle 1997).

The belief in traditional healing systems that human health is an extension of environmental health and that it is the relationship between the two upon which health is dependent, is in stark contrast to the philosophical basis of modern anatomy and physiology. Harvey’s (1578–1657) articulation of the circulatory system in the 17th century provided fertile soil for new mechanistic theories that challenged old humoral theory.

However, the concept of circulation was described in the foundational text of TCM, the Neijing and by Galen centuries before. Noted French physiologist Claude Bernard (1813–1878) posited that the human environment (milieu intérieur) was separate from the external environment.

Others, such as the noted German physician Rudolf Virchow (1821–1902) stated the cell was the basic unit of the body that had to be studied in order to understand disease. Bloodletting and purging with Paracelsun-type mercury compounds, the primary medical therapies of the 18th and 19th centuries employed by allopaths, were being used with little documentation of their clinical effects (Riise 1997).

While traditional health practitioners gave focus to the macrocosm of all that makes up an individual’s life and health status (constitution, diet, lifestyle, environment, physical activity, stress, sleep) (Risse 1997), modern medical research gave focus to the microcosm of cellular biology. The visualization of microbes with the advent of the microscope by Holland’s Anton Van Leeuwenhoek (1632–1723), Pasteur’s (1822–1895) confirmation of the potential pathogenicity of germs, and Fleming’s (born 1881) discovery of antibiotics, further concretized the material cause and cure of disease, which in turn solidified the reductionist, militaristic, search and destroy approach typical of western medicine today and completely ignored the intimate relationship between human and environmental health.

Rudolf Virchow
Rudolf Virchow

In both Ayurveda and TCM, as well as naturopathic medicine, patient therapies are very much individualized and have remained physician- and patient-centered, the practitioner predominantly making their assessment through observational means reflected in the eight methods of diagnosis of Ayurveda (astavidha pariksa) and four examinations (si zhen) of TCM.

Similarly, the traditional health practitioner takes into consideration the cause of disease, which for chronic illnesses, is almost always due to unhealthy lifestyle practices, and then work to correct the underlying causative factors while providing therapeutic options to address both cause and symptoms, codified in TCM as biao and ben or treating the “root and branch”.

This is in stark contrast to research-based Western medical practices, which develop “standards of care” for diseases, in contrast to individualized healing protocols for patients.

Rather, western diagnostics is not guided by any understanding of the individual’s lifestyle that initially led to the disease state, but rather relies on mechanized diagnostic tests of specific biomarkers that reflect the end result of the disease process not the cause. This results in an almost exclusive focus on the symptom and an almost complete neglect of the cause. This perhaps represents the primary differentiation between traditional and conventional healing philosophies.

Dioscorides
Dioscorides

Prior to the 15th century, the majority of medicinal agents were plant-based. While numerous medicinal agents of mineral and animal origin were also used, the overwhelming majority of medicines, as reflected in the De Materia Medica of Dioscorides, were plants (Gunther 1934; Riddle 1985).

In the 15th century, the Swiss-German physician Philippus Aureolus Theophrastus Bombastus von Hohenheim, otherwise known as Paracelsus (1493–1541), pioneered the use of concentrated and relatively pure (for the time) chemicals in medicine. Perhaps more importantly, Paracelsus challenged, what at the time, was a relatively strict adherence to the medical philosophies of ancient texts, including those of Galen, Avicenna, and others, books of whom he actually burned at the University of Basel, Switzerland on St. John’s Day in 1527. The earlier teachings of Galen posited there were four physiological humors (blood, phlegm, yellow bile, and black bile) originally taught by the Greek philosopher Pythagoras (570 BCE-495 BCE) and that when in balance, there was health.

The humoral theory persisted as a prominent medical theory until the middle 1800s (Estes 1997). Paracelsus argued there were three humors; salt representing stability, sulfur representing combustibility, and mercury representing fluidity. While both theories are considered by today’s theories as archaic and inherently limited, this shift marked a significant divergence in medical thought that has great impact today. In contrast to the foundational principles of Galenic thought that were physiologically based, Paracelsus shifted medical thought by giving focus to the actions of drugs, in other words, a pharmacological basis of understanding medicine, which predominates today.

Another seminal change credited to Paracelsus was that, while Galenists believed that a disease of a certain character or nature would be cured by a remedy possessing the opposite effect, a precept similarly espoused by the famed Chinese Tang Dynasty physician and alchemist Sun Simiao (581–682 CE), Paracelsus and his followers argued that “a poison in the body would be cured by a similar poison”. While contemporaries of Paracelsus felt the substances he was recommending were too toxic to be used safely, Paracelsus defended his position with his oft quoted:

“Alle Ding sind Gift, und nichts ohne Gift; allein die Dosis macht, daß ein Ding kein Gift ist.”
(“All things are poison, and nothing is without poison; only the dose permits something not to be poisonous.”)

His challenging of the medical authority of the day resulted in the banishment of  Paracelsus from Basel and the revolutionary physician died at the young age of 48 (Borzelleca 2000). Never-the-less, the teachings and writings of Paracelsus took on many adherents and charted a path in medicine that was alternative to the current medical thinking of the day and can be characterized as the progenitor of the modern, chemically refined, and highly toxic pharmaceutical medicines of today.

Serturner

Other seminal events in medical history charted the course that led to today’s medicine. In 1805, a German apothecary apprentice named Friedrich Wilhelm Adam Sertürner isolated what was to become the first pure, presumably “active” compound of a plant—the alkaloid morphine from the opium poppy (Papaver somniferum) (Kapoor 1997).

With the isolation, of morphine, an alkaloid making up approximately 10% of the total alkaloids of the plant (Kapoor 1995), medical researchers suggested that the whole plant need not be used as a medicinal preparation but rather that one could extract an active constituent. Sertürner referred to his new compound as principium somniferum or “sleep making principle”, later naming it morphium, after Morpheus the Greek God of dreams or sleep (Booth 1996).

Subsequent decades witnessed the isolation and eventual synthesization of pure compounds and the race for “active” constituents began changing medicine from whole plant-based to individual chemical-based entities.

Whereas Serturner posited that the whole plant was no longer needed, the emergence of synthetic chemistry posited that the plant was not needed at all changing the nature of drug development that has persisted to the present day.

Traditional herbalists wonder what effects the other 90% of compounds in poppy contribute to either the safety or efficacy of the drug, while traditional herbalists and WHO continue to regard the whole plant as representing the activity of a traditional medicine.

During the same time period, the medical and pharmacy professions were undergoing rapid changes. Originally, it was physicians, often referred to as “medical botanists”, who were the primary teachers of materia medica and founders of early pharmacopoeias.

As the pharmacy profession evolved, pharmacists began assuming an oversight role on the quality control of medicines. Later, pharmacognosy evolved as a sub-discipline of pharmacy, initially with an emphasis in the quality of crude drug materials. In modern times, this focus changed to searching for compounds in plants that were candidates for modern drugs.

Subsequently, physicians became the sole prescribers of medicines, pharmacists became the primary and formal dispensers of medicines, and pharmacists and pharmacognosists assumed the primary role of drug development and quality control, as represented in the development of early pharmacopoeias.

The switch from botanical- to chemical-based medicine is clearly evidenced in the evolution of the United States Pharmacopeia (USP), which in the first edition of 1820 included approximately 150 herbal drugs, or 50% of the total approximately 300 listed drugs at the time (USP 1820). By 1950, herbal drug monographs in the USP numbered approximately 50 of the more than 1100 preparation entries (a little more than 4%) (Boyle 1991; USP 1950). This lack of representation of herbal drugs is in sharp contrast to the almost exclusive inclusion of herbal medicines that comprised the Pharmacopoeia Augustana of 1564 (Husemann 1927).

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Traditional herbal medicine, pharmacognosy, and pharmacopoeial standards: A discussion at the crossroads https://www.herbalreality.com/herbalism/western-herbal-medicine/traditional-herbal-medicine-pharmacognosy-pharmacopoeial-standards-discussion-crossroads/ https://www.herbalreality.com/herbalism/western-herbal-medicine/traditional-herbal-medicine-pharmacognosy-pharmacopoeial-standards-discussion-crossroads/#comments Fri, 29 Oct 2021 15:21:51 +0000 https://www.herbalreality.com/?p=4073 Herbal medicine remains the mainstay of medicine for most underdeveloped and developing nations.

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Despite the development of modern medicines, traditional herbal medicine remains the mainstay of medicine for most underdeveloped and developing nations.

Traditional herbal medicine, pharmacognosy, and pharmacopoeial standards A discussion at the crossroads

For multiple millennia, humans have relied on plant-based materials for all aspects of human existence including for food, fuel, our homes and clothing, and not the least, our medicines. Through hundreds of thousands of years of co-evolution, plants have developed protective mechanisms, secondary metabolites, to curtail predation and ensure the plant’s continued survival.

In like fashion, humans have developed biological pathways and processes that allow us to consume numerous plants to our benefit.

Despite the technological advancements that gave rise to the development of modern medicines in the past few hundred years, herbal medicine remains the mainstay of medicine for most underdeveloped and developing nations. Similarly, recognition of the health potential both of botanical medicines and traditional healing systems, along with the many failures of conventional medicines and the paradigm by which they are used, has resulted in increased use of medicinal plants in most developed nations.

The rapid and increasing rise in the worldwide use of herbal medicines in recent decades suggests botanical medicines, both traditional and modern, fulfill a therapeutic niche not adequately addressed in modern health care delivery systems. Since the introduction of COVID, botanical medicines specifically have exponentially grown in popularity in great part fueled by recognition of the importance of immune health and the complete lack of Western medical therapies to address this beyond vaccinations.

At the same time, there is a propensity, predominantly in developed, but also developing nations, to research herbal medicines in the same manner as modern chemically characterized drugs. This trend is driven partly by a belief that the same regulatory requirements that are applied to modern pharmaceuticals should be applied to herbal medicines and partly by economics.

The economics of the conventional and even medicinal plant market aside, central to the needs of a patient is to have a botanical medicine that is first safe and secondarily effective for its intended use. In turn, the safety and efficacy of a botanical medicine requires adherence to good agricultural and manufacturing practices that encompass proper harvesting or cultivation, processing, identity, purity, quality, and potency.

Early herbalists devoted a great amount of time in the quality assessment of herbal drugs with specific emphasis placed on appropriate growing regions, harvest times, processing conditions, and the detection of inferior quality or adulterated materials. This was prior to the advent of chemistry and molecular techniques.

Herbal quality assessment was based on what an herbalist could discern through her or his senses; predominantly as reflected in the growing habit, color, aroma, feel, and taste of the plant. Most every consumer can recognize an apple from an orange as well as discern its relative quality. Every chef knows the not-so-subtle difference between fresh and dry ginger.

As chemical techniques developed, focus on the plant itself greatly diminished and the skills at discerning quality all but disappeared in Western herbal traditions and science, though has remained in more intact systems of Ayurveda and traditional Chinese medicine. Emphasis on quality shifted from the field to the laboratory; from human senses to mechanical methods of analysis; from the plant to isolated plant compounds.

Similarly, in the same time period, the use of herbal medicines was rapidly declining as use of chemical medicines was on the rise. In developed nations, the responsibility of herb quality passed from herbalists to medical doctors who became among the first teachers of materia medica, and then to pharmacognosists—pharmacists specialising in the development of drugs from natural products. Subsequently, this pharmacognostic knowledge was codified into national pharmacopoeias, which became the quality standard for drugs within national health care approval systems. Thus, modern drug approval systems, and subsequently, modern pharmacopoeias, were modeled for the needs of modern drugs not traditional herbal medicines or traditional healing systems.

In parallel, the economics of medicine changed with greater focus on research, specialization, technology, high cost drug approval processes, and a medical system more driven by research findings and profits than practitioner or patient need. This greatly influenced the way in which the practice of medicine and approval of medicinal agents evolved, including creating significant positive bias in pharmaceutical research and substantial negative bias against traditional medical practices overall and specifically herbal medicines.

Ginger (Zingiber officinale)
Ginger (Zingiber officinale)

Because of the importance traditional medical systems, as well as herbal medicines, play in world health the World Health Organization (WHO) reports that among the most salient benefits of both, are accessibility and affordability (WHO 1978; 2013). Applying the same regulatory models to traditional medicines as is applied to modern drugs negates these two advantages. WHO, however, does not explicitly recognize other very unique benefits of traditional medicines.

Specifically in the United States (US), arguably among the most technologically advanced of countries, 58% of consumers who use traditional healing modalities, do so not for the treatment of disease, but rather to “prevent future illness from occurring or to maintain health and vitality” (Eisenberg et al. 1998). Similar findings were reported in a later survey of dietary supplement users in the US in which “preservation of health was by far the most predictive indicator for use of herbal products and dietary supplements” (Marinac et al. 2007) and in a similar survey in Australia (MacLennan et al. 2002). There is not a single western drug in the world designed to “maintain health and vitality” or “preserve health”.

Another unique characteristic of traditional healing systems, especially, Ayurveda, traditional Chinese medicine (TCM), Unani, Tibetan, etc., is the utilization of a completely different diagnostic system than is applied in the West. Traditional systems are meant to be applied to the individual needs of the patient. This allows for an understanding of health and pathology and subsequently the development of unique therapeutic strategies, thus broadening patient options.

Additionally, amongst these healing traditions is an inherent belief of the relationship between human and environmental health, a belief completely integrated into the diagnostic construct of most herbal traditions, and completely ignored in modern medicine.

These traditional healing strategies are in stark contrast to the prevalence of Western conventional medical strategies, which are predominantly focused on disease management more than the promotion or restoration of health. The specificity inherent in western medical therapies gives those therapies a targeted focus, often to the neglect of the general health status of the individual.

Generally speaking, in western conventional medicine, if tissue or organ structures are not functioning properly the treatment is to basically attack them leading to the removal of tonsils (a first line of defense against infectious disease), gallbladders (integral to digestive and eliminative processes), cataracts; transplants of hearts, livers, and kidneys; radiation or poison (in cancers); or interfering with normal processes, such as pharmacological agents designed to either up regulate, down regulate, or otherwise completely obviate normal physiological processes.

A good example of this is the widespread use of anti-inflammatories, inflammation actually reflecting a biological response of the body to an inflammatory mediator.

Rather than seeking to identify and remove the inflammatory trigger, the conventional western medical strategy is to shut down, what ultimately is a healing response. From a natural health care perspective, such a strategy is the antithesis of what is needed to support human health. This does not mean there is no value in such a strategy.

Militaristic search and destroy therapies such as these are uniquely suited for crisis intervention and emergency medicine. Severed limbs, acute poisonings, intractable severe pain, ruptured organs, etc. respond well to a militaristic approach; in contrast, pregnancy does not, a fact reflected in the appalling high rate of infant mortality in the US, whose system of medicine is almost completely militaristic.

To have a medical system entirely based on militaristic therapies is inherently limited; a fact equally evidenced by the high rates of iatrogenesis, deaths due to pharmaceuticals, and chronic illness associated with modern health care systems. Perhaps of greatest consequence is that western medical strategies focus on the treatment of diseases not the treatment of people.

Thus, conventional and traditional healing practices represent two very different paradigms of medicine. Traditional healing practices offer a different paradigm and different therapeutic solutions than conventional medical care. This is precisely why traditional healing systems, and herbal medicines are growing in popularity. If the two systems can be harmonized there is a greater potential for healing than either system can deliver on its own.

However, regulating chamomile tea, valerian root, and hawthorn berry syrup, with their hundreds of compounds, in the same way as Prilosec, Ambien, and artificial hearts, disregards the fact that each botanical medicine has several hundred years of historical use, has been in the public domain for those several hundred years, and threatens to undermine the potential herbal medicines possess.

In contrast, a rigorous safety and efficacy evaluation is necessary for the chemicals used in modern drug development, as most have never been in human use. Whereas with botanicals that have been used for centuries, there is a reasonable basis based on human experience and, in many cases, formal scientific evaluation to assure there is a reasonable basis both for safety and efficacy, whereas in modern drug development, no basis at all for safety or efficacy exists, thus necessitating detailed scientific exploration of compounds that have never before existed prior to their being administered to humans; think broccoli and carrots for which no formal toxicology data exists.

Throughout much of the world herbal medicine is in transition from the collection and processing of crude herbal materials of varying strengths and potencies, such as are used as powders, teas, simple syrups, and extracts by local healers and communities to well characterized preparations made according to pharmacopoeial standards predominantly supplied through a highly regulated market.

The former more crude preparations are characteristic of undeveloped and developing nations, while the latter are typical of developed nations. Each country is at a different point in its evolution regarding herbal medicine. A new paradigm that takes into consideration the unique characters of herbal medicines is needed with a focus on the quality and sourcing of raw material based on the myriad of constituents found in single herbs and formulas.

Ironically, and perhaps most saliently, practitioners of traditional healing systems are seldom part of traditional health care policy decisions. Rather, commercial interests by traditional medicine producers often drive national and international health care policies, frequently leading to a restriction in materia medica and impeded access to herbal drugs. Thus, it is questionable whether traditional herbal medicine will thrive, and in many cases, survive within national health care systems.

If policy makers, regulatory bodies, medicinal plant researchers, and pharmacopoeias can once again place emphasis on the quality of the plant material itself rather than viewing herbal drugs as cocktails of chemicals to be pulled apart, isolated, and manipulated, there is a chance.

Similarly, medicinal plant research should reorient itself to investigate the traditional use of herbal medicines within the traditional healing system from whence they came, investigating the physiological and pharmacological subtleties that give the medicine its unique healing quality, rather than simply looking at the application of herbal drugs for Western disease patterns.

Truly honoring traditional healing systems and herbal medicines and maximizing their healing potential is an international challenge that minimally should be discussed as part of national and international health care policy if humankind is to continue to reap the benefits of medicinal plants based on the systems in which they were traditionally used.

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Kratom leaf: An alternative to opioids for chronic pain management? https://www.herbalreality.com/herbalism/western-herbal-medicine/kratom-lead-alternative-opioids-chronic-pain-management/ https://www.herbalreality.com/herbalism/western-herbal-medicine/kratom-lead-alternative-opioids-chronic-pain-management/#comments Fri, 29 Oct 2021 15:21:47 +0000 https://www.herbalreality.com/?p=4008 With the exploration of alternative routes for managing chronic pain, we take a look at the therapeutic use of Kratom as a substitute to opiates.

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With the exploration of alternative routes for managing chronic pain, we take a look at the therapeutic use of Kratom as a substitute to opiates.

As chronic pain and addiction to painkillers are becoming an ever-growing issue, the exploration of potential alternative routes for managing chronic pain symptoms could be considered a necessity. The therapeutic use of kratom (Mitragyna speciosa) for the management of chronic pain as a substitute to opiates with reference to its pharmacodynamics, pharmacokinetics, dosage and safety will be presented in the following article.

Kratom leaf: An alternative to opioids for chronic pain management?
Kratom (Mitragyna speciosa)

Pain is a normal neurological response to a real or impending injury aimed at triggering an appropriate conservational response. Chronic pain is defined as a pain that is perceived beyond the accepted time involved in tissue healing (approximately 3 months) (1).

Interestingly, when pain receptors (called nociceptors) which respond to chemical, thermal or mechanical changes get stimulated over a large period of time, the brain neurons responsible for pain processing become over-sensitive, reducing the overall pain threshold of the individual. This process is called central sensitisation and plays a crucial part in the development of chronic pain conditions (2).

Moreover, medical literature provides evidence of the complex multidimensionality of chronic pain conditions, meaning that the psychological, emotional, social and behavioural aspects of an individual’s life play a role in the dynamics related to pain perception (3).

Chronic inflammation and chronic pain go hand in hand: a prolonged and abnormal inflammatory response mediated by the immune system can lead over time to an increased sensitisation of pain receptors (31). Nutritional deficiencies, excess consumption of pro-inflammatory foods, sedentary lifestyle, exposure to pollutants, gut flora imbalance and inappropriate exercise can all contribute to the process of inflammation and hence chronic pain (32, 33, 34, 35).

Additionally, when the survival mechanism of the body is abnormally activated, stress hormones such as adrenaline, noradrenaline and cortisol change the homeostasis of the tissues, leading to detrimental consequences, such as a decrease in pain tolerance and increase in tissue degeneration. Moreover, the cognitive part of the brain under the influence of stress hormones is less capable to detach the focus from the pain stimulus, meaning that the more stressed the individual is, the more physical pain becomes a burden in his/her life (30).

Kratom (Mitragyna speciosa)
Kratom (Mitragyna speciosa)

In terms of epidemiological data, The Global Burden of Disease Study 2016 stated that chronic pain-related diseases are the leading cause of disability and disease burden globally (4). In the UK only, a survey from 2017 reported that 34% of adults in the UK are affected by some forms of chronic pain (5).

As chronic pain is a condition that has psychological, emotional and social aspects, disciplines specialised in addressing the different dimensions of pain perception management have become popular; therapies such as hypnosis, acupuncture, CBT and massage therapy (36). Despite the existence of these alternative ways to deal with pain, pharmaceuticals are still extremely popular and among them one of the most prescribed classes of drugs are opiates.

Opiates are a double edge sword: although they are effective at reducing the symptoms, the risk of developing a physiological addiction is dangerously high (7). In the USA the prescription opiates abuse is at such a critical level to be considered an epidemic: deaths related to prescription opiates in 2010 was double of 2002 while 70% of drug related deaths in 2019 was linked to opiates (roughly 50.000 individuals) (8,9). In the UK the situation is not as dramatic as overseas, but prescription (and illegal) opioid related deaths are on the rise (10).

The lack of a side effect-free solution for managing chronic pain is putting many individuals on their knees; nevertheless, an ever-growing number of people who persisted in the quest for an effective alternative treatment for their condition are finding a possible solution in a herbal medicine native to Southeast Asia.

Kratom (Mytragina speciosa) is a widely cultivated tropical tree belonging to the Rubiaceae botanical family and indigenous to Southeast Asia. kratom has been used for centuries by the indigenous people of Southeast Asia both as a stimulant and a sedative. There are three main varieties of kratom whose names are given by the colour of the veins: green, white and red. Green strain kratom is said to be more potent of the other two, but the evidence is only anecdotal (39).

Its leaves, which are usually chewed or consumed as tea or powder, contain psychoactive indole alkaloids which have shown to have a strong affinity with the opioid receptors in the central nervous system (11).  These psychoactive compounds are mitragynine (the most abundant), 7-OH-mitragynine (the most bioactive), speciociliatine and corynantheidine.

Most of the research has been conducted on mitragynine and 7-OH-Mitragynine, which appear to bind agonistically mainly to µ-, κ- and δ- opiate receptors, causing analgesia and euphoria. Interestingly, these molecules are structurally different from common opiates such as morphine and they have been called ‘atypical opiates’.

This denomination has been given to them because they act as opiate receptor agonists without triggering the potentially harmful side effect common to opiate drugs use such as respiratory depression, sedation and constipation; this process is thought to happen because kratom indole alkaloids do not activate β-arrestin, a protein linked to cascade activation of opiates side effects (13). Because of this unique selective property, kratom could have a therapeutic potential as an opiate drug substitute in the mitigation of withdrawal syndrome (14).

The first document on kratom as an opioid alternative was published in 1988 and it concludes by stating that kratom might be a successful substitute for methadone as a rehab strategy (15).

Following this study, experiments on mice confirmed that kratom alkaloids cause significantly lower addictive behaviors compared to morphine-addicted control groups (16), while individuals using kratom alongside other narcotics reported higher quality social life and improved management of withdrawal syndrome.

In addition, kratom users alongside opiates report longer abstinence periods (up to one year) and have remarkably less chances to develop an opiate addiction (17,18,19).

In one online survey from 2017 involving 2798 American kratom users, 91% of them selected ‘pain management’ as a reason for using the herb, while another survey from the same year conducted by the American Kratom Association on 2867 individuals showed that 48% of participants used kratom to relieve pain and 10% used it as an opioid drug substitute (20, 21). Although specific studies on kratom and chronic pain management are still limited, there is significant evidence showing it to be a safer remedy compared to synthetic opioids when used long-term.

Kratom (Mitragyna speciosa)
Kratom (Mitragyna speciosa)

Kratom leaves can be consumed in different ways: hot infusions, chewed (the traditional way in Southeast Asia) and smoked. Most people take it in forms of pills, capsules, extract or as a powder mixed with a beverage (37, 40). A unique characteristic of kratom is to be both a stimulant and sedative depending on the dosage.

A few grams of dried leaves, cause an excitatory response in the central nervous system, while larger doses (5+ g) give the opiate-like euphoria and sedation (12).  In terms of safety, the available literature is controversial; although its use poses a risk of overdosing a thousand times smaller than opiates (25, 26), kratom use has been associated with liver toxicity and withdrawal syndrome.

In a detailed report from 2020 on liver toxicity associated with kratom consumption the FDA flagged 25 individual cases related to the toxic effects of kratom on the hepatic system. 37% of the individuals concerned have taken 5g to 20g daily of kratom in a powdered form for an average of 21 days before starting to notice signs and symptoms of malaise, jaundice and dark urine.

Nevertheless, there is no information regarding the existence of pre-existing medical condition of the consumers, nor specific hepatotoxic mechanism have been identified in human and animal studies. It is postulated that some compounds other than mitragynine could be cytotoxic to hepatocytes although there is no clear evidence (38). 

On the other hand, other sources state that no cases of death have been confirmed to be caused by kratom alone and most of the fatalities associated with its intake also involved the clear overconsumption of other drugs. There are high chances then that the fatality cases signaled by the FDA and other organisations might be biased by inadequate postmortem toxicology data and testing protocols (25).

The symptomatic side effects of taking kratom are somewhat similar to the opiate ones; these include nausea, vomiting withdrawal symptoms such as hostility, aggression, aching of muscles and bones and insomnia with potential increase of tolerance to the herb (27, 28).

Nevertheless, these symptoms are exceptionally milder compared to opiates, presenting with less intensity, the onset within about 12 to 16 hours and a duration of 1 to 3 days (26). In addition, a survey conducted on 2798 kratom users showed that less than 10% of participants developed the aforementioned withdrawal symptoms after one or more years of use (18).

Kratom (Mitragyna speciosa)
Kratom (Mitragyna speciosa)

Due to lack of research, there is no accepted standard safe dosage of kratom powder or extract but it is widely accepted that long-term use of kratom leaves for treating chronic pain and opiates withdrawal is not recommended due to its potential for addiction and hepatotoxicity (26).

Nevertheless, short-term use of kratom leaf powder appears to be relatively safe; a survey involving more than 8000 individuals revealed that withdrawal symptoms are dose/frequency dependent and a dosage of 5g three times a day elicited the desired analgesic effects in most of the participants while causing severe side effects only in 0.65% of the population (40).

Kratom quality is also another important factor to consider; due to the restricted regulations about the marketing of kratom products, most of the available kratom on the UK market is likely to come from the dark web or other illicit channels of trade. These unregulated products are a potential threat as they are likely to not have been subjected to quality tests, might not give the desired effects or could even be harmful (41).

To safely consume kratom then only use it under the guidance of a qualified practitioner in countries where it is legal and subjected to quality controls; to start with a low dosage (no more than 15g a day) and to quit immediately if side effects start to appear.

The legal status of kratom varies from country to country. In Europe, for instance, it is legal in Belgium, Netherlands and Germany but illegal in Italy and Switzerland, while controlled In Denmark and Portugal. Even in the US different states have contradictory laws about kratom. In the UK, the 2016 Psychoactive Substance Act put a ban on all substances and herbs known to have psychotropic effects unless regulated. This turned kratom into an illegal substance and made it unavailable on the market (29).

Kratom (Mitragyna speciosa)
Kratom (Mitragyna speciosa)

This article evaluated the potential of Mitragyna speciosa, kratom leaves, as a substitute for opioid and opiate drugs in the management of chronic pain. Chronic pain is a condition which burdens both the individual and the medical system in most countries worldwide; commonly prescribed drugs for managing chronic pain are opioids and opiates, which effectively modulate the symptoms but cause undesirable side effects, cause addiction and increase the risk of death by overdose when used long-term

Mitragynine and 7-OH-Mitragynine, the predominant indole alkaloids in kratom leaves, act as opiate receptors agonist causing opiate-like euphoria, analgesia and sedation without depressing the respiratory system and posing a far lower risk of developing serious addiction and withdrawal symptoms.

Despite its potential therapeutic benefits, various studies report side effects from kratom use such as hepatotoxicity and withdrawal symptoms. In conclusion, even though kratom appears to be an effective but less harmful remedy to manage chronic pain when compared to opiate drugs, its prolonged use could also have a negative impact on human health. In order to allow kratom to be legally prescribed, further pharmacological investigations on its safety and toxicity are required.

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First do no harm: A call for sustainable herbalism in clinical practice https://www.herbalreality.com/herbalism/western-herbal-medicine/sustainable-herbalism-clinical-practice/ https://www.herbalreality.com/herbalism/western-herbal-medicine/sustainable-herbalism-clinical-practice/#comments Fri, 29 Oct 2021 15:21:46 +0000 https://www.herbalreality.com/?p=3987 Josef Brinckmann explores what it takes to make a herbal medicine practice part of the sustainable herbal supply chain.

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Josef Brinckmann explores sustainable herbalism, including what it takes to make a herbal medicine practice part of the sustainable herbal supply chain.

First do no harm: A call for sustainable herbalism in clinical practice

First, do no harm… neither to the patients nor to the natural habitats of medicinal plants

As a medicinal plant researcher, I (really) enjoy digging around in the intersections of traditional medical knowledge, biogeography, ethnoecology, conservation biology, history of trade, and archaeobotany. Over thirty years ago, when working in San Francisco at the community clinic of the American College of Traditional Chinese Medicine (ACTCM), I wondered about the geographic origins, the ecosystems, the lives of the people, where the several hundreds of dried medicinal plants in our pharmacy came from.

The herbs were simply procured from importer/traders in Chinatown. No traceability to a specific production site back then. Those importer/traders had procured the herbs from their counterpart exporter/traders, far across the ocean in China, the world’s most populous country and third largest country in terms of area. End of story…

…until around the start of the 21st century… by the early 2000’s, botanical supply chain visibility (transparency and traceability) into verifiably sustainable production sites around the world, gradually became more-and-more possible with the emergence of credible international voluntary sustainability standards (VSS) (1), some that were designed specifically for medicinal plants, coupled with the emergence of good agricultural and collection practice (GACP) standards for medicinal plants (2). Nearly impenetrable since colonial times, the veil of botanical supply chain secrecy was slowly being lifted.

About ten years ago, after having worked on a medicinal plant sustainable production initiative in China (3), I brought a Chinese delegation to ACTCM, including representatives from the World Wide Fund for Nature (WWF China), the State Forestry Administration of China, and Chengdu University of TCM, to discuss a proposed new curriculum that aimed to educate TCM students and practitioners on the conservation status and sustainability of medicinal plants used in clinical practice, and other innovations to modernize formulations in order to substitute the use of animal ingredients with sustainably harvested plants (4).

By the 2010’s, significantly increasing quantities of medicinal plants in global trade were becoming traceable to specific harvest sites, to the commercial enterprises managing the harvest, and the people who handle and process the herbs throughout the value chain.

This new reality was one of the positive outcomes of a consumer-driven market trend that had been growing slowly but steadily since the 1990’s, driving increased demand for herbs that are harvested, handled, processed, and traded sustainably, as determined by audits of independent third-party inspection and certification organizations (5).

In the 2020’s, while not common enough (yet!), it is also not rare for herbal medicinal raw material batches to be traded between companies with documentary evidence of sustainable production (albeit for discerning customers willing to pay the fair price), i.e., with certification(s) showing compliance with one or more VSS, such as the

  • Organic Wild-crop Harvesting Practice Standard (6)
  • FairWild® Standard (7)
  • Ethical BioTrade Standard (8)
  • Fair For Life Standard (9)
  • Fairtrade International Standard For Herbs, Herbal Teas & Spices (9,10)
  • Fair Trade USA Agricultural Practice Standard (11)

as well as wildlife-friendly standards such as the

  • Certified Elephant Friendly™ Standards (12)
  • Giant Panda Friendly Products Standard (13)

While VSS certification logos are increasingly visible on consumer herbal healthcare product labels at retail, it is not as clear how practitioners and patients can participate in the sustainable herb trade in the clinical setting. If every medical herbalist were able to dispense safe and effective medicines, prepared from local native species, obtained from (verifiably) sustainable wild collection operations or from local medicinal plant farms that follow biodynamic (14), or permaculture, or regenerative organic agricultural practices (15) that would be awesome, would it not?

While I am a proponent of local self-reliance, especially local food, in the case of herbal medicine, I think it may be a bit more complicated for the busy clinician serving an urban population. Of course, the situation varies by region. In the United Kingdom, some medical herbalists do maintain dispensaries of 100 to 200 herbs, prepare their own tinctures and mixtures of dried herbs for preparation as decoctions or infusions.

On the other hand, here in California, many (possibly most) herbalists, whether they practice as a licensed acupuncturist (LAc), Ayurvedic doctor (AyD), naturopathic doctor (ND), or certified nurse midwife (CNM), do not generally stock dried herbs in their private practice. Generally, they stock a small range of packaged “professional products”, supplied by selected trusted brands that primarily service practitioner’s clinics – with products that are not commercially available in retail shops. Practitioners also recommend selected commercially available herbal products that the patient can pick up at a natural food store or purchase online for home delivery.

Furthermore, there are TCM compounding pharmacies, which enable the LAc to login, enter the prescribed formula with the patient’s details, for same day pick-up or delivery. While such practices are understandable, they can place a greater distance between the herbalist and the herbs – and the ability to know, with any degree of certainty, when, where and how the herbs were harvested, by whom, and under what conditions.

In reality – many practitioners are serving urban patient populations, and do not live in a megadiverse ecozone – one that could keep their dispensaries stocked with the possibly hundreds of medicinal plants needed for formulations. The fact is that apothecaries and clinics in Europe and the Americas have relied on a range of imported herbs for many hundreds of years.

Even China, where most herbs used in TCM, until recent years, were harvested within China, has become an importer of some herbs. Due to dwindling plant populations, certain herbs are being imported into China from neighboring countries, especially from Vietnam (16), Bhutan, Nepal (17), Kazakhstan, and Russian Federation (18).

I hesitate to recommend a practice that I could not practice myself. Most of the medicinal plants that I choose to use – as healthy food or as medicine (or both!) – do not occur in Northern California, nor would many of them grow well here if transplanted. If I insisted on using only local herbs for food and medicine, I would need to move, far away! To illustrate this point:

  • Firstly, food and beverage: The CNS stimulant Arabica coffee that I drink in the morning is native to tropical forests of Ethiopia and Sudan (19) (but introduced and grown in forests of Central- and South America). The carminative and stomachic cardamom seed that I mix in the coffee, is native to rainforests of the Western Ghats region of South India (20). And, the carminative and stomachic cinnamon tree bark, sprinkled on morning toast, comes from forests of Indonesia, Vietnam, and Southern China (21).
  • Secondly, preventive medicine: The extract of wild bilberry fruit, that I take to improve microcirculation, is native to forests of Europe. And the turmeric rhizome, taken as an anti-inflammatory, originates from the Indo-Malayan Region of southern and southeastern Asia.
  • Thirdly, treatment: When a sore throat is coming on, I rely on a Chinese preparation ‘chuan xin lian’ antiphlogistic pills (andrographis herb, isatis root, and Mongolian dandelion herb). And for allergic rhinitis symptoms, I experience good results with a 12-herb formulation ‘bi yan pian’ nose inflammation pills (magnolia flower, xanthium fruit, phellodendron bark, forsythia fruit, liquorice root, schisandra fruit, anemarrhena rhizome, chrysanthemum flower, schizonepeta herb, platycodon root, fragrant angelica root, Siler root).

None of the aforementioned daily – or occasional – use botanicals in my cupboard or home medicine chest are produced anywhere near my neck of the woods. What is the herbal practitioner and patient to do? – to have some certainty, that the herbs, having travelled from distant deserts, meadows or forests to the clinic or pharmacy (or kitchen), have been harvested non-destructively, without detriment to the survival of the species, or its pollinators, or to any of the flora and fauna that share habitat.

How do the practitioner and patient know if the herbs were valued fairly and traded ethically, not dependent on exploitive labour of marginalized people to keep the prices low?

Likely an overwhelming feeling, for an individual practitioner, to aim towards dispensing herbal medicinal preparations, composed only of herbs that possess documentary evidence of sustainable production.

Firstly, you are not alone in this. Fortunately, much (but not enough) progress has been made in recent decades with the advent of VSS that have been designed with medicinal plants in mind, whether wild-collected or grown on farms.

Secondly, be curious enough to ask your bulk herb and herbal product supplier(s) tough questions about the herbs.

Thirdly, be insistent enough to encourage answers. You can also ask your preferred supplier(s) to begin stocking certified fair and organic dried herbs and herbal medicinal products on your behalf – bolstered by your commitment to pay the premium that covers the cost of sustainable production.

Uncertified, undocumented, non-traceable herbs will, of course, cost less. The assurance of sustainable and ethical production is important in my view, in part, because I believe that the medicine is impacted in some way by every person who has handled it on its journey from the alpine forest or the semi-arid steppe to the urban clinic.

No person in the natural medicine value chain should be struggling in abject poverty or be subject to exploitive labor and trade practices, nor should the natural environment be damaged, in the course of bringing medicinal herbs to the clinic for the health and wellbeing of the client or patient.

Today, there are increasing numbers of small-to-medium-size distributors, making some visible level of commitment to sustainable herbs, that service cottage industry, small health food or herb shops with bulk bins, and individual practitioners. The practitioner can find these progressive handlers in the databases of the standards-setting-organizations. For example, one can find information on the certified producers and registered processors and traders operating in the FairWild trading system.

Certificate holders in the Union for Ethical BioTrade Programme can be found on UEBT Sourcing. And details on certified operations in the Fair for Life – Social & Fair Trade Certification Programme are provided by FairForLife. However, for “voluntary” sustainability standards to be part of the solution, clients, consumers, patients, everyone, must also “voluntarily” agree to pay higher prices to cover the true costs of sustainable production, equitable and ethical trade. It is not free. The costs for an herb production operation to implement standards with annual audits and fees for inspection and certification, and the additional personnel needed to manage standards compliance, is not insignificant.

You may not be able to prescribe certified sustainable herbs and formulations straight away. Be pragmatic, start small and build gradually. Pick one herb at a time, to get better acquainted with, then another, and so on. In my experience, once I started looking into this fascinating area of sustainable resource management in the botanical supply chain, it was not long before I was hooked. No turning back! Enjoy the journey.

  1. Brinckmann JA. The long road to sustainable licorice. Journal of Medicinal Plant Conservation. Spring 2020:19-21. Available at: https://unitedplantsavers.org/ups-journal-2020/.
  2. World Health Organization. WHO Guidelines on Good Agricultural and Collection Practices (GACP) for Medicinal Plants. Geneva, Switzerland: World Health Organization; 2003. Available at: https://www.who.int/.
  3. Brinckmann JA, Morgan B. Linking a wild medicinal plant cooperative to socially responsible companies: Experiences from China and USA. In: Asen A, Savenije H, Schmidt F, eds. Good Business: Making Private Investments Work for Tropical Forests. Wageningen, the Netherlands: Tropenbos International; December 2012:54: 73-80.
  4. Larson B. ACTCM meets with delegates from China to discuss innovative herbal curriculum pilot. American College of Traditional Chinese Medicine Blog. 01 February 2011.
  5. Brinckmann JA. Sustainable Sourcing: Markets for Certified Chinese Medicinal and Aromatic Plants. Geneva, Switzerland: International Trade Centre (ITC); 2016; Available at: https://www.intracen.org/publication/Sustainable-Sourcing/.
  6. United States Department of Agriculture. NOP 5022 Wild Crop Harvesting Internal Rev01 07 22 11. Washington, D.C.: United States Department of Agriculture; 22 July 2011. Available at: https://www.ams.usda.gov/sites/default/files/media/5022.pdf.
  7. FairWild Foundation. FairWild Standard: Version 2.0. Weinfelden, Switzerland: FairWild Foundation; 2010; Available at: https://www.fairwild.org.
  8. Union for Ethical BioTrade. Ethical BioTrade Standard. Amsterdam, The Netherlands: Union for Ethical BioTrade; 2020; Available at: https://www.ethicalbiotrade.org/resource-pages/standard.
  9. Ecocert SA. Fair for Life Certification Standard for Fair Trade and Responsible Supply-chains. L’Isle Jourdain, France: Ecocert SA; 2020; Available at: https://www.fairforlife.org.
  10. Fairtrade International. Fairtrade Standard for Herbs, Herbal Teas & Spices for Small Producer Organizations and Traders. Current version: 01.05.2011_v1.2. Bonn, Germany: Fairtrade International; 2011; Available at: https://www.fairtradeamerica.org/app/uploads/2020/08/HerbsHerbalTeasSpices_SPO_SP.pdf.
  11. Fair Trade USA. Fair Trade Agricultural Production Standard. Version 1.1.0. Oakland, CA: Fair Trade USA; 2019. Available at: https://www.fairtradecertified.org.
  12. Wildlife Friendly Enterprise Network. Certified Elephant Friendly™ Standards. Bainbridge Island, Washington: Wildlife Friendly Enterprise Network; 2019; Available at: https://wildlifefriendly.org.
  13. Brinckmann JA, Luo W, Xu Q, et al. Sustainable harvest, people and pandas: Assessing a decade of managed wild harvest and trade in Schisandra sphenanthera. J Ethnopharmacol. 2018;224:522-534.
  14. Biodynamic Federation Standards Committee. Production, Processing and Labelling. International Standard for the use and certification of Demeter, Biodynamic and related trademarks. Darmstadt, Germany: Biodynamic Federation – Demeter-International e.V.; 2021. Available at: https://www.demeter.net/.
  15. Regenerative Organic Alliance. Framework for Regenerative Organic Certified™. Ventura, CA: Regenerative Organic Alliance; 2021. Available at: https://regenorganic.org/.
  16. Cunningham AB, Brinckmann JA, Bi YF, et al. Paris in the spring: A review of the trade, conservation and opportunities in the shift from wild harvest to cultivation of Paris polyphylla (Trilliaceae). J. Ethnopharm. 2018/08/10/ 2018;222:208-216.
  17. Cunningham AB, Brinckmann JA, Schippmann U, Pyakurel D. Production from both wild harvest and cultivation: The cross-border Swertia chirayita (Gentianaceae) trade. Journal of Ethnopharmacology. 2018;225:42-52.
  18. Brinckmann JA, Cunningham AB, Harter DEV. Running out of time to smell the roseroots: Reviewing threats and trade in wild Rhodiola rosea L. Journal of Ethnopharmacology. 2021;269:113710.
  19. Moat J, O’Sullivan RJ, Gole T, Davis AP. Coffea arabica (amended version of 2018 assessment). The IUCN Red List of Threatened Species 2020: e.T18289789A174149937. https://dx.doi.org/10.2305/IUCN.UK.2020-2.RLTS.T18289789A174149937.en. 2020.
  20. ICAR-Indian Institute of Spices Research. Cardamom – Extension Pamphlet. Kozhikode, Kerala: ICAR- Indian Institute of Spices Research; 2015.
  21. Oketch-Rabah HA, Marles RJ, Brinckmann JA. Cinnamon and Cassia Nomenclature Confusion: A Challenge to the Applicability of Clinical Data. Clinical Pharmacology & Therapeutics. 2018;104(3):435-445.

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Medicinal mushrooms: An introduction https://www.herbalreality.com/herbalism/western-herbal-medicine/medicinal-mushrooms-introduction/ https://www.herbalreality.com/herbalism/western-herbal-medicine/medicinal-mushrooms-introduction/#comments Fri, 29 Oct 2021 15:21:45 +0000 https://www.herbalreality.com/?p=3945 Neither plants nor animals but sharing characteristics of both, mushrooms have much to offer to modern medicine.

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Neither plants nor animals but sharing characteristics of both, mushrooms have much to offer to modern medicine.

Medicinal mushrooms represent a fascinating and hitherto neglected category of nature’s pharmacopoeia. Neither plants nor animals but sharing characteristics of both mushrooms have much to offer for a number of disease categories including:

  • Cancer
  • Auto-immune conditions
  • Neurodegenerative conditions
  • Chronic viral infections
Medicinal mushrooms An introduction

Key to their ability to assist with many of these areas is the immune-modulating activity of the beta-glucans, proteoglycans and related polysaccharides which are important structural components of the mushroom cell wall.

Receptors with specific binding sites for such polysaccharides are found on many of the cells that make up the immune system and they have also been shown to have a prebiotic effect on the gut flora, promoting the growth of beneficial bacteria, enhancing intestinal barrier integrity, increasing levels of short-chain fatty acids and enzyme activity.

Given their positive immunological and prebiotic activity it is perhaps not surprising that increased mushroom consumption has been correlated with reduction in the risk of developing cancer in a number of large-scale epidemiological studies including three looking specifically at breast cancer risk and one at prostate cancer with regular mushroom consumption linked to a lower cancer risk in all cases, especially in older age groups.

As if that was not enough reason to reconsider mushrooms as an important food category for health maintenance, especially as we get older, mushrooms also produce an array of secondary metabolites with diverse health benefits.

Of these one of the most common is lovastatin, which like most other such secondary metabolites is produced by mushrooms and other fungi for its anti-microbial properties, in this case its anti-fungal action.

Other such compounds include:

  • Triterpenes from several species including Reishi with actions including anti-inflammatory, sedative, anti-allergic, anti-hypertensive
  • Diterpenes including erinacines and hericenones from Hericium species with NGF-promoting properties
  • Nuceoside-derivatives such as Cordycepin with anti-viral, anti-inflammatory properties in Cordyceps species
  • Ergothioneine, an antioxidant amino acid found in porcini and oyster mushrooms with anti-ageing properties
  • Cordycepin and Long-Covid: Cordycepin (3’-deoxyadenosine) one of the key active molecules found in Cordyceps species, especially Cordyceps militaris is a close relative of Didanosine (2’,3’-dideoxyadenosine – used as part of HAART treatment for HIV/AIDS under the brand name Videx) and like Didanosine exhibits strong anti-viral activity. In addition it is a potent anti-inflammatory and contributes to Cordyceps’ traditional therapeutic use to increase energy and support the Lungs and Kidneys, including promoting steroid hormone production. With recent studies also pointing to protective properties for both cordycepin and Cordyceps militaris against lung injury from acute inflammation it is rapidly emerging as a promising candidate to help address the symptoms associated with Long Covid.

Mushrooms are also the only non-animal food to contain significant quantities of vitamin D with ergosterol in the cell wall converted to vitamin D2 on UV-exposure.

Reishi mushroom (Ganoderma lucidum)
Reishi mushroom (Ganoderma lucidum)

While awareness of mushrooms’ health benefits is relatively recent in countries such as the UK and USA, in others, especially in East Asia it has long been part of herbal traditions with the earliest Chinese materia medica, the Shen Nong Ben Cao, dating to around 200AD, including several still in use today:

  • Ling zhi (Ganoderma lucidum – Reishi)
  • Fu ling (Poria cocos)
  • Zhu ling (Polyporus umbellatus)

All of these are classified in the ‘Superior’ category of herbs, herbs which are considered safe to take for long periods of time without side effects and of which it is said that prolonged use will ‘lighten the body and confer longevity’. Indeed, G. lucidum has long been thought to be the plant Chi mentioned in a number of Taoist texts as a plant that brings happiness and immortality, although it is now believed that Chi and its classical categorisation according to six colours actually refers to a number of different species.

Over time the incorporation of mushrooms into the materia medica expanded so that in Li Shi Zhen’s authoritative work, the Ben Cao Gang Mu (1578), 21 mushrooms are listed as having medicinal properties and the reverence with which medicinal mushrooms, especially Reishi are held in Chinese culture is attested to by their extensive depiction in paintings, carvings and embroidery.

Turkey tail (Trametes versicolor)
Turkey tail (Trametes versicolor)

In the last few years awareness of mushrooms’ health benefits and the commercial possibilities they offer has seen interest in them take off in Europe and North America with a proliferation of new mushroom-based products and extended coverage in mainstream media such as the BBC and National Geographic magazine.

Unfortunately, even more so than with other herbs this increased interest has been accompanied by a proliferation of conflicting and competing claims and together with an opaque supply chain has resulted in a confusing landscape for those wishing to explore this area.

In order to address the need for education around medicinal mushrooms Mycology Press recently launched The Mushroom magazine and is currently setting up the Medicinal Mushroom Information Centre.

  • Mycotherapy of cancer: an update on cytotoxic and antitumor activities of mushrooms, bioactive principles and molecular mechanisms of their action.
  • Popović V et al. Curr Top Med Chem. 2013;13(21):2791-806.
  • A Critical Review on Health Promoting Benefits of Edible Mushrooms through Gut Microbiota.
  • Jayachandran M, Xiao J, Xu B. Int J Mol Sci. 2017 Sep 8;18(9):1934. 
  • A Review of Mushrooms as a Potential Source of Dietary Vitamin D. Cardwell G, Bornman JF, James AP, Black LJ. Nutrients. 2018 Oct 13;10(10):1498. 
  • Cordycepin: a bioactive metabolite of Cordyceps militaris and polyadenylation inhibitor with therapeutic potential against COVID-19.
  • Akalesh Kumar Verma. J Biomol Struct Dyn. 2020 Nov 23;1-8.

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The relevance of complementary and integrative medicine in the COVID-19 pandemic: A qualitative review https://www.herbalreality.com/herbalism/western-herbal-medicine/relevance-complementary-integrative-medicine-covid19-pandemic/ https://www.herbalreality.com/herbalism/western-herbal-medicine/relevance-complementary-integrative-medicine-covid19-pandemic/#comments Fri, 29 Oct 2021 15:21:44 +0000 https://www.herbalreality.com/?p=3863 Dr Vijay Murthy and his colleagues conducted a review of scientific evidence on Complementary and Integrative Medicine (CIM).

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With health risks during the COVID-19 pandemic, Dr Vijay Murthy conducted a review of scientific evidence on Complementary and Integrative Medicine.

The relevance of complementary and integrative medicine in the COVID-19 pandemic: A qualitative review of the literature

This article was first published as a Research paper.

In light of the adverse health risks faced both at the population and individual levels, we conducted a review of scientific evidence on Complementary and Integrative Medicine (CIM) that might be useful during the COVID-19 pandemic. This qualitative literature review is published in Frontiers in Medicine in December 2020.  We reviewed the scientific literature to summarise CIM practices that could be beneficial for improving physical and mental health and well-being of the population under the current pandemic circumstances. The review highlights the role of specific dietary measures, micronutrients, physical activity, Mind–Body Medicine techniques, single botanicals, botanical compounds, and spending time in nature in reducing adverse health risks. The review can possibly help in identifying the role of CIM on immune functions and preventative and therapeutic potential of CIM in viral respiratory conditions. This review can of help to clinicians, patients, and the general population during the current pandemic when discussing and/or considering CIM options.

Nutrition can play an important role in the “individual susceptibility” to bacterial or viral infections and, the outcome of infectious diseases. An optimized nutritional status can have a range of positive effects on the immune system. A predominantly plant-based diet, including e.g., fruits, vegetables, legumes, nuts, and olive oil, may have an influence on the susceptibility to infectious diseases; particularly foods containing potentially antimicrobial, antioxidant, anti-inflammatory, and immunomodulatory phytochemicals, such as bitter substances, vitamin C, mustard oils, herbs and spices, and herbal teas. A 5% higher proportional intake of fruit and vegetables is associated with a 12% lower hospitalization due to influenza infections. The effectiveness of vaccination may be higher when the plant part of the diet increases. In a recent systematic review, vitamins A and D showed a potential benefit in viral respiratory infections, especially in deficient populations. Among the trace elements, selenium and zinc have also shown beneficial immunomodulatory effects in viral respiratory infections. 

Echinacea (Echinacea purpurea)
Echinacea (Echinacea purpurea)

A selection of promising herbal medicines (Pelargonium root extract, Elderberry (Sambucus nigra), green tea (Camellia sinensis), liquorice (Glycyrrhiza glabra), echinacea (Echinacea spp.), rock rose (Cistus incanus) that may be relevant to the current COVID-19 pandemic. Catechins as a class of polyphenolic flavonoids are the main active ingredients of green tea as well as many other teas, which among other properties can strengthen the immunity against viral, especially influenza infections. The saponin glycyrrhizin from Glycyrrhiza glabra, extracts of echinacea species may decrease  pro-inflammatory cytokines that play a role in the progression of cytokine storm and  acute respiratory distress syndrome. 

The review emphasises the importance of Mind–Body Medicine and relaxation, strengthening relationships, focussing on developing a positive attitude as means to improve mental resilience. The review recommends 15–30 minutes of exercise a day of morning stretches, walking, jogging or any other activity. The article recommends healthy eating habits, to eat regularly, eating at least one warm main meal a day, preferably freshly cooked. It recommends use a variety of kitchen herbs and spices, drinking plenty of water and incorporating warm drinks such as unsweetened herbal teas, ginger tea, teas with liquorice, green tea. The article recommends use of herbs and spices (e.g., thyme, oregano, cloves, bay leaves, ginger, turmeric, basil, lemon balm, peppermint, rosemary, cinnamon). Last but not least, the review highlights the importance of good sleep as long and restful sleep strengthens the immune system. 

Read the full article here: https://www.frontiersin.org/articles/10.3389/fmed.2020.587749/full

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The role of adaptogens in prophylaxis and treatment of viral respiratory infections https://www.herbalreality.com/herbalism/western-herbal-medicine/role-adaptogens-prophylaxis-treatment-viral-respiratory-infections/ https://www.herbalreality.com/herbalism/western-herbal-medicine/role-adaptogens-prophylaxis-treatment-viral-respiratory-infections/#comments Fri, 29 Oct 2021 15:21:43 +0000 https://www.herbalreality.com/?p=3824 Adaptogens are a class of botanicals that offer promise in the prevention and adjunctive treatment of acute viral infections, such as SARS-CoV-2.

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Adaptogens are a class of botanicals that offer promise in the prevention and adjunctive treatment of acute viral infections, such as SARS-CoV-2.

This article was first published in The role of adaptogens in prophylaxis and treatment of viral respiratory infections

The COVID-19 pandemic has brought new challenges to biomedical sciences, specifically, the development of effective therapeutics for prevention and treatment of acute viral and stress-induced diseases. Adaptogens are a class of botanicals that offer promise in the prevention and adjunctive treatment of acute viral infections, such as SARS-CoV-2.

Adaptogens are natural stress-protective plants or plant compounds that increase adaptability, resilience, survival and “the state of non-specific resistance” to harmful factors, including bacterial and viral pathogens.

Over 100 species of botanicals have been reported to have adaptogenic activity, however, only few, have been shown to exhibit multitarget effects on the neuroendocrine-immune system by triggering adaptive stress response, including stimulating cellular and organismal defense systems, activating intracellular and extracellular adaptive signaling pathways, expression of stress-activated proteins resulting in transient change of the protection or repair capacity and increase of non-specific resistance and adaptation in stress (Panossian 2017). These are, eleuthero (Eleutherococcus senticosus), ginseng (Panax spp.), rhodiola (Rhodiola rosea), schisandra (Schisandra chinensis), ashwagandha (Withania somnifera), and andrographis (Andrographis paniculata).

Acute viral infections have four distinct stages: infection, viral replication, escalating inflammation, and pathogenic inflammation. In the initial infection phase, there are numerous interactions between components of host defense and the viral pathogen —genomic, transcriptomic, proteomic, metabolomic and macrobiotic (Yang et al. 2020). Consequently, effective prevention or treatment of a viral infection and other viral infections requires therapeutic intervention affecting the innate and adaptive immune system, phases I–III metabolizing enzymes of detoxifying and repair systems, as well as the virus’ life cycle and proliferation (Panossian et al. 2020).

Pre-clinical trials on extracts or isolated constituents from andrographis, eleuthero, ginseng, rhodiola, schisandra, and ashwagandha have shown direct viricidal effects on various strains of influenza and rhinovirus, specific antiviral actions (including inhibition of non-structural proteins involved in the replication of SARS virus), and indirect non-specific antiviral actions via activation innate immunity , anti-inflammatory effects, detoxification and repair of cellular and tissue damage induced by oxidative stress, and other effects of potential relevance in the progression of viral infections, see Figure 1 for details (Panossian et al. 2020).

Key elements of innate immunity stimulation are activation of first-line defense response, followed by inhibition of NF-κB and inflammation mediated by proinflammatory cytokines. Important features of adaptogens are their beneficial effects on detoxification and repair processes, leading to recovery and increased survival in virus-induced oxidative stress. Key to this are activation of the antioxidant NRf2-mediated oxidative stress response signaling pathway, the production of detoxification enzymes, the activation of molecular chaperon Hsp70, which mediate cytoprotectant and repair processes, and the activation of the melatonin signaling pathway for regulation of homeostasis (Panossian et al. 2018).

Figure 1. Schematic diagram of various phases of immune and inflammatory responses to SARS-CoV-2 infection and stages of COVID-19 progression with (highlighted in green color) and without (highlighted in red color) considering potential effects of adaptogenic plants on prevention, infection, inflammation, and recovery phases of viral infection.
Andrographis (Andrographis paniculata)
Andrographis (Andrographis paniculata)

Adaptogens have been subject to numerous clinical trials. Although these are not specific to SARS-CoV-2, the available clinical data provide support for the hypothesis that adaptogens may be beneficial in all stages of viral infections.

A meta-analysis of andrographis clinical trials (including over 7000 patients) demonstrated improved cough and sore throat and reduced the duration of these and other related respiratory symptoms (Hu et al. 2017). Other studies indicated that Andrographis at a dose of 1.2 g daily reduced intensity of symptoms and signs of rhinitis, sinus pain and headache, as compared to placebo (Panossian et al. 2020).

Much of the research on eleuthero is from observational studies done in the Soviet Union during the 1970s, with studies involving over 4500 subjects. In addition to showing improvement of performance under stress, cardiovascular and pulmonary disorders, trials indicated that eleuthero given prophylactically can reduce influenza mortality rates and typical complications, such as pneumonia, bronchitis, and otitis media. Positive effects of eleuthero were seen in both adults and children (Panossian et al. 2020).

Adaptogenic effects of rhodiola have been well-established in clinical trials, and rhodiola has demonstrated utility in specific pulmonary indications. As an adjunctive therapy in chronic obstructive pulmonary disease, rhodiola significantly improved tidal breathing and ventilation efficiency. A significant decrease in acute respiratory distress syndrome complications was observed in patients preventatively treated for acute lung injury caused by post-traumatic/inflammatory and thoracic-cardiovascular operations (Panossian et al. 2020; Tao et al. 2019).

Numerous clinical investigations on schisandra have confirmed that in viral respiratory tract infections, schisandra targets viral RNA synthesis and replication, and stimulates innate and adaptive immunity. Trials have also demonstrated improvement in chemotherapy-induced immunosuppression, COPD, and fatigue (Nowak et al. 2019; Panossian et al. 2020).

Ashwagandha (Withania somnifera)
Ashwagandha (Withania somnifera)

A review of 30 human clinical trials of ashwagandha, indicated the safety and efficacy in subclinical hypothyroidism, chronic stress, insomnia and anxiety, cognitive impairment, among others (Tandon et al. 2020). Adaptogenic effects were studied in three clinical trials, one of which reported significantly increased oxygen consumption, maximum velocity, and average absolute and relative power under exercise conditions with ashwagandha supplementation, an outcome that may be relevant in convalescence from respiratory disease (Panossian et al. 2020).

Reviews of clinical trials on ginseng species on immune response to respiratory tract infections, indicated significant evidence for immunomodulatory activity of ginseng. The studies also demonstrated that ginseng elicited a reduction in cytokine levels, decreased severity of oxidative stress, reduced the duration and frequency of symptoms, and demonstrated potential for prevention of respiratory infections (Iqbal et al. 2020; Panossian et al. 2020; Ratan et al. 2020).

Multiple clinical trials on a fixed combination of andrographis and eleuthero confirmed a significant relief of symptoms of uncomplicated respiratory tract infections caused by the common cold. Studies showed relief of sinusitis, headache, myalgia, nasal congestion and nasal secretion, and an acceleration of recovery time (Panossian et al. 2020).

The multitarget effects of adaptogens on the neuroendocrine-immune system make them a potentially important preventative and adjunctive treatment for SARS-CoV-2 infections. They provide baseline support through their immunomodulatory, immunostimulatory, and antioxidant effect through all phases.

Adaptogens help to combat infection through their specific and non-specific antiviral properties, alleviate escalating inflammation through their anti-inflammatory effects, as well as their capacity to repair oxidative stress-induced injuries in compromised cells and tissues, and address secondary disease states and comorbidities through various, infection-related activities.

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  • Iqbal H, Rhee DK. 2020. Ginseng alleviates microbial infections of the respiratory tract: a review. J Ginseng Res 44(2):194-204.
  • Kwon YJ, Son DH, Chung TH, Lee YJ. 2020. A Review of the Pharmacological Efficacy and Safety of Licorice Root from Corroborative Clinical Trial Findings. J Med Food 23(1):12-20.
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  • Panossian A, Seo EJ, Efferth T. 2018. Novel molecular mechanisms for the adaptogenic effects of herbal extracts on isolated brain cells using systems biology. Phytomedicine 50:257-284.
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  • Ratan ZA, Youn SH, Kwak YS, Han CK, Haidere MF, Kim JK, Min H, Jung YJ, Hosseinzadeh H, Hyun SH, Cho JY. Adaptogenic effects of Panax ginseng on modulation of immune functions. Journal of Ginseng Research, in press  JGR532_proof ,  22 September 2020,  1-9.
  • Tandon N, Yadav SS. 2020. Safety and clinical effectiveness of Withania Somnifera (Linn.) Dunal root in human ailments. J Ethnopharmacol 255:112768.
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Botanical drugs and supplements affecting the immune response https://www.herbalreality.com/herbalism/western-herbal-medicine/botanical-drugs-immune-response-covid/ https://www.herbalreality.com/herbalism/western-herbal-medicine/botanical-drugs-immune-response-covid/#comments Fri, 29 Oct 2021 15:21:43 +0000 https://www.herbalreality.com/?p=3836 The potential benefit of botanical drugs and supplements emerges as a focus of attention, although controversial efficacy claims are rightly a concern.

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In times of health crisis, the potential benefit of botanical drugs and supplements emerges as a focus of attention.

This article was first published as a Research paper and by The American Botanical Council

Botanical drugs and supplements affecting the immune response

In times of health crisis, including the current COVID-19 pandemic, the potential benefit of botanical drugs and supplements emerges as a focus of attention, although controversial efficacy claims are rightly a concern.

Phytotherapy has an established role in everyday self-care and health care, but, since botanical preparations contain many chemical constituents rather than single compounds, challenges arise in demonstrating efficacy and safety.

However, there is ample traditional, empirical, and clinical evidence that botanicals can offer some protection and alleviation of disease symptoms as well as promoting general well-being. Newly emerging viral infections, specifically COVID-19, represent a unique challenge in their novelty and absence of established antiviral treatment or immunization. We discuss here the roles and limitations of phytotherapy in helping to prevent and address viral infections, especially regarding their effects on immune response.

Botanicals with a documented immunomodulatory, immunostimulatory, and antiinflammatory effects include adaptogens, Boswellia spp., Curcuma longa, Echinacea spp., Glycyrrhiza spp., medicinal fungi, Pelargonium sidoides, salicylate-yielding herbs, and Sambucus spp. We further provide a clinical perspective on applications and safety of these herbs in prevention, onset, progression, and convalescence from respiratory viral infections.

Read the full article here: https://onlinelibrary.wiley.com/doi/epdf/10.1002/ptr.7008

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Herbs suitable for diabetics https://www.herbalreality.com/health-lifestyle/digestion-nutrition/herbs-suitable-for-diabetics/ https://www.herbalreality.com/health-lifestyle/digestion-nutrition/herbs-suitable-for-diabetics/#comments Fri, 29 Oct 2021 15:21:42 +0000 https://www.herbalreality.com/?p=3761 Simon Mills explores the onset and management of Type 2 diabetes.

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Type 2 diabetes is increasingly common in industrially developed societies. Simon Mills explores the onset and management of Type 2 diabetes, and suitable herbs for diabetics.

Herbs suitable for diabetics

Type 2 or late-onset diabetes, marked by persistently high levels of glucose in the blood, is increasingly common in industrially developed societies. It is also rocketing in countries which have been industrialising most rapidly (e.g. India and China). It has been linked to excessive food intake, especially carbohydrate and sugar consumption, and a reduction in exercise. It is particularly associated with obesity and cardiovascular disease.

There are serious health complications of diabetes, especially if not controlled. There is a greater risk of cardiovascular disease and dementia, and in severe cases, of kidney disease, blindness and amputations. The World Health Organization (WHO) reports that diabetes is one of the leading causes of death in the world, and rapidly increasing in its impact.

Fortunately most cases of Type 2 diabetes can be controlled by diet and exercise, and particularly by weight loss. There are likely to be added benefits with incorporating plant foods, spices and supplements into the diet. We will look at these opportunities.

Firstly we can consider five ways to address the onset and management of Type 2 diabetes.

Type 2 diabetes mellitus is most often preceded and is accompanied by an increasing resistance to the action of insulin in moving glucose from the blood into the cells.

This condition has been referred to as metabolic syndrome, insulin resistance syndrome, or syndrome X. It is a disorder of energy utilisation and storage, diagnosed by a co-occurrence of three out of five of the following medical conditions:

  • Abdominal (central) obesity
  • Elevated blood pressure
  • Elevated fasting plasma glucose
  • High serum triglycerides
  • Low high-density cholesterol (HDL) levels

Metabolic syndrome increases the risk of developing cardiovascular disease, particularly heart failure, and diabetes itself. Some studies have shown the prevalence in the UK to be over a third of the adult population (1) and this increases with age.

We will see there are a number of ways in which we can use plants to reduce insulin resistance.

An immediate impact of increased insulin resistance is on the integrity of the endothelium, the cell wall lining of the blood vessels, and the single interface between blood and tissues at the capillaries.

The endothelium is the frontline in inflammation: this is where the white blood cells are activated and switch on inflammatory cytokines and other initiators. Many long-term complications of diabetes can be laid directly to the direct inflammatory pressures of insulin resistance.

Endothelial dysfunction leads to the following:

  • Increased vascular endothelial growth factor (VEGF)
  • Capillary basement membrane thickening
  • Increased inflammatory cell adhesion
  • Increased leptin and inflammatory adipocytokines (from increased fatty tissue)
  • Increased inflammatory activity and cytokine concentrations
  • Yet more insulin resistance

This in turn leading to the following pathological developments:

  •  Oxidation-induced reduction in vasodilation
  •  Reduced tissue perfusion and hypoxia
  •  Impaired tissue oxidation – fatty infiltration and its pathological consequences
  •  Adiposity

There was a recent dramatic illustration of the importance of this endothelial interface in early observations of the incidence of severe complications of Covid-19: that these were associated with health conditions (obesity, cardiovascular disease, diabetes) associated with insulin resistance and endothelial dysfunction.

We will see that there are promising plant based approaches to improving endothelial function.

The most distressing consequences of poorly managed diabetes follow from endothelial dysfunction and disruption in blood supply.

  • Retinopathy: Damage to capillary blood supply to the retina, with the development of microaneurysms, retinal haemorrhages, and exudates; this progresses to a ‘proliferative’ phase with the presence of new blood vessels. Blindness is a possible outcome.
  • Nephropathy: A persistent proteinuria which can progress to a decline in renal function and end-stage renal disease.
  • Neuropathy: Various nerve pathologies with symptoms determined by the nerves involved.

Such macrovascular problems are associated with atherosclerotic plaque formation, affecting blood supply to the heart, brain, limbs, and other organs. Later stages involve complete obstruction of these vessels, which can increase the risks of wider cardiovascular disease, including myocardial infarction, stroke, and gangrene (leading to amputation).

As in the previous section there is considerable evidence that a number of important plant constituents can improve endothelial integrity, and there are indications that this may reduce the incidence of diabetic complications.

Fatty tissues are inherently inflammatory. Adipose cells secrete a variety of cytokines, known as adipokines, including leptin, tumour necrosis factor (TNF)-α, and plasminogen-activator inhibitor type 1 (PAI-1). Fat tissue is also a key regulator of C-reactive protein.

Adipokines generate a state of low-grade generalised inflammation resulting in pathological defects in metabolism and blood flow. These inflammatory agents have been shown as a major mechanism for inducing insulin resistance and diabetes (2).

We shall see that there is promising research pointers to benefits of spices in reducing adipokine activities and in reducing the consequent rises in insulin resistance.

It has long been confirmed that the most effective way to reduce diabetic complications is to bring down the raised levels of blood sugar that accompany the resistance to insulin.

The most useful first approach is to cut the rate at which glucose is produced and absorbed from food. This means at its simplest the reduction in amount of simple sugars, refined carbohydrates and alcohol in the diet and replacing them by complex, slow-release carbohydrates and proteins. To reduce complicating obesity and high cholesterol levels it also makes sense to cut back consumption of saturated fats.

A quick guide to the likelihood of a food pushing up blood glucose levels is its glycaemic index. This is defined by the American Diabetes Association as ‘a ranking of carbohydrates on a scale from 0 to 100 according to the extent to which they raise blood sugar levels after eating.’ Foods with a high GI are those which are rapidly digested and absorbed and result in marked fluctuations in blood sugar levels. Low-GI foods, by virtue of their slow digestion and absorption, produce gradual rises in blood sugar and insulin levels, and have proven benefits for health.

Low GI diets have been shown to improve both glucose and lipid levels in people with diabetes (type 1 and type 2). They have benefits for weight control because they help control appetite and delay hunger. Low GI diets also reduce insulin levels and insulin resistance.

A good GI Index is produced by the Harvard Medical School.

We shall see there are further ways in which we can reduce blood glucose levels using plant foods.

Balanced nutrition diet

There are several categories of fibre.

  • β-glucans such as cellulose in cereals, fruit, vegetables (in all plants in general)

and the mushroom glucans

  • Hemicelluloses in cereals, bran, legume
  • Lignin invegetables, fruits and cereals
  • Resistant starch in barley, wheat, legumes, bananas, etc.
  • Fructans such as inulin in onions, bananas, leeks, Jerusalem artichokes, and asparagus
  • Polyuronides such as pectin in the fruit skins and vegetables, and alginic acids in agar and other algae

Various fibres are known to have laxative effects, and assist with cholesterol lowering (3). Specific glucose management effects include

  • attenuated blood glucose responses (4,5,6)
  • prebiotic benefits on gut microbiome (increased Bifidobacteria, Lactobacilli, Faecalibacteria) (7)
  • increased production of glucose-sparing short-chain fatty acids (SCFAs) (8)
  • increased incretins: glucagon like peptide (GLP-1), peptide YY (PYY) (9)
  • reduced body weight (10)
  • reduced lipogenesis, adipogenesis, adipocyte numbers and size, inflammation, oxidative stress (11)

Apart form increasing the amount of wholegrains, vegetables, pulses and fruit in the diet, high fibre remedies include linseed (flaxseed), psyllium seed and husk, ispaghula, guar gum, and agar agar.

Andrographis (Andrographis paniculata)
Andrographis (Andrographis paniculata)

Bitters have been used for their immediate effect in reducing sugar cravings associated with hypoglycaemic episodes.  They have also been components of traditional formulations in diabetes, accompanied by hyperglycaemia. It has even been possible to speculate from these experiences that such an ‘adaptogenic’ effect is linked with a capacity to modulate insulin release.

Bitter principles in plants activate a family of around 30 receptors (TAS2Rs) tuned to each detect multiple bitter substances (perhaps as a defence mechanism against poisons) and with a wide range of physiological consequences, including changes in digestive activity (12,13) and an increase in blood flow to the digestive tract (14).

They are found throughout the GI tract, airways, and other tissues (15), including pancreatic beta-cells. This latter location adds to the speculation that there is an explanation for the insulin modulating capacity of bitters.

Bitters have been shown to help manage glucose levels (16,17) with effects including the regulation of the hunger hormone ghrelin (18,19) increase in cholecystokinin (20) and regulation of key agents PYY and GLP-1 (21).

Classic bitter remedies associated with managing blood sugar levels include andrographis, neem, gentian root, wormwood, barberry bark (22) and golden seal.

There is increasing evidence that polyphenols, including flavonoids, anthocyanidins (the colours of fruits and vegetables), have a significant effect in glycaemic control (23), and on various aspects of metabolic syndrome (24,25).

Green tea (Camellia sinensis)
Green tea (Camellia sinensis)

In one trial daily cranberry juice (240 mL) consumption for 12 weeks and blueberry extract or powder supplementation (= 9-10 mg of anthocyanins) for 8 to 12 weeks showed a beneficial effect on glucose control in late-onset diabetic subjects (26).

In a major study (PREDIMED-Plus) involving observations over several years of 7447 elderly participants at high cardiovascular risk, polyphenol intakes were calculated from food frequency questionnaires. Analyses were stratified by sex and BMI groups (overweight and obese).

Consumption of polyphenols were inversely associated with incidence of type 2 diabetes, especially on women and those overweight (27). In a subgroup of 3430 elderly persons at higher cardiovascular risk in this same study, a high intake of total polyphenols was also associated with a reduced risk of diabetes (28).

There are several possible mechanisms for such benefits (29). A number of clinical trials point to an improvement of endothelial function in patients whose diets were supplemented with cocoa (30), green tea (31) and anthocyanin-rich berries (32,33,34).

Polyphenols are also prebiotic (35,36) and it may be that changes in gut microbiome can be a significant factor (37,38). The microbiota also process polyphenols (by cleavage into simple phenols) so that large molecules that are poorly absorbed become active modulators of inflammation (39).

Foods that are likely to be helpful in providing useful levels of polyphenols include berries, green tea and high-cocoa, low-sugar chocolate (which has been shown significantly to improve insulin sensitivity and lipid profile (40)), as well as a range of herbal products (41).

Common kitchen spices are showing increasing signs of being very important in the management of metabolic syndrome, blood sugar levels, and particularly vascular complications (42,43).

Cloves (Syzygium aromaticum)
Cloves (Syzygium aromaticum)

Cinnamon has been shown to directly regulate blood sugar levels (44,45), to reduce insulin resistance (46,47).

A beneficial effect of various spices on endothelial factors in diabetes is very likely (48).

Turmeric has been shown directly to interact with adipocytes to suppress adipokines. These curcumin-induced alterations reverse insulin resistance, hyperglycaemia, hyperlipidaemia, and other symptoms linked to obesity. Other structurally similar constituents derived from red chili, cinnamon, cloves, black pepper, and ginger, also exhibit effects against obesity and insulin resistance (49).

Turmeric, ginger and other spices also reduce inflammatory activity originating from adipose tissue (50,51)

Ginger has been shown to regulate blood sugar levels by increasing thermogenesis and lipolysis, suppressing lipogenesis, inhibiting intestinal fat absorption, and controlling appetite (52), as well as by reducing insulin resistance (53,54).

The Asian paradox

The rampant increase in the incidence of diabetes in India (55) and China suggests that a high daily spice intake is not sufficient protection against the condition. However the prevalence of peripheral vascular disease in these countries is lower than that reported in European populations (56,57). Levels of retinopathy approximately half that found in the west have been seen in India, Pakistan, Sri Lanka, China (58). This reduces the likelihood that this is due to genetic differences and reinforces the idea that there are dietary reasons, and that it is increased spice intake that reduces vascular complications of diabetes.

Turmeric root (Curcuma longa)
Turmeric root (Curcuma longa)

After basic exercise and low GI diet:

  • Increase consumption in the diet of spices, especially cinnamon, turmeric and ginger.
  • Increase polyphenol consumption: green tea, black currant, blueberry, pomegranate, with rewards of 70% chocolate, with any alcohol ration restricted to red wine!
  • Ensure high fibre consumption, with supplementation by seaweed and seed sources.
  • Consider supplements with spice extracts such as turmeric, and ginger (especially if extra heating appropriate) and also careful use of bitters.

All these measures are on the assumption that the diabetes is being managed without the use of insulin or other medical prescriptions. In these cases there needs to be more care, especially if glycaemic management is not stabilised, as too abrupt a change in regime might precipitate a glycaemic crisis. For the same reason it is not advisable to attempt to add to the management of Type 1 diabetes without careful coordination with medical professionals and monitoring of blood sugar levels.

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  22. Zhao Y, Yang YY, Yang BL, et al. (2021) Efficacy and safety of berberine for dyslipidemia: study protocol for a randomized double-blind placebo-controlled trial. Trials. 22(1): 85.
  23. Rienks J, Barbaresko J, Oluwagbemigun K, et al. (2018) Polyphenol exposure and risk of type 2 diabetes: dose-response meta-analyses and systematic review of prospective cohort studies. Am J Clin Nutr. 108(1): 49-61.
  24. Amiot MJ, Riva C, Vinet A. (2016) Effects of dietary polyphenols on metabolic syndrome features in humans: a systematic review. Obes Rev. 17(7): 573-86.
  25. Raman G, Avendano EE, Chen S, et al. (2019)  Dietary intakes of flavan-3-ols and cardiometabolic health: systematic review and meta-analysis of randomized trials and prospective cohort studies. Am J Clin Nutr. 110(5): 1067-1078.
  26. Rocha DMUP, Caldas APS, da Silva BP et al. (2019) Effects of blueberry and cranberry consumption on type 2 diabetes glycemic control: A systematic review. Crit Rev Food Sci Nutr. 59(11): 1816-1828.
  27. Tresserra-Rimbau A, Castro-Barquero S, Vitelli-Storelli F, et al. (2019) Associations between Dietary Polyphenols and Type 2 Diabetes in a Cross-Sectional Analysis of the PREDIMED-Plus Trial: Role of Body Mass Index and Sex. Antioxidants (Basel). 8(11): 537.
  28. PREDIMED study investigators. (2015) Intake of Total Polyphenols and Some Classes of Polyphenols Is Inversely Associated with Diabetes in Elderly People at High Cardiovascular Disease Risk. J Nutr. 146(4): 767-777.
  29. Munir KM, Chandrasekaran S, Gao F, Quon MJ. (2013)  Mechanisms for food polyphenols to ameliorate insulin resistance and endothelial dysfunction: therapeutic implications for diabetes and its cardiovascular complications. Am J Physiol Endocrinol Metab. 305(6): E679-86.
  30. Sun Y , Zimmermann D , De Castro CA , Actis-Goretta L . (2019) Dose-response relationship between cocoa flavanols and human endothelial function: a systematic review and meta-analysis of randomized trials. Food Funct. 10(10): 6322-6330.
  31. Alexopoulos N, Vlachopoulos C, Aznaouridis K, et al. (2008)  The acute effect of green tea consumption on endothelial function in healthy individuals. Eur J Cardiovasc Prev Rehabil. 15(3): 300-5.
  32. Amiot MJ, Riva C, Vinet A. (2016) Effects of dietary polyphenols on metabolic syndrome features in humans: a systematic review. Obes Rev. 17(7): 573-86.
  33. Martini D, Marino M, Angelino D, et al. (2020) Role of berries in vascular function: a systematic review of human intervention studies. Nutr Rev. 78(3): 189-206.
  34. Fairlie-Jones L, Davison K, Fromentin E, Hill AM. (2017) The Effect of Anthocyanin-Rich Foods or Extracts on Vascular Function in Adults: A Systematic Review and Meta-Analysis of Randomised Controlled Trials. Nutrients. 9(8): 908.
  35. Igwe EO, Charlton KE, Probst YC, et al. (2019) A systematic literature review of the effect of anthocyanins on gut microbiota populations. J Hum Nutr Diet. 32(1): 53-62.
  36. Bond T, Derbyshire E. (2019) Tea Compounds and the Gut Microbiome: Findings from Trials and Mechanistic Studies. Nutrients. 11(10): 2364.
  37. Ejtahed HS, Angoorani P, Soroush AR. (2020) Gut microbiota-derived metabolites in obesity: a systematic review. Biosci Microbiota Food Health. 39(3): 65-76.
  38. Houghton D, Hardy T, Stewart C, et al. (2018) Systematic review assessing the effectiveness of dietary intervention on gut microbiota in adults with type 2 diabetes. Diabetologia. 61(8): 1700-1711.
  39. Nash V, Ranadheera CS, Georgousopoulou EN, et al.(2018)  The effects of grape and red wine polyphenols on gut microbiota – A systematic review. Food Res Int. 113: 277-287.
  40. Lin X, Zhang I, Li A, et al. (2016) Cocoa Flavanol Intake and Biomarkers for Cardiometabolic Health: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. J Nutr. 146(11): 2325-2333.
  41. Ejtahed HS, Soroush AR, Siadat SD, et al. (2019) Targeting obesity management through gut microbiota modulation by herbal products: A systematic review. Complement Ther Med. 42: 184-204.
  42. Panickar KS. (2013) Beneficial effects of herbs, spices, and medicinal plants on the metabolic syndrome, brain, and cognitive function. Cent Nerv Syst Agents Med Chem. 13(1): 13-29.
  43. Skulas-Ray AC, Kris-Etherton PM, Teeter DL, et al. (2011) A high antioxidant spice blend attenuates postprandial insulin and triglyceride responses and increases some plasma measures of antioxidant activity in healthy, overweight men. J Nutr. 141(8): 1451-7.
  44. Namazi N, Khodamoradi K, Khamechi SP, et al. (2019) The impact of cinnamon on anthropometric indices and glycemic status in patients with type 2 diabetes: A systematic review and meta-analysis of clinical trials. Complement Ther Med. 43: 92-101
  45. Deyno S, Eneyew K, Seyfe S, et al. (2019) Efficacy and safety of cinnamon in type 2 diabetes mellitus and pre-diabetes patients: A meta-analysis and meta-regression. Diabetes Res Clin Pract. 156:107815
  46. Sheng X, Zhang Y, Gong Z, et al. (2008) Improved Insulin Resistance and Lipid Metabolism by Cinnamon Extract through Activation of Peroxisome Proliferator-Activated Receptors. PPAR Res. 2008:581348.
  47. Qin B, Panickar KS, Anderson RA. (2010) Cinnamon: potential role in the prevention of insulin resistance, metabolic syndrome, and type 2 diabetes. J Diabetes Sci Technol. 4(3): 685-93.
  48. Azimi P, Ghiasvand R, Feizi A, et al. (2016 Effect of cinnamon, cardamom, saffron and ginger consumption on blood pressure and a marker of endothelial function in patients with type 2 diabetes mellitus: A randomized controlled clinical trial. Blood Press. 25(3):133-40.
  49. Aggarwal BB. (2010) Targeting inflammation-induced obesity and metabolic diseases by curcumin and other nutraceuticals. Annu Rev Nutr. 30:173-99.
  50. Woo HM, Kang JH, Kawada T, et al. (2007) Active spice-derived components can inhibit inflammatory responses of adipose tissue in obesity by suppressing inflammatory actions of macrophages and release of monocyte chemoattractant protein-1 from adipocytes. Life Sci. 80(10): 926-31
  51. Ebrahimzadeh Attari V, Ostadrahimi A, Asghari Jafarabadi M, et al. (2016) Changes of serum adipocytokines and body weight following Zingiber officinale supplementation in obese women: a RCT. Eur J Nutr. 55(6): 2129-36
  52. Ebrahimzadeh Attari V, Malek Mahdavi A, Javadivala Z, et al. (2018) A systematic review of the anti-obesity and weight lowering effect of ginger (Zingiber officinale Roscoe) and its mechanisms of action. Phytother Res. 32(4): 577-585
  53. Li Y, Tran VH, Kota BP, et al. (2014) Preventative Effect of Zingiber Officinale on Insulin Resistance and its Mechanism of Action. Basic Clin Pharmacol Toxicol. 115 (2): 209-215.
  54. Mahluji S, Attari VE, Mobasseri M, et al.(2013) Effects of ginger (Zingiber officinale) on plasma glucose level, HbA1c and insulin sensitivity in type 2 diabetic patients. Int J Food Sci Nutr. 64(6): 682-6.
  55. Ramachandran A, Snehalatha C. (2009) Current scenario of diabetes in India. J Diabetes. 1(1): 18-28.
  56. Premalatha G, Shanthirani S, Deepa R, et al.(2000) Prevalence and risk factors of peripheral vascular disease in a selected south Indian population. Diabetes Care. 23: 1295–300.
  57. Ramachandran A, Snehalatha C, Satyavani K et al. (1999) Prevalence of vascular complications and their risk factors in type 2 diabetes. J Assoc Physicians India. 47: 1152–6.
  58. Narendran V, John R K, Raghuram A. (2002) Diabetic retinopathy among self reported diabetics in southern India: a population based assessment. Br J Ophthalmol 86(9): 1014–1018

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Psilocybin and depression: Where are we currently at with the psilocybin revolution? https://www.herbalreality.com/herbalism/western-herbal-medicine/psilocybin-depression-revolution/ https://www.herbalreality.com/herbalism/western-herbal-medicine/psilocybin-depression-revolution/#comments Fri, 29 Oct 2021 15:21:42 +0000 https://www.herbalreality.com/?p=3802 Efforts by scientists bring in major changes with the decriminalisation of the therapeutic use of psychoactive plants, such as psilocybin, as medicine.

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Psilocybin and depression Where are we currently at with the psilocybin revolution

Efforts by scientists bring in major changes with the decriminalisation of the therapeutic use of psychoactive plant and fungi, such as psilocybin, as medicine.

You may or may not be familiar with changing laws surrounding psychedelics around the world, but it seems that collective efforts by researchers, scientists & psychedelic activists are bringing in major changes in the West with the decriminalisation and in some cases even legalisation of the therapeutic use of psychoactive plant & fungi as medicine.

One of the most exciting areas of research and legislative developments is on the use of psilocybin to treat major depressive disorder (MDD) and treatment resistant depression (1). Depression is the number one cause of disability in the world with approximately 300 million people affected. Costing an annual $210 billion dollars to the global economy (2) with an estimated 10% to 30% considered treatment-resistant to pharmaceutical antidepressants (3), MDD is a growing problem that requires healthcare systems to consider new methods of help.

P. cubensis
P. cubensis

Psilocybin is a naturally occurring tryptamine alkaloid discovered within the hundred plus species of psychedelic mushrooms occurring in many of the temperate or tropical climates of the world. Most commonly referenced as being an isolated constituent within the fungi genus of Psilocybe (4), psilocybin is just one constituent within a cocktail of potent compounds found within psychoactive mushrooms. Other constituents found within the Psilocybe genus include the alkaloid psilocin and a range of beta-carbolines including harmane and harmine. Both of which are potent inhibitors of monoamine oxidase enzyme (5).

The average psilocybin content within the psilocybe species is about 1%. Meaning one gram of mushrooms provides approximately 10mg of psilocybin (6). A number of modern human trials using psilocybin to treat depression follow the guide of 20mg-30mg psilocybin per 70kg of human body weight (7).

Like many psychoactive compounds, psilocybin exerts its effect on the nervous system via the 5-HT2A receptor. This is the same receptor targeted by selective serotonin reuptake inhibitor (SSRI) anti-depressant drugs. The difference is that psilocybin works as an agonist of the receptor, thereby producing a different and a potentially much more profound psychoactive reaction than SSRI.

This much needed help is looking like it is found within one of nature’s most magical gifts, the humble psychedelic mushroom. In recent decades ethnobotanists have discovered that the use of mushrooms for religious, healing and divinatory experiences spans across multiple indigenous cultures. From a herbalist’s point of view, what unites all of the global distribution of psychedelic mushrooms is the collection of potent neuro-active metabolites that inhabit each mushroom. Psilocybin being one of these inherent metabolites of particular interest to scientists, researchers and psychiatry.

The traditional view taken by governments of the world is one of great caution and criminality when considering the cultivation, possession, consumption and/or prescription of psilocybin containing mushrooms. The majority of countries around the world have legislation that makes it illegal to pick, grow, possess and consume psilocybin containing mushrooms.

After many decades of protest by indigenous communities, scientists and organisations such as the Multi-disciplinary Association for Psychedelic Studies (MAPS) endlessly campaigning for the safe and legal use of psilocybin containing mushrooms we can now see a positive momentum of change across the western world.

Ayahuasca has also been explored as a psychedelic treatment for depression
Ayahuasca has also been explored as a psychedelic treatment for depression

In November 2019 the United States Food and Drug Administration granted the Usona Institute ‘Breakthrough Therapy’ designation to conduct clinical trials on the use of psilocybin for treating MDD [viii]. This phase 2 trial involving 80 participants is due to finish in Spring 2021 (9) with results most likely showing psilocybin can produce sustained and substantial decreases in symptoms of anxiety and depression.

These healing effects have been shown before in sporadic trials with some even reporting sustained improvements in depressive symptoms following a single high dose treatment of psilocybin at the 6 month follow-up for almost 80% of the participants involved (10).

In 2016 the Beckley Foundation, based in London (UK) published results from a trial that involved 12 patients with moderate to severe, treatment resistant depression (11). After prescribing two dosages (10mg and 25mg, seven days apart) in a supportive setting, 67% of patients were depression free one week after treatment.

42% were still in remission three months later. These results are revolutionary when compared to conventional pharmaceutical options. Similar research has also been explored with other plant based psychedelic treatments for depression such as Ayahuasca (12).

Psilocybe semilanceata
Psilocybe semilanceata

Given the current conventional medical paradigm of patenting medicines, the trials involving psilocybin for depression remains in this exploratory stage. It could be that in years to come as more evidence emerges on how therapeutic isolated psilocybin can be, that we see a global distribution of this treatment. This does however bring up the question as to how taking isolated psilocybin on its own as a patented medicine compares to using the whole mushroom as found in the wild or through cultivation. This is a debate that has gone on for many decades between herbalists, pharmacists and scientists. The discussion of reductionism versus holism.

Many users of psilocybin containing mushrooms consume the whole mushroom on its own without considering the legal situation or cost of attaining a pharmaceutical isolate of psilocybin. This is all with the backdrop of the growing movement towards drug decriminalisation moving through the world, particularly the U.S.

In November 2020 the state of Oregon went further than decriminalisation and became the first state in the U.S to pass legislation that legalised the medicinal use of psilocybin (13). At the moment this doesn’t mean that whole psilocybin containing mushrooms can be openly sold at dispensaries like cannabis is, but it does mean they are drafting proposals for how and which treatment centres can provide psilocybin for those who wish to explore this method of treatment. This may follow other examples around the world, such as Holland, where Psilocybin mushrooms in the form of truffles are offered as a tool for healing and self-development (14).

It is forecasted that as more research on psilocybin is produced and the evidence-base is enhanced, then it is inevitable that more parts of the world will follow the path that medicinal cannabis has taken. Fewer prosecutions and ‘turning a blind eye’ to decriminalisation, to legalisation for medical treatment, and finally to potential legal cultivation, possession and consumption.

It remains to be seen how this movement of research, science, recreational use and overall discussion will lead us to. Each individual country will decide on the path they decide to take but it finally feels like the healing role of our more misunderstood plant and fungi allies is finally being acknowledged.

  1. Davis, A. K. Barrett, F. S. May, D. G. et al. (2020) Effects of Psilocybin-Assisted Therapy on Major Depressive Disorder – A Randomized Clinical Trial, JAMA Psychiatry, 10.1001/jamapsychiatry.2020.3285
  2. Greenberg, P. E. Fournier, A. A. Sisitsky, T. Pike, C. T. Kessler, R. C. (2015) The Economic Burden of Adults with Major Depressive Disorder in the United States (2005 and 2010), Journal of Clinicla Psychiatry, Feb;76(2): p. 155-162.
  3. Nemeroff, C. B. (2007) Prevalence and Management of Treatment-Resistant Depression, Journal of Clinical Psychiatry, 68 Suppl 8: p. 17-25.
  4. Peredy, T. Bradford, H. (2014) Mushroom, Psilocybin, Encyclopaedia of Toxicology (Third Edition), p. 418-419.
  5. Blei, F. Dorner, S. Fricke, J. Baldeweg, F. Trottman, F. Komor, A. Meyer, F. Hertwick, C. Hoffmeister, D. (2019) Simultaneous Production of Psilocybin and a Cocktail of β‐Carboline Monoamine Oxidase Inhibitors in “Magic” Mushrooms, Chemistry – A European Journal, Vol. 26 (3) p. 729.734.
  6. https://psychedelicreview.com/chemical-composition-variability-in-magic-mushrooms/
  7. https://newatlas.com/johns-hopkins-psilocybin-study-finds-optimum-beneficial-dosage/18981/
  8. https://www.businesswire.com/news/home/20191122005452/en/FDA-grants-Breakthrough-Therapy-Designation-Usona-Institutes
  9. https://usonaclinicaltrials.org/major-depressive-disorder-psilocybin-clinical-trial-psil201
  10. Griffiths, R. R. Johnson, M. W. Carducci, M. A. et al. (2016) Psilocybin produces substantial and sustained decreases in depression and anxiety in patients with life-threatening cancer: A randomized double-blind trial, The Journal of Psychopharmacology, Dec;30(12): p. 1181-1197.
  11. Carhart-Harris, R. L. Bolstridge, M. Rucker, J. Day, C. M. J. Erritzoe, D. Kaelen, M. et al. (2016) Psilocybin with psychological support for treatment-resistant depression: an open-label feasibility study, Lancet Psychiatry, May 17.
  12. Jimenez-Garrido, D. F. Gomez-Sousa, M. Ona, G. Dos Santos, R. G. Hallak, J. E. C. Alcazar-Corcoles, M. A. Bouso, J. C. (2020) Effects of Ayahuasca on mental health and quality of life in naïve user: a longitudinal and cross-sectional study combination, Scientific Reports 10, 4075.
  13. https://www.nytimes.com/interactive/2020/11/03/us/elections/results-oregon-measure-109-legalize-psilocybin.html
  14. https://www.synthesisretreat.com

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Ephedra: ma huang or ephedrine? A lesson for herbal practitioners https://www.herbalreality.com/herbalism/western-herbal-medicine/ephedra-ephedrine-lesson-herbal-practitioners/ https://www.herbalreality.com/herbalism/western-herbal-medicine/ephedra-ephedrine-lesson-herbal-practitioners/#comments Fri, 29 Oct 2021 15:21:39 +0000 https://www.herbalreality.com/?p=3721 Ephedra is a valuable herb. It is however banned in the USA. We take a look at this story and what we can learn.

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Ephedra is a valuable herb. It is however banned in the USA. We take a look at this story and what we can learn.

Ephedra sinica

Ephedra or ma huang, is provided commercially as the dried young stems of three species of perennial herbs, Ephedra sinica Stapf., E. equisetina Bge., or E. intermedia Schrenk + C.A. Meyer.  

Ephedra sinica is a native of northern China and Inner Mongolia. Each of the three species has slightly different appearances and characteristics.

E. sinica is the less branched, with nodes more spaced out on the stem. All samples are dry and brittle, with little odour and a slightly bitter taste.

Note: The North American ephedra E. nevadensis (known as Mormon tea), contains little or no ephedrine or other alkaloids.

Ma huang is mentioned in the Han dynasty Shen Nong Ben Cao Jing (Divine Farmer’s Classic of the Materia Medica) (1) for its benefits on lung obstructions like wheezing. Its principal action through Chinese traditions was as a heating medicine, to treat febrile congested catarrhal conditions of the respiratory system. It promotes sweating, calms dyspnoea and is indicated for ‘exterior repletion cold damage patterns with aversion to cold’ (2).

It features frequently in formulae recorded in the Shang Han Lun (on Cold Damage) (3) in which it is often combined for additional warming effect with cinnamon and ginger. In modern terms the old indications translate as some of the preliminary symptoms of ‘flu, at the stage where the patient is feeling chilled and is shivering, and when sweating has not yet broken out (when the body temperature is showing as high yet the person still feels chilled: this means the temperature is still rising).

Headaches and diffuse pains around the body which appear at this stage are additional indications for the use of this remedy. Its effect in such cases is to provide a considerable perspiration and to provide a feeling of warmth, this (vasodilation and diaphoresis) leading to a fall in actual body temperature.

Its virtues are also evident in dealing with symptoms of dyspnoea: breathlessness and a feeling of constriction in the chest, including asthma. It may be applied generally to associated conditions of hypersensitivity in the airways, such as allergic rhinitis (including hayfever and ragweed sensitivity).

The warming quality of this remedy however dominate all its other effects. It is reflected in its role as as a circulatory stimulant, in dispersing catarrhal congestion, and as a diaphoretic in fevers. Closely associated with the above is the action of ma huang on fluid accumulations in the body.

Whether through its diaphoretic or diuretic effects, it acts to relieve symptoms of oedema. The total combination means for example that as far as the lungs are concerned, the remedy is applicable to bronchial congestive conditions as well as to asthmatic drying of the airways, and that it is ideal for bronchial asthma.

Traditional doses range from 1-5 grams per day, with lower amounts in many classic formulae.

As with other traditional remedies there has been a modern adaptation in the use of ma huang to new indications. Other heroic remedies that have switched roles (and reduced doses) include hawthorn (from fever management to heart and vascular remedy), feverfew (to a migraine treatment), and valerian (from a robust convalescent tonic to a sleep remedy) and, in each case with a reduction in dose and extension of treatment time.

Ma huang has morphed into ‘ephedra’, a prime modern remedy for bronchospasm, especially associated with allergic conditions. From being a marvellous treatment for healthcare emergencies it became a remedy that could be used in the long term, and at lower doses. Modern herbal practitioners have found it also useful in other symptoms of allergy as well, such as urticaria and atopic eczema.

Ephedra sinica contains phenylalanine-derived protoalkaloids, notably ephedrine, pseudoephedrine, norephedrine, norpseudoephedrine, and l-methylephedrine. Pharmacopoeial specifications are that the herbs should contain not less than 1.25% of alkaloids calculated as ephedrine. Analyses show the range in commercial samples is between 0.5-2.5% and that ephedrine can account for between 30-90% of the alkaloid content; pseudoephedrine can go as high as 27%, though usually less (4).

Ephedrine is a sympathomimetic agent, acting indirectly to enhance the release of norepinephrine from sympathetic neurons, and directly by stimulating alpha and beta adrenergic receptors. It increases heart rate and cardiac output, and because it also constricts blood vessels, has a hypertensive effect.

In the lung, ephedrine acts via the beta-adrenergic receptors to relax bronchial smooth muscle, achieving an effect analogous to adrenaline without the need for injection. Because of its lipid solubility, ephedrine crosses the blood-brain barrier where it acts as a central nervous system stimulant, promoting both noradrenaline and dopamine levels (5). It has an action here comparable to amphetamines (6).

In the whole plant, this impact is qualified by the action of pseudoephedrine, the basis of a familiar decongestant medicine (e.g. Sudafed), which has more beta-adrenergic activity.

Although it is a banned in sports by the World Anti-Doping Agency (WADA) a recent meta-analysis (7) concluded that pseudoephedrine had minimal stimulant action, and is less hypertensive action than ephedrine. This means that blood supply to the skeletal muscle and periphery is increased, the bronchial airways are dilated, there is relaxation of the gut and reproductive musculature.

With the contribution of other constituents, e.g. alkaloids phenylpropanolamine (norephedrine), and cathine, as well as non-alkaloidal fractions that have demonstrated to be safer (8), this means that the whole herb does not have the same effects as the isolated ephedrine.

Dose levels in therapeutic use usually deliver less ephedrine than taken in isolation for weight loss or athletic performance. In traditional practice the higher doses in a range are generally applied to acute indications, in this case mostly fever management. Most herbal practice and traditional formulations provide ephedra at the lower end of the range, with modern western herbalists rarely prescribing more than 1g equivalent per day.

At this level the patient could be consuming between 10-25 mg of ephedrine equivalent. The highest therapeutic intake, for a high alkaloid yielding batch taken at maximum dose could be around 100mg per day. Doses under 50mg are not thought to raise blood pressure (9).

Clinical trials for ephedrine use daily doses ranging from 24-150mg. However commercial supplements can deliver many hundred milligrams.

Commercial decongestants like Sudafed deliver a dose of up to 240mg of pseudoephedrine, up to a hundred times that found in a daily dose of ephedra.

Even with a corresponding lower level of risk the herbal practitioner will be cautioned against the use of ephedra in cases of hypertension, a history of cardiovascular disease, and to use with care at the same time as antidepressant medication.

Dry ephedra
Dry ephedra

In 2001 the RAND Corporation (the USA’s largest independent health policy research organization, often used by government agencies) was engaged by the federal Agency for Healthcare Research and Quality to review the alarming increase in adverse case reports and litigation following the widespread use of ephedrine products in weight loss and athletic enhancement.

In 2003 Agency released the report of Rand’s Southern California Evidence-Based Practice Center (10) which concluded that there was evidence that these products are related to a two- or three-fold increase in side effects such as nausea, vomiting, jitteriness, and palpitations. Furthermore, the evidence suggested a link between these products and catastrophic events such as sudden death, heart attack or stroke.

RAND researchers based their findings on a detailed review of 52 clinical trials of ephedrine or herbal ephedra for weight loss or athletic performance in humans.

They searched the medical literature and other sources for both published and unpublished medical trials of the substances. They also analyzed more than 1,500 “adverse event reports” related to herbal ephedra and 125 such reports related to synthetic ephedrine-containing products, which were collected by the U.S. Food and Drug Administration. Researchers discovered 70 additional adverse events in the medical literature and received a computer file of more than 18,000 adverse events from Metabolife, a maker of ephedra products.

Paul Shekelle, the RAND and Veterans Affairs physician who headed the study noted that “with regard to catastrophic events, these findings are a strong signal that there is a link between use of ephedra or ephedrine and the occurrence of death, heart attack, stroke, seizures, and serious psychiatric symptoms…. It is more likely than not that there is a relationship, although the available evidence falls short of the conventional level of scientific proof.”

The RAND study also found some evidence of benefits of ephedra and ephedrine for weight loss. Dietary supplements containing ephedra, the drug ephedrine, and ephedrine plus caffeine promoted modest short-term weight loss, averaging about two pounds per month more than among people taking a placebo. However, none of the studies reviewed followed participants for longer than six months, less than the 12 months accepted as necessary to establish a drug’s value as a weight-loss aid.

Although many of the ephedra supplements and ephedrine products are taken for boosting athletic performance, researchers found no evidence that ephedra—and only a little evidence that ephedrine—enhances physical performance. They found no evidence that any of the products improve long-term physical performance among athletes or the general public.

I was invited on the Technical Expert Panel to review this report. Our reviews were recorded in the archives of the US National Institutes of Health, including my contribution.

“After reading the RAND report, my first impression is the following: What are we evaluating — ephedrine or herb ephedra? The latter is not a single-chemical entity and cannot be assumed to be ephedrine. Even assuming the herb ephedra in the literature is defined to contain specific dosage levels of ‘ephedrine,’ what efforts were made to ascertain that this ‘ephedrine’ is indeed ephedrine and not a mixture of ephedrine-type alkaloids, or, worse, different types of alkaloids that are also present in ephedra? Any study or report on a natural product (not just a single-chemical compound) must clearly define what the material under study or being reported is. I don’t see such a definition in this report. Despite the limited availability of useful data, this report’s conclusions regarding the efficacy of ephedrine (the single-chemical drug), in the presence and the absence of caffeine, in short-term weight loss and athletic performance, appears to be sound.“

This generated a reply from the authors that did not completely address the point.

“We agree that the lack of specificity is a problem. We have modified the conclusions to be more specific to only these herbal combinations studied. In the RCTs of herbal ephedra included in the efficacy analysis, the dose of ephedrine alkaloid was stated.“

On February 9, 2004, the US Food and Drug Administration (FDA) issued a final rule prohibiting the sale of dietary supplements containing ephedrine alkaloids (ephedra) because such supplements present an unreasonable risk of illness or injury.

Practitioners have continued to be grateful for the benefits of ephedra in the UK. However in recent years reliable supplies have been very hard to source.

Ephedra is included on a list of the Schedule 20 Part 2 herbs in the European Medicines Regulation 2012. These herbs may only be used by ‘qualified Medical Herbalists’ in their prescriptions and are not on General Sale. Other herbs on this list are:

  • Adonis vernalis
  • Aspidosperma quebracho-blanco
  • Atropa belladonna (herba)
  • Atropa belladonna (radix)
  • Chelidonium majus
  • Cinchona spp.
  • Colchicum autumnale
  • Convallaria majalis
  • Datura stramonium
  • Gelsemium sempervirens
  • Hyoscyamus niger
  • Lobelia inflata

Since the 2012 legislation there have been suggestions that the status of all Schedule 20 herbs will be reviewed.

The US experience of ephedra and ephedrine should provide us with a heads up … we should tell our story better.

  1. J. Needham, L. Gwei-Djen, H. Hsing-Tsung (2013) Science & civilisation in China-Vol 6-1: biology and biological technology Cambridge University Press ed.
  2. Yen Kun-Ying (1992) The Illustrated Chinese Materia Medica. SMC Publishing Taipei.
  3. Mitchell C, Feng Y, Wiseman N. transl. (1999) Shang Han Lun on Cold Damage. Paradigm Publications, Brookline, Massachusetts.
  4. Evans WC. (1989) Trease and Evans’ Pharmacognosy. 16th Ed. WB Saunders, London p 376
  5. Hardman JG, Limbird LE, Gilman A. Eds (2001). Goodman and Gilman’s The Pharmacologic Basis of Disease. McGraw-Hill, New York.
  6. Martin W R, Sloan J W, Sapira J D, Jasinski D R. (1971) Physiologic, subjective, and behavioral effects of amphetamine, methamphetamine, ephedrine, phenmetrazine, and methylphenidate in man. Clin Pharmacol Ther. 12(2): 245–58
  7. Gheorghiev MD, Hosseini F, Moran J, Cooper CE. (2018) Effects of pseudoephedrine on parameters affecting exercise performance: a meta-analysis. Sports Med Open. 5;4(1): 44
  8. Odaguchi H, Hyuga S, Sekine M, et al. (2019) [The Adverse Effects of Ephedra Herb and the Safety of Ephedrine Alkaloids-free Ephedra Herb Extract (EFE)]. Yakugaku Zasshi. 139(11): 1417-1425
  9. Astrup A, Toubro S. (1993) Thermogenic, metabolic, and cardiovascular responses to ephedrine and caffeine in man. Int J Obes Relat Metab Disord. 17(Suppl 1):S41–3
  10. Shekelle P, Morton SC, Maglione M, et al. (2003) Ephedra and Ephedrine for Weight Loss and Athletic Performance Enhancement: Clinical Efficacy and Side Effects. Rockville (MD): Agency for Healthcare Research and Quality (US); (Evidence Reports/Technology Assessments, No. 76.)

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Back to the future: How plant medicine can save us from antibiotic resistance https://www.herbalreality.com/herbalism/western-herbal-medicine/how-plant-medicine-can-save-from-antibiotic-resistance/ https://www.herbalreality.com/herbalism/western-herbal-medicine/how-plant-medicine-can-save-from-antibiotic-resistance/#comments Fri, 29 Oct 2021 15:21:35 +0000 https://www.herbalreality.com/?p=3421 Antibiotics have undoubtedly saved millions of lives but the assumption that they are safe has led to their overuse and increased microbial resistance.

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Antibiotics have undoubtedly saved millions of lives but the assumption that they are safe has led to their overuse and, as a result, increased microbial resistance.

Back to the future: How plant medicine can save us from antibiotic resistance

We are reaching a crisis in modern healthcare, and the entire paradigm of how we manage human and animal infections is being questioned. The fear is that our saviour, the antibiotic, is now causing more harm than good.

Antibiotics have undoubtedly saved millions of lives but the assumption that they are safe has led to their overuse and, as a result, increased microbial resistance.

MRSA, C. difficile and E. coli are just a few well-known examples of microbes showing antibiotic resistance. Given the levels of antibiotic use, it is perhaps no wonder that this is happening. In the USA, for example, by the time the average 18 year old leaves school he or she will have received 10–20 courses of antibiotics.

Meanwhile, most intensively reared farm animals receive antibiotics when they are not even ill as a cheap form of insurance to prevent the spread of disease when stocking levels are high. Sow pigs receive as many eight courses of antibiotics in their short six-month life. In Britain 42% of all antibiotics are given to farm animals, and 80% of these are put into feed or water to treat a whole flock or herd at once. The widespread use of antibiotics in farming is a significant contributor to the problem of resistance among humans too.

The perception of antibiotics as a kind of magic bullet and their consequent proliferation is having three dramatic effects: escalating antibiotic resistance, a disturbed microbiome, and disrupted immuno-neurological-psychological systems in animals and humans. There is more and more evidence that the proliferation of antibiotic use since the 1940s is implicated in the explosion of Type 1 diabetes, allergies, respiratory disorders, psychological imbalances and inflammatory bowel diseases.

From the standpoint of evolutionary history, the whole concept of an antibiotic is an oxymoron. We cannot live in a microbe free world, nor do we want to: there is nothing living that does. The rhizosphere (the part of the soil that interacts with plant roots) has 100 billionmicrobial cells per gram root comprising more than 30,000 species. Our microbiome influences our innate immunity, our neurology and our psychology keeping us stronger, happier and wiser. We need to live symbiotically with the 100 trillion or so microbiota populating our body (made up of 10 trillion cells), so how can we preserve health in the face of infections without damaging this critical community that we depend upon?

It appears that the answer is right in front of us. For the past billion years of our multi-celled evolution we have been in a dialogue with the world around us. Our ancestors knew the benefits of the antimicrobial defence mechanisms that plants have developed through their co-evolutionary dance with the environment.

Traditional health systems have identified that 50,000 of the 250,000 flowering species in the world have therapeutic properties. These plants still remain effective today. Mankind’s use of these species over millennia suggests that bacteria, fungi and viruses have less ability to develop resistance to a broad-spectrum botanical pharmacy than to a narrow pharmaceutical one as used in our modern health system. But why is this and how do the herbs work?

Plants contain hundreds to thousands of  plant chemicals that carry particular properties that have evolved to protect the static plant from ever-evolving microbial and environmental challenges. Essential oils, aromatic terpenes and colourful flavonoids optimise interaction with the environment enhancing the survival of the plant.

Humans and animals have receptors and enzyme pathways that can harness these compounds for our benefit, which points to a positive path ahead for our future healthcare. This is the wonder of synergy as the multiple compounds work together at pharmacodynamic (what the drug does to the body) and pharmacokinetic (what the body does to the drug) levels. These multi-dimensional synergistic effects of plants optimise the chances of efficacy and reduce the likelihood of resistance via multiple mechanisms. So how do herbs work in the face of infection?

Essential oil compounds, such as carvacrol and thymol (the hot and spicy compound found in oregano and thyme), destroy the bacterial cell membrane rendering them inactive. Green tea also does this.

Epigallocatechin gallate (EGCG), a polyphenol in green tea,impedes the bacteria’s own enzymes that are released to deactivate antibiotic activity. Tannins also do this and Triphala, one of Ayurveda’s most famous formulas made from the fruits of amla, bibhitaki and haritaki, is often used in antimicrobial formulas.

This system, called the efflux pump, is designed to stop antibiotics entering the bacterial cell and is a major cause of drug resistance. Certain compounds in some herbs inhibit this pump, allowing the antibiotics to deactivate the microbe. Baicalen found in thyme and some Scutellaria species reverses MRSA resistance to ciproflaxin by inhibiting the bacteria’s efflux pump.

Quorum sensing is the bacteria’s own protective mechanism enabling it to rally against compounds that are toxic to it, for example, by creating defensive-matrix biofilms, that act as a inhibitory barriers. Cinnamon, cranberry, garlic, ginseng and propolis interfere with this process, breaking down the web and preventing the microbes adhering together as a powerful conglomerate.

Herbs such as clove, dill and tea tree oil interfere with microbial energy cycles thus weakening its life cycle and rendering the microbe useless.

Tulsi (Ocimum tenuiflorum)
Tulsi (Ocimum tenuiflorum)

By targeting viral proteins, herbs can disrupt the life cycle of the microbe and block the proliferation of the invading virus. Andrographis has been shown to do this with the cold sores caused by herpes simplex 1 as well as with various flu viruses. Elderberry has been shown to deactivate the neuraminidase enzyme released by eight strains of flu.

Herbs work independently to limit microbial advance as well as enhancing the effects of antibiotics when they are most needed. They work synergistically as a single plant and when used in multi-herb combinations. They also work collaboratively with pharmaceutical antibiotics.

As healthcare professionals face the daily onslaught of sore throats, sinus problems, urinary infections and superficial wounds, it begs the question of why we are so readily using antibiotics known to cause resistance when the history, tradition and science for using plants is so robust? This question is particularly urgent given that the big antibiotic guns are being disempowered by overuse rather than preserved for life-threatening situations.

The list of medicinal plants that can enhance immunity and protect from infection is extensive. Further to the above-mentioned species, some of the most favoured in modern herbal clinical practice, also available for over the counter (OTC)  use and with solid scientific backing, are andrographis (Andrographis paniculata), echinacea (Echinacea purpurea/angustifolia), elderberry (Sambucus nigra), neem (Azadirachta indica) and tulsi (Ocimum sanctum). Their potential for helping solve the current healthcare crisis of antibiotic resistance is enormous.

Here we have only really discussed the way herbs defend against an attack by bacteria, but the herbal paradigm also embraces the concept of strengthening immunity by galvanizing both innate and acquired immunity. Herbalists use immune modulators to treat the broader spectrum of autoimmune, inflammatory and proliferative disorders so prevalent in modern healthcare. Again, the multi-dimensional and synergistic impact of herbs interfaces with our health in the broadest possible sense; herbs help us adapt to our environment and enhance our response to it.

One of the most interesting ways that these plants, with their complex phytochemical components, appear to work is by interfacing with our microbiome in our gut. As many plant compounds are not actually absorbed into the blood stream, it appears that they initiate signalling through our own probiotic bacteria. Signalling is when herbs initiate a response within our own probiotic bacteria so that a chain reaction occurs from herb to bacteria to our physiology. This is even more of a reason to not disturb unnecessarily our intestinal gut bacteria with antibiotics and keep our microbiome intact by using natural plants to keep us at our best.

  • A paper from the European Herbal and Traditional Medicine Practitioners Association (EHTPA) for the House of Commons Select Committee on Science and Technology’s antimicrobial resistance (AMR) inquiry.
  • Coon JT, Ernst E. Andrographis paniculata in the treatment of upper respiratory tract infections: a systematic review of safety and efficacy. Planta Med. 2004 Apr;70(4):293-8. Review.
  • Chan BC, Ip M, Lau CB, Lui SL, Jolivalt C, Ganem-Elbaz C, Li taudon M, Reiner NE, Gong H, See RH, Fung KP, Leung PC. Synergistic effects of baicalein with ciprofloxacin against NorA overexpressed methicillin-resistant Staphylococcus aureus (MRSA) and inhibition of MRSA pyruvate kinase. J Ethnopharmacol. 2011 Sep 1;137(1):767-73.
  • Hemaiswarya S, Kruthiventi AK, Doble M. Synergism between natural products and antibiotics against infectious diseases. Phytomedicine. 2008 Aug;15(8):639-52.
  • Mondal S, Varma S, Bamola VD, Naik SN, Mirdha BR, Padhi MM, Mehta N, Mahapatra SC. Double-blinded randomized controlled trial for immunomodulatory effects of Tulsi (Ocimum sanctum Linn.) leaf extract on healthy volunteers. J Ethnopharmacol. 2011 Jul 14;136(3):452-6.
  • Poolsup N, Suthisisang C, Prathanturarug S, Asawamekin A, Chanchareon U. Andrographis paniculata in the symptomatic treatment of uncomplicated upper respiratory tract infection: systematic review of randomized controlled trials. J Clin Pharm Ther. 2004 Feb;29(1):37-45. Review.
  • Ponnusamy K, Ramasamy M, Savarimuthu L, Paul raj MG. (2010). Indirubin potentiates ciprofloxacin activi ty in the NorA efflux pump of Staphylococcus aureus. Scandinavian Journal of Infectious Diseases. 42, (6-7) :500-505.
  • Sharma SM, Anderson M, Schoop SR, Hudson JB. Bactericidal and anti -inflammatory properties of a s tandardi zed Echinacea extract (Echinaforce): dual actions agains t respi ratory bacteria. Phytomedicine. 2010 Jul ;17(8-9):563-8.
  • Vanka A, Tandon S, Rao SR, et al. The effect of indigenous Neem ( Adirachta indica) mouth wash on Streptococcus mutans and lactobacilli growth. Indian J Dent Res. 2001;12:133-144.
  • Wagner H, Ul rich-Merzenich G. Synergy research: approaching a new generation of phytopharmaceuticals. Phytomedicine. 2009 Mar;16(2-3):97-110. Review part 1.
  • Zakay-Rones Z, Varsano N., Zlotnik M, Manor O., et al Inhibition of several strains of influenza virus in vitro and redution of symptoms by an elderberry extract (Sambucus nigra L.) during an outbreak of influenza B in Panama. Journal of Alternative and Complementary Medicine. 1995;1(4):361-369

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Do you know where your herbs come from? https://www.herbalreality.com/herbalism/western-herbal-medicine/where-your-herbs-come-from/ https://www.herbalreality.com/herbalism/western-herbal-medicine/where-your-herbs-come-from/#comments Fri, 29 Oct 2021 15:21:33 +0000 https://www.herbalreality.com/?p=3404 Paying attention to the conditions that fall under the word “sustainability” determines whether herbal products truly are helping to create more wellness in the world.

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Paying attention to the conditions that fall under the word “sustainability” determines whether herbal products truly are helping create more wellness in the world.

Do you know where your herbs come from?

“Herbs are the same as chocolate or beer. There’s a difference between a micro-brewery’s India Pale Ale and a bottle of Budweiser. There’s a difference between a Snickers bar and a Swiss chocolate bar. It’s the same with herbs. You can get the Snickers or the Bud or you can get the microbrew or the Swiss chocolate bar. What you get depends on where you look and what you are willing to pay.”  —  Josef Brinckmann

Do you know where the mint or turmeric or echinacea in your cup of tea comes from?

Do you know how it was harvested and by whom? Whether the plants were wild harvested or cultivated in a field? Where the soils were cared for? What kind of sacks were used and where were the herbs stored? How much the workers were paid for their work?

Most importantly, do you know why these and so many more questions matter?

Consumers of herbal supplements tend to believe that in buying products made with plants, they’re making the environmentally responsible choice. Yet outside of the herb community, few of us understand the crucial connections between the quality of the finished product, traceability, and sustainable and ethical sourcing. Even for those seeking to know more, in an industry known for secrecy, it is very difficult to find accurate information about the supply chain or the human and environmental costs.

Where plants come from and how they are handled along the way matters to the quality and efficacy of the finished product. If those processes are good – ‘good’ meaning people are paying attention each step of the way – the finished product will more likely be good. Especially with bulk herbs or herbal teas, the quality of the supply chain directly impacts the quality of the finished product.

Details matter: whether workers have washed their hands, what lotion or insect repellent collectors used while collecting the raw materials, what the collection bags were previously used for, whether the plants were harvested in the rain or left in a pile in a tarp for a few days until workers had time to process them. Attention through the supply chain costs money.

Changing this system begins with being curious and asking questions. It begins with recognizing that the finished product on the shelf is only the end of a long journey and that every step of that journey matters in whether that finished product has the effect we hope it will have or not. Sustainability isn’t an add on to consider if we have the money. Paying attention to the conditions that fall under the word “sustainability” determines whether these products truly are helping create more wellness in the world and helping restore the biological and cultural diversity on which all of us depend.

You can use the following resources to learn more about sustainable herbal medicine and sustainable herbs:

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Are herbs safe? https://www.herbalreality.com/herbalism/safety/are-herbs-safe/ https://www.herbalreality.com/herbalism/safety/are-herbs-safe/#comments Fri, 29 Oct 2021 15:21:32 +0000 https://www.herbalreality.com/?p=3049 In this review we understand that herbs are not a public hazard, and that humans have always been very good at avoiding plants that upset them.

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Are herbs safe?

In this review, we explore whether herbs are not a public hazard, and that humans have always been very good at avoiding plants that upset them.

This is a longer thought piece that reflects the many levels at which this question can be addressed. However it is still a summary review and we have not included detailed literature references.

The foundations for these arguments were thoroughly researched in our seminal text (1). This has stood up well over the years and is recommended as a basis for any detailed personal updating.

In this review we conclude that herbs are not a public hazard, and that humans have always been very good at avoiding plants that upset them.

However we have never been as sure of the effects of long-term exposure, and there are other reasons to be aware of what can go wrong. A few sensible precautions are warranted.

If we read all the safety threats in plants we might be too frightened to eat.  Wheat, rye, and barley contain a protein called gluten that is hydrolysed in the digestive system to a peptide alpha-gliadin, a well-established intestinal irritant, that has caused many thousands of deaths around the world through coeliac disease and sprue.

Apple seeds, and the kernels of apricots, plums and other stone fruits, as well as bitter almonds, contain glycosides that generate cyanide in the digestive system. Potatoes are members of the deadly nightshade family and produce the same poisonous alkaloids when they turn green under the influence of light.

Many common household pulses, like soya bean, red kidney bean, and haricot bean (used in “baked beans”), contain various toxins, notably types of lectins called phytohaemagglutinins, as well as trypsin-inhibitors, that can only reliably be neutralised by boiling for at least 30 minutes.

Of course the foods listed above are generally safe to eat. The real point is to show how difficult it is to predict the toxicity of a plant only from the presence of toxic constituents. The action of the whole plant, and the way in which it is normally consumed, counts for more than any individual constituent list. We will see here that for the most widely used plant remedies there are similar reassurances.

A key reason why people turn to herbs appears to be the assumption that they are free from side effects, “not like those drugs”.

On the other hand medical opinion is generally that any medicine that is effective must also be a risk, that it is impossible to have effects without side effects, that if herbs are claimed to be free from side effects they cannot then be effective at all.

Paradoxically, this aligns with the idea of the person being seen as a whole: the living body is so complex, so intricately interwoven that any intervention at one site may spark off reactions at other sites.

Yet we restate the principle that herbs are safer than conventional medicines. We refer to the uninterrupted use of the most established remedies by millions of people since prehistory. Even today the major herb formulations sold in health food shops sell in millions of units per year with remarkably few problems. There have also been extremely few cases of malpractice litigation brought against herbal practitioners (a fact reflected in the very low level of professional insurance premiums).

If we are right, how can we be both safe AND effective? These questions may be resolved if we look again at the nature of our remedies and the way they may work.

The remedies we use represent only a tiny proportion of available plant species around the world. It is certain that humans through history moved to using those plants that were quickly effective with minimum adverse effects. Short-term safety at least is built in to these millions of human experiences through the ages.

Further the benign qualities of these herbs arise from their complexity. The existence of tannins, mucilages, saponins, or other constituents in different ways buffer or modulate the effect of more active constituents, which are often in any case present in only low levels.

It is after all the essential feature of herbal pharmacology that the whole package has potential that no isolated principle can mimic.

Most importantly the whole thrust of treatment with plants is different from that of conventional medicine. The herbs are used ideally to nudge healing responses in the body rather than directly attack the symptoms or pathology.

A bitter stimulates digestive activity, a hot spice the digestion and circulation as well; laxatives provoke bile, bowel and urinary elimination; expectorants, diuretics, hepatics and lymphatics produce their own detoxifications, and so on. We trust the body to look after its affairs and seek only to help it on its way without disturbing it unduly.

If that is after all our claim, what is the evidence that our remedies are inherently safe to use?

There are two potential sources of safety information about any medicine:

  • Toxicological research, usually from animal studies
  • Reported adverse effects from actual human use:
    • Published clinical reports
    • Post-marketing surveillance of herbal medicines

Animal studies are still widely used to assess the safety of conventional medicines in spite of commitments to find reliable alternatives. In various parts of the world and over many decades herbal remedies have also been screened in this way and the evidence is available in the scientific literature. This generally shows that herbs are relatively safe, especially on oral consumption, with any adverse effects mostly tied to very high doses and injections.

Medicine manufacturers are generally required to pass on adverse effects reported to them and in some European countries doctors also have to report adverse drug reactions (ADRs) to the authorities. These post-marketing surveillance (pharmacovigilance) schemes also include herbs where they are categorised as medicines.

Most countries of the world pass their ADRs (as well as miscellaneous poisoning reports) to the WHO Uppsala Monitoring Centre in Sweden. In 2006 their director Ralph Edwards reported (2) that they had received 3.6 million ADR reports from around the world. Of these over 41,000 (1.1%) had listed a herb and just over 17,000 (0.5%) had listed one as ‘suspected’.

The reported ADRs most often associated with herbs were generally minor and transient symptoms: itching skin, urticaria and rash, nausea, vomiting, abdominal pain and diarrhoea and dyspnoea. “Very rare” serious symptoms included facial oedema, angioedema and anaphylactic shock, hepatitis, purpura, thrombocytopenia, Stevens Johnson syndrome, convulsions, erythema multiforme and circulatory failure.

Most herbal ADRs per head of population arise from France and Germany where herbal medicine is part of the mandatory reporting system and where the true level of herbal ADRs relative to those of synthetic drugs might be clearer; yet even here the levels of reports are very low.

Where local research has been conducted, including in Asian countries where herb use is more widespread, a proportion of 1% of all adverse medicine reports keeps recurring. Even allowing for the relative inefficiency of ADR schemes this figure is reassuring. Another way to see the relative hazard involved with herbal and other natural supplements is to look at overall deaths involved compared to other causes. The following chart compiles mortality data from all 27 European member states (view the full size chart here).

When we look more closely at the adverse effects that have been published we see that they can fit into five main categories.

Belladonna
Belladonna

Some plants medicines are dangerous when used incorrectly. A few were used as arrow poisons in days when much food was sourced by hunting. One of these, foxglove, is the origin of digoxin, a very widely prescribed medicine for a failing heart.

Others like mandrake, bryony, aconite have been used in carefully prepared dosages in traditional medicine as well. Opium has been the most widely used pain relief since antiquity but is well known to cause problems in long term use and high doses.

These are plants whose effects are more like conventional prescriptions: with both positive effects and negative side effects or adverse effects. These often contain strong phytochemicals called alkaloids which can have activity on the nerves, heart and other susceptible tissues.

Other examples include the alkaloids of tobacco, lobelia, nux vomica, henbane, belladonna and stramonium.

Powerful toxic or near toxic activity from plants include blocking parasympathetic (or cholinergic) activity (eg the nightshades), damaging the liver (eg. pyrrolizidines alkaloids found in ragworts, comfrey, borage and coltsfoot – see also section on long-term safety), the kidney (eg aristolochia, amaranthus, colchicine), and increasing sensitivity to light (eg. excessive doses of St Johns’ wort).

There are a few plants restricted for sale to the public that herbal practitioners are permitted to use with careful dosing and application. These include poke root, lobelia, mistletoe, greater celandine, lily-of-the-valley, and ephedra. There are no reported adverse reports following such professional use.

The main safety concern with toxic plants is accidental consumption through foraging or by children, of plants such as hemlock, hogweed, deadly nightshade, arum lily, oleander, delphinium, bryony, laburnum, mandrake, mistletoe and columbine. National poisons units hold information about treatment and antidotes if such exposure has occurred.

Inferior products are the most common causes of reported herbal adverse events.

Unfortunately there have always been perverse incentives for providers of medicinal products to doctor their wares. A classic and ancient example is ‘wetting’: a grower or gatherer paid by weight will be tempted not to dry the plant completely as even a couple of extra percentage points of water can substantially increase its weight.

Unfortunately any dampness in stored ‘drugs’ (from the old European word drogen meaning ‘dried plant’) can encourage mould and associated toxins. Finding creative ways to make up orders or prices were to be expected. Harsh penalties for providing poor quality medicines were recorded as far back as ancient Egypt and throughout the mediaeval world, and as Jacob Bell, the founder the Royal Pharmaceutical Society of Great Britain, noted in 1841: “In reviewing the history of pharmacy in all ages we find that fraud has always prevailed to a remarkable extent”.

In response to such experiences, the supply of conventional medicines around the world is tightly controlled by ‘pharmaceutical standards’ of manufacture, involving detailed quality control and associated paper trails, with independent inspections, sometimes unannounced, as the ultimate sanction. In a few jurisdictions the supply of herbal remedies is as tightly controlled (‘herbal medicinal products’ in Europe and ‘therapeutic goods’ in Australia). 

Medicinal standards are published in official national reference texts called ‘pharmacopoeia’. These set agreed definitions and analytical standards required to meet pharmaceutical standards. The early pharmacopoeia were largely devoted to plant drugs (Valeriana officinalis is one of many botanical plant names that reminds us that the plant was ‘official’ in the pharmacopoeia). Many herbs are still listed in pharmacopoeia (e.g. the European Pharmacopoeia, British Pharmacopoeia and those of China, India and elsewhere).

There are also specialist references, the British Herbal Pharmacopoeia and the American Herbal Pharmacopoeia that provide rigorous monographs not covered in the official texts. Manufacturers may choose to use these standards to assure the quality of their products. There are some voluntary assurance schemes aim to apply similar standards, eg, the British Herbal Medicine Association’s HerbMark, that is rolling out for herbal practitioner suppliers.

Most herbal remedies on the market are supplied as food supplements. These are required to meet local food hygiene laws, have accurate labelling, recommended consumption levels, and appropriate allergen and information regarding safe use (eg in children and pregnancy). In the UK enforcement is provided by local trading standards offices and inaccurate information relating to allergens and other known risks renders the supplier liable to other legal measures. These are safeguards when purchasing herbal supplements from responsible manufacturers.

However the buyer needs to beware of less reliable sources.

Compromised quality in herbal products can come about through contamination, adulteration or substitution:

  • Contamination is the (often unintended) presence of other materials, including soil and related matter, soil-based heavy metals (some herbs, eg St John’s wort, bacopa, and gotu kola naturally accumulate these and need closer testing before entering the market), infective organisms or pesticides, all these most often due to loose quality controls. Testing for these is a key part of normal herb manufacturer quality control; of course sourcing herbs with organic certification is one way to reduce the pervasive contamination of all the food chain with pesticides.  Recently specific controls have been widely instituted to reduce contamination of herb crops with ragworts containing high levels of hepatoxic pyrrolizidine alkaloids.
  • Adulteration is the intended addition of different materials to enhance appearance or intended effect: this can include pigments, isolated phytochemicals like polyphenols, or in modern times even synthetic drugs like steroids. In some early traditions heavy metals were added to plants to increase potency and this is still found occasionally.
  • Substitution is when the plant is not what is labeled, either in error, due to linguistic confusion, or to reduce cost or when there is limited availability.

A notable example of the latter is the Chinese herb Aristolochia fangchi which has long been a commercial substitute for Stephania tetrandra (mandarin name: hang fang ji).

Unfortunately its constituent aristolochic acid has been associated with serious kidney damage in Europe, notably when the substituted ‘stephania’ was administered by doctors as part of a conventional intensive dieting regime in Belgium, with many suffering cancer and terminal kidney failure. This single episode in the early 1990s led to a major review of herbal quality in the UK and other countries. A similar occurrence followed widespread substitution of skullcap by a species of germander (Teucrium chamaedrys) and associated cases of liver toxicity reported in France.

Another substitution example relates to black cohosh, which has been identified as linked to a cluster of severe liver complications; however suspect products were found to contain a different species entirely. Unfortunately adulteration of this valuable plant is common.  In general the more expensive or in-demand the herb, the more likely it is that it will be substituted. Golden seal and ginseng are other classic examples.

Ginkgo leaf is often adulterated with added polyphenols and there are reports of adding pigments to sometimes substituted products marketed as elderberry and bilberry.

The best protection against consuming contaminated, adulterated or substituted herbs  (and where there is no external quality controls) is to buy only from reliable and well-established producers, with transparent quality control measures, and reputations to protect. Avoid buying from suppliers you do not recognise and particularly so if these are marketed over the internet. In general if the product is surprisingly cheap it should be avoided.

There are three types of adverse reactions that cannot be predicted, but which can occasionally have serious consequences.

Intolerance

Intolerance is the least severe and is an exaggeration of the activity of the substance in a few individuals. It is more likely to occur with foods than herbal remedies. With foods it is sometimes erroneously referred to as ‘food allergy’: however this is a much less common immunological reaction (see below).

Allergic/hypersensitivity reactions

Allergic or hypersensitivity reactions are dramatic over-responses of one part of the immune system associated with surface defences (perhaps originally targeted against parasites). They involve activation of a type of white blood cell (the mast cell) to release histamine and other inflammatory chemicals, and also the development of immunoglobulin (Ig) E antibodies.

Hayfever (in response to pollen) is the most common, but true allergies can be to almost anything. In the case of food substances such as gluten or lactoglobulin from milk they are often ‘masked’ so that the direct cause-effect connection can be difficult to make. Dangerous frank hypersensitivity reactions are increasingly recorded to peanuts, shrimps and other crustaceans.

Among conventional drugs such reactions are most likely with NSAIDs, angiotensin-converting enzyme (ACE) inhibitors and antibiotics. Very rarely these can include herbal remedies, with members of the daisy family (Compositae, including chamomile and echinacea) and mugworts among those most encountered. By definition the reaction once established is almost instantaneous.

Confusingly the term “allergic” is sometimes used to describe immune-related idiosyncratic reactions, when toxicity appears after several asymptomatic administrations of the compound (see below).

Idiosyncratic drug reactions (IDRs)

Idiosyncratic drug reactions (IDRs) are rare, unpredictable reactions to a substance that are not dose related and usually are delayed (although rapid on re-exposure). They include complex immune responses and are caused by the combination of a reactive metabolite of the substance with cellular proteins, and the production of DNA adducts. Symptoms can be severe and include anaphylaxis, fever, skin reactions, arthritis and lupus syndrome. Blood tests often show increased levels of eosinophil white blood cells. A notable type of IDR involves the liver and can closely mimic viral hepatitis.

IDRs account for most of the rare severe herbal adverse reactions. The observed liver problems that were associated with taking standardized kava-kava were probably idiosyncratic (Our safety book included a detailed case-by-case analysis of these reports and showed in forensic detail how misleading most were, concluding that the few clear cases were idiosyncratic rather than toxic, and incidentally giving a clean bill of health to traditional water extracts).

Some conventional drugs, eg antiepileptics and antidepressants, are more likely to induce IDRs and there seem some chemical types more likely to do the same in plants: kava contains one such group, lactones, and they occur also in the germander responsible for the French cluster of liver disease reported earlier.

IDRs are rare and unpredictable and generally do not suggest inherent toxicity. However, this has not stopped prohibition of kava across UK and Europe and risks to the availability of black cohosh (even with adverse effects linked to an adulterant – see above). If there is a cluster of IDRs (as can happen for several reasons) then the fate of any herb involved can be threatened.

Grapefruit
Grapefruit

There is always the possibility that two ingested substances will interact in their metabolism within the body. This is particularly likely in the liver: here there are many complex mechanisms for processing any molecules that are not core food materials.

Notable among these are cytochrome P-450 (CYP450) enzymes, a hierarchy of 14 enzyme families in the liver and most organs and tissues of the body. They are almost as adaptable as the body’s immune system and are designed to be able to metabolise an almost infinite range of molecules that might be taken in from the environment.

Such foreign molecules (sometimes referred to as xenobiotics) include medicines, and also most plant chemicals. Their metabolism includes engagement in complex dynamics with the hundreds of enzymes involved. Each CYP450 substrate can also inhibit the enzyme acting upon it, or by contrast can induce it, so that its effect on other molecules is changed.

One classic example is grapefruit. This is known to inhibit two enzymes: CYP2A6 and CYP3A4. The latter breaks down a wide range of medicines, including blood thinners, anti-cholesterol, heart and blood pressure medicines, anti-depressants, antihistamines, viagra and contraceptives, and notably anti-HIV and immunosuppressive drugs. In other words taking grapefruit at the same time as these medicines will reduce their breakdown rate and increase their activity in the body.

By contrast St John’s wort induces CYP3A4, so increasing the breakdown rate of the same medicines above. This means their effects may be reduced and St John’s wort remains the herb that doctors most worry about for its unintended potential for compromising the activity of sometimes critical medicines.

Low levels of interactions of these types are common between medicines and foods. Simple foods like garlic, brassicas, red wine and many common culinary spices can all interact with CYP450 enzymes and affect the availability of prescription medicines. However the key point is that most of these are:

  1. Theoretical interactions (mostly observed in the test tube)
  2. With very little reported evidence of impact in the real world

Additional scope for interactions lie with the physical properties of some plant constituents. Plant tannins, mucilages, saponins, and resins can theoretically slow absorption from the gut; hot spices may increase it. However again the real impact is doubtful and in any case food is more likely to be concern than herbal remedies.

Serious herb-drug interactions are probably rare. This is the view of all those in the regulatory field who have watched the surveillance data closely over many years. However many modern medicines are very strong and are used in critical situations. The challenge is that powerful prescription medicines may also have a ‘narrow therapeutic window’: problems can occur if they are either over- or under dosed. If one is on a such a regime it is important to be careful to monitor the effects of taking other medicines, herbs and foods.

Most reported reactions to herbs are not a threat to health, nor long term. Minor reactions to herbal treatment are quite common, especially at the beginning of a course of treatment.

There is an ancient precedent here. In the past herbal treatments were often robust and even unpleasant, to reflect the fact that they were often emergency medicine. Nowadays the emphasis is on supportive herbal treatments but in bringing about healthy changes in the body it is not surprising that there may be associated discomforts.

However the majority of such changes are transient and minor, including diuresis, changes in bowel performance, more productive coughing to clear an obstructed chest, or more sleepiness. It is also possible to see ‘healing crises’: short-term flare-ups in skin or headache symptoms, transitionary increases in menstrual symptoms.

Practitioners usually include calming components into their initial herbal blends to reduce the tendency of some conditions to exacerbate but a few people’s constitutions are trigger-happy.

The placebo effect is noted in controlled clinical research trials among subjects taking the sham treatment. Surprisingly, placebo benefits can occur in any proportion of a treatment group, from almost none to most, depending on the condition and circumstances. Distilling much debate on this, placebo can best be seen as a testament to the powerful healing forces that the body has, and how little it sometimes takes to mobilise them. It also suggests that providing support and reassurance can exert real physiological effects on the body.

However placebos can also generate significant levels of adverse effects. This is referred to as the nocebo phenomenon. In one review of placebo-controlled trials involving healthy volunteers, adverse responses were reported in almost a fifth taking placebo, increasing up to a third on repeated dosing. Overall the most frequent adverse reports were headache, drowsiness, and energy loss. In another review of studies of five different medications in the areas of cardiology, neurology/psychiatry, metabolism, and gastroenterology, it was shown that the placebo side effect profile was largely similar to the side effect profile of the active treatment.

It appears that having expectations of adverse effects from taking a medicine is more likely to lead to their happening (doctors should never say “there is nothing more we can do”). It also seems that people with anxieties can more easily generate physical symptoms. If nocebo effects can happen to dummy pills then they will feature after any remedy. Most practitioners will know patients who react badly to almost anything they are given.

Whereas we can be reasonably confident that short-term (‘acute’) side effects will have been well understood over thousands of years of human experience, we can not be so sure about the possibility of long-term (‘chronic’) consequences. Delayed effects of a substance can be hard to connect if they occur many years later, even with modern databases and record keeping. It is almost unimagineable that such connections would have been possible in the past.

Root Of Healthy Vision

The types of long term problems that might follow exposure to hidden ‘iceberg’ dangers include cancers, chronic inflammatory and auto-immune diseases, and chronic liver and kidney problems. However there is not much evidence that plant ingredients of any sort are linked to such conditions. Most evidence of connection comes from epidemiological observations of the effect of diet, lifestyle and environmental exposures.

For example the International Agency for Research on Cancer, part of the World Health Organization lists about 200 known or probable carcinogens, including coal tar, asbestos and processed meat. The only plants that make the list are Aristolochia (see above), betel nut and tobacco.

Some individual plant constituents have demonstrated mutagenic or carcinogenic activity in the laboratory or in animals (an example is the isolated compounds estragole and methyleugenol variously found in fennel, nutmeg, basil and tarragon, and coumarin found in Cassia cinnamon) but the case that these are dangerous to humans is contentious and  there are only limited measures to restrict access to the plants that contain them. Exposure to some dietary ingredients (like gluten, animal products) has been linked to inflammatory and immunological problems. However the case against dietary plants is very limited.

There is one part of the body relatively vulnerable to untoward impacts of some plants: the liver. As we have seen this is central to the metabolism of non-dietary constituents, including from plants. The very things that can be valuable as medicines can pose extra work for liver metabolism, this compounded by excess alcohol consumption, fatty diets and prescription or other medication.

Some of the most serious rare idiosyncratic adverse effects linked to plants, such as to germander, kava, and black cohosh (or substitute), also lead to chronic hepatic damage and consequent health problems in later years. This risk, even if rare, has led to such plants being widely restricted. However the rarity means that the risk of trouble to most plants is considered to be too small to present a public hazard.

However one case demonstrates the need for caution. Pyrrolizidine alkaloids (PAs) are a group of constituents in many plants, including ragworts, comfrey, borage and coltsfoot. Most of their toxicity data comes from animal studies and indicates that some PAs are hepatotoxic, genotoxic and carcinogenic. There are also human case reports of poisonings due to PA-containing plants, including deaths associated with grain crops contaminated with PA-containing weeds.

PA poisoning in humans is characterised by acute hepatic veno-occlusive disease. The acute disease is associated with high mortality, and a sub-acute or chronic onset may lead to liver cirrhosis. There is more information on PAs in our article “Pyrrolizidine alkaloids: What you need to know“.

Because some of the plants involved have been valuable remedies there has been resistance among the herbal community to restrictions as these particular plants have not yet been linked to harm and there is reasonable doubt about the dangers of all PAs. However others have taken the view that the risks and uncertainties do not adequately reassure the public that taking these plants is safe and have voluntarily stopped supplying them.

As far back as the early 1980’s the root of comfrey in internal remedies was withdrawn from trade catalogues for this reason (it remains an excellent external healing remedy). Most concluded that this was a case was not worth fighting, given a significant risk to the public, and a mode of action and delay that meant trouble could not be safely ruled out.

Breastfeeding Naturally

Be cautious with herbs during pregnancy and breastfeeding

There are always extra cautions in taking any remedies during pregnancy and a professional herbalist’s default position is to back off altogether during the first trimester (while the baby’s organs are forming) unless really necessary. Practitioners will not use strong herbs at all during pregnancy and any listed as risky elsewhere in this article should particularly be avoided. Many reference texts on herbs assume that if a herb has not been proved to be safe in pregnancy it should be avoided, without medical opinion at least.

On the other hand many herbs have a good combination of widespread use by pregnant women with reassuring research evidence: our textbook rates many western herbs by tight criteria and finds many a pregnant woman can choose from.

There is evidence that regular consumption of large amounts of licorice through pregnancy might interfere with the birth and even embryonic development. This effect is linked to the hormonal properties of licorice (inhibition of an enzyme that converts cortisol to cortisone). The available evidence is that a safe to take up to 6 g of (or up to 250mg of glycyrrhizin) per week during pregnancy. If there is associated high blood pressure (e.g. pre-eclampsia) liquorice should be avoided altogether.

Although precautionary statements have been made about the use of some herbal remedies during breastfeeding the evidence for risk is minimal. Plants with high levels of volatile oils will pass these easily through breastmilk so nursing mothers should be aware that these may affect their babies. This can actually be helpful, as in the case of reducing colic in infants by the mother consuming kitchen spices (although occasionally the reverse can happen). Some of these have additional reputations for enhancing breast milk production.

Don’t overdo it!

In traditional medicine herbs were often taken in ‘heroic’ doses for maximum short-term effect and at much higher levels than are usually applied today. Nowadays doses may range from 0.25g-100g/day, with most in the lower range consistent with their use as supportive and gently nudging remedies. This provides a good margin of safety.

There are some cases where higher doses can present problems. Obviously all the risky herbs mentioned above are very dose sensitive. If you have high blood pressure you should restrict your licorice consumption to a few grams or less a day.

You should avoid huge regular doses (more than 30g a day) of some of the spices like fennel with high estragole and methyleugenol content. Be particularly aware of dosing if you are also on prescription medicines with a narrow therapeutic window.

However common sense should prevail and the best advice is to observe recommended doses. Using herbs as part of our everyday diet, like chamomile, ginger and peppermint, or a sprinkle of a spice or herb on our food is, of course, completely safe.

When using herbs more  ‘medicinally’, in general one should always be looking for an exit plan in starting a herbal programme: the best herbal treatment is one that nudges the body to better performance. However there are some situations where long term use is needed, for example, adaptogenic herbs have incrementally benefit into the long term.

But, as we have seen, we cannot be absolutely sure what long term effects might build up and focused use of herbs is always the best option. Do review what your plan is if you are taking the same herbs for more than a year. It is always a good idea to have a break within this time to check that the herbs are still being useful.

Be sensible and all will be well.

  1. Mills S & Bone K (2005) The Essential Guide to Herbal Safety. Elsevier/Churchill Livingstone, Edinburgh.
  2. Ralph Edwards, Director, WHO Collaborating Centre, Uppsala. Reporting to Pharmacovigilance of herbal medicines: current state and future direction London 24-26 April 2006.

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What is herbal medicine? https://www.herbalreality.com/herbalism/western-herbal-medicine/what-is-herbal-medicine/ https://www.herbalreality.com/herbalism/western-herbal-medicine/what-is-herbal-medicine/#comments Fri, 29 Oct 2021 15:21:29 +0000 https://www.herbalreality.com/?p=2887 Herbs are very well suited to expert personalised health care, and were the basis of all systems of medicine until modern times.

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Herbs are very well suited to expert personalised health care, and were the basis of all systems of medicine until modern times.

What is herbal medicine?

There is no one type of herbal specialist. Due to a wide variety of national regulations different titles and approaches to herbal practice will be used around the world. In most countries of the world herbalism is the default local community option. However industrialised countries have lost much of that connection, and have often restricted healthcare delivery to registered medical practitioners. Signposts are needed in these countries and the following is a partial guide. Note that when the practitioner does not include ‘herbal’ in the title this may be for legal reasons (prescribing herbs as medicines is restricted to doctors in many parts of the world): one can check whether they provide substantial herbal treatment when making enquiries.

  • United Kingdom and Ireland: ‘Herbal practitioners’, ‘medical herbalists’, traditional Chinese medicine and Ayurvedic practitioners, ‘phytotherapists’.
  • USA: Nutritional therapists, herbalists, naturopaths (depending on the State); chiropractors often provide herbal support.
  • Australia, New Zealand, Canada: Naturopaths, herbalists, medical herbalists, nutritional therapists.
  • Europe: Across most of the continent herbal medicine is restricted to doctors and pharmacists and is referred to as ‘phytotherapy’; in some German states Heilpraktikers provide an alternative that usually includes phytotherapy; herboristas practise a form of nutritional therapy in Italy, and there are a few similar exemptions elsewhere.

In the UK ancient Common Law rights to consult the practitioners of one’s choice have not been eclipsed by prescriptive state laws as in Europe and the USA, and to a certain extent this is also true in Ireland, Australia, New Zealand and Canada. The UK provides a particularly diverse range of opportunities. Here there are many different traditions and schools of practice, and also a wide range of techniques. However, there are four dominant cultures of herbal practice.

Western herbal medicine

‘Western’ herbal medicine combines approaches inherited from the ancient Greeks and Romans (‘Galenic medicine’) with folk practices from around Europe and also from North America. It tends also to adopt the language and some of the approaches of conventional medicine and can usually provide complementary treatment options for modern disease conditions in terms that fit relatively well with the conventional language about health. These practitioners are most likely to provide liquid prescriptions, as individual mixes of tinctures and liquid extracts, along with herbal teas and syrups.

Traditional Chinese medicine

Traditional Chinese Medicine (TCM) practitioners apply principles drawn from thousands of years of practice and classical texts in China. Various interpretations are applied, although most reflect the harmonisation that followed the formal adoption of TCM after the founding of the Peoples Republic of China in 1949. TCM has a very clear system of assessing physical and mental health using a dynamic system of energetic principles. It often applies well-established and sophisticated herbal formulae though also maintains a tradition of using individualised blends. Pulse and tongue are most often integral to practitioner assessments.

Ayurveda

Ayurveda distils thousands of years of practice and lifestyle in India and is much broader than the prescription of medicines. Although suffering particularly from cultural overshadowing through the 400 years of the British Raj, its roots are very deep indeed and it has flowered strongly, increasingly finding its voice separate from the language of the west. Ayurvedic herbal remedies have also emerged as exciting potential contributions to modern health care needs and we focus on some on Herbal Reality.

Unani medicine

Unani medicine is named from the Arabic for ‘Greek’ and is a thousand-year old revival of Galenic medicine widely practised across the Islamic world, and supported by many university medical schools. Galen was a Graeco-Roman physician of the 2nd  century who gave his name to a medicine comparable to that emerging at the same time in India and China. In true Galenic tradition, Islamic medicine is notable for its regard for the specific quality of individual medicines as contributions to prescription blends. In western countries this option is most often provided within Islamic communities rather than into the mainstream.

To find out more where to look for herbal practitioners it is wise to start with their professional associations. These will require standards of education and training, and provide professional codes of practice, insurance cover and other reassurances for patients. You can learn how to find a herbalist on our resources page.

Latest News In Herbalism And Healthcare

Herbs are the most accessible self care remedies, and for anyone wanting to look after themselves and their families we introduce many on Herbal Reality. However, they are also what physicians have used, and even today around the globe many thousands of doctors and other practitioners still regularly prescribe herbs to their patients.

Herbs are very well suited to expert personalised health care, and were the basis of all systems of medicine until modern times. Indeed the classic traditional systems were largely framed by the innate qualities of plant medicines.

A herbal practitioner identifies your signs and symptoms and then, following from a detailed conversation with you, clusters them into identifiable patterns. This then leads to a treatment plan and a selection of specific herbs and other life-style advice to form a treatment journey ahead. 

Anyone who finds that their healthcare situation is more complex or challenging for self care may find consulting a well-trained herbal practitioner very productive.

In the hour or so of a first session it is very encouraging how a careful herb-based treatment plan can break through health logjams.

So where to start?

A visit to a herbal practitioner is usually very different from a conventional medical consultation (although in Europe some conventional physicians do prescribe ‘phytomedicines’ in their usual practice).

The most obvious difference is that the herbal practitioner usually has no prior case notes to refer to and will want to build a treatment plan from scratch. So a first consultation often takes a good time, usually at least an hour. This allows the personal story to emerge, so that what might start as arthritis or indigestion, turns into an individual journey with unique causes and characteristics.

The technical medical name for this process is anamnesis (from the Greek for ‘opening memory’) and this has been contrasted with the usual doctor’s role of diagnosis (Greek for ‘distinguish’): it can simply be summarised as sharing stories.

Story sharing is fundamental to the herbal approach. Although symptom relief is the priority, the way plants best work is to mobilise healthy body functions rather than attack the end results of disease. Rather than focus on the diagnosis of the symptoms, the work of the practitioner is to assess the internal disturbances that lead to them. This will also include learning more of the person’s circumstances, lifestyle and environment, to understand some of the external pressures. However, “herbs do not change the weather” and rather are applied to support the individual’s internal responses to the outer world.

The practitioner will be interested in

  1. The illness story: Learning how the problems unfolded, whether perhaps there are primary events that started the train and which deserve focus; and
  2. The bedrock: Understanding how this particular body jumps when it is pushed. The constitutional assessment is a core feature of traditional systems, recognising that different constitutions account for different reactions to problems.

The aim will be to integrate the constitutional tendencies with the course of events to work out where to apply the herbs most productively, to change the way the body performs. In TCM they call this ‘addressing the root and the branch’.

Herbal medicines have sometimes been thought of as performance enhancers rather than ‘fixers’. They can ‘nudge’ healing functions, improve coping in the face of adversities, and calm disruptions. Using them entails a different sort of conversation with the patient, one that takes time, and effectively draws the story out. An excellent description of the ideal consultation is as a shared ‘healing presence’.

The different languages that practitioners adopt to make assessments are usually derived from various traditional approaches; they can seem confusing. However, all have in common deep roots in the fundamental principles and language of nature.

To understand the origins and power of herbal medicine one needs to step back in time. Before modern scientific measurements and investigations, humans had only their senses and wits to survive. Hunters needed to read all the signs, the terrain, the wind direction, the marks in the ground.

Sailors depended for their lives and livelihoods on understanding the seasons, weather, the tides, and like hunters the behaviour of their catch. Farmers would learn to read all the signals for optimum planting and cropping.

Physicians did likewise. For them the body was a microcosm of the rest of the universe, subject to the same climatic and seasonal influences; looking for causes of disease entailed all the primal skills of the hunter. Wise women and the other first herbal healers needed to learn how to read the body’s behaviour in responding to adversities. Early medicine depended on sharp observations of nature. The ancient classic texts of medicine wrote them down.

Modern smart commentators often mock references to hot and cold, damp and dry, yin and yang, the doshas, ‘elements’ and other descriptors from traditional medicine. What they ignore is the real wisdom these terms distil, the valuable insights into the way the human organism behaves as a being in nature, manifesting patterns like any river, sea, field or forest.

They confuse the modern science of quantities with the earliest science of qualities: the ability to make sense of and survive our natural environment. As it happens modern science can find useful rationales for these old ideas and the scope for a reconciliation is very promising.

Medicine making with children: Recipes to try at home

Beneath all the vast diversity of languages and approaches to the use of healing plants there is an obvious point: there is only one species involved, Homo sapiens. There is an other less obvious point, but as important: the impact of plants on humans is also remarkably constant, around the world and through history.

In our Insight article about herbal evidence we look at classic ways in which plant constituents act on the body, ways that were understood before history, described fully in various classic texts around the world, and reinforced by modern science.

If we dig beneath the thousands of medicinal plants we can find common features, mostly detected by our ancestors through taste, smell and other senses.

Those with mucilages are soothing and healing, with resins antiseptic, with aromatic volatile oils settling, with bitters stimulating digestion, with hot spices stimulating circulation, and so on. There is a powerful tool chest of remedies to support healing in the body that we can all share.

The most common medical view today is that mind and body are separate, mental is different from physical, consciousness is something outside the body. This dualism was first clearly articulated by Rene Descartes (and is referred to as ‘Cartesian’ in his memory) but has origins also in religious traditions of a separate perhaps eternal soul.

In a fundamental sense the work of the original physicians, from wise women through the practitioners of classic traditions of medicine, has been based on an opposite view that there is no real separation between bodily, mental and spiritual functions. Most traditions of medicine see the world in energetic terms, in which the body, mind and spirit are different manifestations of the same being.

Some practitioners do work in a specific religious context, deferring to a higher and separate force, but in industrialised societies these are a minority. For most herbal practitioners all elements of a person’s story are relevant to understanding how to help that person get better. Although herbs are usually seen to move at a physical or physiological level, they can affect the person at any level.

asian couple doing yoga

Consulting a herbal practitioner is different from a visit to a conventional doctor because the work is different. Herbalism applies the characteristics of plant medicines to do what they do best: to help the body do its normal job of maintaining health.

Symptoms are seen as signs that the body is not coping as it should and that it needs help. Herbalists are therefore more interested in understanding how the body performs and where it is slipping up than in diagnosing or fixing a disease.

This means a different sort of enquiry: rather than list or measure what has gone wrong they prefer to assess and support what should go right, and apply the plants because they nudge corrective functions in that individual.

The early human insights into medicine based on plants gave us tools that we can use to gently and powerfully nudge ourselves to better health.

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Where is the herbal evidence? https://www.herbalreality.com/herbalism/western-herbal-medicine/herbal-evidence/ https://www.herbalreality.com/herbalism/western-herbal-medicine/herbal-evidence/#comments Fri, 29 Oct 2021 15:21:27 +0000 https://www.herbalreality.com/?p=2718 How our use of herbs is founded on both science and intelligence.

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Many say that herbal remedies have not met certain standards. We address that charge and argue for more herbal evidence.

Modern expectations for medicines are that they should have been thoroughly tested to make sure that they work and are safe. Doctors and health regulators use the term ‘evidence-based medicine’ (EBM) as their default for approving treatments.

Although this principle does not always apply in medical practice, many say that herbal remedies have not met these standards and should not be recommended. Here we will address that charge and argue that the appropriate use of herbs is fully justified.

Where is the herbal evidence?

The ‘gold standard’ measure of efficacy is the randomised double-blind controlled clinical trial (RCT). The remedy to be tested is given to a population of subjects on the same basis as a placebo or comparison medicine in a way that neither the subjects nor the investigators know who is getting which.

This is intended to reduce conscious and unconscious bias, and by careful matching of each comparison group, and choosing a large enough population, to eliminate other factors such as natural improvements in the condition, suggestion and expectations, that may affect outcome.

There are many arguments about the reliability of the RCT to all circumstances and conditions. It does not reflect individual experiences of illness, is less useful in complex, rare and long-term conditions and blinding is often hard to assure.

‘Publication bias’ results when authors and sponsors hold back on results that do not reflect their expectations and tends to skew reports towards those that are positive. RCTs are very demanding and methodological rigour is also not assured. Nevertheless there is no substitute for a good RCT if we want to get some measure of the independent activity of a remedy.

RCTs require complex organisational capacity, specialist statistical and other skills, are subject to intensive ethical scrutiny, and therefore are notoriously expensive. However there are increasing numbers of such studies being published for herbs.

There is no doubt however that the RCT inventory for herbs is patchy and usually not conclusive. The best way to consider the evidence base is to link it to the most substantial resource we do have: the many centuries of human experience.

We can claim really useful information by distilling out the vast store of historical and anthropological records for the use of herbs as medicines (the science of ethnopharmacology). We can note that there would have been little room for sentiment and idealism in the life-and-death situations that prevailed through most of history.

The herbal remedies that have floated to the top of popular reputation around the world will have been tried and tested in the most adverse conditions, as the only medicines available and without backup ambulances and hospital emergency rooms: if they did not work they would not have been continuously and widely used.

However without rigorous screening the record of traditional use can appear motley. Each community and even family will have its own favourites. The placebo effect of a cultural icon is very powerful: if everyone around you is convinced that the remedy will work then it likely will.  Assessing traditional reputations is only reliable if we take broad overviews of the multitude of local stories.

Fortunately we can do this. We can take anthropological records from around the world. We can discount one tradition as a local fashion; if we can find a similar use in two discrete locations that looks like something more substantial; three or more distinct uses becomes a much stronger lead.

Some of our most popular remedies, like green tea, liquorice, chamomile, dandelion, mint, ginger, turmeric, cinnamon and other spices, have all established global reputations by being rediscovered anew in many parts of the world.

Some of the regional high flyers have grown their reputation across many distinct regions in their own continents and have established themselves more widely as well.

We can also go deeper and look at what emerge as universal core pharmaceutical principles of early medicine, applying the simplest of all technologies: taste, smell and other senses.

When animals encounter plants they use their senses to understand them. Taste and smell are the main judges of quality and safety. Humans inherited these same instincts and then elaborated them to construct basic pharmaceutical standards for evaluating their remedies.

All classical medical traditions, from India, China, Islam and Europe categorised their medicines by taste and sensory quality. Although the language and cultural meanings were different the core insights were astonishing consistent and we can distil simple principles that each of us can use today.

If you look at the descriptions of the herbs on this site you will see that we invite you to do what our ancestors did: taste the herb! This is often a striking revelation. From what is often a powerful simple sensory hit we can often feel for ourselves what our elders understood about these remedies.

The following presents commonly encountered impacts of herbal remedies and how they translate into modern descriptions of their effects when we consume them. Key phytochemical groups are in bold: these most clearly transfer sensory experiences into pharmacology and are like the Rosetta stone – they provide instant translation of multiple local traditions into modern language.

Lavender (Lavandula angustifolia)
Lavender (Lavandula angustifolia)

Aromatic flavour

An ‘aromatic’ remedy, high in volatile essential oils, was most often associated with calming and sometimes ‘warming’ the digestion. Most kitchen spices and herbs have this quality: they were used both as flavouring and to ease the digestion of sometimes challenging pre-industrial foods. Many aromatics are classed as ‘carminatives’ and are used to reduce colic, bloating and agitated digestion.

They also often feature in respiratory remedies for colds, chest and other airway infections. They are also classic calming inhalants and massage oils, and are the basis of aromatherapy for their mental benefits.

Astringent taste

The puckering, astringent taste you get with many plants (the most familiar is black tea after being stewed too long, or some red wines) is produced by complex polyphenols such as tannins. Tannins are used in concentrated form (e.g. from oak bark) to make leather from animal skins. The process of ‘tanning’ involves the coagulation of relatively fluid proteins in living tissues into tight clotted fibres (similar to the process of boiling an egg).

Tannins in effect turn exposed surfaces on the body into leather. In the case of the lining of mouth and upper digestive tract this is only temporary as new mucosa are replenished, but in the meantime can calm inflamed or irritated surfaces. In the case of open wounds tannins can be a life-saver – when strong (as in the bark of broadleaved trees like oak) they can seal a damaged surface.

One group of tannins, the reddish-brown ‘condensed tannins’ are classified as procyanidins, which can reduce inflammation and oxidative damage.

Bitter taste

Bitters are a very complex group of phytochemicals with one thing in common: they stimulate the bitter receptors in the mouth. They were some of the most valuable remedies in ancient medicine. They were experienced as stimulating appetite and switching on a wide range of key digestive functions, including increasing bile clearance from the liver (as bile is a key factor in bowel health this can now be translated into improving bowel functions and the microbiome).

Many of these reputations are being supported by new research on the role of bitter receptors in the mouth and elsewhere round the body.

Bitters were also seen as ‘cooling’ reducing the intensity of some fevers and inflammatory diseases.

Blue/purple colour

Any fruits with a blue-purple colouring contain high levels of the polyphenols known as anthocyanidins. These work:

  1. On the walls of small blood vessels, helping to maintain capillary structure to reduce a key stage in inflammation, and improving the microcirculation to the tissues
  2. To improve retinal function and vision
  3. To support connective tissue repair around the body.
Chilli pepper plant (Capsicum annuum)
Chilli pepper plant (Capsicum annuum)

Hot/spicy taste

Traditional ‘hot’ or ‘heating’ remedies, often containing spice ingredients like capsaicin, the gingerols (ginger), piperine (black or long pepper), curcumin (turmeric) or the sulfurous isothiocyanates from mustard, horseradich or wasabi, generate warmth when taken. In modern times this might translate as thermogenic and circulatory stimulant effects.

There is evidence of improved tissue blood flow with such remedies: this would lead to a reduction in build-up of metabolites and tissue damage.
Heating remedies were used to counter the impact of cold, reducing any symptoms made worse in the cold. The proof of this effect is in the doing of it: the results are often almost immediate!

Mucilaginous quality

Mucilages are complex carbohydrate based plant constituents with a slimy or ‘unctuous’ feel especially when chewed or macerated in water. Their effect is due simply to their physical coating exposed surfaces. From prehistory they were most often used as wound remedies for their soothing and healing effects on damaged tissues.

Nowadays they are used more for these effects on the digestive lining, from the throat to the stomach, where they can relieve irritation and inflammation such as pharyngitis and gastritis. Some of the prominent mucilaginous remedies like slippery elm, aloe vera and the seaweeds can be used as physical buffers to reduce the harm and pain caused by reflux of excess stomach acid.

Mucilages are also widely used to reduce dry coughing. Here the effect seems to be by reflex through embryonic nerve connections: reduced signals from the upper digestive wall appear to translate as reduced activity of airway muscles and increased activity of airway mucus cells. Some seed mucilages, such as in psyllium seed, flaxseed (linseed) or guar bean survive digestion to provide bulking laxative effects in the bowel. These can also reduce rate of absorption of sugar and cholesterol

Resinous taste

Resins are most familiar as tacky discharges from pine trees (and as the substance in amber, and rosin for violin bows). They were most valued however as the basis of ancient commodities like frankincense and myrrh (two of the three gifts of the Three Wise Men to the baby Jesus) and getting access to their source was one benefit to Solomon for marrying the Queen of Sheba (now Ethiopia). Resins were the original antiseptic remedies, ground and applied as powders or pastes to wounds or inflamed tissues, and were also used for mummification.

With alcohol distillation it was found that they could be dissolved in 90% alcohol and in this form they remain a most powerful mouthwash and gargle, for infected sore throats and gum disease. They never attracted much early research interest because they permanently coat and damage expensive glassware! For use in the mouth, gums and throat they are best combined with concentrated licorice extracts to keep the resins in suspension and add extra soothing properties. It appears that they work both as local antiseptics and by stimulating white blood cell activity under the mucosal surface. They feel extremely effective!

Sharp taste

The sharp taste of some fruits, and almost all unripe fruits, as well as vinegar and fermented foods, is produced by weak acids (the taste is generated by H+ ions from acids stimulating the sour taste buds). Sour taste buds are hard-wired to generate immediate reflex responses elsewhere in the body. Anyone who likes the refreshing taste of lemon or other citrus in the morning will know that one reflex effect is increased saliva production.
Other effects are subjective rather than confirmed by research but there is a consistent view that they include increased digestive activity and contraction of the gallbladder.

Smell of hay

The familiar country odour of haymaking, of drying grass and other plants, is largely produced by coumarins (originally isolated from tonka beans – in French coumarou) and widely used in perfumery. They have strong antioxidant activity in the laboratory and likely effects in modulating inflammation. They were most often associated with plants used in stuffing mattresses and pillows to encourage sleep.

Soapiness

When extracted in water some plants cause a lather and are used for washing. This property is due to the presence of saponins (from the Latin for soap), which are plant steroids.

Plants that are rich in saponins keep appearing across the world as important gynaecological and adaptogenic remedies (examples are shatavari, ashwagandha, astragalus, brahmi, ginseng, eleutherococcus, liquorice, kava, wild yam, and several important Native North American women’s remedies). Given this striking association it has been speculated that these plant steroids may modulate steroids metabolism in the adrenal cortex, ovary, and testes. Saponins are discussed briefly in a similar context under the sweet taste below.

Other saponins are used for their detergent properties as cough remedies: examples are the primulas, soapwort, senega, and ivy leaf. These exert a minor irritant effect similar to that of emetics and induce a well-known expectorant response by reflex from the upper gut to the airways.

Sweet taste

In the days when most people never tasted sugar, ‘sweetness’ was associated with the taste of basic foods: that of cooked vegetables, cereals and meat. In other words sweet was the quality of nourishment, and ‘tonic’ remedies. Describing a remedy as sweet generally led to that remedy being used in convalescence or recovery from illness.

Interestingly, the plant constituents most often found in classic tonics like licorice, ginseng are plant steroids including saponins, which also have a sweet taste.

A key point about these sensory guides to the action of herbs is that they led to a quite different understanding of what a medicine does. In herbal tradition medicines were classified by what they did for the body rather than what diseases you used them for. Medicines were warming or cooling, drying or moistening; they moved variously through the body, they aided eliminations from various quarters, they tonified.

The aim in herbal treatment is to match the action of the medicine to the needs of each individual. It is critical in understanding the traditional evidence base to understand this distinction and to incorporate it into any practice-based judgment.

Willow bark (Salix alba)
Willow bark (Salix alba)

Even however taking a modern medical view, there are many other cases where scientific research can illuminate and validate traditional practices, and vice versa. The early use of salicylate-rich willow bark to reduce fever and inflammation, the widespread use of liquorice sticks as tooth brushes, the 3000-year use of psoralen-rich plants in the treatment of vitiligo in India, the use in ancient Egypt of a treatment for angina pectoris based on visnagin and khellin, the unusual traditional practices in the growth and preparation of kava for reducing anxiety: all have all been validated by modern research and lessons have been learnt.

Ethnopharmacological studies show countless examples where pharmacological activity can be demonstrated in traditional remedies and practices.

Such tie-ups are clearly interesting; in effect the early reputation provides “human bioassay data” as a basis for future research and an assurance of relative safety. By contrast modern medicinal research has to start with novel chemicals that have never been used by humans before, and most promising new leads fail for safety reasons.

The examples above suggest that being able to combine two or more incomplete data sources can provide useful pointers to benefit, especially as the calculations are bedded in longterm human use over centuries.

All such evidence is circumstantial until fully verified. However if you are looking for promising leads to help someone whose conditions are not otherwise being well managed, then you can do worse than apply that other law-court principle, “on the balance of probabilities”, and try out one of the established traditional herbal remedies described on this site.

Herbal Medicine Contaminants

Evidence-base for herbal practice

There are many robust sources of herbal evidence, with online libraries like PubMed (free), Embase and Scopus (subscription) providing updated clinical trial reports, systematic reviews and meta-analyses in real time. There are also a range of paid-for herb-specific literature review services such as ESCOP, Natural Standard, HerbMedPro, the American Herbal Pharmacopeia and other specialist services.

The following texts are useful resources for practitioners wishing to use the evidence base in support of their clinical application of herbal remedies:

  • Barnes, J, Anderson L, Phillipson JD (2007)  Herbal Medicines 3rd Edition. Pharmaceutical Press, London [leading pharmacy-oriented guide to the evidence]
  • Bone K and Mills S (2013) Principles and Practice of Phytotherapy, 2nd Edition. Churchill Livingstone/Elsevier. [standard evidence-based text used in herbal medicine courses]
  • Mills, S and Bone K eds (2005) The Essential Guide to Herbal Safety. Churchill Livingstone/Elsevier [a pragmatic guide to real and imagined safety evidence]

Rigorous consensus reviews of efficacy and safety evidence for many herbs used in Europe as medicines are available free online from The European Medicines Agency

Traditional use information

There are few original resources for those starting out on a search of traditional uses of herbal remdies. The following are recommended as including original anthropological accounts of traditional use. The focus here is on how earlier traditions were articulated in modern times, particularly the 19th and 20th centuries, rather than going to pre-modern original texts. Serious scholars will go to major resources like the Wellcome Library for the History of Medicine in London, or pursue ethnopharmacological literature at various schools of pharmacy and universities around the world.

These texts are suggested as introductions to traditional use of plants in different cultures.

  • British Herbal Medicine Association. (1983) The British Herbal Pharmacopoeia 1983. Bournemouth, England. [UK herbal practitioner practices up to the mid-20th century]
  • Dalby, A (2000) Dangerous tastes: the story of spices.British Museum Press, London. [fascinating story of the world spice traditions and trading histories]
  • Kaptchuk, T.J. (1983) The Web that has no Weaver: Understanding Chinese Medicine. Congdon & Weed, New York. [the most accessible introduction to the therapeutic principles]
  • Lassak EV. and McCarthy T. (1983) Australian Medicinal Plants. Methuen Australia
  • MacDonald, C (1974) Medicines of the Maori. Collins, New Zealand. [a great example of traditional use uninfluenced by other cultures]
  • Moerman D.E. (1998) Native American Ethnobotany. Timber Press, Portland, Oregon [the most comprehensive resource of indigenous North American tribal uses]
  • Perry L.R. (1980) Medicinal Plants of East and Southeast Asia. The Massachusetts Institute of Technology Press. [an absolute classic resource  of Asian folk use]
  • Pole, S (2013). Ayurvedic Medicine. Elsevier [a great modern review of this tradition for the modern world]
  • Ullman, M. (1978) Islamic Medicine. Edinburgh University Press
  • Unschuld, P.U. (1985) Medicine in China: A history of Ideas. University of California Press. [a masterful review of the context]
  • Vogel V.J. (1970) American Indian Medicine. University of Oklahoma Press. [a classic review]

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Green gold: The incredible benefits of matcha https://www.herbalreality.com/health-lifestyle/digestion-nutrition/green-gold-benefits-matcha/ https://www.herbalreality.com/health-lifestyle/digestion-nutrition/green-gold-benefits-matcha/#comments Fri, 29 Oct 2021 15:21:23 +0000 https://www.herbalreality.com/?p=2437 Matcha is a unique form of bright emerald green tea. Here we discuss its amazing health benefits and tradition of use.

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Matcha is a unique form of bright emerald green tea. Here we discuss its amazing health benefits and tradition of use.

Matcha is a unique form of bright emerald green tea. Here we discuss its amazing health benefits and tradition of use.

Matcha is green gold. It is made from a special type of powdered green tea that is grown under shade for a few weeks before being harvested. The stem and veins are then removed before being powdered into the finest verdant grains that dissolve easily in water.

Matcha is the tea used in the ancient Japanese tea ceremony and has been used by Buddhist monks for the last 1,000 years. Its light and ascendant properties take ones awareness and energy upwards through the heart to the head bringing clarity and insight. It’s this almost spiritual quality that makes Matcha such an appropriate drink for today’s busy world.

Green gold: The incredible benefits of matcha

Growing the Matcha under shade increases the volume of healing chlorophyll as well as the L-Theanine, amino acids and polyphenols such as EGCG (epi-gallo-catechin-gallate). These natural compounds add to the sweet and savoury-mineral flavour, known as umami- umami, helping to reduce the bitterness of the iridescent green Matcha.

The rare amino acid L-Theanine helps to nourish neurotransmitters in the brain having a positive influence on our mood and sense of inner peace. L-Theanine works synergistically with the low levels of caffeine in green tea and Matcha; it is one of the reasons why it brings such a deep sense of calm as well as alertness. (L-Theanine is five times higher in Matcha than green tea). It actually increases serotonin, dopamine and GABA – all essential neurotransmitters associated with the feel-good factor bringing happiness, inner peace and the general all-round clarity of shanti-ness.

We all know that these qualities help us feel at our best in the midst of our over-stimulated world because they help us focus and feel centered. These more subjective experiences flow into measurable affects such as lowering blood pressure, reducing anxiety and influencing alpha-waves (associated with a relaxed state of mind and also regulated by deep meditation).

Green tea (Camellia sinensis)
Green tea (Camellia sinensis)

We get these effects because humans and plants have evolved so closely together. We can benefit from eating plants that have developed these special compounds because they evolved the ability to protect themselves from invasion by microbes as well as adapting to stressful environments to be successful reproducers.

For example, many of the colourful pigments in plants that protect them from extreme climates help protect us from extreme stresses. It’s now well known that the traditional Indian diet full of healthy spices such as turmeric, cinnamon and ginger help to protect from inflammatory disorders such as heart disease and cancer that are the scourge of modern healthcare.

And green tea is a powerful addition to this protective diet with matcha being the king of all green tea protectors; one cup of Matcha has 100 times the antioxidants compared to green tea (and green has about double the levels in black tea).

Gram for gram it is about 15 times more antioxidant than pomegranates and 100 times more than spinach. So a little goes a long way.

In fact a little can help you to become a little more little because Matcha also helps to burn body fat through a process known as thermogenesis. By enhancing metabolic processes the nearly calorie-free Matcha helps you burn fat four times faster than your usual metabolism.

Green tea (Camellia sinensis)
Green tea (Camellia sinensis)

It’s also important to ensure your Matcha and your green tea (and black for that matter) are organic. Conventionally grown tea has had numerous reports of its pervasive contamination with fat-stored and life-depleting pesticides and herbicides.

This has recently been highlighted by a report by Greenpeace India ‘Trouble brewing: Pesticide residues in tea samples from India.’

Green tea and Matcha don’t have a long history of use in India as the British introduction of the sweet-milky chai has had a more prominent place. Whilst a masala-chai from our favourite chai-wallah is a delight, it’s now questionable if so much sugar and milk are actually healthy.

Perhaps it’s worth reflecting on the goal of Ayurveda; ‘swasta samatva’ or ‘to be established in yourself with balanced health’ and consider how you can include some delicious, uplifting and even spiritual Matcha in your daily experience of drinking some green gold.

  • Brunswick Laboratories, Lipophilic and Hydrophilic Antioxidant Capacities of Common Foods in the United States, Journal of Agricultural Food Chemistry 2004, 52, 4026-4037 // ORAC Analysis on Matcha Green Tea.
  • Ferrucci et al, Measurement of spices and seasonings in India: Opportunities for cancer epidemiology and prevention, Asian Pac J Cancer Prev . 2010; 11(6): 1621–1629.
  • Greenpeace India 2014, Trouble Brewing: Pesticide residues from tea sample in India.
  • Hutchins-Wolfbrandt et al,Dietary Turmeric Potentially Reduces the Risk of Cancer, Asian Pacific J Cancer Prev, 12, 3169-3173.
  • Mason, R. 200 mg of Zen. L-Theanine Boosts Alpha Waves, Promotes Alert Relaxation. Alternative and Complementary Therapies 2001.
  • Weiss, D.J. et al. Determination Of Catechins In Matcha Green Tea By Micellar Electrokinetic Chromatography. Journal of Chromatography. 2003; 1011(1-2): 173-180.

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Healthy oils: Good and bad fats https://www.herbalreality.com/herbalism/western-herbal-medicine/healthy-oils/ https://www.herbalreality.com/herbalism/western-herbal-medicine/healthy-oils/#comments Fri, 29 Oct 2021 15:21:22 +0000 https://www.herbalreality.com/?p=2433 We will take you through the good and bad fats, and explain how fat can be incredibly important at maintaining our vitality.

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Healthy oils Good and bad fats

We will take you through the good and bad fats, and explain how fat can be incredibly important at maintaining our vitality.

Fat can be healthy, you just have to pick the right ones. We will take you through the good and bad fats, and explain how fat can be incredibly important at maintaining our vitality.

Fat is good for you. That is a fact. The body absolutely requires good quality fat in the diet in order to process such fat-soluble nutrients such as vitamins A, D, E, and K as well as to absorb protective phytochemicals (the colourful flavonoids and carotenoids) and certain minerals.

It is essential for creating enough digestive enzymes. We need it to regulate hormone production. It gives us energy. It helps regulate our moods. It protects our organs. It keeps us warm. Our brains are 60% fat. Our nervous system, our brains, our eyes, our joints are all comprised in part from fat.

Fats are divided into saturated and un-saturated fats.

Saturated fats

Saturated fats are made from short, medium and long chain fatty acids (also known as triglycerides). Short and medium chain fatty acids are easy to digest whereas long chain fatty acids are not. The short and medium chain fatty acids are absorbed in the upper part of the small intestine, not requiring the liver or gall-bladder for digestion and are used immediately for energy.

Long chain fatty acids have to go through a much more complex process involving being broken down by bile acids and pancreatic lipase into glycerol and free fatty acids. These are absorbed and then reconstitution into triglycerides which need to be bonded with a lipoprotein before they are transported to a site that can use them. This process takes up to 8 hours before they are stored as fat before becoming energy.

Excessive consumption of long chain fatty acids is associated with blood clotting, thrombosis and cancer. Medium chain fatty acids are known to increase metabolism and promote weight loss. Short chain fatty acids help to promote the production of hormones and strengthening cellular membranes. Ghee is high in short chain fatty acids, whilst coconut oil is high in medium chain fatty acids. Commercial margarines, lard and butter are high in long chain fatty acids.

What is the fad with fat?

Saturated fats have a bad public image as excessive consumption of them has become associated with an increased risk of high cholesterol, atherosclerosis, stroke and coronary heart disease. The Seven Countries Trial which began in the late 1950s, was set up to determine the causes of Coronary Heart Disease (CHD). It associated CHD with saturated fats and this has led to a host of ‘low-fat fads’ and an entire low fat industry.

This study is now largely discredited as is the association between saturated fat intake and CHD. Just think what the Eskimos eat…lots of saturated seal and whale blubber. Before westernisation the incidence of CHD amongst traditional Eskimo communities was virtually zero. Another example is Japan, where the rate of saturated fat is increasing but CHD is falling.

The causes of heart disease are much more complex then the ‘fat-heart disease’ hypothesis and involves a balance between the forces of degeneration and the energy of protection including genetic tendency, life-style factors, anti-oxidant status, stress, hostility, hypertension, exercise, sugar metabolism, correct LDL/HDL balance and, of course, dietary factors ensuring sufficient vitamin C, E, soluble fibre, EFAs, flavonoids and carotenoids.

One of the reasons for the controversy regarding the ‘fat-heart disease theory’ is that much research has not differentiated between true saturated fats and synthetically generated saturated transfatty acids. However, this is a misunderstanding of the nature of the saturated fats as some, containing high levels of short and medium chain fatty acids are healthy, such as ghee and coconut oil.

Healthy Fats

Also many of the saturated fats that people eat come from animals raised in intensive farming where they are grain fed. This leads to a reduction in the heart healthy Omega-3 Essential Fatty Acids made available to grass fed animals. This confusion that all ‘fats’ lead to high cholesterol has led people to embrace a ‘low-fat’ diet which may result in low cholesterol.

Low cholesterol levels and fat free diets have been associated with depression, and violence. Cholesterol helps us ‘feel good’ as it is an important component of serotonin receptors. Cholesterol also helps us to produce essential hormones such as Vitamin D, oestrogen and adrenaline.

So, saturated fats are important to health, benefiting certain specific metabolic functions, cellular interactions and immune responses. Used at an appropriate quantity and with good quality polyunsaturated essential fatty acids they are beneficial to health. My favourite saturated fats are coconut and ghee as they are easy to digest and have numerous health benefits. (Knopp 2004, Lancet 1992)

Unsaturated fats

Unsaturated fats are divided into monounsaturated fats (olive, mustard) and polyunsaturated fats (sesame, sunflower, flax, corn, hemp). Both are required for healthy life. Polyunsaturated fats (PUFAs) are ‘unstable’ oils. If they are not handled properly they can pose a health risk as their cell structure leaves many ‘bond’ sites that are potential sites for oxidisation to occur. They easily go rancid. Essentially this means that under poor processing and storage conditions (i.e. heat and light) they can become oxidised, a process similar to metals rusting, which allows for the release of free radicals in the body. This leads to accelerated ageing and other degenerative diseases.

Interestingly, sesame oil does not become oxidised under heat as its linoleic acid content actually improves its anti-oxidant status but hemp seed does oxidise easily under heat and light which is why it should not be used for cooking.

So, polyunsaturated fats that are handled properly (cold pressed, kept cool, stored away from light) are extremely beneficial for health. If they are not, i.e. when they are processed and stripped of their inherent protective anti-oxidants, then they can create Lipid Oxidation Products (LOPs). As they are toxic to cells, they can damage the lining of the arteries which increases the risk of heart disease and they use up valuable anti-oxidant reserves leaving us exposed to free radical damage.

Because of the way they are processed and handled most commercial, non-organic, PUFAs (sunflower, corn etc.) contain levels of LOPs and so should never be used for frying as this will create more oxidation. Olive oil as a mono-unsaturated fatty acid contains minimal amounts of LOPs and is safe for cooking. However, no oil should ever be re-used as it will harm your health.

Healthy Fats Diet

Fats and carbs

If carbohydrate or fat consumption exceeds your needs then the glucose-like molecules are stored as glycogen reserves for potentially needed energy release in the muscles and liver. If the glycogen bank is full then the overflow gets laid down as fat molecules in the fat cells. As you reduce your dietary intake and/or increase metabolic needs, fat gets converted back to glycogen. As glycogen gets broken down water is also lost in a ratio of 1 part glycogen to 9 parts water. This is why fasting can bring about rapid weight loss but as food is resumed then glycogen levels go back up and an increase in water retention returns.

Calories

Counting calories is one method of monitoring how much ‘energy’ you are putting into yourself. Men require approximately 2,500 calories/day and women 2,000. One pound of fat is created from 4,000 calories. Whilst calorie counting may be useful for raising awareness of the nutritional components of the food you eat it does not consider the individual metabolic rate which is at the crux of all healthy weight diet and life-style regimes.

Glycaemic Index (GI)

The Glycaemic Index describes how the body’s sugar levels respond to certain foods. It has become an important indicator of how certain foods will affect weight loss and diabetic control. Foods with a low GI release sugar into the bloodstream slowly whilst those with a high GI can cause a rapid increase. Glucose and refined sugars have the highest GI and whole grains and lentils the lowest.

Insulin resistance

Insulin is the hormone that allows for the absorption of various nutrients including glucose and amino acids and keeps the blood sugar within ‘normal’ limits. Whilst insulin production is stimulated by eating carbohydrates it can also reduce the metabolism of fats and proteins thus leading to greater storage of fats. It is estimated that 8 out of 10 overweight people have a blood sugar imbalance including possible insulin resistance.

The term “insulin resistance” means that your body cells are more resistant to the action of insulin than normal. If you are insulin resistant, your pancreas has to make more insulin to keep your sugar normal. As long as your pancreas can meet the excess demand placed upon it, you are OK. If your pancreas cannot keep up with the increased demand, your blood sugar will rise and you will become diabetic.

Evidence points to an inherited abnormal form of insulin that is inefficient at regulating blood sugar levels. There also appears to be a problem with the insulin receptor not allowing insulin to facilitate the entrance of glucose into the cell.

It is fairly easy to determine whether someone is insulin resistant. One of the most common ways to find out is simply to measure the fasting blood sugar and fasting insulin level in the morning. It is also possible to undergo a Glucose Tolerance Test, measuring both blood sugar levels and insulin levels. If the insulin levels are higher than they ought to be, this indicates insulin resistance.

Insulin resistance is affected by:

  • A high GI diet as these foods promote the release of high levels of insulin
  • A high fat diet helps to lower the GI by slowing digestion and delaying the entrance of sugars into the blood stream
  • Excessive insulin secretion creates a negative cycle through over-stimulation. When a cell is exposed to high levels of insulin it starts to alter its relationship with insulin and reduce the number of insulin receptors. This leads to lower levels of fat breakdown and leads to obesity
  • Mineral deficiency in chromium and magnesium (also zinc and B vits)
  • Obesity creates insulin resistance and insulin resistance creates obesity

Insulin resistance leads to ‘hyperinsulinemia’. It is another vicious cycle. As a tissue becomes increasingly insulin resistant, the uptake of blood glucose becomes more inefficient. As a result, blood glucose levels begin to rise and continue to be raised over ever increasing periods of time. The pancreas, in its efforts to effectively store the glucose, responds by secreting progressively higher levels of insulin. When this pattern occurs insulin levels are higher for longer such that the total hours of insulin exposure in the body may be increased to 50-100% beyond that of normal.

Hyperinsulinemia can cause:

  • Sodium metabolism disruption, increased water retention and hypertension
  • Oxidative damage and initiation of atherosclerosis and neoplasia (cancer)
  • Decrease in the total daily secretion of growth hormone with negative effects throughout the body.One notable effect of this is to inhibit the conversion of the inactive thyroid hormone (T-4) to its active form (T-3). This creates a “functional hypothyroidism,” which is difficult to detect because a routine thyroid blood test will display an otherwise normal level of circulating thyroid hormones
  • Compensatory hypercortisolemia (high blood cortisol levels), poor tolerance to stress, depressed immunity, and eventually, adrenal exhaustion
  • Chronic, high levels of insulin secretion will eventually exhaust the beta cells of the pancreas, increasing the likelihood of a functional deficit of these tissues, resulting in adult-onset diabetes
Woman with healthy food

The dreaded transfatty acids have become synonymous with poor quality foods and bad health. They are formed when certain polyunsaturated oils are intentionally saturated with hydrogenation under high temperature to make solid fats (an oil is liquid at room temperature and a fat is solid).

The technique of creating transfats was developed in the early 1900s in order to extend the shelf-life of unstable fish and vegetable oils. Widespread introduction of transfats into commercial foods began just after the 1920s with disastrous effects. Because of their harmful effects on health the recommendation to remove them from foods is now being legislated around the world.

Transfatty acids are associated with an accumulation of the potentially harmful LDL, the increased risk of heart disease, prostate cancer, diabetes, fertility and liver dysfunction. Transfats are ‘oxidised’ fats and create harmful free radical generating substances called lipid peroxides. Lipid peroxides (oxidised lipids) actually take up residence on cell walls and obstruct the correct working metabolisms of cells. As they interfere with the delta-6-desaturase enzyme conversion of Omega-3 and Omega-6 fatty acids into inflammation modulating prostaglandins they obstruct this crucial protective process.

Transfatty acids can:

  • Increase cancer risk factors by disrupting liver detoxification of carcinogens, change B and T immune cell ratios, interfere with the functions of cancer protecting fatty acids
  • Elevate cardiovascular risk factors by increasing total cholesterol levels and potentially harmful LDL cholesterol, lowering protective HDL cholesterol, make platelets more likely to stick to together to form a clot, increase the strongest known risk factor for cardiovascular disease (lipoprotein)
  • Interfere with insulin function hence increasing the risk of diabetes
  • Disrupt fertility by decreasing testosterone and increasing abnormal sperm
  • Be associated with low birth weight babies and lower human breast milk quality
  • Interfere with essential fatty acids metabolism
  • Interfere with nutrient absorption by reducing Vitamin K absorption
Cannabis oil (Cannabis sativa)
Cannabis oil (Cannabis sativa)

PUFAs contain the fragile Essential Fatty Acids (EFAs) which are found in high concentration in the cells of our brain, nervous system and skin. The cell membranes of the 63 trillion cells we have in us all contain EFAs.

There are three types of EFAs:

  1. Omega-3 fatty acids, including alpha-linolenic acid
  2. Omega-6 fatty acids, including linoleic acid and gamma-linolenic acid
  3. Omega-9 fatty acids, including oleic acid

Examples of some Omega containing oils are;

  • Fish oil is all Omega-3
  • Flax oil is 60% Omega-3 and 20% Omega-6
  • Hemp seed oil is 20% Omega-3, 60% Omega-6, 12% Omega-9 oleic acid and 3% GLA totaling more than 90% unsaturated fatty acid.

We need the EFAs Omega 3 to 6 in a certain ratio. The ratio of 1:3 is considered ideal for health (the ratio is debated, but this is the current most accepted figure). This is the ratio that hemp seed has. Flax has the opposite ratio, which can be beneficial for redressing imbalances in the short-term but not for long-term health as it can lead to omega-6 deficiencies. Commonly people have a ratio of 1 to 10 or 20 Omega 3 to 6! This is because animal fats and many commonly used vegetable oils (soy, corn, safflower, peanut and sesame) are high in Omega 6.

Cells that have a rapid evolution, such as those in the skin, immune and nervous systems, and in growing babies and children, need lots of essential fatty acids to stay healthy. It is vitally important that the correct ratio of Omega 3 to 6 is received or imbalances will occur.

Mental health

60% of the weight of our brain, the fat-richest organ in our body, is fat, and one third of that is EFAs. The ratio of omega 3s to omega 6s in the brain is 1:1. EFAs have been shown to help ADHD, Schizophrenic symptoms, Alzheimer’s disease and senile dementia, Parkinson’s, Lou Gehrig’s disease (ALS), and multiple sclerosis.

Skin health

EFAs help to moisten and nourish the skin preventing dry and flaky skin. As EFAs help form cell membranes they help to keep moisture in the skin and keep cell membrane function at optimum levels. This can positively influence eczema, psoriasis and other inflammatory skin conditions.

Women’s health

EFAs help to reduce Arachidonic Acid levels which can help to reduce menstrual pain. Its mood balancing qualities can also help with PMS.

Fertility

Pregnant women need a larger intake of EFAs to nourish their child, and this need increases with each extra child. Low EFA levels are also associated with post partum depression and some diseases that have a higher incidence in women; multiple sclerosis, thyroiditis, fibromyalgia and lupus. EFAs also help build male fertility through boosting sperm quality and quantity.

Blood

An important function of EFAs is that they make red blood cells more flexible, which means that they can find their way through capillaries more easily. The result is that tissues and cells receive their supply of nutrients and oxygen more effectively, and stamina therefore increases. EFAs also assist in the transport of oxygen and essentially draw oxygen into the cells.

Weight

Getting up to 12% of your diet from EFAs can actually help you to loose weight as EFAs help with our metabolism.

Cardiovascular health

EFAs can reduce blood lipid triglycerides by 65% and have been shown to increase HDL and lower LDL in some people. However they are not sufficient on their own to achieve this in everybody and should be used as a part of a cholesterol reducing programme if this is indicated. They also make platelets less sticky which can reduce the chance of blood clots arising.

Immunity

EFAs are involved in the correct functioning of the DNA and so may help prevent cancers, enhance wound healing and protein metabolism that are so essential for correct immune function. Another important role is that EFAs make hormone-like prostaglandins. There are different forms of prostaglandins, which can either reduce inflammation or be pro-inflammation depending on the source and quality of oil and how it is metabolised in the body. Beneficial prostaglandins (PGE 1 and 3) work to;

  • Protect the skin and joints from inflammation
  • Reduce cholesterol levels, dilate blood vessels and reduces blood pressure
  • Protect integrity of blood vessels and prevent platelet aggregation
  • Reduce auto immune inflammation; psoriasis, lupus, crohn’s disease
  • Help to reduce menstrual pain
  • Reduce the complications of diabetes
  • Keep cells functioning properly and reducing cancerous behaviour 

If there is not enough Omega-3 in the diet then the prostaglandin metabolites will convert Omega-6 into a pro-inflammatory Arachidonic Acid process. (Simopoulos 1999, Cullis 1991, Grimble 1998, James 2000)

Omega-3 oils are medium chain fatty acids that are metabolised to long-chain eicosapentaenoic acid (EPA) and decosahexaenoic acid (DHA). EPA, is an Omega-3 derived fatty acid that is a precursor to the eicosanoids; prostaglandin-3, leukotrine-5 and thromboxane-5.  It is associated with a healthy inflammatory, nervous and emotional balance. DHA is another Omega-3 derived fatty acid associated with brain health, retina health, foetal development and immunity.

Omega-3 deficiency leads to dry skin, growth retardation, weakness, impaired learning ability, poor motor coordination, behavioural changes, impaired vision, high blood pressure, sticky platelets, oedema, mental deterioration, low metabolic rate, and immune dysfunction

Nothing in itself, it’s just that we have too much of it in our diets. Although Omega-6 is an EFA, and we need a certain amount of it, unfortunately Omega -6 linoleic acids in excess to Omega-3 can create Arachidonic Acid which can cause an inflammatory cascade disrupting the health of the skin, brain, nervous system, fertility, joints and circulatory system. Excess poor quality Omega-6 linoleic acids in our diet are potentially a causative factor in the increase in heart disease in ‘developed countries’ over the last 90 years.

Some authorities believe that we should be aiming for a 1:1, Omega-3:6 ratio in our diet to redress the imbalances we face from long-term destabilisation in our fatty acid profile.  Others recommend a ratio of 1:3.

Some suggestions for achieving this are (Wallace 2002):

  1. Restrict intake of animal-based foods: Meat, dairy, poultry as they are dietary sources of Arachidonic Acid and are precursors to inflammatory PGE2, LTB4, 5-HETE, and 12-HETE
  2. Substantially increase dietary sources of omega-3 polyunsaturated fatty acids (PUFAs) ensuring sufficient levels of eicosapentaenoic acid and docosahexaenoic acid that block metabolism of Arachidonic Acid
  3. Limit intake of plant-source omega-6 PUFAs, targeting a 1:1 ratio of w3 to w6 PUFAs in severe disease. This helps to prevent enzyme competition and reduce the inadvertent shunt to Arachidonic Acid and inflammatory eicosanoids
  4. Increase dietary antioxidants: 7 to 9 servings a day of deeply pigmented fruits and vegetables. This reduces oxidative biosynthesis of inflammatory eicosanoids and isoprostanes
  5. Eliminate hydrogenated and trans-fatty acids, alcohol, simple sugars, and refined carbohydrates, and reduce elevated cholesterol levels as these are inhibitors of the desaturase enzyme responsible for converting EFAs to EPA/DHA
  6. Ensure adequate intake of zinc, magnesium, ascorbate, niacin, and pyridoxine as these are coenzymes for desaturase metabolism of omega-3 PUFAS
  7. Optimize blood glucose regulation: Address hyperinsulinemia as excess insulin shifts dihomogammalinolenic acid toward PGE2 synthesis
  8. Provide a combination of several anti-inflammatory botanical agents that help to modulate the inflammatory cascade through multiple and synergistic actions, including COX and LOX inhibition.
  9. Monitor inflammatory markers (e.g. C-reactive protein, ceruloplasmin) at baseline and interval and adjust protocol as required

Some authorities (in the fish oil industry?) have said that vegetarian sources of Omega-3 alpha-linolenic acid cannot be efficiently converted into EPA and DHA. However, two studies published in the British Journal of Nutrition which measured the conversion of alpha-linolenic acid (ALA) into EPA, DPA, and DHA have shown otherwise. The first study, carried out with six women, showed that these women converted an average of 36% of the ALA they were given into long-chain Omega-3 derivatives (21% EPA, 6%DPA, 9%DHA).

The second study, done with six men, showed that the men converted an average of 16% of the ALA they received into long-chain Omega-3 derivatives (8%EPA, 8%DPA). In this study, the men produced no DHA. However, another study showed that men convert ALA to DHA as well. It is considered that men can convert 1% of ALA to DHA (Burdge 2002, Emken, Brenna 2002).

It is surmised that women have a better conversion rate as they need to metabolise EPA and DHA for their children as well.

What can influence conversion?

  • Too little ALA or Omega-3 intake
  • High Omega-6 intake interferes with conversion of Omega-3
  • Lack of the vitamins B3, B6 and C and the minerals zinc, calcium, biotin and magnesium necessary for assisting conversion of ALA to EPA and DHA
  • Toxic influences
  • High carbohydrate diets slow down conversion
  • Diets higher in proteins enhance conversion.
  • Diets high in saturated or transfats blocks conversion
  • Too low a ratio, such as 1 to 10 Omega-3:6 (the average found in Western diets) can lead to symptoms of Omega-3 deficiency. Omega-3 deficiency increases the risk of increasing cardiovascular, immune, autoimmune, diabetic, and inflammatory disease, and leads to sub-optimal intelligence, concentration, mood, and performance. In the two conversion studies published in the BNJ, the diet contained only 1/7th as much Omega-3 as Omega-6. A better ratio would consist of more Omega-3 and less Omega-6 to redress this imbalance

The global fish stocks are hugely depleted and as it takes 1000Kg of fish to make 1Kg fish oil using fish oil as a health product is not advisable due to the damage it inflicts on our ocean fish stocks. Secondly, our seas are highly polluted. Taking fish oils increases the chance of industrial pollutant toxicity from mercury, dioxins and polychlorinated biphenyls (PCBs). As these toxins tend to accumulate in the fatty parts of fish they are concentrated in the fish oils. They are implicated with a range of diseases from increased aging to neural disorders to cancer.

It is also interesting that the Omega oils and there derivatives ALA and LA are not actually found is fish oils. However EPA and DHA are, but these are metabolised from the ALA and LA found in micro-algae present in the sea. There are all sorts of risks associated with the processing and storage of EPA and DHA due to their tendency to oxidise as they are 5 times less stable than ALA.

So, vegetarian sources are more ethical, more stable and very effective sources of Omega oils.

The National Institute of Health in the US published a report that on average we should have 3% Omega-6 and 1% Omega-3 and 0.3% EPA and DHA as a total of our calorific diet. Pregnant women are recommended to have 650mg/day of EPA and DHA/ day. Other sources recommend 600mg EPA and 400mg DHA per day.

I am giving the following recommended dose based on the profile in hemp seed oil as it contains the perfect balance of Omega oils.

Recommended dose for women

Women with an average weight of 50 kg: Recommended dose 2-3 tablespoons

In order to receive the recommended dose of EPA and DHA from a vegetarian source:

  • 1 tablespoon per day of hemp seed oil = 9g (9,000mg)
  • 9g hemp seed oil has 6.6g LA and 2.2g ALA

The 36% conversion rate of ALA mentioned in the British Journal of Nutrition means that 1 tablespoon hemp seed oil will give you 792mg of long chain Omega-3 with 21% or 166mg EPA, 6% or 48mg DPA and 9% or 71mg DHA.

If you take the recommended 2 tablespoons per day it will give you a total of 1584mg long chain Omega-3s or 388mg EPA, 96mg DPA and 142mg DHA.

Recommended dose for men

Men with an average weight of 50 kg: Recommended dose 3-4 tablespoons per day

At a conversion rate of 16% ALA to EPA will get 352mg long chain Omega 3s made up of EPA and DPA from 1 tablespoon hemp seed oil. Taking the recommended 3 tablespoons per day will give him 1056mg/day.

This will lead to benefits including lower cardiovascular risk, smoother skin, higher energy levels, better stamina, improved performance and recovery, better insulin sensitivity, lowered cancer risk, lowered inflammation, greater heat production, and improved mood, learning, IQ and calmness, and better ability to handle stress.

  • Arnesen H N-3 fatty acids and revascularization procedures. Lipids. 2001;36 Suppl:S103-6. Review.
  • Brenna JT. Efficiency of conversion of alpha-linolenic acid to long chain n-3 fatty acids in man. Curr Opin Clin Nutr Metab Care. 2002 Mar;5(2):127-32.
  • Burdge G, Conversion of alpha-linolenic acid to eicosapentaenoic, docosapenta-enoic and docosahexaenoic acids in young women. British Journal of Nutrition 2002 Oct;88(4):411-20.
  • Burdge G , Jones A, Wootton S , Eicosapentaenoic and docosapentaenoic acids are the principal products of alpha-linolenic acid metabolism in young men, British Journal of Nutrition 2002 Oct;88(4):355-63.
  • Cullis P, Hope MJ. Physical properties and functional roles of lipids in membranes. In:V ance DE, Vance JE, eds. Biochemistry of Lipids, Lipoproteins and Membranes. Amsterdam:Elsevier; 1991.
  • Emken EA et al Dietary linoleic acid influences desaturation and acylation of deuterium-labelled linoleic and linolenic acids in young adult males. Biochimica et Biophysica Acta 1213, 277-88.
  • Grimble RF, Tappia PS. Modulation of pro-inflammatory cytokine biology by unsaturated fatty acids. Z Ernahrungswiss. 1998;37 (suppl 1):57-65.
  • James MJ, Gibson RA, Cleland LG. Dietary polyunsaturated fatty acids and inflammatory mediator production. Am J Clin Nutr. 2000;71(1 suppl):S343-S348.
  • Knopp R and Retzlaff B,Saturated fat prevents coronary artery disease? An American paradox American Journal of Clinical Nutrition, Vol. 80, No. 5, 1102-1103, November 2004.
  • Pereira C et al, 2001. The Alpha-Linolenic Acid Content of Green Vegetables Commonly Available in Australia. Int. J. Vitam. Nutr. Res.;71(4):223-228.
  • Simopoulos AP. Essential fatty acids in health and chronic disease. Am J Clin Nutr. 1999;70(3 suppl):S560-S569.
  • Storelli MM et al, 2002. Total and Methylmercury Residues in Tuna-Fishfrom the Mediterranean Sea. Food Add. And Contam.;19(8):715-720.
  • Wallace J, Nutritional and Botanical Modulation of the Inflammatory Cascade—Eicosanoids, Cyclooxygenases, and Lipoxygenases—as an Adjunct in Cancer Therapy, Integrative Cancer Therapies Vol 1, Number 1, 2002.

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Healthy weight: Herbs to support weight loss https://www.herbalreality.com/health-lifestyle/mobility-fitness/healthy-weight/ https://www.herbalreality.com/health-lifestyle/mobility-fitness/healthy-weight/#comments Fri, 29 Oct 2021 15:21:21 +0000 https://www.herbalreality.com/?p=2429 We discuss how you can achieve this and what the real causes of weight gain are.

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Maintaining a balanced body weight and appearance is a constant pressure in the modern world. Here we will discuss how you can achieve this and what the real causes of weight gain are.

Healthy weight

A healthy weight is a balanced proportion of body weight to body height. There is no one ideal weight as we are all uniquely different but a general guide has been devised and is described via the Body Mass Index (BMI). A healthy weight is 20-25, overweight is 25+, obesity is defined as a BMI of 30 or more and gross obesity as 40+. Your BMI can be worked out by taking your weight in kilograms and divide it by your height in metres and then divide the result by your height in metres again.

With obesity being described as a global epidemic by the World Health Organisation (WHO) a balanced perspective to eating, exercise and life-style is evidently required.

In the UK, 68% of adults are overweight with 22% of these being obese and 20% of children are overweight. Unhealthy weight levels are a real problem. However, there is also a cultural gender bias with regards to attitudes towards weight loss; 37% of men are overweight whilst only 22% of women but twice as many women diet as men!

The simple fact is that taking in more energy than you use creates an excess that accumulates as fat. There is also a genetic factor that can increase your tendency for a large appetite and also affect metabolism, but the quantity and types of foods consumed in relation to exercise has the greatest effect on your weight. Of course behind these external factors of food consumption and exercise are the internal emotional reasons why we ‘over’ eat and ‘under’ exercise. Resolving these patterns are at the heart of achieving a healthy weight.

Obesity sets up vicious malevolent circles that degrade health. For example, obesity increases insulin resistance which prevents the metabolism of sugars which are stored as fats and increase obesity. The upward spiral of weight gain becomes a downward spiral of health quality.

The proliferation of diets (Atkins, Zone, F Plan, South Beach, Mayo clinic, Mediterranean, Low carb etc.) clearly shows the need for our modern society to regulate its weight. It also displays the high level of confusion associated with the issue of body weight. The bottom line is that there is no right diet for everybody but Ayurveda offers some very personal and insightful advice.

Fats and carbs

If carbohydrate or fat consumption exceeds your needs then the glucose-like molecules are stored as glycogen reserves for potentially needed energy release in the muscles and liver. If the glycogen bank is full then the overflow gets laid down as fat molecules in the fat cells.

As you reduce your dietary intake and/or increase metabolic needs, fat gets converted back to glycogen. As glycogen gets broken down water is also lost in a ratio of 1 part glycogen to 9 parts water. This is why fasting can bring about rapid weight loss but as food is resumed then glycogen levels go back up and an increase in water retention returns.

Calories

Counting calories is one method of monitoring how much ‘energy’ you are putting into yourself. Men require approximately 2,500 calories/day and women 2,000. One pound of fat is created from 4,000 calories. Whilst calorie counting may be useful for raising awareness of the nutritional components of the food you eat it does not consider the individual metabolic rate which is at the crux of all healthy weight diet and life-style regimes.

Glycaemic Index (GI)

The Glycaemic Index describes how the body’s sugar levels respond to certain foods. It has become an important indicator of how certain foods will affect weight loss and diabetic control. Foods with a low GI release sugar into the bloodstream slowly whilst those with a high GI can cause a rapid increase. Glucose and refined sugars have the highest GI and whole grains and lentils the lowest.

Insulin resistance

Insulin is the hormone that allows for the absorption of various nutrients including glucose and amino acids and keeps the blood sugar within ‘normal’ limits. Whilst insulin production is stimulated by eating carbohydrates it can also reduce the metabolism of fats and proteins thus leading to greater storage of fats. It is estimated that 8 out of 10 overweight people have a blood sugar imbalance including possible insulin resistance.

The term “insulin resistance” means that your body cells are more resistant to the action of insulin than normal. If you are insulin resistant, your pancreas has to make more insulin to keep your sugar normal. As long as your pancreas can meet the excess demand placed upon it, you are OK. If your pancreas cannot keep up with the increased demand, your blood sugar will rise and you will become diabetic.

Evidence points to an inherited abnormal form of insulin that is inefficient at regulating blood sugar levels. There also appears to be a problem with the insulin receptor not allowing insulin to facilitate the entrance of glucose into the cell.

It is fairly easy to determine whether someone is insulin resistant. One of the most common ways to find out is simply to measure the fasting blood sugar and fasting insulin level in the morning. It is also possible to undergo a Glucose Tolerance Test, measuring both blood sugar levels and insulin levels. If the insulin levels are higher than they ought to be, this indicates insulin resistance.

Insulin resistance is affected by:

  • A high GI diet as these foods promote the release of high levels of insulin
  • A high fat diet helps to lower the GI by slowing digestion and delaying the entrance of sugars into the blood stream
  • Excessive insulin secretion creates a negative cycle through over-stimulation. When a cell is exposed to high levels of insulin it starts to alter its relationship with insulin and reduce the number of insulin receptors. This leads to lower levels of fat breakdown and leads to obesity
  • Mineral deficiency in chromium and magnesium (also zinc and B vits)
  • Obesity creates insulin resistance and insulin resistance creates obesity

Insulin resistance leads to ‘hyperinsulinemia’. It is another vicious cycle. As a tissue becomes increasingly insulin resistant, the uptake of blood glucose becomes more inefficient. As a result, blood glucose levels begin to rise and continue to be raised over ever increasing periods of time.

The pancreas, in its efforts to effectively store the glucose, responds by secreting progressively higher levels of insulin. When this pattern occurs insulin levels are higher for longer such that the total hours of insulin exposure in the body may be increased to 50-100% beyond that of normal.

Hyperinsulinemia can cause:

  • Sodium metabolism disruption, increased water retention and hypertension.
  • Oxidative damage and initiation of atherosclerosis and neoplasia (cancer).
  • Decrease in the total daily secretion of growth hormone with negative effects throughout the body. One notable effect of this is to inhibit the conversion of the inactive thyroid hormone (T-4) to its active form (T-3). This creates a “functional hypothyroidism,” which is difficult to detect because a routine thyroid blood test will display an otherwise normal level of circulating thyroid hormones.
  • Compensatory hypercortisolemia (high blood cortisol levels), poor tolerance to stress, depressed immunity, and eventually, adrenal exhaustion.
  • Chronic, high levels of insulin secretion will eventually exhaust the beta cells of the pancreas, increasing the likelihood of a functional deficit of these tissues, resulting in adult-onset diabetes.
  • Excess fat around the buttocks, breasts, abdomen, hips and extremities
  • Decreased activity, tiredness
  • Shortness of breath on exertion
  • Excessive sweating
  • Low back pain
  • Joint pain

Involving the complications of:

  • Diabetes (NIDDM)
  • Arthritis and Osteoporosis
  • Ischaemic Heart Disease
  • Hypertension
  • High cholesterol
  • Congestive heart failure
  • Gall bladder disease
  • Various cancers; breast, uterus, prostate (caused by excess adipose tissue aromatase and increased free sex hormones)
  • Hypothyroidism
  • Low libido
  • Impotence
  • Infertility
  • Menstrual irregularities
  • Depression
  • Snoring, sleep apnoea

Rule out pregnancy, cyclic premenstrual oedema, ascites, kidney disease in the diagnosis of obesity.

  • Excessive intake of heavy, fatty and sweet foods
  • Alcohol
  • Lack of exercise
  • Excessive sleeping during the day
  • Excessive steroid use causing increased weight

Described by the Caraka Samhita* as one of the “eight despicable diseases” as it is hard to treat and because patient willpower is essential for any management plan to be effective.

Ayurvedic view

Obesity is characteristically a disease of low digestive fire and an excess of kapha. The qualities of kapha become predominant in the person’s diet and life-style; cold, damp, heavy, slow, oily, static, sticky, cloudy.

Foods such as dairy, wheat, sugars, cold drinks, ice, refrigerated foods have these qualities. They also weaken the digestive fire. Activities such as sleeping in the day time, sleeping straight after a meal, regular snacking, lack of exercise, living in a damp climate all promote these qualities and increase kapha.

The digestive fire in the fat tissue is sluggish and this leads to an accumulation of fat throughout the adipose system; central abdomen, hips, thighs. Fatty tissue accumulates around the abdomen and blocks the natural flow of digestive energy downwards. This obstructs vata dosha (the bodily humour responsible for all movement in the body). 

This causes vata to reverse backwards and to accumulate in the stomach which – because vata’s predominant element is air – fans the digestive fire leading to a hyperactive digestive system.  Any food ingested thereafter “cooks” too quickly causing rapid stomach emptying with a resultant excessive hunger and the patient to continually over-eat. However the food is not utilised and the result of this over-eating builds up in the fat tissue.

Eventually all three dosas become imbalanced and improper nourishment of the tissues leads to a chronic depletion of the body’s natural immunity leading to multiple complications and premature death.

So fat metabolism is weak, the channels are obstructed, digestive fire is low but the appetite is large.

Conventional treatments

  • Xenical (orlistat) is a lipase inhibitor. Lipase is an enzyme that helps to metabolise fats to become available for the body. By obstructing the activity of lipase about 30% less fat is available to the body. Its use may result in various digestive disorders such as cramping, diarrhoea, flatulence and fatty stools.
  • Meridia (sibutramine) is an appetite suppressant. It appears to have serious effects on the heart and may increase blood-pressure, irregular heartbeat, congestive heart failure and headaches.
  • Surgery: Various techniques have been evolved to induce a feeling of satiation and hence prevent over eating. Complications such as pulmonary embolisms, liver disorders, kidney disease, cancer of stomach, bowel and pancreas.

* The definitive Ayurvedic text written circa 2000 BC

  • Empowering the individual towards a life-long healthy eating pattern that regulates weight and brings good health.
  • Engender willpower and motivation.
  • The diet must be simple, delicious and nourishing but also help you loose weight.
Period pain yoga

Diet

  • Avoidyeast, salt, cheese, yoghurt, chocolate, alcohol, refined sugars, oils and flours as these reduce digestive fire and increase weight. It is also advisable to avoid saturated fats in meat and fried foods.
  • Include ginger in your daily diet: take a pinch of fresh ginger root with a few drops of lemon juice before each meal.
  • Favour foods that are light, dry, and warm as these reduce mucus (e.g. soups, basmati rice).
  • Reduce foods that are heavy, oily, and cold as these increase weight and mucus (e.g. pizza, ice cream, bananas).
  • Favour foods that are spicy, bitter, and astringent (e.g. ginger, asparagus, tea) as these help to dry excess fluids in the body.
  • Reduce foods that are sweet, salty, and sour (e.g., cakes, crisps, vinegar) as these increase fluids in the body.
  • Eat foods which are heavy, and therefore “filling”, but which have a lightening effect e.g. barley, green mung and black urad lentils, honey and buttermilk. This will quell feelings of hunger while promoting weight-loss.
  • Eating complex carbohydrates encourages an even hunger and a slow release of energy that allows for a balanced use of the food without any excess being turned into fat.
  • Include natural fibre from vegetables, wholegrains, lentils and nuts to assist a slow release of energy helping to control blood sugar levels.
  • Drink plenty of tepid water mixed with honey morning and evening (4:1 water:honey). Honey helps to satiate the appetite and removes fat.
  • Drink plenty of warm water and Revitalising tea throughout the day.
  • Maintain the rules of healthy eating e.g.
  • Wait until the previous meal is digested before eating again.
  • Eat slowly with concentration.
  • Do not overeat (ideal ratio is 1/3 liquid: 1/3 solid food: leave 1/3 portion of the belly empty to allow for circulation to promote proper digestion).
  • Eat lightly at night.
  • Do not eat when you are not hungry. 
  • Do not eat between meals.
  • Do not eat cold foods and ice.
  • Avoid too much water (especially cold from the ‘fridge).
  • A primarily vegetarian diet is highly recommended.

A note on ghee: Clarified butter is praised in Ayurveda for its ability to nourish all the tissues. It has been shown that as part of a whole-grain vegetarian diet (using up to 2 tsp per day) it can actually increase the HDL cholesterol (the positive aspect) and reduce the LDL cholesterol (the negative aspect). However if the person has high cholesterol ghee (and other saturated fats) should be avoided. However, as we have seen above, low fat diets can increase the GI and lead to weight increase as well, so some high quality fats should be included in the daily diet.

Lifestyle

  • Gradually increase mental and physical activity.
  • Practice anaerobic activity that builds muscle rather than stamina. Practice for 20 minutes 5 times per week.
  • Yoga; dynamic sun salutation, bellows breath, twists, backward bends, cobra, bow, locust.

Trikatu, triphala, turmeric, fenugreek and guggul

Triphala (Terminalia chebula, Terminala belerica & Emblica officinalis)
Triphala (Terminalia chebula, Terminala belerica and Emblica officinalis)

For weight loss these herbs help to increase metabolism, clear excess fluids, reduce fat, regulate digestion and aid the body in its natural elimination of excess wastes. They can also be used to reduce cholesterol and prevent clogging of the arteries.

  • Guggul, turmeric and fenugreek to clear excess weight. Guggul literally ‘scrapes’ excess fat deposits from the body.
  • Trikatu stimulates the digestive tissues. The black pepper in this blend of ginger and long pepper contains chromium forming part of Glucose tolerance factor (GTF) essential for normalising blood sugar levels and food cravings.
  • Triphala clears toxins, regulates the liver and stimulates bowel movements.

Gymnema, guduchi, amla, turmeric, fenugreek, triphala, neem and black pepper

These herbs balance blood sugar levels, increase insulin resistance and can help manage diabetes. They can also reduce sugar cravings and help with weight management programmes.

Triphala, rhubarb root, psyllium seed, linseed, liquorice and fennel

These herbs act as a combination of purgative and bulk laxatives to help eliminate accumulated waste and toxic congestion.

Trikatu formula (Long pepper, ginger, black pepper)

Trikatu can be used as part of a weight loss regime to increase metabolism, digest fats and balance appetite. It is traditionally taken with honey. It will correct digestive sluggishness.

Effects of Sweetness Perception and Caloric Value of a Preload on Short Term Intake (BRALA, P.M. AND R. L. HAGEN. Effects of sweetness perception and caloric value of a preload on short term intake. PHYSIOL BEHAV 30(1) 1—9, 1983).

To determine the effects of calories and sweetness perception on intake, fasted normal weight subjects drank a preload sweetened with sucrose (1.1 g/kg) or L-asparthyl-L-phenylalanyl-methyl ester (Aspartame, 0.011 g/kg), or with no added sweetener.

Sweetness perception of the load was reduced in half of the subjects by oral application of Gymnema sylvestre extracts. One hour after the preload, a meal of snack foods was presented and amounts of nutrients eaten were calculated. Subjects whose perception of sweetness had been decreased for the preload ate less total and sweet calories than did those with normal perception. Calories did not affect intake. The effect of calories and perception of the load was also assessed on variables presumed to correlate with satiety.

Sucrose pleasantness ratings were not related to calories, perception or intake. Subjects’ estimates of the amount of milkshake that they would drink if given the opportunity to do so and hunger ratings were related to overall intake and carbohydrate intake, respectively. The findings indicate that hedonistic aspects of taste are of greater importance than calories in determining short term intake.

GUGULIPID: A natural cholesterol-lowering agent (Urizar NL, Moore DD. Annual Review of Nutrition. 2003;23:303-13. Epub 2003 Feb 26).

The resin of the Commiphora mukul tree has been used in Ayurvedic medicine for more than 2000 years to treat a variety of ailments. Studies in both animal models and humans have shown that this resin, termed gum guggul, can decrease elevated lipid levels. The stereoisomers E- and Z-guggulsterone have been identified as the active agents in this resin. Recent studies have shown that these compounds are antagonist ligands for the bile acid receptor farnesoid X receptor (FXR), which is an important regulator of cholesterol homeostasis. It is likely that this effect accounts for the hypolipidemic activity of these phytosteroids.

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The joys of being a vegetarian https://www.herbalreality.com/health-lifestyle/mobility-fitness/joys-being-vegetarian/ https://www.herbalreality.com/health-lifestyle/mobility-fitness/joys-being-vegetarian/#comments Fri, 29 Oct 2021 15:21:08 +0000 https://www.herbalreality.com/?p=2413 The vegetarian world is a colourful, nutritious and exciting place; perhaps more than you might think. Read on to discover more.

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The vegetarian world is a colourful, nutritious and exciting place; perhaps more than you might think. Read on to discover more.

Although not for everyone, the vegetarian world is a colourful, nutritious and exciting place; perhaps more than you might think. Read on to discover more.

I love being vegetarian. It tastes good, makes me feel good and helps me feel a part of a caring world. Its in my blood. My grandparents were pacifist vegetarian Quakers.

My Mum had a brief relapse which meant I did too but then, after visiting India and living in America for a while I fell back within the fold. I am not saying it is the right choice for everyone but secretly believe it is. In my early days of recently converted over-zealous youthful enthusiasm I verged on the side of extremist. I even asked my most red-blooded Alpha male friend to not cook bacon in his own house. Not a good move! I am more accepting now. A bit…

When I am asked why am I vegetarian I say ‘for every reason that there is to be’; environmental, moral, health, financial, spiritual and (now I know how to cook) because it’s so utterly delicious.

The joys of being a vegetarian

Environmentally vegetarianism is more sustainable Its that simple. The livestock industry is one of the largest contributors to environmental damage. It takes 7 Kg of grain to produce 1 Kg of red meat and 2 Kg grain to produce 1Kg of poultry. One quarter of the earth’s surface is now pastureland to support livestock.  

¾ of all grains and beans grown in the US are destined for animal feed which would feed 800million people. The livestock industry uses 50% of all US water resources. These easily could be used to satisfy humans nutritional needs.

It is estimated that 50% of the world’s rainforests have been cleared to support livestock for the meat industry. And 70% of the world’s fish populations are threatened by over fishing.  The livestock industry (meat, dairy, poultry, fisheries) contributes towards 17% of greenhouse gases (Transportation is 13.5%).

All these figures means that it takes ten times more resources to get our nutrition from meat as from grains. Whilst not an absolute answer to the earth’s environmental problems (as modern farming techniques as a whole need to be addressed) becoming a vegetarian is THE single most influential impact that an individual can have on the environment.

Changing your diet blood sugar stabilising foods

I don’t think that being a vegetarian makes you ‘absolutely’ a better or more moral person, but I do think it makes you relatively better. I mean, why would we kill another animal when we can get plenty of nutrition from plants? Of course, if you think we are superior to other animals then maybe that is your answer. Why would we impose such fear and pain on another animal if we don’t have to?

If you have ever visited a battery chicken farm or seen cattle slaughtered at an abattoir you will know what I mean. However hard they try all meat eaters end up eating this sort of mass processed meat because that is what is generally available in restaurants. Fortunately I have chosen to be vegetarian.  I don’t live in the Khalahari desert and ‘need’ animal flesh to support me and my family. I live in the UK where vegetarian options are plentiful.

It’s about a choice. The very nature of our existence means that we kill all the time; washing our hands destroys millions of bacteria, driving a car kills lots of insects, digging the earth kills lots of worms. So to live we must kill. But to live consciously we do not need necessarily have to eat another being. It’s a balance.

For me, this is the intention. To try and live a life that causes no other beings intentional pain. This is the yogic attitude known as ahmsa  or non-violence. Of course I trip up. Ask my calm but chicken loving-wife about my occasional lapse of sense of humour. But in essence the intention of vegetarianism induces a moral code by which I can attempt to live.

The health reasons to be vegetarian are legendary. Of course, it is about what is appropriate for each individual but generally speaking vegetarians suffer less heart disease, diabetes, cancer (breast, bowel, prostate, pancreatic), hypertension, gall bladder problems, obesity and osteoporosis than non-vegetarians.

Vegetarians also make less visits to their GPs and spend less time in hospital (about 22% less than the meat eater). Sounds like a good opportunity for a tax break and an insurance premium! Although it is very easy to eat an ‘unhealthy’ vegetarian diet of white bread, loads of cheese and processed foods. You can still be a meat eater and include high levels of these healthy foods (in fact I would recommend it).

Eating a healthy vegetarian diet means that you comply with the government recommended levels of fruit, vegetable, whole grain, fibre and low saturated fat consumption. These volumes of vegetarian foods also contain a high amount of various ‘super-nutrients’ such as protective anti-oxidants, healing phytochemicals and essential micronutrients.

Ayurveda considers that different foods have different qualities that effect the make-up of our mind and body. You are what you eat and all that. Ayurveda divides all of nature into three qualities called sattva, rajas and tamas. Sattva  refers to qualities of balance, equality, stability. It is light and luminous and holds the capacity for happiness. It is conscious and intelligent, moving inwards and upwards.

Think Gandhi, Mother Teresa, sunrise, hugs and meditation. Rajas generates activity, change and disturbance. It is mobile and excitable. It is the motivator and expressor. It has a centrifugal force causing dispersion and disintegration. Think Led Zeppelin, volcanoes, arguing and Saturday night in the pub.

Tamas is the immobile, still and stuck quality. It is heavy and causes obstruction or lack of perception. It moves down and is responsible for degeneration. Through the force of tamas there is delusion and confusion. Think  being lazy, night time, hangovers and Boxing day.

Generally speaking vegetables, fruits, nuts, grains and milk (organic) are considered to be sattvic and increase awareness, meat is considered to be rajasic and increasing the passions and processed foods are considered to be tamasic.

There are a few good reasons not to be vegetarian. Anyone who is undernourished or recovering from a debilitating illness is a candidate for a bit of chicken soup. New mums often need a bit of extra protein. If you do eat meat keep the portions low to about 30g a couple of times a week and insist on organic.

Indian culture has been associated with vegetarianism (Hinduism, Buddhism and Jainsim all support vegetarianism) from antiquity and it was prevalent in Greece around 6th century BCE. The rise of Christianity wiped vegetarianism from Europe and its green shoots did not reemerge with significance until the 19th century.  From the traditional medical point of view Ayurveda is primarily but not wholly vegetarian. Ayurveda is a science in pursuit of health. It is not a moralistic system, although morality does creep into its practices.

If someone’s health can benefit from the properties of eating some animal meat, then this is recommended. Ayurveda would understand that there is some karma, or effect, from using animal products, but argues that the health of the individual is paramount. That being said it does recommend a primarily vegetarian diet that is easy to digest. In accordance with Ayurvedic principles it would also encourage an awareness of one’s actions and there is little doubt that the massive impact of the meat industry on the environment, economy and health of society would influence the opinion of the original propounders of Ayurveda.

Any vegetarian who has visited a Chinese medicine practitioner will know what they think. Chinese medicine likes people to eat meat to build the strength of the blood, qi and tissues. Whilst it can help some people regain certain aspects of health when needed it reveals Chinese medicine’s interest in the quantitative approach (how much one is getting) versus Ayurveda’s qualitative (the essence of what one gets) approach to health.

I have seen too many unhealthy vegetarians in my clinic. It is essential for vegetarians to eat an especially healthy diet and supplement their diet with super tonics. This takes a fair bit of effort; soaking, boiling and kneading….but its fun and has results. You MUST eat lots of whole grains, pulses and nuts. Include seaweeds and herbs in your diet.

Ginger, turmeric and coriander are essentials. In both India and China it is a tradition to make herbal decoctions and boil rice and vegetables in them. Try making teas of astragalus and boiling rice in this, add goji berries to porridge, mix amla berries into soups.

Definitely take chywanaprash which is a super herbal tonic jam. Where appropriate, use rejuvenating herbs such as ashwagandha, shatavari, Aloe vera juice and the ginsengs. Make sure you are getting the correct balance of healthy oils, especially Omega-3 to Omega-6s (it should be a 1:2 proportion). Vegetarian sources of Omega-3 do not convert to DHA and EPA very well and so keep your levels of hemp and flax seed high. Ayurveda recommends taking ghee (clarified butter) with food (2 tsp/day) to nourish the tissues. I would recommend supplementing with a wholefood multi-vitamin as well.

Ingredients

  • 100g rice pudding rice (You can also try with black or red rice)
  • 1 I litre of cow’s, almond, coconut or rice milk
  • 3 tbs almond powder
  • 7 strands of saffron
  • 5 cardamom pods
  • Rose jam or water
  • Ghee, hemp seed or honey, optional

How to make a nourishing vegetarian breakfast

  • Place the rice in a heavy pan and add the milk. Bring to boil and simmer for 1 hour. Add the almond powder. Add more milk as desired. (coconut milk is an interesting change).
  • Soak the strands of saffron in a tablespoon of milk for 10 minutes to extract its golden pigment and then add to rice pudding. Add cardamom and rose jam.  Serve and add ghee or honey as desired.
  • You can also add grated carrots or beetroots to this recipe for a colourful and nourishing variation. Also try with roasted walnuts, hazelnuts or raisins or goji berries.

This is a very nourishing food for strengthening the tissues and building deep strength.

At the very heart of being a vegetarian is its spiritual quality. Spiritual in the sense of connecting with that part of life that honours all beings as being an expression of the unconditional love that we all are.

Spiritual in the sense of slightly removing oneself from the material world to a more contemplative place where you can reflect on who you are and what you are doing here. Spiritual in distinction to material flesh. I am sure that many enlightened yogis have eaten meat so lets not get too high and mighty about this ‘spiritualism of vegetarians’ but some of us need all the help we can get! If you want it to be vegetarianism can be a part of your spiritual practice.

Blessings to you all. Blessings to the plants. Blessings to the animals. Blessings to the earth.

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